Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the California serogroup, circulates in the eastern and midwestern United States. While LACV infection is often asymptomatic, dozens of cases of encephalitis are reported yearly. Unfortunately, no antivirals have been approved to treat LACV infection. Here, we developed a method to rapidly test potential antivirals against LACV infection. From this screen, we identified several potential antiviral molecules, including known antivirals. Additionally, we identified many novel antivirals that exhibited antiviral activity without affecting cellular viability. Valinomycin, a potassium ionophore, was among our top targets. We found that valinomycin exhibited potent anti-LACV activity in multiple cell types in a dose-dependent manner. Valinomycin did not affect particle stability or infectivity, suggesting that it may preclude virus replication by altering cellular potassium ions, a known determinant of LACV entry. We extended these results to other ionophores and found that the antiviral activity of valinomycin extended to other viral families including bunyaviruses (Rift Valley fever virus, Keystone virus), enteroviruses (Coxsackievirus, rhinovirus), flavirivuses (Zika), and coronaviruses (HCoV-229E and MERS-CoV). In all viral infections, we observed significant reductions in virus titer in valinomycin-treated cells. In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.

Importance No antivirals are approved for the treatment of bunyavirus infection. The ability to rapidly screen compounds and identify novel antivirals is one means to accelerate drug discovery for viruses with no approved treatments. We used this approach to screen hundreds of compounds against La Crosse virus, an emerging bunyavirus that causes significant disease, including encephalitis. We identified several known and previously unidentified antivirals. We focused on a potassium ionophore, valinomycin, due to its promising in vitro antiviral activity. We demonstrate that valinomycin, as well as a selection of other ionophores, exhibits activity against La Crosse virus as well as several other distantly related bunyaviruses. We finally observe that valinomycin has activity against a wide array of human viral pathogens, suggesting that disrupting potassium ion homeostasis with valinomycin may be a potent host pathway to target to quell virus infection.

Peroxidases are a group of heterogeneous family of enzyme that plays diverse biological functions. Ascorbate peroxidase is a redox enzyme that is reduced by trypanothione, which plays a central role in the redox defence system of Leishmania. In view of developing new and novel therapeutics, we have performed in silico studies in order to search for ligand library and identification of new drug candidates and its physiological role against promastigotes and intracellular amastigotes of Leishmania donovani. Our results demonstrated that the selected inhibitor ZINC96021026 has significant anti-leishmanial effect and effectively killed both free and intracellular forms of the parasite. ZINC96021026 was found to be identical to ML-240, a selective inhibitor of Valosin-containing protein (VCP) or p97, a member of AAA-ATPase protein family which was derived from the scaffold of DBeQ, targeting the D2-ATPase domain of the enzyme. ZINC96021026 (ML-240) thus have broad range of cellular functions, thought to be derived from its ability to unfold proteins or disassemble protein complexes besides inhibiting the ascorbate peroxidase activity. ML-240 may inhibits the parasite's ascorbate peroxidase leading to extensive apoptosis and inducing generation of reactive oxygen species. Taken together, our results demonstrated that ML-240 could be an attractive therapeutic option for treatment against leishmaniasis.

Malware on an air-gapped computer can transmit data like Morse code by changing screen brightness in a way that's invisible to the naked eye but easily recorded with a camera.

BACKGROUND:

Current guidelines from the American Academy of Pediatrics recommend screening children for developmental problems by using a standardized screening tool and referring at-risk patients to early intervention (EI) or subspecialists. Adoption of guidelines has been gradual, with research showing many children still not being screened and referred.

Don't settle for the default settings on your Android device. With the right launcher, you can customize the screens and layouts of your phone.

At CES, LG Display is showing off a 65-inch concept TV that can bend at the edges, allowing it to switch from a flat-screen display to a curved one in about five seconds. The company also put a bendable OLED on a foldable tablet/laptop.

Philip M. Farrell
Jan 1, 2001; 107:1-13
ARTICLES

Regulations promulgated by the Secretary of State and slated to take effect Jan. 1 will require that new business entities formed in Delaware be screened against lists of persons and groups that have been prohibited from doing business in the United States.

Free outdoor, family-fun event also includes activities and food.

People are seen going about their lives while a doctor is able to monitor them remotely. Although the ad evokes curiosity, it does not address people’s fear of inserting a device into the body or reveal how the ‘breakthrough’ technology works.

OTT platforms are sexing up their original content library with bigger budgets, foreign locales and slick production values

Ashnoor Kaur is an Indian child actress associated with Hindi television and films. She is known for portraying Naira Singhania in Yeh Rishta Kya Kehlata Hai on Star Plus and Mini Khuranna on Patiala Babes that airs on Sony Entertainment Television

Free HIV testing will be offered through the Division of Public Health (DPH) at two Delaware state service centers on Wednesday, June 27, 2018, in observance of National HIV Testing Day. The Centers for Disease Control and Prevention (CDC) recommends that everyone between the ages of 13 and 64 get tested for HIV at least once as part of routine health care.

April Designated as Lung Cancer Screening Awareness Month DOVER – Dramatic “before-and-after-smoking” inflatable lungs shared center stage with Governor John Carney as he urged Delawareans at high risk of lung cancer to get life-saving screenings. Governor Carney proclaimed April as Lung Cancer Screening Awareness Month in Delaware at the Delaware Cancer Consortium’s (DCC) annual retreat […]

To encourage Delawareans to support fall prevention strategies, Governor John Carney and Lieutenant Governor Bethany Hall-Long proclaimed the week of September 22-28, 2019 as Falls Prevention Awareness Week in Delaware. The National Council on Aging (NCOA) designates the first day of the fall season as National Falls Prevention Awareness Day, which is September 23 this year.

The detailed list of equipment that the 2020 Datsun Redi-Go will offer once it is launched has been leaked online which has revealed that the Redi-Go will feature a new dash that offers an 8-inch touchscreen infotainment system.

Touchscreen infotainment systems have become one of the defining characteristics of modern SUVs. Here are five of the largest touchscreens that are available under the Rs 25 lakh bracket.

The upcoming Datsun Redi-Go has been teased, but the styling of the little city hatchback has been leaked online. And now we also know what new features it will offer and with which variant it will be offered in.

The White House’s persistent claim that Covid-19 is a Chinese lab creation is nothing but a calculated move meant to divert Americans’ anger away from how Trump handles the crisis, German spies reportedly believe.  
Read Full Article at RT.com

  This post is to help you learn on how to use Intel WiDi technology to project/beam your app onto a bigger screen (TV, Laptop, Monitor). We will be using the example of an app named "Grace" f...

These kits will help the state in quick screening of suspected Covid-19 patients. The chief minister said RTKs will be sent to all districts the very next day.

A House report found that Americans fleeing Asia and Europe to beat the president’s travel bans faced few temperature checks or other rigorous screenings to see if they were bringing the virus home.

Have you ever manufactured a printed circuit board (PCB) without analyzing all the routed signal traces? Most designers will say “yes, all the time.” Trace widths and spacing are set by constraints,...

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Have you ever manufactured a printed circuit board (PCB) without analyzing all the routed signal traces? Most designers will say “yes, all the time.” Trace widths and spacing are set by constraints, and many designers simply don’t h...(read more)

Hi All,

I want to capture the transition values of certain nodes in a design (i.e. a digital multiplier built with standard cells) and I use probe -screen command to dump the nodal values in text format. Since I only need to capture these values in the ideal situation, I use -nospecify switch with the xrun command :

xrun -clean R16FA_2009.v R4BE_Test.v tb_stop16.v -v stdlib_verilog_models-sdf30.v -access +rwc -mess -timescale 1ns/1ps -nospecify -gui &

and the probe command goes like this : 

probe -screen tb_stop16.mul16.test.L1 -redirect probe1.txt -format "%T L1 Value: %b"  //Here L1 is an array of wires

Although I expect a single transition at a given time instance, I see multiple transitions occurring in the dumped probe1.txt file. i.e. 

Time: 300 PS : 48'bxx0xx0xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx0xx0xx11x
Time: 300 PS : 48'b000000000000000000000000000000000000000000000110
Time: 4 NS : 48'b001000000000000000000000000000000000000000000100
Time: 4 NS : 48'b011000000010111111111001000000110011011001010101
Time: 8 NS : 48'b010000000010111111111001000000110011011001010101
Time: 8 NS : 48'b110100101100000110000111100001010010111001011100
Time: 12 NS : 48'b010000110011100010001110011100010101010001010101
Time: 16 NS : 48'b000010000010000000000000000010000000010010010100
Time: 20 NS : 48'b000011000010000000000000000010000000010010010100
Time: 20 NS : 48'b000001001001001001011011000010001010011010010100

From the waveform, it appears that only the second value (bold)  of the time instance is correct. Since the simulation is without annotated delays, there are no intermediate transitions in the waveform. How could this be possible ?

Thanks in advance

9 bytes small Microsoft Windows 7 screen locking shellcode.

Solaris version 11.4 xscreensaver local privilege escalation exploit.

This Metasploit module exploits a vulnerability in xscreensaver versions since 5.06 on unpatched Solaris 11 systems which allows users to gain root privileges. xscreensaver allows users to create a user-owned file at any location on the filesystem using the -log command line argument introduced in version 5.06. This module uses xscreensaver to create a log file in /usr/lib/secure/, overwrites the log file with a shared object, and executes the shared object using the LD_PRELOAD environment variable. This module has been tested successfully on xscreensaver version 5.15 on Solaris 11.1 (x86) and xscreensaver version 5.15 on Solaris 11.3 (x86).

PTP-RAT is a proof of concept that allows data theft via screen-share protocols. Each screen flash starts with a header. This contains a magic string, "PTP-RAT-CHUNK" followed by a sequence number. When the receiver is activated, it starts taking screenshots at twice the transmission frequency (the Nyquist rate). When it detects a valid header, it decodes the pixel colour information and waits on the next flash. As soon as a valid header is not detected, it reconstructs all the flashes and saves the result to a file. To transfer a file, you run an instance of the Rat locally on your hacktop, and set that up as a receiver. Another instance is run on the remote server and this acts as a sender. You simply click on send file, and select a file to send. The mouse pointer disappears and the screen begins to flash as the file is transmitted via the pixel colour values. At the end of the transfer, a file-save dialog appears on the receiver, and the file is saved.

Investors in France will face greater scrutiny under extended legislation.

Authorities in the US, the EU and across the developed world are stepping up efforts to scrutinise foreign investment on the grounds of both national security and tech sovereignty.

The trend towards the vetting of foreign investment, especially projects that involve advanced technology and national data or pose potential security threats, is on the rise. David Gabathuler and Matthew T West give a trans-Atlantic perspective.

Introduction On 5 July 2019, the Minister of Environment, Forestry and Fisheries, Barbara Dallas Creecy, published a notice requiring that when submitting an application for environmental authorisation in terms of regulation 19 and regulation 21 of ...

mXT2912TD Touchscreen Controller Product Datasheet_V2.0.pdf

mXT2113TD Touchscreen Controller Product Datasheet_V2.0.pdf

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