En este programa analizamos la llegada de Hernán Darío Gómez al Atlético Bucaramanga. También dialogamos con el presidente del equipo santandereano.

Caracol Radio conoció en exclusiva que, los magistrados del Consejo Nacional Electoral, encontraron pruebas contundentes que los llevarían a radicar el proyecto de resolución en el que formulan cargos al presidente Gustavo Petro, a su gerente de campaña, Ricardo Roa, y a los auditores de la campaña.

Víctor Eduardo Muñoz, abogado defensor de Omar Hernández respondió en 6AM a las declaraciones de Gustavo Petro, y aseguró que el presidente debe respetar la autonomía judicial.

La Procuraduría los investigará por presuntas irregularidades en la revocatoria de la concesión del muelle 13 de Buenaventura

El tribunal lo señaló al trasladar a la Comisión de Acusación una demanda a la campaña de Gustavo Petro. Define así las competencias del Congreso y del Consejo Electoral

El tribunal lo señaló al trasladar a la Comisión de Acusación una demanda a la campaña de Gustavo Petro. Define así las competencias del Congreso y del Consejo Electoral.

Luis Eduardo López Rosero, el dueño de la empresa Impoamericana Roger, contratista de los carrotanques de la Guajira, intentó atentar contra su vida.

El principio de oportunidad de Omar Hernández, uno de los involucrados en el escándalo de Daily Cop, está cerca de concretarse.

En Caracol Radio estuvo Paula Bernal, country manager (Gerente) de IATA en Colombia

El viceministro de la Conectividad habló en 6AM y aseguró que no hubo ninguna duplicidad en la firma del contrato.

El magistrado del Consejo Nacional Electoral, Álvaro Hernán Prada, tuvo que sacar a su esposa, y a sus cuatro hijos, del país por amenazas contra su integridad.

En 6AM de Caracol Radio, estuvo Fernando García, director de Migración Colombia, quien habló sobre qué hay detrás de su renuncia a la dirección de Migración Colombia.

THE ICAC is investigating planning decisions taken by the former Canterbury Council after investigators raided Campsie council offices last week.

The Denver district attorney has launched an investigation into how a spreadsheet of voting system passwords ended up on the Colorado secretary of state's website earlier this year.

A recent spate of Xcel power outages across metro Denver has prompted the Colorado Public Utilities Commission to consider opening an investigation.

"Hundreds of voting machine passwords were accidentally released but what exactly was Secretary of State Jena Griswold doing to address the security breach?" -- The Denver Post Editorial Board

The listed phone number for Wyatts rings to Elite Towing. An operator who answered the phone on Tuesday said “Wyatts Towing no longer exists.”

The owners of several dilapidated apartment buildings in Aurora and Denver have faced a new threat: an investigation by the Colorado Attorney General's Office.

Video of the shocking incident went viral.

Police reportedly applied pressure to his neck.

Today marks the seventh anniversary of the murder of Patrick Dill — who was fatally shot in Pembroke in 2016 — and the police are renewing their appeal for anyone with any information to please come forward. A police spokesperson said, “Today is the seventh year anniversary of the murder of Patrick Dill. Mr. Dill […]

Police received reports of “multiple gunshots heard in the area of West Park Lane, Pembroke,” units were dispatched to the location to carry out checks and it “was reported that a bullet was found inside a residence in the area of Ingham Vale, Pembroke.” A police spokesperson said, “Around 11:10 pm on Tuesday, March 19th, […]

Police are investigating an “attempted shooting” in Devonshire that took place shortly after 10.30am this morning [April 26], confirming that “the complainant was seated inside a vehicle at the time” and “thankfully, they escaped without injury.” A police spokesperson said, “Police are investigating a confirmed attempted shooting which took place in the area of Alexandra Road, […]

Police received reports of “multiple gunshots heard in the Parson’s Roads, Pembroke” area and officers were able to confirm that “a firearm was discharged based on forensic evidence recovered.” A police spokesperson said, “Shortly after 11:00 p.m. on Sunday, April 28th, 2024, police received reports of multiple gunshots heard in the Parson’s Roads, Pembroke, area. […]

“Between 2021 and the present, five people have been convicted and monies seized following investigations into suspected money laundering offences,” the police said. A police spokesperson said, “Investigations by the Bermuda Police Service [BPS] Financial Crime Unit into acts of money laundering have led to a number of convictions and resulted in the seizure of […]

The police said they are “aware of a video clip currently circulating on social media purporting to show two persons engaging in sexual activity in public at Cup Match,” and said they are looking into the matter, and reminded the public “that offenses under the telecommunications act are committed even when only sharing material such […]

Police responded to a report of a robbery at Food Hub on Angle Street, stating that “one of the suspects entered the premises and apparently brandished a firearm to the female staff member.” A police spokesperson said, “Around 6:40pm Monday, 4th December 2023, police responded to a report of a robbery which occurred at the Food Hub […]

The police have renewed their appeal for information about the murder of Jahkoby Smith in 2017. A police spokesperson said, “Around 7:15pm on Saturday 29th July, 2017, Jahkoby Smith, was fatally stabbed after he was involved in an altercation that took place at the West End Sailboat Club, Sandys. At that time, there was a wake […]

THE SECURITY STATE HAS EXISTED SINCE THE END OF WORLD WAR II. THEY'VE BEEN OPERATING IN SECRET AND WITH NO DEMOCRATIC ACCOUNTABILITY FOR EIGHT OR NINE DECADES NOW. DWIGHT EISENHOWER WHEN HE LEFT OFFICE WARNED THE COUNTRY ABOUT THE DANGERS THAT THEY POSE. Continue reading →

1. Man die slapende dakloze in Rotterdam ernstig verwondde met steen mogelijk aangehouden in Franse stad Toulon  VRT.be
2. Man die zware tegel op hoofd van slapende dakloze gooide mogelijk gearresteerd in Frankrijk  Het Laatste Nieuws
3. Verdachte (32) van aanval met betonblok op slapende dakloze in Rotterdam opgepakt in Franse stad Toulon  Het Nieuwsblad
4. Poging moord op slapende, dakloze man  Opsporing Verzocht
5. Arrestatie in Frankrijk na dood dakloze, link met Rotterdamse zaak onderzocht  NOS

Four Princeton researchers won major awards from the National Institutes of Health to support their blue-sky research.

The Football Association launches its own investigation into the video that appears to show Premier League referee David Coote using foul language to describe former Liverpool boss Jurgen Klopp.

The following article, ‘Blatant Weaponization’: FEMA Facing Investigations For Targeting Suffering Trump Supporters, was first published on Conservative Firing Line.

Republicans are calling for investigations, or are already launching their own, into charges that the federal government deliberately and willfully discriminated against supporters of President-elect Donald Trump following a hurricane disaster in Florida. It was the Daily Wire that initially documented how Marn’I Washington, a Federal Emergency Management Agency supervisor, instructed employees under her authority …

Continue reading ‘Blatant Weaponization’: FEMA Facing Investigations For Targeting Suffering Trump Supporters ...

Staphylococcus aureus adhesion to the host's skin and mucosae enables asymptomatic colonization and the establishment of infection. This process is facilitated by cell wall-anchored adhesins that bind to host ligands. Therapeutics targeting this process could provide significant clinical benefits; however, the development of anti-adhesives requires an in-depth knowledge of adhesion-associated factors and an assay amenable to high-throughput applications. Here, we describe the development of a sensitive and robust whole cell assay to enable the large-scale profiling of S. aureus adhesion to host ligands. To validate the assay, and to gain insight into cellular factors contributing to adhesion, we profiled a sequence-defined S. aureus transposon mutant library, identifying mutants with attenuated adhesion to human-derived fibronectin, keratin, and fibrinogen. Our screening approach was validated by the identification of known adhesion-related proteins, such as the housekeeping sortase responsible for covalently linking adhesins to the cell wall. In addition, we also identified genetic loci that could represent undescribed anti-adhesive targets. To compare and contrast the genetic requirements of adhesion to each host ligand, we generated a S. aureus Genetic Adhesion Network, which identified a core gene set involved in adhesion to all three host ligands, and unique genetic signatures. In summary, this assay will enable high-throughput chemical screens to identify anti-adhesives and our findings provide insight into the target space of such an approach.

Lipoprotein (a) [Lp(a)] is a well-known risk factor for cardiovascular disease, but analysis on Lp(a) and renal dysfunction is scarce. We aimed to investigate prospectively the association of serum Lp(a) with the risk of reduced renal function, and further investigated whether diabetic or hypertensive status modified such association. Six thousand two hundred and fifty-seven Chinese adults aged ≤40 years and free of reduced renal function at baseline were included in the study. Reduced renal function was defined as estimated glomerular filtration rate <60 ml/min/1.73 m². During a mean follow-up of 4.4 years, 158 participants developed reduced renal function. Each one-unit increase in log₁₀-Lp(a) (milligrams per deciliter) was associated with a 1.99-fold (95% CI 1.15–3.43) increased risk of incident reduced renal function; the multivariable-adjusted odds ratio (OR) for the highest tertile of Lp(a) was 1.61 (95% CI 1.03–2.52) compared with the lowest tertile (P for trend = 0.03). The stratified analysis showed the association of serum Lp(a) and incident reduced renal function was more prominent in participants with prevalent diabetes [OR 4.04, 95% CI (1.42–11.54)] or hypertension [OR 2.18, 95% CI (1.22–3.89)]. A stronger association was observed in the group with diabetes and high Lp(a) (>25 mg/dl), indicating a combined effect of diabetes and high Lp(a) on the reduced renal function risk. An elevated Lp(a) level was independently associated with risk of incident reduced renal function, especially in diabetic or hypertensive patients.

In eukaryotic DNA replication, DNA polymerase ε (Polε) is responsible for leading strand synthesis, whereas DNA polymerases α and δ synthesize the lagging strand. The human Polε (hPolε) holoenzyme is comprised of the catalytic p261 subunit and the noncatalytic p59, p17, and p12 small subunits. So far, the contribution of the noncatalytic subunits to hPolε function is not well understood. Using pre-steady-state kinetic methods, we established a minimal kinetic mechanism for DNA polymerization and editing catalyzed by the hPolε holoenzyme. Compared with the 140-kDa N-terminal catalytic fragment of p261 (p261N), which we kinetically characterized in our earlier studies, the presence of the p261 C-terminal domain (p261C) and the three small subunits increased the DNA binding affinity and the base substitution fidelity. Although the small subunits enhanced correct nucleotide incorporation efficiency, there was a wide range of rate constants when incorporating a correct nucleotide over a single-base mismatch. Surprisingly, the 3'→5' exonuclease activity of the hPolε holoenzyme was significantly slower than that of p261N when editing both matched and mismatched DNA substrates. This suggests that the presence of p261C and the three small subunits regulates the 3'→5' exonuclease activity of the hPolε holoenzyme. Together, the 3'→5' exonuclease activity and the variable mismatch extension activity modulate the overall fidelity of the hPolε holoenzyme by up to 3 orders of magnitude. Thus, the presence of p261C and the three noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit and makes the hPolε holoenzyme an efficient and faithful replicative DNA polymerase.

President-elect Donald Trump wants legal authorities to investigate what he said were possibly illegal rumors he is going to sell his majority stock stake in Trump Media. He claims he won't sell.

The U.S. Army is investigating the suspected suicides of three soldiers based at New York's Fort Drum.

Researchers have a clearer picture than ever before of how common conditions that involve aggressive behavior emerge and how treatment can help