The student newspaper at duPont Manual High School in Louisville, Ky., first reported on the state's problematic police training material.

Low-intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for noninvasive brain stimulation (NIBS). TUS delivered in a theta (5 Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30–60 min, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity; depotentiation is the reversal of long-term potentiation (LTP) by a subsequent protocol with no effect alone. Metaplasticity can enhance plasticity induction and clinical efficacy of NIBS protocols. In our study, we compared four NIBS protocol combinations to investigate metaplasticity on tbTUS in humans of either sex. We delivered four interventions: (1) sham continuous theta burst stimulation with 150 pulses (cTBS150) followed by real tbTUS (tbTUS only), (2) real cTBS150 followed by sham tbTUS (cTBS only), (3) real cTBS150 followed by real tbTUS (metaplasticity), and (4) real tbTUS followed by real cTBS150 (depotentiation). We measured motor-evoked potential amplitude, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation (ICF), and short-interval intracortical facilitation before and up to 90 min after plasticity intervention. Plasticity effects lasted at least 60 min longer when tbTUS was primed with cTBS150 compared with tbTUS alone. Plasticity was abolished when cTBS150 was delivered after tbTUS. cTBS150 alone had no significant effect. No changes in M1 intracortical circuits were observed. Plasticity induction by tbTUS can be modified in manners consistent with homeostatic metaplasticity and depotentiation. This substantiates evidence that tbTUS induces LTP-like processes and suggests that metaplasticity can be harnessed in the therapeutic development of TUS.

Forensic anthropologist Doug Owsley discusses the skeletal specimens in a new exhibit at the Natural History Museum (Meredith Bragg). Read more at: https://www.smithsonianmag.com/smithsonian-institution/meet-the-scientist-who-reads-bones-40315000/

Renaissance paintings, medieval archives, cloistered orchards—how one Italian scientist is uncovering secrets that could help combat a growing agricultural crisis

RCMP are investigating after officers discovered human remains in an abandoned, burned vehicle in Greenhill, N.S.

Elections Nova Scotia is investigating PC candidate Susan Corkum-Greek's campaign to determine whether it broke the law by handing out gift cards on Saturday outside a Tim Hortons in Lunenburg, N.S. 

Saskatchewan's Serious Incident Response Team (SIRT) is investigating the role the Moose Jaw Police Service played in a crash that killed a 31-year-old man.

The president of the Canadian Japanese Cultural Centre of Hamilton is Mitchell Akira Kawasaki — an Olympian, judo master, on-call mail carrier and recent recipient of an award from the Japanese government.

A 43-year-old man is dead after being shot by police at a west-end Hamilton apartment building Saturday, in an incident which also sent an officer to hospital, Ontario's police watchdog says. 

Details remain scarce surrounding the death of a Canada Border Services Agency (CBSA) officer at the Ambassador Bridge on Saturday. The border authority and union said an employee died by suicide while on the job on the Windsor, Ont., side of the border. 

Ontario Provincial Police (OPP) have released dashcam footage of a crash that sent two people to hospital in life-threatening condition, linked to an ongoing investigation into rocks being thrown at moving vehicles in the GTA.

Design that Matters wins for contribution to humanity in education category

The Penn State DuBois Office of Student Engagement will welcome students and members of the public to Hiller Auditorium on Thursday, Oct. 17, when paranormal investigator John Zaffis visits campus.

A New Castle County grand jury has indicted a New Castle woman for 53 felonies following the alleged murder of an infant and the abuse of four other children at a Bear daycare facility. Dejoynay Ferguson, 20, is alleged to have suffocated a 4-month-old child to death and to have abused that child and four other children between July […]

Police seek information on suspect Prosecutors have secured the indictment of Justin Michael Chaffier in a February 2021 killing. Chaffier, 35, is charged with Murder First Degree and Stalking following a New Castle County police investigation into the murder of Nicole Crawford. “Nobody should ever have to know the pain that the Crawford family is […]

Attorney General Jennings today joined a nationwide investigation into Meta Platforms, Inc., formerly known as Facebook, for providing and promoting its social media platform – Instagram – to children and young adults despite knowing that such use is associated with physical and mental health harms. Attorneys General across the country are examining whether the company […]

Attorney General Kathleen Jennings announced today that the Delaware Department of Justice Consumer Protection Unit is investigating tech sales bootcamp Prehired and its CEO, Joshua Jordan. The investigation began in March, after Prehired filed nearly 300 debt-collection lawsuits in the Delaware Justice of the Peace Court seeking to enforce its income share agreements. Prehired started […]

Manila, Philippines — Former Philippine President Rodrigo Duterte said the International Criminal Court (ICC) should 'hurry up' with its probe of his war on drugs, remaining firm in his defense of the brutal campaign as he said the investigation should start immediately. "I'm asking the ICC to hurry up, and if possible, they can come here and start the investigation tomorrow," Duterte said in a congressional inquiry on his war on drugs. "If I am found guilty, I will go to prison." According to police data, more than 6,200 people died in anti-drug operations under Duterte's presidency, during which police typically said they had killed suspects in self-defense. Human rights groups believe the real toll to be far greater, with thousands more users and small-time peddlers killed in mysterious circumstances by unknown assailants. "I assume full responsibility for whatever happened in the actions taken by law enforcement agencies of this country to... stop the serious problem of drugs affecting our people," said Duterte, who served as president from 2016 to 2022. The ICC last year cleared the way for an investigation into the several thousand deaths and other suspected rights abuses. The Philippines withdrew from the ICC in March 2019. Appeals judges at the ICC subsequently ruled prosecutors still had jurisdiction over the alleged crimes because they occurred when the Philippines was an ICC member.

Financial Investigative Reporting and Mentorship Initiative

Information manipulation and misinformation are not new phenomena, but they have taken on exaggerated importance, especially with the massive use of social media. Hostile and stigmatizing narratives against civil society and civic activism, whether intentional or not, especially when propagated by authorities, create undue restrictions and hinder the exercise of the rights to freedom of […]

“While the investigation takes place, the town will refrain from any additional comment on this matter," according to a press release.

What is it like to be a dog? And what can we learn from them? Mark Rowlands's take, in his book The Happiness of Dogs, is full of insights, finds Abigail Beall

Title: VA Hospital Delays Didn't Cause Deaths, Investigators Say
Category: Health News
Created: 8/26/2014 12:35:00 PM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: CDC Investigating E. coli Outbreak in Ohio, Michigan
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

The role of gastrin-releasing peptide receptor (GRPR) in various diseases, including cancer, has been extensively studied and has emerged as a promising therapeutic target. In this study, we successfully achieved the use of [²¹²Pb]Pb-DOTAM-GRPR1, comprising the α-particle generator, ²¹²Pb, combined with a GRPR-targeting peptide, GRPR1, in a prostate cancer model. Methods: Pharmacokinetics, toxicity, radiation dosimetry, and efficacy were assessed in GRPR-positive prostate tumor–bearing mice after intravenous administration of [²¹²Pb]Pb-DOTAM-GRPR1 (where DOTAM is 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane). Results: Preclinical studies have shown tumor targeting of up to 5 percent injected dose per gram over 24 h, and optimization of the drug formulation and quantity has led to minimized oxidation and off-target binding, respectively. Particularly, an increase in peptide amount from 28 to 280 ng was shown to reduce off-target uptake, especially at the level of the pancreas, by about 30%. Furthermore, dosimetry studies confirmed the kidney as the dose-limiting organ, and toxicity studies revealed that a nontoxic dose of up to 1,665 kBq could be injected into mice. Efficacy studies indicated a median survival time of 9 wk in the control group, which received only a buffer solution, compared with 19 wk in the group that received 4 injections of 370 kBq at 3-wk intervals. Conclusion: Taken together, these combined data demonstrate the safety, tolerability, and efficacy of [²¹²Pb]Pb-DOTAM-GRPR1, thus warranting further exploration in clinical trials.

Chris takes his horse in for an oil change. Kelley droplifts bootleg amiibos at Target. Josh fantasizes about Nopon Tom Cruise.

The post RPG Cast – Episode 641: “It’s a Vestigial Wheel” appeared first on RPGamer.

The European Space Agency's Hera spacecraft must be thoroughly tested before being sent to investigate the aftermath of the collision of NASA's DART probe with Dimorphos

AI tools could help eliminate human bias in forensic investigations, say UCL scientists, who are using eye-tracking technology to study decision-making in skeletal analysis and crime scene examinations

The Competition Bureau has announced that it has expanded its investigation into Google’s online ad practices. This is the first major update to the investigation since it began in 2020, and a year later the competition watchdog obtained a court order from the Federal Courts of Appeal, requiring Google to produce records and written information […]

Greater Manchester Police launched a public appeal to help find Jane Burton on Tuesday morning but have paused the search after a body was found

DNA methylation is one of several epigenetic mechanisms crucial for regulating gene expression in eukaryotic organisms.

The post Scientists Investigate Inner Workings of DNA Methylation in Plants appeared first on Sci.News: Breaking Science News.

An investigation into a Salmonella outbreak in Sweden has been restarted after more people fell sick. From August to October, 81 people from 18 regions contracted Salmonella Typhimurium with sequence type (ST) 36. Where information about the country of infection is available, all cases were infected in Sweden. Folkhälsomyndigheten (the Public... Continue Reading

The Centers for Disease Control and Prevention typically coordinates between 17 and 36 investigations of foodborne illnesses involving multiple states each week.  A report is posted weekly, but does not include any information about where the outbreaks are occurring, what foods are involved, or how many patients have been identified.... Continue Reading

Montana public health officials are investigating an outbreak of infections caused by Salmonella. The Cascade City-County Health Department in Great Falls is reporting that six students at Sacajawea and Valley View elementary schools have tested positive for the pathogen. A staff member at another school has also tested positive. There... Continue Reading

More than 20 people are believed to have died in one South African province after consuming food from local shops. Gauteng Premier Panyaza Lesufi said the majority of deaths have been children aged between six and nine. “The first uniform approach across the province was to adopt a mechanism of... Continue Reading

Solar storms have the ability to harm astronauts and force massive blackouts

Tamannaah Bhatia, Avinash Tiwary and Rajiv Mehta play three unlikely suspects in director Neeraj Pandey’s latest

Bev Priestman is out as head coach of the Canadian women's soccer team in the wake of an independent report into the Olympic drone-spying scandal.

Among Us (Free) has done loads of crossovers and collaborations over the years, but one I didn’t expect at all …

Continue reading "‘Among Us’ Is Collaborating With ‘Ace Attorney Investigations’ for Its Newest Free Cosmetic DLC Out Next Week"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for September 4th, 2024. The long summer has more or less …

Continue reading "SwitchArcade Round-Up: Reviews Featuring ‘Ace Attorney Investigations Collection’, Plus New Releases and Sales"

Canada’s privacy commissioner has launched an investigation into the World Anti-Doping Agency (WADA) and “its handling of biological samples collected from athletes.”

Canada's intelligence agency amassed a sizable file on Abousfian Abdelrazik's suspected terrorism ties in the early 2000s, although the validity of that intelligence was called into question during the Montreal man's Federal Court case.