A mathematical proof shows that some quantum states can resist nature’s tendency to disorder – but only under very specific conditions

Title: Newborns' Immune Systems Ramp Up After Birth
Category: Health News
Created: 8/24/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

The analysis of extractables and leachables and subsequent risk assessment is an important aspect of the determination of biocompatibility for many medical devices. Leachable chemicals have the potential to pose a toxicological risk to patients, and therefore it is required that they be adequately characterized and assessed for potential safety concerns. One important consideration in the assessment of leachables is the choice of a suitable simulating solvent intended to replicate the use condition for the device and its biological environment. This aspect of study design is especially difficult for blood-contacting medical devices due to the complexity of simulating the biological matrix. This publication reports a comparison of the extracting power of different binary solvent mixtures and saline in comparison with whole blood for a bloodline tubing set connected to a hemodialyzer. Ten different known extractables, spanning a range of physicochemical properties and molecular weights, were quantified. The results indicated that for low-molecular-weight analytes, a suitable exaggeration for whole blood can be obtained using a low-concentration ethanol/water mixture (20%), and in general, extracted quantity increases with the concentration of alcohol cosolvent. For polyvinylpyrrolidone, the opposite trend was observed, as solubility of the polymer was found to decrease with increasing alcohol concentration, resulting in lower extracted quantities at high alcohol concentrations. Analysis of ethanol/water concentrations in the extract solutions post extraction indicated no change in solvent composition.

Drug–drug interaction (DDI) assessment of therapeutic peptides is an evolving area. The industry generally follows DDI guidelines for small molecules, but the translation of data generated with commonly used in vitro systems to in vivo is sparse. In the current study, we investigated the ability of advanced human hepatocyte in vitro systems, namely HepatoPac, spheroids, and Liver-on-a-chip, to assess potential changes in regulation of CYP1A2, CYP2B6, CYP3A4, SLCO1B1, and ABCC2 in the presence of selected therapeutic peptides, proteins, and small molecules. The peptide NN1177, a glucagon and GLP-1 receptor co-agonist, did not suppress mRNA expression or activity of CYP1A2, CYP2B6, and CYP3A4 in HepatoPac, spheroids, or Liver-on-a-chip; these findings were in contrast to the data obtained in sandwich cultured hepatocytes. No effect of NN1177 on SLCO1B1 and ABCC2 mRNA was observed in any of the complex systems. The induction magnitude differed across the systems (e.g., rifampicin induction of CYP3A4 mRNA ranged from 2.8-fold in spheroids to 81.2-fold in Liver-on-a-chip). Small molecules, obeticholic acid and abemaciclib, showed varying responses in HepatoPac, spheroids, and Liver-on-a-chip, indicating a need for EC₅₀ determinations to fully assess translatability data. HepatoPac, the most extensively investigated in this study (3 donors), showed high potential to investigate DDIs associated with CYP regulation by therapeutic peptides. Spheroids and Liver-on-a-chip were only assessed in one hepatocyte donor and further evaluations are required to confirm their potential. This study establishes an excellent foundation toward the establishment of more clinically-relevant in vitro tools for evaluation of potential DDIs with therapeutic peptides.

Stroll on down to Uncle Capcom's garage, girls and boys, because it's time to meddle with a cat's voicebox, ride a combat peacock and meticulously injure a vast, blubbery teddybear. By which I mean, the Monster Hunter Wilds beta is now live on Steam through to 4th November at 2.59am GMT. That's 2.59am sharp. If you're hurrying along at 3am on Monday absolutely desperate to polish the aesthetics of a small enslaved catperson, you can sod off and play Dragon Age: The Veilguard instead.

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Combining two neural networks has helped researchers predict potentially disastrous collapses in complex systems, such as financial crashes or power blackouts

In an interview with IT World Canada, consulting giant Deloitte highlighted the importance of an ecosystem-based approach to tackle issues around digital equity in Canada and service delivery challenges in the public sector. “Our strong view is that the people of Canada benefit when there’s effective collaboration between public and private organizations, including on critical […]

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Here’s how four different health systems are partnering with Microsoft to save time for clinicians.

The post How 4 Health Systems Are Partnering with Microsoft appeared first on MedCity News.

May 24, 2024

Quantum computers are probably coming—and when they arrive, they will, most likely, be able to break our standard public-key cryptography algorithms.

The New Bank Systems & Technology

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Power washing is made even easier with POWERflow+ Technology by Briggs & Stratton. This pressure washer allows you to do deep cleaning, remove mold and mildew and reach second stories.

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The post Healthy ecosystems are the key to productive agriculture first appeared on International Water Management Institute (IWMI).

2nd February 2014 – Colombo, Sri Lanka Agriculture and wetlands should be managed in unison in order to conserve vital ecosystems and support the livelihoods of millions of people, according to a new report published to coincide with World Wetlands Day, today. Download the full media release Download the report

The post Millions affected, billions at stake: Scientists urge ‘wiser’ use of wetlands to tackle poverty and conserve ecosystems first appeared on International Water Management Institute (IWMI).

Creating the food systems that people want & need across Central Asia will depend in part on how water is managed under climate uncertainty.

The post Innovations and smart water technologies key to food systems transformation in Central Asia first appeared on International Water Management Institute (IWMI).

The Food Systems Summit Global Dialogue; Water – the Game-changer for Food Systems has concluded with consensus that water has unmatched utility to support the necessary transformation of food systems.

The post Ahead of UN Summit consensus that action on water critical to transforming food systems first appeared on International Water Management Institute (IWMI).

IWMI will implement the Innovation Lab for Irrigation & Mechanization Systems, funded by USAID and led by University of Nebraska.

The post IWMI part of global, five-year program to build sustainable food systems first appeared on International Water Management Institute (IWMI).

The 'Resilience' project, implemented by IWMI, aims to enhance the adoption of efficient micro irrigation systems, including sprinklers and drip irrigation, among smallholder farmers in the Indian states of Odisha and Assam.

The post Save Water Save Money — Farmers In Odisha & Assam Benefit From Micro Irrigation Systems first appeared on International Water Management Institute (IWMI).

medlinkArtificial intelligence/medlink (AI) can help reduce unexpected deaths in hospitals by accurately identifying patients at high risk of health

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Nikhil Kulkarni's work exemplifies metallurgy's crucial role in creating a sustainable future for the steel industry and construction sector.

Suckmal Kommidi's research demonstrates how integrating LLMs with HPC systems can revolutionize scientific computing

Announcement Number: SE-18-EI-00844-DE
Closing Date: 13 November 2018

Announcement Number: SE-18-EI-00844-MP
Closing Date: 13 November 2018

Ransomware attacks are a growing threat in the digital world. These attacks can cripple businesses and individuals alike. Understanding how to avoid them is crucial for tech enthusiasts. This article explores advanced tips to safeguard your systems from ransomware. Ransomware encrypts

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Milltek introduces new exhaust systems for Toyota Landcruiser, Tacoma, Dodge RAM 1500, Ford F150, and Bronco to enhance sound and performance.

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Wilcox, Merrie-Ellen, author