Stress, fluid flow, and motion analysis lend credence to company's designs for Boeing, Airbus, and other major aerospace companies

Will provide Naloxone kits and training at Seaford event Insurance Commissioner Trinidad Navarro, the Town of Seaford, and Aquila Behavioral Health of Delaware have joined forces to deliver life-saving overdose reversal medication to residents on July 27 from 4:00 to 6:00PM at Williams Pond Park. Free opioid rescue kits provided by the Division of Public […]

Commissioner Navarro to provide Naloxone kits and training at event Insurance Commissioner Trinidad Navarro, in collaboration with Public Health’s Kent County Community Response Team, the First Presbyterian Church of Smyrna, and the Smyrna-Clayton Ministerium will provide free training and opioid rescue kits to residents on Wednesday, October 14 from 2:00 to 5:00PM. The event, taking […]

Anushka Sharma and Virat Kohli seemed to have a good South Indian meal at the restaurant. Anushka also reposted the restaurants post ionher Instagram Stories

The video of dosa served with aloo masala and tomato chutney has clocked 5.7 million views

Recommendations include housing, trauma training, expanding recovery resources in the criminal justice system The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its second annual report to Governor John Carney and the General Assembly. The 18-page report, released Tuesday, details five policy recommendations based on its review of a sample of 130 overdose fatalities […]

Recommendations include a whole-person approach to substance use disorder treatment and broadened non-opioid options for chronic pain treatment  The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its second annual report to Governor John Carney and the General Assembly, announced Attorney General Kathy Jennings. The report examines a sample of 108 cases from fatal overdoses that occurred […]

Governor John Carney has ordered the Delaware state flag at State facilities be lowered to half staff on Monday, August 31 in observance of Overdose Awareness Day. The Governor’s order only applies to State facilities, however local governments, businesses and Delawareans flying the Delaware state flag are encouraged to participate as well. The Delaware state […]

Governor Carney has ordered the Delaware flag to be lowered to half-staff on Tuesday, August 31, 2021, in recognition of International Overdose Awareness Day, as declared through his signing of SJR4. We encourage local governments, businesses and Delawareans to do the same to promote awareness of overdose prevention and acknowledge all who have suffered the […]

Flag Lowering for International Overdose Awareness Day Governor Carney has ordered the Delaware flag to be lowered to half-staff on Wednesday, August 31, 2022, from sunrise to sunset, in recognition of International Overdose Awareness Day, as declared by Senate Joint Resolution 6. We encourage local governments, businesses and Delawareans to do the same to promote […]

Governor John Carney has ordered the Delaware flag to be lowered to half-staff at all state facilities on Thursday, August 31, 2023, from sunrise to sunset, in recognition of International Overdose Awareness Day, as declared by Senate Joint Resolution 2.

La agencia también lanza una campaña de marketing para animar a las personas con discapacidades y a las personas mayores a vacunarse WILMINGTON (14 de Diciembre de 2021) – El Departamento de Salud y Servicios Sociales (DHSS) lanzó hoy un número gratuito para que los habitantes de Delaware soliciten vacunas de COVID-19 para personas mayores […]

DOVER, DE (March 15, 2022) – The Division of Public Health’s (DPH) Office of Health Crisis Response (OHCR), has initiated a Restaurant Accolade Program to train and educate restaurant industry staff on how to reverse an opioid overdose and support coworkers with substance use disorder (SUD). The program was developed to assist restaurants, hospitality groups, and […]

Delawareans struggling with substance use disorder can call DHSS’ Division of Substance Abuse and Mental Health’s 24/7 Delaware Hope Line – a single point of contact where callers can connect to a variety of resources and information, including support from clinicians and peer specialists plus crisis assistance.

DOVER, DE (21 de Julio de 2022) – La División de Salud Pública de Delaware (DPH) anuncia el segundo y tercer caso del virus de viruela símica en el estado. Ambos casos se consideran probables a la espera de pruebas de confirmación por parte de los Centros para el Control y la Prevención de Enfermedades […]

DOVER, DE (August 30, 2022) – The Division of Public Health (DPH) is releasing a 2020 State Unintentional Drug Overdose Reporting System (SUDORS) fact sheet on all drug overdose deaths that occurred in Delaware. This snapshot contains fatality data abstracted from the state’s Overdose Data to Action (OD2A) collaborative. DPH collects and analyzes unintentional drug overdose […]

NEW CASTLE (Nov. 4, 2022) – The Division of Substance Abuse and Mental Health, in collaboration with the Lt. Governor’s Office and the Delaware Art Museum, is seeking personal stories and photos from Delaware families who have lost loved ones to drug overdoses. The submissions will be used to create an emotional and educational exhibition […]

Health Officials Fear Opioid Epidemic Has Not Plateaued   NEW CASTLE (Dec. 8, 2022) – In a heartbreaking sign that the opioid epidemic has not plateaued in Delaware, deaths from suspected overdoses in November set a new monthly high total, according to death investigation reports from the Division of Forensic Science. In November 2022, 43 […]

DOVER, DE (Jan. 3, 2023) – Through the Centers for Disease Control and Prevention’s State Unintentional Drug Overdose Reporting System (SUDORS), Delaware was recently among 47 states to contribute data to the CDC’s Dec. 16, 2022, Morbidity and Mortality Weekly Report, titled “Drug Overdose Deaths Among Persons Aged 10-19 Years – United States, July 2019-December 2021.” The Division of Public Health (DPH) utilizes SUDORS to track available trends and characteristics of […]

Over the past three months (November and December 2022 and January 2023), preliminary data indicates that suspected overdose deaths in Delaware have increased. Suspected accidental overdose data is reported by the Division of Forensic Science (DFS) and is considered preliminary until all data is finalized. Since November, the average monthly increase of suspected overdose deaths is 18.4%. In January 2023, 53 people died from suspected overdoses in Delaware, which represents a 47% increase over […]

NEW CASTLE – The Delaware Division of Substance Abuse and Mental Health (DSAMH) announces the launch of the Health Equity Advancement Project, consisting of two funding opportunities that seek to develop strategies for addressing rising opioid overdose deaths among Black and African American communities in Delaware. DSAMH will award eight mini grants as well as […]

In collaboration with the Delaware Division of Forensic Science (DFS), the Delaware Division of Public Health (DPH) announces the addition of suspected drug overdose death counts to the agency’s publicly available My Healthy Community (MHC) data dashboard. These data can be viewed on the Drug Overdose Deaths tab within the Mental Health and Substance Use Disorder section of MHC. […]

Division of Forensic Science Annual Report Finds Fentanyl Still Involved in More Than 80% of Deaths; Cocaine Link on the Rise NEW CASTLE (May 24, 2022) – In what health officials fear is another consequence of the uncertainty associated with the COVID-19 pandemic, Delaware’s overdose deaths increased more than 15% in 2021 to a record […]

NEWARK (Jan. 18, 2023) – Today, Lieutenant Governor Bethany Hall-Long, along with top leaders from the Delaware Department of Health and Social Services (DHSS) and Delaware Department of Safety and Homeland Security (DSHS), led a community response briefing to provide the latest information about suspected drug overdose deaths in the state, current and emerging dangers […]

The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its third annual report to Governor John Carney and the General Assembly, announced Attorney General Kathy Jennings. The report examines a sample of 148 cases from fatal overdoses that occurred in 2021, and includes data collected from death certificates, medical records, legal records, and treatment history.  The […]

Australian Hass avocados have received provisional access to the Indian market. New access was granted after Australia demonstrated that its high-quality avocados could meet India’s biosecurity and food import requirements.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Title: Melioidosis
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/10/2021 12:00:00 AM

Title: Low-Dose Aspirin, Other Painkillers May Lower Colon Cancer Risk
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Title: Synthetic Fentanyl Fueling Surge in Overdose Deaths: CDC
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Background

Quality of life is impaired in patients with sarcoidosis. The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health-related quality of life in patients with sarcoidosis, comprising subdomains of General Health Status (GHS), Lung, Medication, Skin and Eyes. The aim of this study was to enhance the validation of the KSQ, incorporating longitudinal validation and known-groups validity in a cohort with mild sarcoidosis.

The regulation of drug-metabolizing enzymes and transporters by cytokines has been extensively studied in vitro and in clinic. Cytokine-mediated suppression of cytochrome P450 (CYP) or drug transporters may increase or decrease the systemic clearance of drug substrates that are primarily cleared via these pathways; neutralization of cytokines by therapeutic proteins may thereby alter systemic exposures of such drug substrates. The Food and Drug Administration recommends evaluating such clinical drug interactions during clinical development and has provided labeling recommendations for therapeutic proteins. To determine the clinical relevance of these drug interactions to dose adjustments, trends in steady-state exposures of CYP-sensitive substrates coadministered with cytokine modulators as reported in the University of Washington Drug Interaction Database were extracted and examined for each of the CYPs. Coadministration of cytochrome P450 family 3 subfamily A (CYP3A) (midazolam/simvastatin), cytochrome P450 subfamily 2C19 (omeprazole), or cytochrome P450 subfamily 1A2 (caffeine/tizanidine) substrates with anti-interleukin-6 and with anti-interleukin-23 therapeutics led to changes in systemic exposures of CYP substrates ranging from ~ –58% to ~35%; no significant trends were observed for cytochrome P450 subfamily 2D6 (dextromethorphan) and cytochrome P450 subfamily 2C9 (warfarin) substrates. Although none of these changes in systemic exposures have been reported as clinically meaningful, dose adjustment of midazolam for optimal sedation in acute care settings has been reported. Simulated concentration-time profiles of midazolam under conditions of elevated cytokine levels when coadministered with tocilizumab, suggest a ~six- to sevenfold increase in midazolam clearance, suggesting potential implications of cytokine–CYP drug interactions on dose adjustments of sensitive CYP3A substrates in acute care settings. Additionally, this article also provides a brief overview of nonclinical and clinical assessments of cytokine–CYP drug interactions in drug discovery and development.

The consumption of ⁹-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; however, the behavioral and neural circuit effects of such consumption remain unknown, especially in the context of ingestion of higher doses resulting in cannabis intoxication. We examined the neural and behavioral effects of acute high-dose edible cannabis consumption (AHDECC). Sprague-Dawley rats (six males, seven females) were implanted with electrodes in the prefrontal cortex (PFC), dorsal hippocampus (dHipp), cingulate cortex (Cg), and nucleus accumbens (NAc). Rats were provided access to a mixture of Nutella (6 g/kg) and THC-containing cannabis oil (20 mg/kg) for 10 minutes, during which they voluntarily consumed all of the provided Nutella and THC mixture. Cannabis tetrad and neural oscillations were examined 2, 4, 8, and 24 hours after exposure. In another cohort (16 males, 15 females), we examined the effects of AHDECC on learning and prepulse inhibition and serum and brain THC and 11-hydroxy-THC concentrations. AHDECC resulted in higher brain and serum THC and 11-hydroxy-THC levels in female rats over 24 hours. AHDECC also produced: 1) Cg, dHipp, and NAc gamma power suppression, with the suppression being greater in female rats, in a time-dependent manner; 2) hypolocomotion, hypothermia, and antinociception in a time-dependent manner; and 3) learning and prepulse inhibition impairments. Additionally, most neural activity and behavior changes appear 2 hours after ingestion, suggesting that interventions around this time might be effective in reversing/reducing the effects of AHDECC.

In nuclear medicine, estimating the number of radioactive decays that occur in a source organ per unit administered activity of a radiopharmaceutical (i.e., the time-integrated activity coefficient [TIAC]) is an essential task within the internal dosimetry workflow. TIAC estimation is commonly derived by least-squares fitting of various exponential models to organ time–activity data (radiopharmaceutical biodistribution). Rarely, however, are methods used to objectively determine the model that best characterizes the data. Additionally, the uncertainty associated with the resultant TIAC is generally not evaluated. As part of the MIRDsoft initiative, MIRDfit has been developed to offer a biodistribution fitting software solution that provides the following essential features and advantages for internal dose assessment: nuclear medicine–appropriate fit functions; objective metrics for guiding best-fit selection; TIAC uncertainty calculation; quality control and data archiving; integration with MIRDcalc software for dose calculation; and a user-friendly Excel-based interface. For demonstration and comparative validation of MIRDfit’s performance, TIACs were derived from serial imaging studies involving ¹⁸F-FDG and ¹⁷⁷Lu-DOTATATE using MIRDfit. These TIACs were then compared with TIAC estimates obtained using other software. In most cases, the TIACs agreed within approximately 10% between MIRDfit and the other software. MIRDfit has been endorsed by the MIRD Committee of the Society of Nuclear Medicine and Molecular Imaging and has been integrated into the MIRDsoft suite of free dosimetry software; it is available for download at no user cost (https://mirdsoft.org/).

²²⁶Ac (t_1/2 = 29.37 h) has been proposed as a theranostic radioisotope leveraging both its diagnostic -emissions and therapeutic α-emissions. ²²⁶Ac emits 158 and 230 keV -photons ideal for quantitative SPECT imaging and acts as an in vivo generator of 4 high-energy α-particles. Because of these nuclear decay properties, ²²⁶Ac has potential to act as a standalone theranostic isotope. In this proof-of-concept study, we evaluated a preclinical ²²⁶Ac-radiopharmaceutical for its theranostic efficacy and present the first ²²⁶Ac-targeted α-therapy study. Methods: ²²⁶Ac was produced at TRIUMF and labeled with the chelator-peptide bioconjugate crown-TATE. [²²⁶Ac]Ac-crown-TATE was selected to target neuroendocrine tumors in male NRG mice bearing AR42J tumor xenografts for SPECT imaging, biodistribution, and therapy studies. A preclinical SPECT/CT scanner acquired quantitative images reconstructed from both the 158 and the 230 keV emissions. Mice in the biodistribution study were euthanized at 1, 3, 5, 24, and 48 h after injection, and internal radiation dosimetry was derived for the tumor and organs of interest to establish appropriate therapeutic activity levels. Mice in the therapy study were administered 125, 250, or 375 kBq treatments and were monitored for tumor size and body condition. Results: We present quantitative SPECT images of the in vivo biodistribution of [²²⁶Ac]Ac-crown-TATE, which showed agreement with ex vivo measurements. Biodistribution studies demonstrated high uptake (>30%IA/g at 5 h after injection) and retention in the tumor, with an estimated mean absorbed dose coefficient of 222 mGy/kBq. [²²⁶Ac]Ac-crown-TATE treatments significantly extended the median survival from 7 d in the control groups to 16, 24, and 27 d in the 125, 250, and 375 kBq treatment groups, respectively. Survival was prolonged by slowing tumor growth, and no weight loss or toxicities were observed. Conclusion: This study highlights the theranostic potential of ²²⁶Ac as a standalone therapeutic isotope in addition to its demonstrated diagnostic capabilities to assess dosimetry in matched ²²⁵Ac-radiopharmaceuticals. Future studies will investigate maximum dose and toxicity to further explore the therapeutic potential of ²²⁶Ac-radiopharmaceuticals.

BACKGROUND AND PURPOSE:

Gadolinium-based contrast agents are widely used for meningioma imaging; however, concerns exist regarding their side effects, cost, and environmental impact. At the standard gadolinium dose, most meningiomas show avid contrast enhancement, suggesting that administering a smaller dose may be feasible. The purpose of this study was to evaluate the impact of a lower gadolinium dose on the differentiation between meningiomas and adjacent intracranial tissues.

A single dose of a smallpox vaccine seems to lower the risk of catching mpox by around 60 per cent, and two doses would probably be even better

Fox News host Sean Hannity says the "decentralization of power as our founders intended is very much on its way to DC."