The FLIR Brickstream 3D+ sensor is vulnerable to unauthenticated config download and file disclosure vulnerability when calling the ExportConfig REST API (getConfigExportFile.cgi). This will enable the attacker to disclose sensitive information and help her in authentication bypass, privilege escalation and/or full system access.

Commercial property owners with existing energy storage systems, or owners considering implementing an energy storage system, may be able to benefit from a recent order by the Massachusetts Department of Public Utilities (DPU) allowing utility companies to pay customers who agree to rely upon their energy storage systems and dispatch the energy during peak events.

Walmart Inc. sued Tesla Inc., claiming it failed to live up to industry standards in the installation of solar panels on top of hundreds of stores, resulting in multiple fires across the U.S.

Building solar and wind energy projects on potentially contaminated lands can be a golden opportunity, both effective and cost-effective, for developers. The 120-acre Reilly Tar & Chemical Corporation Superfund site was recently redeveloped with a utility-scale solar farm and is a prime example of the reuse potential inherent in thousands of Superfund sites, brownfields, retired power plants, and landfills.

The fact that approximately 74 percent of Europe’s population are city-dwellers is a testament to how people have been drawn to cities throughout history. Whether for a lack of job opportunities in rural areas or possibilities for a better lifestyle, unfortunately the unprecedented speed and scale of urbanization does put tremendous pressure on a city’s resources, often resulting in detrimental environmental impacts.

This week the University of Nevada, Reno announced two discoveries in the Great Basin by the Nevada Bureau of Mines and Geology using a previously untried method for finding unknown, hidden geothermal resources.

Commercial property owners with existing energy storage systems, or owners considering implementing an energy storage system, may be able to benefit from a recent order by the Massachusetts Department of Public Utilities (DPU) allowing utility companies to pay customers who agree to rely upon their energy storage systems and dispatch the energy during peak events.

UK company BAE Systems has been selected as preferred tenderer for the SEA 5000 program to deliver the Australian Government’s nine Future Frigates for the Royal Australian Navy.

Commercial property owners with existing energy storage systems, or owners considering implementing an energy storage system, may be able to benefit from a recent order by the Massachusetts Department of Public Utilities (DPU) allowing utility companies to pay customers who agree to rely upon their energy storage systems and dispatch the energy during peak events.

Presentation by George Milad of Uyemura International Corporation

Building solar and wind energy projects on potentially contaminated lands can be a golden opportunity, both effective and cost-effective, for developers. The 120-acre Reilly Tar & Chemical Corporation Superfund site was recently redeveloped with a utility-scale solar farm and is a prime example of the reuse potential inherent in thousands of Superfund sites, brownfields, retired power plants, and landfills.

When Ballarat-based Gekko Systems heard the local medical community was worried about access to ventilators needed to respond to the COVID-19 crisis, the company sprang into action.

As the FCA publishes new information on financial crime expectations for firms’ systems and controls during the coronavirus crisis, Ruth Paley and Hayley Astles of Eversheds Sutherland take a look at the key points for regulated firms to note....

The U.S. is pulling two Patriot missile batteries and some fighter aircraft out of Saudi Arabia, an American official said on May 7, amid tensions between the kingdom and the Trump administration over oil production.

WHO has warned that Africa could be become the next epicentre of the pandemic.

The Pentagon is set to pull Patriot missile defense systems from Saudi Arabia amid internal pressure to transfer military assets to counter China.

The idea that rural water schemes are only sustainable if small, simple and locally managed is a bias that must be overcome to get more clean water to the people who need it.

Microchip’s Low-Power Radiation-Tolerant (RT) PolarFire FPGA Enables High-Bandwidth Space Systems with Lower Total System Cost

Protect Against Rootkit and Bootkit Malware in Systems that Boot from External SPI Flash Memory

This week we’re very fortunate to speak with Rayner Saggers. Rayner is a Senior Systems Engineer on the F-35 Program at BAE Systems in the UK. That’s already pretty cool, but in addition to that, he’s a pillar of the MATLAB community at BAE Systems. He is the editor of... read more >>

Financial sector development can play a crucial role in driving economic growth.

This publication presents an overview of the Water Efficiency Improvement in Drought-Affected Provinces (WEIDAP) Project that aims to apply cost-effective technology for irrigation modernization and agricultural development in Viet Nam.

Financial sector development can play a crucial role in driving economic growth.

CES 2019, LAS VEGAS – JANUARY 7, 2019 – HARMAN Professional Solutions, the global leader in audio, video, lighting and control systems, today announced new AKG DMS100 and DMS300 professional digital wireless systems.

DEARBORN, MI – The Lincoln Motor Company announced an exclusive 10-year collaboration with Revel® that will add the premium loudspeaker brand to Lincoln vehicles. The pairing will make Lincoln the only automotive brand to offer Revel audio systems.

The most detailed ever look at Earth's prehistoric climate suggests many habitats changed in the past 800,000 years – and this may be why we evolved big brains

CES 2019, LAS VEGAS – JANUARY 7, 2019 – Today’s discerning audio consumer is seeking sophisticated design and innovative technology that seamlessly blends with their daily lives. When it comes to a multi-room speaker system that means: ease of use, form...

ABSTRACT

Bacterial flagella are rotating nanomachines required for motility. Flagellar gene expression and protein secretion are coordinated for efficient flagellar biogenesis. Polar flagellates, unlike peritrichous bacteria, commonly order flagellar rod and hook gene transcription as a separate step after production of the MS ring, C ring, and flagellar type III secretion system (fT3SS) core proteins that form a competent fT3SS. Conserved regulatory mechanisms in diverse polar flagellates to create this polar flagellar transcriptional program have not been thoroughly assimilated. Using in silico and genetic analyses and our previous findings in Campylobacter jejuni as a foundation, we observed a large subset of Gram-negative bacteria with the FlhF/FlhG regulatory system for polar flagellation to possess flagellum-associated two-component signal transduction systems (TCSs). We present data supporting a general theme in polar flagellates whereby MS ring, rotor, and fT3SS proteins contribute to a regulatory checkpoint during polar flagellar biogenesis. We demonstrate that Vibrio cholerae and Pseudomonas aeruginosa require the formation of this regulatory checkpoint for the TCSs to directly activate subsequent rod and hook gene transcription, which are hallmarks of the polar flagellar transcriptional program. By reprogramming transcription in V. cholerae to more closely follow the peritrichous flagellar transcriptional program, we discovered a link between the polar flagellar transcription program and the activity of FlhF/FlhG flagellar biogenesis regulators in which the transcriptional program allows polar flagellates to continue to produce flagella for motility when FlhF or FlhG activity may be altered. Our findings integrate flagellar transcriptional and biogenesis regulatory processes involved in polar flagellation in many species.

IMPORTANCE Relative to peritrichous bacteria, polar flagellates possess regulatory systems that order flagellar gene transcription differently and produce flagella in specific numbers only at poles. How transcriptional and flagellar biogenesis regulatory systems are interlinked to promote the correct synthesis of polar flagella in diverse species has largely been unexplored. We found evidence for many Gram-negative polar flagellates encoding two-component signal transduction systems with activity linked to the formation of flagellar type III secretion systems to enable production of flagellar rod and hook proteins at a discrete, subsequent stage during flagellar assembly. This polar flagellar transcriptional program assists, in some manner, the FlhF/FlhG flagellar biogenesis regulatory system, which forms specific flagellation patterns in polar flagellates in maintaining flagellation and motility when activity of FlhF or FlhG might be altered. Our work provides insight into the multiple regulatory processes required for polar flagellation.

ABSTRACT

The recent discovery of complete ammonia oxidizers (comammox) contradicts the paradigm that chemolithoautotrophic nitrification is always catalyzed by two different microorganisms. However, our knowledge of the survival strategies of comammox in complex ecosystems, such as full-scale wastewater treatment plants (WWTPs), remains limited. Analyses of genomes and in situ transcriptomes of four comammox organisms from two full-scale WWTPs revealed that comammox were active and showed a surprisingly high metabolic versatility. A gene cluster for the utilization of urea and a gene encoding cyanase suggest that comammox may use diverse organic nitrogen compounds in addition to free ammonia as the substrates. The comammox organisms also encoded the genomic potential for multiple alternative energy metabolisms, including respiration with hydrogen, formate, and sulfite as electron donors. Pathways for the biosynthesis and degradation of polyphosphate, glycogen, and polyhydroxyalkanoates as intracellular storage compounds likely help comammox survive unfavorable conditions and facilitate switches between lifestyles in fluctuating environments. One of the comammox strains acquired from the anaerobic tank encoded and transcribed genes involved in homoacetate fermentation or in the utilization of exogenous acetate, both pathways being unexpected in a nitrifying bacterium. Surprisingly, this strain also encoded a respiratory nitrate reductase which has not yet been found in any other Nitrospira genome and might confer a selective advantage to this strain over other Nitrospira strains in anoxic conditions.

IMPORTANCE The discovery of comammox in the genus Nitrospira changes our perception of nitrification. However, genomes of comammox organisms have not been acquired from full-scale WWTPs, and very little is known about their survival strategies and potential metabolisms in complex wastewater treatment systems. Here, four comammox metagenome-assembled genomes and metatranscriptomic data sets were retrieved from two full-scale WWTPs. Their impressive and—among nitrifiers—unsurpassed ecophysiological versatility could make comammox Nitrospira an interesting target for optimizing nitrification in current and future bioreactor configurations.

Pathway proteomics strategies measure protein expression changes in specific cellular processes that carry out related functions. Using targeted tandem mass tags-based sample multiplexing, hundreds of proteins can be quantified across 10 or more samples simultaneously. To facilitate these highly complex experiments, we introduce a strategy that provides complete control over...

The development of pastoralism transformed human diets and societies in grasslands worldwide. The long-term success of cattle herding in Africa has been sustained by dynamic food systems, consumption of a broad range of primary and secondary livestock products, and the evolution of lactase persistence (LP), which allows digestion of lactose...

The delicate necklace of threaded petals from the tomb of Rameses II, midnineteenth century glass houses built for the newly discovered Victoria amazonica, and Monet’s giant canvases in the Musée de l'Orangerie all testify to a deep human attraction to water lilies: beguiling plants with showy flowers that seem to...

Behavioral flexibility is important in a changing environment. Previous research suggests that systems consolidation, a long-term poststorage process that alters memory traces, may reduce behavioral flexibility. However, exactly how systems consolidation affects flexibility is unknown. Here, we tested how systems consolidation affects: (1) flexibility in response to value changes and (2) flexibility in response to changes in the optimal sequence of actions. Mice were trained to obtain food rewards in a Y-maze by switching nose pokes between three arms. During initial training, all arms were rewarded and mice simply had to switch arms in order to maximize rewards. Then, after either a 1 or 28 d delay, we either devalued one arm, or we reinforced a specific sequence of pokes. We found that after a 1 d delay mice adapted relatively easily to the changes. In contrast, mice given a 28 d delay struggled to adapt, especially for changes to the optimal sequence of actions. Immediate early gene imaging suggested that the 28 d mice were less reliant on their hippocampus and more reliant on their medial prefrontal cortex. These data suggest that systems consolidation reduces behavioral flexibility, particularly for changes to the optimal sequence of actions.

Technology in bioanalysis, -omics, and computation have evolved over the past half century to allow for comprehensive assessments of the molecular to whole body pharmacology of diverse corticosteroids. Such studies have advanced pharmacokinetic and pharmacodynamic (PK/PD) concepts and models that often generalize across various classes of drugs. These models encompass the "pillars" of pharmacology, namely PK and target drug exposure, the mass-law interactions of drugs with receptors/targets, and the consequent turnover and homeostatic control of genes, biomarkers, physiologic responses, and disease symptoms. Pharmacokinetic methodology utilizes noncompartmental, compartmental, reversible, physiologic [full physiologically based pharmacokinetic (PBPK) and minimal PBPK], and target-mediated drug disposition models using a growing array of pharmacometric considerations and software. Basic PK/PD models have emerged (simple direct, biophase, slow receptor binding, indirect response, irreversible, turnover with inactivation, and transduction models) that place emphasis on parsimony, are mechanistic in nature, and serve as highly useful "top-down" methods of quantitating the actions of diverse drugs. These are often components of more complex quantitative systems pharmacology (QSP) models that explain the array of responses to various drugs, including corticosteroids. Progressively deeper mechanistic appreciation of PBPK, drug-target interactions, and systems physiology from the molecular (genomic, proteomic, metabolomic) to cellular to whole body levels provides the foundation for enhanced PK/PD to comprehensive QSP models. Our research based on cell, animal, clinical, and theoretical studies with corticosteroids have provided ideas and quantitative methods that have broadly advanced the fields of PK/PD and QSP modeling and illustrates the transition toward a global, systems understanding of actions of diverse drugs.

The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis in the human body. The combination of distinct, yet interrelated, molecular functions across different cell types make the delineation of factors associated with loss or decline in kidney function challenging. Consequently, there has been a paucity of new diagnostic markers and treatment options becoming available to clinicians and patients in managing kidney diseases. A systems biology approach to understanding the kidney leverages recent advances in computational technology and methods to integrate diverse sets of data. It has the potential to unravel the interplay of multiple genes, proteins, and molecular mechanisms that drive key functions in kidney health and disease. The emergence of large, detailed, multilevel biologic and clinical data from national databases, cohort studies, and trials now provide the critical pieces needed for meaningful application of systems biology approaches in nephrology. The purpose of this review is to provide an overview of the current state in the evolution of the field. Recent successes of systems biology to identify targeted therapies linked to mechanistic biomarkers in the kidney are described to emphasize the relevance to clinical care and the outlook for improving outcomes for patients with kidney diseases.

Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with specific molecular functions, the study used prior knowledge to filter de novo variants from 2,881 probands with sporadic severe CHD. This approach enabled the authors to identify an association between left ventricular outflow tract obstruction lesions and genes associated with the WAVE2 complex and regulation of small GTPase-mediated signal transduction. Using CRISPR zebrafish knockdowns, the study confirmed that WAVE2 complex proteins brk1, nckap1, and wasf2 and the regulators of small GTPase signaling cul3a and racgap1 are critical to cardiac development.

Germline alterations of the tumor suppressor PTEN have been extensively characterized in patients with PTEN hamartoma tumor syndromes, encompassing subsets of Cowden syndrome, Bannayan–Riley–Ruvalcaba syndrome, Proteus and Proteus-like syndromes, as well as autism spectrum disorder. Studies have shown an increase in the risk of developing specific cancer types in the presence of a germline PTEN mutation. Furthermore, outside of the familial setting, somatic variants of PTEN occur in numerous malignancies. Here we introduce and discuss the prospect of moving toward a systems pathology approach for PTEN diagnostics, incorporating clinical and molecular pathology data with the goal of improving the clinical management of patients with a PTEN mutation. Detection of a germline PTEN mutation can inform cancer surveillance and in the case of somatic mutation, have value in predicting disease course. Given that PTEN functions in the PI3K/AKT/mTOR pathway, identification of a PTEN mutation may highlight new therapeutic opportunities and/or inform therapeutic choices.

A startup led by robotics veterans is announcing a pre-seed funding round with participation from Amazon's Alexa Fund and iRobot Ventures

Multiwavelength observations from the NASA/ESA Hubble Space Telescope and Gemini Observatory combined with close-up views from NASA’s Juno spacecraft reveal that lightning strikes and huge storm systems that create them in Jupiter’s atmosphere are formed in and around large convective cells over deep clouds of water ice and liquid; the observations also confirm that dark [...]

For the first time, researchers have succeeded in creating strong coupling between quantum systems over a greater distance. They accomplished this with a novel method in which a laser loop connects the systems, enabling nearly lossless exchange of information and strong interaction between them. The physicists reported that the new method opens up new possibilities in quantum networks and quantum sensor technology.

In many fish species body size plays an important role in sexual selection. Large individuals are preferred mating partners because they can enhance offspring survival by providing better quality resources than small individuals. While large females and males are often favored by sexual selection, fishing targets and removes these reproductively superior individuals.

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