Literacy Month is intended to recognize the extensive efforts of literacy partners to promote reading as an essential skill and a lifelong pleasure.

NEWARK, Del. – First Spouse Tracey Quillen Carney on Thursday recognized September as Literacy Month with a proclamation presentation at the University of Delaware Early Learning Center. Literacy Month is intended to recognize the extensive efforts of literacy partners to promote reading as an essential skill and a lifelong pleasure.   “It’s important to show our […]

SAS software supports two kinds of procedures: interactive and non-interactive. Most SAS procedures are non-interactive. They begin with a PROC statement, include one or more additional statements, and end with a RUN statement. When SAS encounters the RUN statement, the procedure executes all statements, then exits. On the other hand, [...]

The post Interactive procedures in SAS appeared first on The DO Loop.

US President-elect Donald Trump has named Mike Waltz, a Congressman from Florida and co-chair of the India Caucus, as the new National Security Adviser.

Each November, we are reminded of the bravery and dedication of those who have served our country. At Cadence, we thank our Veteran employees for their patriotism by reaffirming our commitment to honoring their sacrifices and recognizing their contributions to our business success. Our diverse and inclusive culture is strengthened by the unique perspective of our Veteran employees, and we are proud to support the Veterans Inclusion Group as a space for community members and their allies to connect. In celebration of Veterans Day, we were excited to catch up with Johnathan Edmonds, Veterans Inclusion Group Lead and Design Engineering Director, for a heartfelt chat on his journey through military service to leadership within Cadence. Throughout the conversation, he shared the importance of creating space for Veterans, the skills they offer, and his aspirations for what the Veterans Inclusion Group will achieve in the years ahead. Oh yeah, and he flies planes, too! Join us as we dive into what makes this holiday special for so many across the nation and how we can respectfully commemorate it together. Johnathan, you’re a retired Air Force Reservist, pilot, and now a Design Engineering Director. Can you tell us about your journey from the military to your current role at Cadence? I started my military and electronics journey in the Navy. I enlisted at 18 and served for six years as an aviation electronics technician. During this time, I was able to learn about and repair electronics on planes. This set me up for success, and when I was honorably discharged, I attended Virginia Tech to study computer engineering. Once I graduated, I continued my career as an engineer, but I still wanted to be a military pilot. From my past experience, I knew the reserves were an option where I could learn to fly and still have a civilian career. Not only was I lucky enough to get selected to go to pilot training, but after I returned from flight school, my luck grew, and I was hired at Cadence. Cadence has supported me throughout my military career, which has been a great benefit, as many companies don’t support reservists. The best thing about serving and being employed at Cadence is how I could blend my skill sets to further the Air Force’s mission and achieve great things in engineering. As the first lead of Cadence’s Veterans Inclusion Group, you played an integral part in growing our culture and building community at the company since launching the group four years ago. What inspired you to take on the role of Inclusion Group Lead? I was inspired by three things: camaraderie, service, and outreach. I wanted to see if we could achieve a similar sense of community through the Veterans Inclusion Group as we had during our service life. I also wanted to see how we could better serve our Veterans here at Cadence. I wanted to explore any benefits that could be expanded, roles that could be developed by Vets, and, lastly, I wanted to serve a broader community. COVID-19 put a damper on some of the community support, but we are getting back on track with Veteran employment programs and volunteer efforts like Carry the Load and Gold Star Families. Why is it important to have this space dedicated to Veteran employees? There are many reasons! Networking, for one, creates a stronger, more unified Cadence culture. Two, Vets face a variety of issues not generally understood by those who have not served, such as PTSD, where to get help for disabilities, how to get an old medical record, etc. As I mentioned, I’m also passionate about connecting Veterans with employment and job opportunities. It is so nice to work for a company that actively recruits Vets. We have our own “language,” if you will, so it’s nice to have a space to talk in the language that we are familiar with. What have been some of your favorite moments leading this group over the past few years? Are there any “wins” that you would like to recognize? We have a lot of wins. Events held during COVID-19 and getting past COVID-19, donating to worthwhile causes, and hosting guest speakers are all fantastic milestones and accomplishments. That said, the biggest win is the hiring of new Veteran employees. Mark Murphy, Corporate VP of Sales Operations, and I have both welcomed Vets to our team during this time, and it is such a joy to watch what someone can do when given the opportunity to succeed in the right environment. As you are set to transition out of the lead role next year, what do you hope to see the Veterans Inclusion Group accomplish next? My hope is that the Veterans Inclusion Group partners with other companies, expanding our reach externally and exploring new opportunities to engage Veterans outside of Cadence. Johnathan (left) speaks on an inclusion group panel, along with David Sallard (center), lead of Cadence's Black Inclusion Group and Sr. Principal Application Engineer; Christina Jamerson (on screen), lead of Cadence's Abilities Inclusion Group and Demand Generation Director; and Dianne Rambke (right), lead of Cadence's Latinx Inclusion Group and Marketing Communications Director. What are the important ways that people can signal inclusion and respectfully honor Veterans at work? What are the most meaningful or impactful actions employees everywhere can take to support Veteran coworkers? I think there is one answer to both questions. I recommend that people engage with their companies’ employee resource groups (ERGs) and have conversations with them. Opening up the lines of communication will lead to new paths in their journeys. What are you looking forward to in 2025, both personally and professionally? In 2025, professionally, I am looking forward to taking mixed-signal systems and verification to another level by including emulation, automatic model generation, and seeing which boundaries we can push in our SerDes and Chiplets products. Personally, I am looking forward to making my SXS street legal so I can drive places without getting a ticket, seeing my children participate in sports, church, and school, and taking my wife on vacation to Europe or somewhere else we can unplug. Learn more about Cadence’s Inclusion Groups, diverse culture, and commitment to belonging.

Hello,

I am aware of command script .svcf file that saves signals and loads them in while opening Simvision.

I am wondering, if there is a way for saving signals while we are in an interactive session and loading them next time when we open Simvision interactively.

Any ideas on how to do this?

Thank you in advance.

Swetha. C

Read through this blog to know more about the new Reliability Report view in Virtuoso ADE Assembler and Virtuoso ADE Explorer.(read more)

A Porsche Taycan 4 and revised GTS model join the 2025 lineup The Porsche Taycan is now available in 13 different versions When they arrive in 2025 the Taycan 4 will cost $105,295 while the GTS will cost $149,895 The 2025 Porsche Taycan received an engineering-focused refresh that improved range and efficiency, the benefits of which are now being...

TikTok is divided over whether books are inherently political after Donald Trump's win in the U.S. presidential election.

For many soldiers on the front lines, the trauma of war can be as hard to fight as the war itself. To help, the U.S. Agency for International Development, or USAID, has created a program to support Ukrainian women veterans, the families of internally displaced persons, and military relatives. The program is part of the USAID Self-Reliance Learning Agenda. Anna Kosstutschenko has the story.

US-ROK-Japan Trilateral Global Leadership Youth Summit

Females perform better than males • Malta’s computer literacy score is within international average for computer literacy and substantially below average in computational thinking

At upcoming multilateral summits, Prime Minister Narendra Modi has an opportunity to expand India's regional position and economic links, and address issues such as terrorism and a rising China.

Beauty queen-dentist Shaila Rebortera tied the knot with her non-showbiz fiancé, Luigi, in an intimate garden ceremony witnessed by their family and friends. Rebortera gave a glimpse of their special day through her Instagram Stories on Tuesday, Nov. 12, sharing photos and videos taken by their guests. The beauty queen donned an off-shoulder balloon dress for the wedding that was held on Nov. 11 at an undisclosed location. Among the photos she shared was of her and Luigi slicing their wedding cake that has the vow “‘Til death do us part.” Luigi also showed a stitched photo in which he […]...

Keep on reading: Shaila Rebortera now married

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 21st Annual Meeting of the Independent Accountability Mechanisms of Multilateral Banks and International Financial Institutions, 1 October 2024, ADB headquarters, Manila, Philippines

Intervention by Masatsugu Asakawa, President, Asian Development Bank, on behalf of the multilateral development banks at COP29, World Leaders Summit, 12 November 2024

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Title: Biden to Sign Bill That Helps Veterans Exposed to Toxic Burn Pits
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM

Title: Veterans' Painkiller Abuse Can Raise Odds for Heroin Use
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: Disability Payments Can Help Keep Veterans With Diabetes Out of the Hospital
Category: Health News
Created: 7/8/2022 12:00:00 AM
Last Editorial Review: 7/8/2022 12:00:00 AM

Title: MS (Multiple Sclerosis) vs. ALS (Amyotrophic Lateral Sclerosis)
Category: Diseases and Conditions
Created: 6/16/2017 12:00:00 AM
Last Editorial Review: 8/4/2022 12:00:00 AM

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

As a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that noncoding enhancers are also affected by duplications leading to the activation of oncogenes that are inside or outside of the duplicated regions. However, the prevalence of enhancer duplication and the identity of their target genes remains largely unknown in the cancer genome. Here, by analyzing whole-genome sequencing data in a non-gene-centric manner, we identify 881 duplication hotspots in 13 major cancer types, most of which do not contain protein-coding genes. We show that the hotspots are enriched with distal enhancer elements and are highly lineage-specific. We develop a HiChIP-based methodology that navigates enhancer–promoter contact maps to prioritize the target genes for the duplication hotspots harboring enhancer elements. The methodology identifies many novel enhancer duplication events activating oncogenes such as ESR1, FOXA1, GATA3, GATA6, TP63, and VEGFA, as well as potentially novel oncogenes such as GRHL2, IRF2BP2, and CREB3L1. In particular, we identify a duplication hotspot on Chromosome 10p15 harboring a cluster of enhancers, which skips over two genes, through a long-range chromatin interaction, to activate an oncogenic isoform of the NET1 gene to promote migration of gastric cancer cells. Focusing on tandem duplications, our study substantially extends the catalog of noncoding driver alterations in multiple cancer types, revealing attractive targets for functional characterization and therapeutic intervention.

BACKGROUND:Practice on fasting prior to extubation in critically ill patients is variable. Efficacy of fasting in reducing gastric volume has not been well established. The primary objective of this study was to assess the effect of 4 h of fasting on prevalence of empty stomach using gastric ultrasonography in critically ill subjects who are fasted for extubation. The secondary objectives were to evaluate the change in gastric volumes during 4 h of fasting and to determine factors associated with empty stomach after fasting.METHODS:This was a single-center, prospective, observational study on adult ICU subjects who were enterally fed for at least 6 h continuously and mechanically ventilated. Gastric ultrasound was performed immediately prior to commencement of fasting, after 4 h of fasting, and after nasogastric (NG) aspiration after 4 h of fasting. An empty stomach was defined as a gastric volume ≤ 1.5 mL/kg.RESULTS:Forty subjects were recruited, and 38 (95%) had images suitable for analysis. The prevalence of empty stomach increased after 4 h of fasting (25 [65.8%] vs 31 [81.6%], P = .041) and after 4 h of fasting with NG aspiration (25 [65.8%] vs 34 [89.5%], P = .008). There was a significant difference in median (interquartile range) gastric volume per body weight between before fasting and 4 h after fasting (1.0 [0.5–1.8] mL/kg vs 0.4 [0.2–1.0] mL/kg, P < .001). No patient factors were associated with higher prevalence of empty stomach after 4 h of fasting.CONCLUSIONS:Most mechanically ventilated subjects had empty stomachs prior to fasting for extubation. Fasting for 4 h further increased the prevalence of empty stomach at extubation to > 80%.

The dorsal vagal complex contains three structures: the area postrema, the nucleus tractus solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both anatomically and functionally, and have important yet distinct roles in not only conveying peripheral bodily signals to the rest of the brain but in the generation of behavioral and physiological responses. Reports on the new discoveries in these structures were highlights of the symposium. In this outlook, we focus on the roles of the area postrema in mediating brain–body interactions and its potential utility as a therapeutic target, especially in cancer cachexia.

Early detection of drug-drug interactions (DDIs) can facilitate timely drug development decisions, prevent unnecessary restrictions on patient enrollment, resulting in clinical study populations that are not representative of the indicated study population, and allow for appropriate dose adjustments to ensure safety in clinical trials. All of these factors contribute to a streamlined drug approval process and enhanced patient safety. Here we describe a new approach for early prediction of the magnitude of change in exposure for cytochrome P450 (P450) CYP3A4-related DDIs of small-molecule anticancer drugs based on the model-based extrapolation of human-CYP3A4-transgenic mice pharmacokinetics to humans. Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. Predictions of the magnitude of change in exposure deviated at most 0.99- to 1.31-fold from clinical trial results for inhibition with itraconazole, whereas exposure predictions for the induction with rifampicin were less accurate, with deviations of 0.22- to 0.48-fold. Results for the early prediction of DDIs and their clinical impact appear promising for CYP3A4 inhibition, but validation with more victim and perpetrator drugs is essential to evaluate the performance of the new method.

The regulation of drug-metabolizing enzymes and transporters by cytokines has been extensively studied in vitro and in clinic. Cytokine-mediated suppression of cytochrome P450 (CYP) or drug transporters may increase or decrease the systemic clearance of drug substrates that are primarily cleared via these pathways; neutralization of cytokines by therapeutic proteins may thereby alter systemic exposures of such drug substrates. The Food and Drug Administration recommends evaluating such clinical drug interactions during clinical development and has provided labeling recommendations for therapeutic proteins. To determine the clinical relevance of these drug interactions to dose adjustments, trends in steady-state exposures of CYP-sensitive substrates coadministered with cytokine modulators as reported in the University of Washington Drug Interaction Database were extracted and examined for each of the CYPs. Coadministration of cytochrome P450 family 3 subfamily A (CYP3A) (midazolam/simvastatin), cytochrome P450 subfamily 2C19 (omeprazole), or cytochrome P450 subfamily 1A2 (caffeine/tizanidine) substrates with anti-interleukin-6 and with anti-interleukin-23 therapeutics led to changes in systemic exposures of CYP substrates ranging from ~ –58% to ~35%; no significant trends were observed for cytochrome P450 subfamily 2D6 (dextromethorphan) and cytochrome P450 subfamily 2C9 (warfarin) substrates. Although none of these changes in systemic exposures have been reported as clinically meaningful, dose adjustment of midazolam for optimal sedation in acute care settings has been reported. Simulated concentration-time profiles of midazolam under conditions of elevated cytokine levels when coadministered with tocilizumab, suggest a ~six- to sevenfold increase in midazolam clearance, suggesting potential implications of cytokine–CYP drug interactions on dose adjustments of sensitive CYP3A substrates in acute care settings. Additionally, this article also provides a brief overview of nonclinical and clinical assessments of cytokine–CYP drug interactions in drug discovery and development.

Drug–drug interaction (DDI) assessment of therapeutic peptides is an evolving area. The industry generally follows DDI guidelines for small molecules, but the translation of data generated with commonly used in vitro systems to in vivo is sparse. In the current study, we investigated the ability of advanced human hepatocyte in vitro systems, namely HepatoPac, spheroids, and Liver-on-a-chip, to assess potential changes in regulation of CYP1A2, CYP2B6, CYP3A4, SLCO1B1, and ABCC2 in the presence of selected therapeutic peptides, proteins, and small molecules. The peptide NN1177, a glucagon and GLP-1 receptor co-agonist, did not suppress mRNA expression or activity of CYP1A2, CYP2B6, and CYP3A4 in HepatoPac, spheroids, or Liver-on-a-chip; these findings were in contrast to the data obtained in sandwich cultured hepatocytes. No effect of NN1177 on SLCO1B1 and ABCC2 mRNA was observed in any of the complex systems. The induction magnitude differed across the systems (e.g., rifampicin induction of CYP3A4 mRNA ranged from 2.8-fold in spheroids to 81.2-fold in Liver-on-a-chip). Small molecules, obeticholic acid and abemaciclib, showed varying responses in HepatoPac, spheroids, and Liver-on-a-chip, indicating a need for EC₅₀ determinations to fully assess translatability data. HepatoPac, the most extensively investigated in this study (3 donors), showed high potential to investigate DDIs associated with CYP regulation by therapeutic peptides. Spheroids and Liver-on-a-chip were only assessed in one hepatocyte donor and further evaluations are required to confirm their potential. This study establishes an excellent foundation toward the establishment of more clinically-relevant in vitro tools for evaluation of potential DDIs with therapeutic peptides.

ABSTRACTToxicological emergencies present a significant health challenge in Nepal. Despite the high burden, the country has inadequate formal toxicology training, medical toxicology expertise, and adequate poison control infrastructure. In recognition of this need, the Nepal Poison Information Center (PIC) was established as a collaborative effort involving local and international partners. Through a comprehensive partnership framework, the Nepal PIC provides 24 hours a day, 7 days a week expert guidance to health care workers, conducts educational webinars, and engages in research. Initial data from the pilot phase indicate successful consultation delivery. Challenges include bureaucratic hurdles and the need for sustainable funding. Despite these challenges, the Nepal PIC demonstrates early feasibility and potential for expansion into a comprehensive toxicology center, contributing to the advancement of clinical toxicology in Nepal. Long-term sustainability relies on governmental support and continued advocacy efforts.

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [¹¹C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.

This review explores the concept of synergy in pharmacology, emphasizing its importance in optimizing treatment outcomes through the combination of drugs with different mechanisms of action. Synergy, defined as an effect greater than the expected additive effect elicited by individual agents according to specific predictive models, offers a promising approach to enhance therapeutic efficacy while minimizing adverse events. The historical evolution of synergy research, from ancient civilizations to modern pharmacology, highlights the ongoing quest to understand and harness synergistic interactions. Key concepts, such as concentration-response curves, additive effects, and predictive models, are discussed in detail, emphasizing the need for accurate assessment methods throughout translational drug development. Although various mathematical models exist for synergy analysis, selecting the appropriate model and software tools remains a challenge, necessitating careful consideration of experimental design and data interpretation. Furthermore, this review addresses practical considerations in synergy assessment, including preclinical and clinical approaches, mechanism of action, and statistical analysis. Optimizing synergy requires attention to concentration/dose ratios, target site localization, and timing of drug administration, ensuring that the benefits of combination therapy detected bench-side are translatable into clinical practice. Overall, the review advocates for a systematic approach to synergy assessment, incorporating robust statistical analysis, effective and simplified predictive models, and collaborative efforts across pivotal sectors, such as academic institutions, pharmaceutical companies, and regulatory agencies. By overcoming critical challenges and maximizing therapeutic potential, effective synergy assessment in drug development holds promise for advancing patient care.

Dihydropyrimidinase (DHP) deficiency is an autosomal recessive metabolic disorder caused by biallelic pathogenic variants of DPYS. Patients with DHP deficiency exhibit a broad spectrum of phenotypes, ranging from severe neurological and gastrointestinal involvement to cases with no apparent symptoms. The biochemical diagnosis of DHP deficiency is based on the detection of a significant amount of dihydropyrimidines in urine, plasma, and cerebrospinal fluid samples. Molecular genetic testing, specifically the identification of biallelic pathogenic variants in DPYS, has proven instrumental in confirming the diagnosis and facilitating family studies. This case study documents the diagnostic journey of an 18-yr-old patient with DHP deficiency, highlighting features at the severe end of the clinical spectrum. Notably, our patient exhibited previously unreported skeletal features that positively responded to bisphosphonate treatment, contributing valuable insights to the clinical characterization of DHP deficiency. Additionally, a novel DPYS variant was identified and confirmed pathogenicity through metabolic testing, further expanding the variant spectrum of the gene. Our case emphasizes the importance of a comprehensive diagnostic approach using genetic sequencing and metabolic testing for accurate diagnosis.

Veterans are at an increased risk for prostate cancer, a disease with extraordinary clinical and molecular heterogeneity, compared with the general population. However, little is known about the underlying molecular heterogeneity within the veteran population and its impact on patient management and treatment. Using clinical and targeted tumor sequencing data from the National Veterans Affairs health system, we conducted a retrospective cohort study on 45 patients with advanced prostate cancer in the Veterans Precision Oncology Data Commons (VPODC), most of whom were metastatic castration-resistant. We characterized the mutational burden in this cohort and conducted unsupervised clustering analysis to stratify patients by molecular alterations. Veterans with prostate cancer exhibited a mutational landscape broadly similar to prior studies, including KMT2A and NOTCH1 mutations associated with neuroendocrine prostate cancer phenotype, previously reported to be enriched in veterans. We also identified several potential novel mutations in PTEN, MSH6, VHL, SMO, and ABL1. Hierarchical clustering analysis revealed two subgroups containing therapeutically targetable molecular features with novel mutational signatures distinct from those reported in the Catalogue of Somatic Mutations in Cancer database. The clustering approach presented in this study can potentially be used to clinically stratify patients based on their distinct mutational profiles and identify actionable somatic mutations for precision oncology.

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have further refined the subclassification of DLBCL, based on recurrent genetic abnormalities. Here, we describe a distinct case of DLBCL that presented in leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations of CD79B, MyD88, TP53, TBL1XR1, and PIM1 genes, indicating that this lymphoma would be best classified as MCD/C5 DLBCL, an ABC subtype. Despite an initial good clinical response to BTK inhibitor ibrutinib, anti-CD20 antibody rituxan, alkylating agent bendamustine, and hematopoietic stem-cell transplant, the lymphoma relapsed, accompanied by morphologic and molecular evidence of disease progression. Specifically, the recurrent tumor developed loss of TP53 heterozygosity (LOH) and additional chromosomal changes central to ABC DLBCL pathogenesis, such as PRDM1 loss. Acquired resistance to ibrutinib and rituxan was indicated by the emergence of BTK and FOXO1 mutations, respectively, as well as apparent activation of alternative cell-activation pathways, through copy-number alterations (CNAs), detected by high-resolution chromosomal microarrays. In vitro, studies of relapsed lymphoma cells confirmed resistance to standard BTK inhibitors but sensitivity to vecabrutinib, a noncovalent inhibitor active against both wild-type as well as mutated BTK. In summary, we provide in-depth molecular characterization of a de novo leukemic DLBCL and discuss mechanisms that may have contributed to the lymphoma establishment, progression, and development of drug resistance.

CNN anchor Anderson Cooper was flabbergasted Wednesday by a surrogate’s defense of Donald Trump, calling his explanation for the former president’s bombastic statements literal “bulls---.”

On AC360, former California Lieutenant Gov. Abel Maldonado, a Republican, said that Trump’s recent comments calling for the military to “handle” Democrats were simply his way of expressing his inner New Yorker. “He’s a fighter,” Maldonado added.

The conversation began when Cooper brought up Trump’s former chairman of the Joint Chiefs of Staff, Mark Milley, who, alongside other military leaders, have begun to warn of the dangers of re-electing the former president. Milley has called Trump a “fascist to his core.”

Read more at The Daily Beast.

Tech expert Kurt “CyberGuy" Knutsson helps you honor our heroes with these powerful podcasts, audiobooks and documentaries this Veterans Day.

This stunning new image from the NASA/ESA Hubble Space Telescope is one of the best ever views of a galaxy duo called MCG+05-31-045.

The post Hubble Spots Pair of Interacting Galaxies in Coma Cluster appeared first on Sci.News: Breaking Science News.

A prolific figure in Tamil cinema, the versatile actor appeared in over 400 films across Tamil, Telugu, and Malayalam languages

The 6th edition of the Dehradun Literature Festival held at Doon International School, Curzon Road, had Imtiaz Ali talking about the raison d’etre behind storytelling

Feral Interactive’s tease seemingly was about Total War: Empire from Creative Assembly and SEGA because the developer just announced that …

Continue reading "‘Total War: Empire’ Is Coming to iOS and Android This Fall From Feral Interactive"

Private ownership, consumer choice, and competition would deliver better benefits to veterans — and force policy-makers to confront the costs of military engagements.

Thousands of veterans, military personnel and their supporters gathered at Canada's National War Memorial in Ottawa to remember those who have fought and died to protect this country and its freedoms.

Pakistan is one of a handful of countries (including India, Brazil, and South Africa) that routinely oppose the United States in multilateral debates despite strong bilateral ties to the U.S.

Jul 25, 2024

Stephen Walt argues that if Trump and Vance win in November, it will do enormous long-term damage to America's global position.

The Bank