USA Gymnastics, which develops the U.S. Olympic team, reportedly failed to inform authorities of numerous allegations regarding sexual abuse by coaches.

A federal grant that enhanced services for veteran students at Pennsylvania College of Technology recently ended, but its benefits will endure.

As 1 million people head to cast ballots, the election results are likely to be announced on Monday.

Microplastics have been steadily increasing in freshwater environments for decades and are directly tied to rising global plastic production since the 1950s, according to a new study by an interdisciplinary team of Penn State researchers.

OM worker in the Arabian Peninsula reflects on his friendship with a local.

Prayer and fasting have been part of the Algerian Church's lifestyle since its beginning. Unity among believers has contributed to ongoing spiritual strength amidst persecution.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

Scientists have spotted microplastics, tiny pieces of plastic smaller than 5 millimeters, in some of the most pristine environments on Earth, from the depths of the Mariana Trench to the snow on Mt. Everest to the mountaintop clouds of China and Japan. Microplastics have been detected in human brains, the bellies of sea turtles and the roots of plants. Now, new research led by Penn State scientists reveals that microplastics in the atmosphere could be affecting weather and climate.

NASA’s Chandra X-ray Observatory has unveiled mysterious "knots" in the jet of a supermassive black hole in Centaurus A, a nearby galaxy. These bright, fast-moving features exhibit a higher speed in X-rays than in radio wavelengths, hinting at unexplored physics in black hole jets. Despite financial uncertainties surrounding Chandra's operations, scientists continue to uncover new phenomena in deep space, underscoring the telescope’s enduring value to astrophysics.

Vidya Balan's weight loss journey offers valuable insights into the connection between chronic inflammation and weight gain

Donated plastic will be used to offset the purchase price of a recycled-plastic bench.

Attorney General Kathy Jennings released the following statement Thursday after the Division of Civil Rights & Public Trust secured a jury conviction against a Dover man for two violent felonies.  Originally indicted in October 2020 after removing and pointing a handgun toward others during a counter-protest, Michael Hastings was convicted today of Reckless Endangering 1st […]

I am gratified to see the continuing adoption of Forecast Value Added by organizations worldwide. FVA is an easy to understand and easy to apply approach for identifying bad practices in your forecasting process. And I'm particularly gratified to see coverage of FVA in two new books, which the authors [...]

The post Vandeput's Data Science for Supply Chain Forecasting (book excerpt) appeared first on The Business Forecasting Deal.

What makes something easy (or difficult) to forecast? This question was answered by Prof. Rob Hyndman on the Forecasting Impact podcast (February 6, 2021), and it's worth a look at his response. Rob was recently named a Fellow of the International Institute of Forecasters, and is someone who is known [...]

The post Hyndman's 5 Conditions for Easy Forecasting appeared first on The Business Forecasting Deal.

M6 Financial Forecasting Competition The Makridakis Open Forecasting Center has announced the M6 Financial Forecasting Competition, to begin in February 2022. This will be a "live" competition running through February 2023, with a focus on forecasts of stock price (returns) and risk, and on investment decisions based on the forecasts. [...]

The post M6 Financial Forecasting Competition announced appeared first on The Business Forecasting Deal.

I've never been much of a fan of forecasting approaches to intermittent demand. In situations like intermittent demand (or other areas where we have little hope of reasonably accurate forecasts), my thinking is "why bother?" If we can't expect to solve the problem with forecasting, we need a different approach. [...]

The post Intermittent Demand Forecasting (new book by Boylan and Syntetos) appeared first on The Business Forecasting Deal.

A body of a man has been found in a plastic bag in seven pieces on Mumbai's Gorai beach, the police said today.

Australian wine was showcased to retailers, distributors, sommeliers and media at key tasting events in Korea.

While the expansion of democracy is a key condition for peace, the Achilles’ heel of democracies is that their leaders are constrained by electoral calendars, forcing them to push for peace or delay, whereas autocracies can afford to play the long game to achieve the favorable outcomes they desire. Take, for example, the current wars […]

In Ephesians 3:16–19, Paul prays that believers would be “strengthened with power through His Spirit in the inner man” in order that they might understand the “love of Christ which surpasses knowledge.” In other words, it takes a lot of Spirit-supplied strength for us to catch even a glimpse of God’s love—and when we do, we’ve only scratched the surface.

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Dolphins in the Gulf of Mexico have tiny bits of plastic in their breath, and this is probably a worldwide problem

A super-stretchy hydrogel can stretch to 15 times its original length and return to its initial shape, and could be used to make soft inflatable robots

Last year’s marine heatwaves saw an unprecedented decline in the growth of phytoplankton and algae, which many animals in the oceans depend on for food

Title: What Can and Can't I Eat When Fasting?
Category: Health and Living
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

Title: What Happens to Metabolism in Fasting?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Scientists Get Closer to Long-Lasting Flu Vaccine
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Title: Looking for a Plastic Surgeon on Instagram? Beware
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/30/2017 12:00:00 AM

Title: Fasting Diet Could Help Folks With Type 2 Diabetes
Category: Health News
Created: 7/26/2022 12:00:00 AM
Last Editorial Review: 7/26/2022 12:00:00 AM

Mapping transcriptomic variations using either short- or long-read RNA sequencing is a staple of genomic research. Long reads are able to capture entire isoforms and overcome repetitive regions, whereas short reads still provide improved coverage and error rates. Yet, open questions remain, such as how to quantitatively compare the technologies, can we combine them, and what is the benefit of such a combined view? We tackle these questions by first creating a pipeline to assess matched long- and short-read data using a variety of transcriptome statistics. We find that across data sets, algorithms, and technologies, matched short-read data detects ~30% more splice junctions, such that ~10%–30% of the splice junctions included at ≥20% by short reads are missed by long reads. In contrast, long reads detect many more intron-retention events and can detect full isoforms, pointing to the benefit of combining the technologies. We introduce MAJIQ-L, an extension of the MAJIQ software, to enable a unified view of transcriptome variations from both technologies and demonstrate its benefits. Our software can be used to assess any future long-read technology or algorithm and can be combined with short-read data for improved transcriptome analysis.

BACKGROUND:Practice on fasting prior to extubation in critically ill patients is variable. Efficacy of fasting in reducing gastric volume has not been well established. The primary objective of this study was to assess the effect of 4 h of fasting on prevalence of empty stomach using gastric ultrasonography in critically ill subjects who are fasted for extubation. The secondary objectives were to evaluate the change in gastric volumes during 4 h of fasting and to determine factors associated with empty stomach after fasting.METHODS:This was a single-center, prospective, observational study on adult ICU subjects who were enterally fed for at least 6 h continuously and mechanically ventilated. Gastric ultrasound was performed immediately prior to commencement of fasting, after 4 h of fasting, and after nasogastric (NG) aspiration after 4 h of fasting. An empty stomach was defined as a gastric volume ≤ 1.5 mL/kg.RESULTS:Forty subjects were recruited, and 38 (95%) had images suitable for analysis. The prevalence of empty stomach increased after 4 h of fasting (25 [65.8%] vs 31 [81.6%], P = .041) and after 4 h of fasting with NG aspiration (25 [65.8%] vs 34 [89.5%], P = .008). There was a significant difference in median (interquartile range) gastric volume per body weight between before fasting and 4 h after fasting (1.0 [0.5–1.8] mL/kg vs 0.4 [0.2–1.0] mL/kg, P < .001). No patient factors were associated with higher prevalence of empty stomach after 4 h of fasting.CONCLUSIONS:Most mechanically ventilated subjects had empty stomachs prior to fasting for extubation. Fasting for 4 h further increased the prevalence of empty stomach at extubation to > 80%.

During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We found here that knockout of YY1 at the pro-B-cell stage eliminates B lineage commitment. YY1 knockout pro-B cells can generate T lineage cells in vitro using the OP9-DL4 feeder system and in vivo after injection into sublethally irradiated Rag1^–/– mice. These T lineage-like cells lose their B lineage transcript profile and gain a T-cell lineage profile. Single-cell RNA-seq experiments showed that as YY1 knockout pro-B cells transition into T lineage cells in vitro, various cell clusters adopt transcript profiles representing a multiplicity of hematopoietic lineages, indicating unusual lineage plasticity. In addition, YY1 KO pro-B cells in vivo can give rise to other hematopoietic lineages in vivo. Evaluation of RNA-seq, scRNA-seq, ChIP-seq, and scATAC-seq data indicates that YY1 controls numerous chromatin-modifying proteins leading to increased accessibility of alternative lineage genes in YY1 knockout pro-B cells. Given the ubiquitous nature of YY1 and its dual activation and repression functions, YY1 may regulate commitment in multiple cell lineages.

Cellular plasticity in adult multicellular organisms is a protective mechanism that allows certain tissues to regenerate in response to injury. Considering that aging involves exposure to repeated injuries over a lifetime, it is conceivable that cell identity itself is more malleable—and potentially erroneous—with age. In this review, we summarize and critically discuss the available evidence that cells undergo age-related shifts in identity, with an emphasis on those that contribute to age-associated pathologies, including neurodegeneration and cancer. Specifically, we focus on reported instances of programs associated with dedifferentiation, biased differentiation, acquisition of features from alternative lineages, and entry into a preneoplastic state. As some of the most promising approaches to rejuvenate cells reportedly also elicit transient changes to cell identity, we further discuss whether cell state change and rejuvenation can be uncoupled to yield more tractable therapeutic strategies.

T-lymphoblastic lymphoma (T-LLy) is the most common lymphoblastic lymphoma in children and often presents with a mediastinal mass. Lymphomatous suprarenal masses are possible but rare. Here, we discuss the case of a previously healthy 3-yr-old male who presented with mediastinal T-LLy with bilateral suprarenal masses. Following initial treatment, surgical biopsy of persisting adrenal masses revealed bilateral neuroblastoma (NBL). A clinical genetics panel for germline cancer predisposition did not identify any pathogenic variants. Combination large panel (864 genes) profiling analysis in the context of a precision oncology study revealed two novel likely pathogenic heterozygous variants: SMARCA4 c.1420-1G > T p.? and EZH2 c.1943G > C p.(Ile631Phefs*44). Somatic analysis revealed potential second hits/somatic variants in EZH2 (in the T-LLy) and a segmental loss in Chromosome 19p encompassing SMARCA4 (in the NBL). Synchronous cancers, especially at a young age, warrant genetic evaluation for cancer predisposition; enrollment in a precision oncology program assessing germline and tumor DNA can fulfill that purpose, particularly when standard first-line genetic testing is negative and in the setting of tumors that are not classic for common cancer predisposition syndromes.

A Spot robot equipped with a blowtorch can locate weeds on farms and precisely heat them up to stop them growing, offering a possible alternative to herbicides

This year’s Fantastic Arcade is happening right now, so if you’re in Austin or a short drive away (n.b., a “short drive” in Texas is anything under 8 hours), you should go. Admission is free, gas is cheap, and Shine Boch actually tastes good if you drink it in the Lone Star State. There’s a […]

Eddie reflects on his favourite scene in cinema.

A flurry of studies has found microplastics in nearly every organ in the human body, from the brain to the testicles. But very few have revealed whether these tiny bits of plastic impact our health

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Signal decoders are vital components in radio broadcasting. Without them, the transmission and reception of clear audio or data would be impossible. They take what is essentially noise and turn it into coherent, useful information. Having worked with radio broadcasting systems for some time, I’ve seen firsthand how essential decoders are to maintaining communication networks. […]

The post How Signal Decoders Are Used in Radio Broadcasting appeared first on Chart Attack.

It turns out microplastics have an effect on the weather and climate.

ITV previously seemed very happy to oblige politicians in urgent need of money, rehabilitation or just missing the attention, writes Sean O’Grady. But this year’s roster is different

Robert Musselle, customer engineering manager EMEA at Protolabs shares what you need to consider with 3D printing and plastics prototyping.

Ampacet has introduced ProVital+ Gamma-Protect, a medical-grade additive designed to preserve mechanical and optical properties of polypropylene-based medical and pharmaceutical articles during gamma and e-beam sterilisation processes.