The Free Press founder urges Jewish leaders to confront rising antisemitism and embrace resilience in her powerful DC speech.

Christian Tiambo has always wished to uplift local farmers’ communities through cutting-edge science. As climate change wreaked havoc on local agriculture, Tiambo, a livestock scientist at the Centre for Tropical Livestock Genetics and Health (CTLGH) and at the International Livestock Research Institute (ILRI), focused on conserving and developing livestock that could withstand environmental stress. Genomics, […]

Tyrannosaurus Rex of London's Natural History Museum, a model like no other

to write a horror story yahoo answers

The graft involved in trying to bring the peregrine falcon, Hawaiian crow and California condor back from the brink in the US makes for compelling reading in Feather Trails by Sophie Osborn

From birds and bats to horses and great apes, Bill Schutt's seriously fun history of teeth, Bite, explains their role in both shaping evolution and our understanding of it

Remote sensing, including lidar, reveals that the Amazon was once home to millions of people. The emerging picture of how they lived challenges ideas of human cultural evolution

The Kikai-Akahoya eruption of an underwater volcano off the coast of Japan ejected enough material to fill Lake Tahoe twice, three times as much as the eruption of Mount Tambora in 1815

The dynamics of how plants and animals change Earth is central to this last book in a trilogy by Other Minds author and "scuba-diving philosopher" Peter Godfrey-Smith

Remote sensing, including lidar, reveals that the Amazon was once home to millions of people. The emerging picture of how they lived challenges ideas of human cultural evolution

A young boy who lived towards the end of the last glacial period had dark skin, blue eyes and a congenital heart condition, a study of his genome reveals

Title: Family History of Mental Illness Ups Odds for Postpartum Depression
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM

BACKGROUND AND PURPOSE:

Neuronal ceroid lipofuscinoses are a group of neurodegenerative disorders. Recently, enzyme replacement therapy (ERT) was approved for neuronal ceroid lipofuscinosis type 2 (CLN2), a subtype of neuronal ceroid lipofuscinoses. The aim of this study was to quantify brain volume loss in CLN2 disease in patients on ERT in comparison with a natural history cohort using MRI.

MATERIALS AND METHODS:

Nineteen (14 female, 5 male) patients with CLN2 disease at 1 UK center were studied using serial 3D T1-weighted MRI (follow-up time, 1–9 years). Brain segmentation was performed using FreeSurfer. Volume measurements for supratentorial gray and white matter, deep gray matter (basal ganglia/thalami), the lateral ventricles, and cerebellar gray and white matter were recorded. The volume change with time was analyzed using a linear mixed-effects model excluding scans before treatment onset. Comparison was made with a published natural history cohort of 12 patients (8 female, 4 male), which was re-analyzed using the same method.

RESULTS:

Brain volume loss of all segmented brain regions was much slower in treated patients compared with the natural history cohort. For example, supratentorial gray matter volume in treated patients decreased by a mean of 3% (SD, 0.74%) (P < .001) annually compared with an annual volume loss of a mean of 16.8% (SD, 1.5%) (P < .001) in the natural history cohort.

CONCLUSIONS:

Our treatment cohort showed a significantly slower rate of brain parenchymal volume loss compared with a natural history cohort in several anatomic regions. Our results complement prior clinical data that found a positive response to ERT. We demonstrate that automated MRI volumetry is a sensitive tool to monitor treatment response in children with CLN2 disease.

Cassian's on a new mission to steal a familiar ship in the next season of his self-titled Star Wars show.

Liam Payne was seemingly having a “lovely day in Argentina” just hours before his death on Wednesday, according to what appear to be a series of final posts made to his Snapchat account.

The former One Direction member was found dead in the courtyard of a Buenos Aires hotel, having apparently plunged 13 to 14 meters from his balcony, according to local police. A cause of death has not officially been determined, and it was unclear whether the fall was accidental or intentional.

On his Snapchat Story, however, it would have appeared to any fan that Payne was having a relaxing vacation. In since-deleted posts in the hours before his death, he posted a front-facing video in which he told followers, “It’s a lovely day here in Argentina. This is the breakfast table. Just enjoying coffee and breakfast even though it’s 1 p.m.”

Read more at The Daily Beast.

Some days, I wonder if every word written before a trailer is actually superfluous. It’s a visual medium, after all. What can a description achieve save to clumsily gesture at the true shape of something; a dog-eared tour brochure for a thrilling weekend spelunking in Plato’s cave? I can usually shake this feeling, but gory zombie action game Showa American Story is my breaking point. There is nothing I can impart about this thing that will not be conveyed better by allowing its new trailer to wash over you like a tide of sheer videogame. Here’s it:

Read more

Put your hand up if you'd forgotten that every Assassin's Creed game is, strictly speaking, set in the present day. I know I had. That's not the actual distant past you're parkouring through. That isn't actual Renaissance architecture you're clambering on. It's a holographic Animus simulation, conjured from ancestral memories flash-frozen within your DNA - convenient, inasmuch as it means that any inconsistencies are your DNA's fault, not Ubisoft's. If the ledge-mantling animations are glitchy, that's simply because you have bad genes.

We can both be forgiven for losing sight of Assassin's Creed's modern day narrative frame. Ubisoft themselves have downplayed it since the era of Desmond Miles, the watery Peter Parker figure who served as puppetmaster protagonist for AC games up to Assassin's Creed 3. In Assassin's Creed Shadows, however, they're planning to bring back the modern day setting in a big way, though details are scanty.

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After nearly a year of public beta honing, the Nvidia App – Team Green’s new one-stop shop for desktop GPU management – is out in full. Not alongside the upcoming RTX 50 series, as rumoured, but right-now-today-this-minute. I’ve been testing out the launch version and while it’s not without some dud features, it does agreeably achieve its stated goal of combining the functions within Nvidia Control Panel and GeForce Experience. And if installing it means never having to use the latter again, well, that’s 149MB well spent.

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Cyborg: A documentary tells the intriguing story of Neil Harbisson, who wears an antenna to “hear” colour, but it is lacking in depth and should have probed its subject more, says Simon Ings

The finale doesn’t look to provide a definitive answer to what drove Aaron’s actions, much to the show’s credit.

Unknown host Charlie Stone analyzes Trump's unprecedented victory with Obama Homeland Security Secretary, Jeh Johnson

As we share our truths and witness each other's, we build unity and community.

This is a sponsored article brought to you by BESydney.

In July 2024, Sydney woman Katherine Bennell-Pegg made history as the first astronaut to graduate under the Australian flag and the first female astronaut in Australia. Her journey, marked by determination and discipline, showcases Australia’s growing prominence in space exploration and research.

From her academic achievements at the University of Sydney (USYD) to her rigorous training at the European Space Agency (ESA), Bennell-Pegg’s success has paved a path forward for aspiring space and aerospace professionals in Australia and globally.

A journey to the stars begins in Sydney

Katherine Bennell-Pegg was born in Sydney, New South Wales, and grew up in the Northern Beaches area. Her fascination with space began at an early age.

“I always dreamed of being an astronaut,” Bennell-Pegg shared in her “Insights from an Australian Astronaut” Space Forum Speech in July 2024. “When I was young, it was for the adventure, but after more than a decade working in space, it’s now because I know the role it plays in tackling real-world problems and developing new knowledge that can benefit our society, environment and science.”

Sydney: A Hub for Space Innovation

Sydney, the vibrant heart of the state of New South Wales (NSW), stands at the forefront of aerospace innovation in Australia. With its world-class research facilities, leading academic institutions and strategic geographic positioning, Sydney is not only Australia’s gateway to the Indo-Pacific but also a burgeoning hub for international aerospace endeavours.

NSW is home to more than 40 per cent of Australia’s aerospace industry. Substantial investments from both the state and federal governments support this concentration of capabilities, underpinning Sydney’s role as a leader in aerospace. From advanced manufacturing and cybersecurity to quantum technologies and space exploration, this progressive city is truly thriving.

Sydney’s appeal as a desirable location for hosting aerospace conferences and business events is bolstered by its comprehensive infrastructure, vibrant startup community and strategic position as a transport hub.

Sydney’s track record of successfully hosting events highlights the city’s ability to organise impactful international gatherings, including:

• Australian Space Summit
• New Horizons Summit
• CubeSatPlus2024 - NEW SPACE: Unbounded Skies

Sydney will also host the 76th International Astronautical Congress from 29 September to 3 October 2025 and the 34th Congress of the International Council for the Aeronautical Sciences (ICAS) to be held 13 to 17 September 2026. Both will take place at ICC Sydney, further solidifying Sydney’s status as a central hub for aerospace events.

Would you like to know more about Sydney’s credentials in Aerospace? Download our Aerospace eBook or visit besydney.com.au

Sydney proved to be the ideal location for Bennell-Pegg’s journey to begin. She studied at the University of Sydney, where she earned a Bachelor of Engineering (Honors) in Aeronautical Engineering (Space) and a Bachelor of Science (Advanced) in Physics.

Sydney’s universities are at the forefront of aerospace education and research. Institutions such as the University of Sydney (USYD), the University of New South Wales (UNSW Sydney) and the University of Technology Sydney (UTS) attract students from around the world. UNSW Sydney, with its School of Aerospace, Mechanical, and Mechatronic Engineering, is renowned for its innovative research in space technology and satellite systems, while UTS provides cutting-edge programs in aerospace engineering and physics, emphasizing practical applications and industry partnerships. USYD excels in aeronautical engineering and space science, supported by advanced facilities and strong ties to major aerospace organisations. Together, these universities offer comprehensive programs that integrate theoretical knowledge with hands-on experience, preparing students for dynamic careers in the rapidly evolving aerospace and space sectors.

Having excelled in her studies at USYD, Bennell-Pegg was awarded the Charles Kuller Graduation Prize for her top-placed undergraduate thesis. Subsequently, her quest for knowledge took her to Europe, where she earned two Master of Science degrees: one in Astronautics and Space Engineering from Cranfield University and another in Space Technology from Luleå University of Technology.

Reflecting on her educational path, Bennell-Pegg stated, “With the encouragement of my parents, I researched what it would take to become an astronaut and worked hard at school, participating in everything from aerobatic flying lessons to amateur astronomy.”

Inside the rigorous training regimen of an astronaut

Bennell-Pegg’s professional career began with roles at Airbus UK, where she contributed to numerous space missions and concept studies, such as Martian in-situ resource utilisation and space debris removal. Her expertise led her to the Australian Space Agency, where she became the Director of Space Technology.

In 2021, Bennell-Pegg was invited by the European Space Agency (ESA) to undertake Basic Astronaut Training at the European Astronaut Centre in Germany. When the ESA application opened in 2021, it was the first opening in 15 years. Bennell-Pegg jumped at the opportunity to apply alongside over 22,000 others from 22 countries. She endured six knock-out rounds, including medical, psychometrics, psychology and technical tests and made it to the group of 25 who passed.

This historic invitation marked the first time an international astronaut candidate was offered training by the ESA.

“The training was demanding, but it was also an incredible opportunity to learn from some of the best minds in the field and to be part of a team that is pushing the boundaries of human exploration.”—Katherine Bennell-Pegg

Bennell-Pegg’s training regimen was intense, encompassing physical conditioning, complex simulations, and theoretical classes designed to prepare candidates for long-duration missions to the International Space Station (ISS) and beyond. This included:

• Studies in biology, astronomy, earth sciences, meteorology, materials, medical and fluids, both in theory and in labs.
• Radiation research – an area of expertise for Australia. This will increase as humans travel back to the Moon.
• Medical operations: Astronauts need to be able to perform medical procedures on themselves and others.
• Training for expeditions: This included honing team dynamics through behavioral training, ocean and winter survival training, rescue and firefighting.

Sharing her thoughts on this transformative experience, Bennell-Pegg said, “The training was demanding, but it was also an incredible opportunity to learn from some of the best minds in the field and to be part of a team that is pushing the boundaries of human exploration.”

In April 2024, Bennell-Pegg completed her training, graduating with her ESA classmates from “The Hoppers” group. Upon graduation, she became fully qualified for assignments on long-duration missions to the ISS, making her the first Australian female astronaut and the first person to train as an astronaut under the Australian flag.

“I want to use this experience to open doors for Australian scientists and engineers to utilize space for their discoveries,” Bennell-Pegg said. “I hope to inspire the pursuit of STEM careers and show all Australians that they too can reach for the stars.”

Elevating Australia’s role in space exploration

Katherine Bennell-Pegg’s achievements represent a significant milestone. Her journey from the University of Sydney to the rigorous training programs at the European Astronaut Centre showcases the potential of Australian talent in the global space community.

“Being the first astronaut trained under the Australian flag is an incredible honor,” Bennell-Pegg said. “I’m grateful for the support that has fueled me through intense training and opened doors for more Australians in space exploration. Whether I fly or not, there is much to accomplish here on Earth. I’m excited to leverage this experience to inspire future generations in STEM and elevate Australia’s presence in the global space community. Becoming an astronaut is just the beginning.”

Bennell-Pegg’s dream to become an Australian astronaut is more than just a personal triumph; it is a win for anyone who aspires to a career in space or aerospace. Sydney, with its world-class educational institutions, advanced manufacturing facilities scheduled for the Western Sydney Aerotropolis and expanding opportunities in aerospace and defence, is an ideal starting point for anyone looking to make their mark in these sectors.

Would you like to know more about Sydney’s credentials in Aerospace? Download our Aerospace eBook or visit besydney.com.au

Harris has made history multiple times over.

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New NatGeo documentary was directed by the same duo who brought us the Oscar-winning Free Solo.

On “The Alex Marlow Show” on Tuesday, Breitbart Editor-in-Chief and host Alex Marlow mocked Ivy League schools like Yale for degrading themselves with things like Yale’s Beyoncé course. Marlow said, “Yale University’s going to offer a Beyoncé makes history course in 2025. So, that’s what they’re doing. We’re just kicking butt and taking names and then they’re — they’ve got a new Beyoncé course over at Yale. Do the Ivy Leagues know that they degrade themselves and debase themselves? I love it. Because, as people have been pointing out, there’s no surer sign of people moving to the left than…when they go to college. That’s where it’s at. That is the fountain of leftism in our society…the universities. … And, not to mention, they infect our cities.” “The Alex Marlow Show,” hosted by Breitbart Editor-in-Chief Alex Marlow, is a weekday podcast produced by Breitbart News and Salem Podcast Network. You can subscribe to the podcast on YouTube, Rumble, Apple Podcasts, and Spotify. Follow Breitbart.tv on Twitter @BreitbartVideo

The post Alex Marlow: Yale Embarrasses Itself with Woke ‘Beyonce Makes History’ Course appeared first on Breitbart.

At Anime NYC this weekend, Aniplex USA shared more details for its upcoming 3D action RPG Alterna Vvelt: Blue Exorcist …

Continue reading "3D Action RPG ‘Alterna Vvelt: Blue Exorcist Another Story’ From Aniplex Gets a New Trailer Ahead of Its Launch on Mobile and PC"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 26th, 2024. In today’s article, we get the week …

Continue reading "SwitchArcade Round-Up: ‘Fragrant Story & Papaya’s Path’, Plus Today’s Other Releases and Sales"

Combining DNA analysis, archeological techniques, and historical records overturns some assumptions of the people of Pompeii.

Go beneath the waves and back in time to explore the incredible story of the German attack on Bell Island. In 1942, four merchant ships were sunk by Hitler’s U-boats, coming to a final rest on the ocean floor. Now, we’ve teamed up with historians and divers to take you on an underwater tour of the shipwrecks.

Los Angeles CA (SPX) Nov 05, 2024
Imagining a vast ice sheet sprawling over Canada and extending down into what is now the northern United States, reaching as far south as Pennsylvania, Ohio, Indiana, Michigan, and Wisconsin, helps us grasp the scope of ancient glacial coverage between 19,000 and 26,000 years ago. Yet, while picturing this immense ice mass is fascinating, the present-day implications of its retreat - parti

As people gather to remember those who fought and died to protect this country in past wars, a new poll suggests many Canadians know little about their country's history.

On this date 349 years ago, Samuel Pepys relates in his famous diary a remarkable story about an upcoming medical experiment. As far as I can tell, this is the first written description of a paid research subject.

According to his account, the man (who he describes as “a little frantic”) was to be paid to undergo a blood transfusion from a sheep. It was hypothesized that the blood of this calm and docile animal would help to calm the man.

Some interesting things to note about this experiment:

• Equipoise. There is explicit disagreement about what effect the experimental treatment will have: according to Pepys, "some think it may have a good effect upon him as a frantic man by cooling his blood, others that it will not have any effect at all".
• Results published. An account of the experiment was published just two weeks later in the journal Philosophical Transactions. 
• Medical Privacy. In this subsequent write-up, the research subject is identified as Arthur Coga, a former Cambridge divinity student. According to at least one account, being publicly identified had a bad effect on Coga, as people who had heard of him allegedly succeeded in getting him to spend his stipend on drink (though no sources are provided to confirm this story).
• Patient Reported Outcome. Coga was apparently chosen because, although mentally ill, he was still considered educated enough to give an accurate description of the treatment effect. 

Depending on your perspective, this may also be a very early account of the placebo effect, or a classic case of ignoring the patient’s experience. Because even though his report was positive, the clinicians remained skeptical. From the journal article:

The Man after this operation, as well as in it, found himself very well, and hath given in his own Narrative under his own hand, enlarging more upon the benefit, he thinks, he hath received by it, than we think fit to own as yet.

…and in fact, a subsequent diary entry from Pepys mentions meeting Coga, with similarly mixed impressions: “he finds himself much better since, and as a new man, but he is cracked a little in his head”.

The amount Coga was paid for his participation? Twenty shillings – at the time, that was exactly one Guinea.

[Image credit: Wellcome Images]

My first editor, Rukun Advani, once described himself as ‘a composite hybrid of the Indian and the Anglo-European’, who sought to reconcile ‘within himself those varying cultural influences which chauvinistic nationalists could only see as contradictions.’ This self-characterization I might avow as my own. One mark of the Anglo-European in me is that, unlike members [...]

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Michael Jones - #NMClientStory

Lee and Lucille Allen share the story of how their Clayton Home changed their lives.

Joining Forces Event at Fort Leonard Wood, MO

The Park Family�s Infertility Story

Trust is critical, especially for a person with autism and their family. Meet the Vollmert family and get a sense of how they approach daily life and planning for a financially secure future with their autistic son, Scott. Learn more: http://u.nm.com/1AQBAsN

A Technology Development Story: meet the SYNERGY� Stent System engineers