ClarkDietrich is adding two new components to its E-Screen entangled-mesh rainscreen rolls, providing a complete exterior cladding moisture management system that is compliant with ASTM performance criteria.

The Rainscreen Association in North America announced the winners of the inaugural RAiNA Awards, recognizing outstanding achievements in rainscreen design and innovation. The award ceremony, which was held on Nov. 7 in Chicago, celebrated projects that exemplify creativity, technical excellence and sustainability in building envelope performance.

Innovation drives progress. And in Amarillo, Texas, there is a new hub for innovation on the campus of Amarillo College. It is called Innovation Outpost, and the building’s renovation nods to the past with an eye on the future.

These mechanic-style gloves feature a leather palm and both gray spandex and flexible impact protection on the back of the hand.

Washington — Coal miners soon will have access to a series of free, confidential health screenings through the NIOSH Coal Workers’ Health Surveillance Program.

Washington – A series of free, confidential health screenings will be available for coal miners as part of the NIOSH Coal Workers’ Health Surveillance Program.

Washington — NIOSH will offer a series of free, confidential health screenings for coal miners through its Coal Workers’ Health Surveillance Program.

Washington — NIOSH has planned a series of free, confidential health screenings for current and former coal miners via the agency’s Coal Workers’ Health Surveillance Program.

Washington — NIOSH will offer a series of free, confidential health screenings for current and former coal miners as part of the agency’s Coal Workers’ Health Surveillance Program.

Melbourne, Australia — A recent study of stone countertop industry workers reveals an “alarmingly high” occurrence of silicosis, indicating that government-mandated screening tests may be inadequate to diagnose the disease.

Washington — In an effort to detect cases of black lung disease, NIOSH will offer free, confidential health screenings for current and former coal miners in Indiana and Texas.

Washington – Screening data for nearly 2,000 chemicals is available through the Environmental Protection Agency’s new Interactive Chemical Safety for Sustainability Dashboard.

The Tool Grabber Cut Protect 4 Glove features ANSI 105, 2011 Cut Level 4; ANSI Abrasion Level 6 (the highest rating); and ANSI Puncture Level 5 (also the highest rating) protection.

Rancho Cordova, CA — More than 4 out of 5 Generation Z employees say they’re working longer hours – and most say their eye health is suffering as a result.

Washington — Aiming to identify cases of black lung disease in current and former miners, NIOSH will provide free, confidential health screenings in Ohio, Pennsylvania, Virginia and West Virginia.

Children's Geographies; 12/01/2021
(AN 153655047); ISSN: 14733285
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The post Suicide Screening and Care Help Lead to Recovery was curated by information for practice.

It’s interesting how things have changed in the last few months, with every single one of my school assemblies, parent workshops, and speaking at conferences postponed. I’ve given more people ZOOM attention in the last 8 weeks than in the last 8 years combined. So here’s an opportunity to get some screen-to-screen love (which isn’t …

Continue reading "Getting Jonathan Screen-to-Screen"

The post Getting Jonathan Screen-to-Screen appeared first on Jonathan's Blog From The Source.

The post Study Confirms Real-World Reliability of a Key Tool for Alcohol Screening was curated by information for practice.

A new movie about OSU alumnus Jesse Owens debuts in theaters this weekend, so we get the whole story on the life of Jesse Owens.

Most of us have used a self-service, multi-user kiosk at some point in our lives, to purchase train tickets, to select our burger at a fast food restaurant, to pay for parking in a multi-story car park, to check-in at a hospital or airport to name just a few.

The question is, will COVID-19, or possibly some future virus strain make people reluctant about using these now necessary machines

Elo, a Silicon Valley-based global provider of interactive solutions, has announced major enhancements to its Elo Access App.

Black Box, a global information technology solutions provider, has introduced the first solution in its Return to Work suite designed to help organisations and businesses in different industries provide a safer environment for their staff, visitors and customers.

The Co-op Media Network (CMN) is to install 300 new front-of-store digital media screens to turbo-charge its retail media offering, taking the total number of screens to over 9,000 across its store estate.

For today’s #MovieSpotlight, we are joined by film critics Jason Bechervaise and Darcy Paquet  to celebrate Han Kang’s Nobel Prize in Literature win! #한강...

[more...]

Crystallographic fragment screening has become a pivotal technique in structure-based drug design, particularly for bacterial targets with a crucial role in infectious disease mechanisms. The enzyme CdaA, which synthesizes an essential second messenger cyclic di-AMP (c-di-AMP) in many pathogenic bacteria, has emerged as a promising candidate for the development of novel antibiotics. To identify crystals suitable for fragment screening, CdaA enzymes from Streptococcus pneumoniae, Bacillus subtilis and Enterococcus faecium were purified and crystallized. Crystals of B. subtilis CdaA, which diffracted to the highest resolution of 1.1 Å, were used to perform the screening of 96 fragments, yielding data sets with resolutions spanning from 1.08 to 1.87 Å. A total of 24 structural hits across eight different sites were identified. Four fragments bind to regions that are highly conserved among pathogenic bacteria, specifically the active site (three fragments) and the dimerization interface (one fragment). The coordinates of the three active-site fragments were used to perform an in silico drug-repurposing screen using the OpenEye suite and the DrugBank database. This screen identified tenofovir, an approved drug, that is predicted to interact with the ATP-binding region of CdaA. Its inhibitory potential against pathogenic E. faecium CdaA has been confirmed by ITC measurements. These findings not only demonstrate the feasibility of this approach for identifying lead compounds for the design of novel antibacterial agents, but also pave the way for further fragment-based lead-optimization efforts targeting CdaA.

Here, an open-source Python library for identifying and screening potential stacking fault models in crystalline materials with planar disorder is presented.

The article presents a non-invasive nanoscale imaging technique that can be used in screening crystallization conditions for protein micro- and nanocrystals.

X-ray diffraction imaging (XDI) is utilized for visualizing the structures of non-crystalline particles in material sciences and biology. In the structural analysis, phase-retrieval (PR) algorithms are applied to the diffraction amplitude data alone to reconstruct the electron density map of a specimen particle projected along the direction of the incident X-rays. However, PR calculations may not lead to good convergence because of a lack of diffraction patterns in small-angle regions and Poisson noise in X-ray detection. Therefore, the PR calculation is still a bottleneck for the efficient application of XDI in the structural analyses of non-crystalline particles. For screening maps from hundreds of trial PR calculations, we have been using a score and measuring the similarity between a pair of retrieved maps. Empirically, probable maps approximating the particle structures gave a score smaller than a threshold value, but the reasons for the effectiveness of the score are still unclear. In this study, the score is characterized in terms of the phase differences between the structure factors of the retrieved maps, the usefulness of the score in screening the maps retrieved from experimental diffraction patterns is demonstrated, and the effective resolution of similarity-score-selected maps is discussed.

To identify starting points for therapeutics targeting SARS-CoV-2, the Paul Scherrer Institute and Idorsia decided to collaboratively perform an X-ray crystallographic fragment screen against its main protease. Fragment-based screening was carried out using crystals with a pronounced open conformation of the substrate-binding pocket. Of 631 soaked fragments, a total of 29 hits bound either in the active site (24 hits), a remote binding pocket (three hits) or at crystal-packing interfaces (two hits). Notably, two fragments with a pose that was sterically incompatible with a more occluded crystal form were identified. Two isatin-based electrophilic fragments bound covalently to the catalytic cysteine residue. The structures also revealed a surprisingly strong influence of the crystal form on the binding pose of three published fragments used as positive controls, with implications for fragment screening by crystallography.

A considerable bottleneck in serial crystallography at XFEL and synchrotron sources is the efficient production of large quantities of homogenous, well diffracting microcrystals. Efficient high-throughput screening of batch-grown microcrystals and the determination of ground-state structures from different conditions is thus of considerable value in the early stages of a project. Here, a highly sample-efficient methodology to measure serial crystallography data from microcrystals by raster scanning within standard in situ 96-well crystallization plates is described. Structures were determined from very small quantities of microcrystal suspension and the results were compared with those from other sample-delivery methods. The analysis of a two-dimensional batch crystallization screen using this method is also described as a useful guide for further optimization and the selection of appropriate conditions for scaling up microcrystallization.

The Swiss Light Source facilitates fragment-based drug-discovery campaigns for academic and industrial users through the Fast Fragment and Compound Screening (FFCS) software suite. This framework is further enriched by the option to utilize the Smart Digital User (SDU) software for automated data collection across the PXI, PXII and PXIII beamlines. In this work, the newly developed HEIDI webpage (https://heidi.psi.ch) is introduced: a platform crafted using state-of-the-art software architecture and web technologies for sample management of rotational data experiments. The HEIDI webpage features a data-review tab for enhanced result visualization and provides programmatic access through a representational state transfer application programming interface (REST API). The migration of the local FFCS MongoDB instance to the cloud is highlighted and detailed. This transition ensures secure, encrypted and consistently accessible data through a robust and reliable REST API tailored for the FFCS software suite. Collectively, these advancements not only significantly elevate the user experience, but also pave the way for future expansions and improvements in the capabilities of the system.

CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug-resistant human pathogens. The enzymatic product of CdaA, cyclic di-AMP, is a secondary messenger that is essential for the viability of many bacteria. Its absence in humans makes CdaA a very promising and attractive target for the development of new antibiotics. Here, the structural results are presented of a crystallographic fragment screen against CdaA from Listeria monocytogenes, a saprophytic Gram-positive bacterium and an opportunistic food-borne pathogen that can cause listeriosis in humans and animals. Two of the eight fragment molecules reported here were localized in the highly conserved ATP-binding site. These fragments could serve as potential starting points for the development of antibiotics against several CdaA-dependent bacterial species.

President Barack Obama presents novelist, essayist and screenwriter Larry McMurtry with a National Humanities Medal in September 2015.; Credit: Leigh Vogel/WireImage/Getty Images

Larry McMurtry, a prolific, Pulitzer Prize-winning author and Oscar-winning screenwriter, has died at age 84. He was beloved for riveting and yet unsentimental depictions of the American West in books like Lonesome Dove, as well as for tales of family drama including Terms of Endearment.

In a statement, his representative Amanda Lundberg said McMurtry "passed away last night, on March 25 of heart failure at 84 years old surrounded by his loved ones who he lived with including long time writing partner Diana Ossana, his wife Norma Faye and their 3 dogs."

In all, McMurtry wrote more than 30 novels as well as over a dozen non-fiction works that spanned memoir, history and essays. He also wrote over 20 screenplays and television scripts.

McMurtry was also famous for his bookstore, Booked Up in Archer City, Texas. Even after selling off more than half of his holdings in 2012, he still had about 200,000 books between his private collection and the store.

When he won an Oscar in 2006 for the screenplay adaption of E. Annie Proulx' short story Brokeback Mountain, which he co-wrote with longtime writing partner Diana Ossana, he thanked booksellers.

"From the humblest paperback exchange to the masters of the great bookshops of the world," he said, "all are contributors to the survival of the culture of the book, a wonderful culture, which we mustn't lose."

Filmmakers were drawn to McMurtry's work; his books Hud, The Last Picture Show and Terms of Endearment were all made into films. Lonesome Dove, which earned him the Pulitzer in 1985, became a successful TV miniseries in 1989, starring Robert Duvall and Tommy Lee Jones.

Born in 1936 on a Texas ranch, McMurtry came to his love of the West through his family. His grandfather broke horses, and his father raised cattle.

"The West is mostly a very beautiful place," he told All Things Considered in 2014. "There are all those lovely spaces. There are all those running horses. It's a poetic imagery and it's been there for a long time."

But he wanted to scour that landscape of sentimental nostalgia for cowboys, he added. "To me it was hollow and I think it was hollow for my father, although he might not have ever brought that to his conscious mind. He totally loved cowboys and so did most of the cowboys we worked with and that got him through his life. But he knew perfectly well, so did we, that it wouldn't last another generation, it just was not going to last."

This content is from Southern California Public Radio. View the original story at SCPR.org.

To ensure that minority students who are poorly prepared for school are not assigned to special education for that reason, educators should be required to first provide them with high-quality instruction and social support in a general education classroom before making a determination that special education is needed.

The federal government should not rely on polygraph examinations for screening prospective or current employees to identify spies or other national-security risks because the test results are too inaccurate when used this way.

EPA should conduct an ecological risk assessment of ultraviolet filters used in sunscreens, given the evidence that aquatic ecosystems in the U.S. and possibly endangered species are exposed to these UV filters, and given the importance of these ingredients in skin cancer prevention.

The widespread IT outages triggered by a faulty CrowdStrike update have put software updates in the spotlight. Here’s why you shouldn’t dread them.

M.O.L.E. EV6 delivers handheld thermal profiling control, freeing bakery operators from time-consuming, offline PC download.

The screenings are designed to support the early detection of black lung disease, a serious but preventable illness caused by prolonged exposure to coal mine dust.

Many companies are still refining how they’ll safely bring employees back to the office. Yet not every business can operate with a 100 percent remote workforce. For some, essential employees need to be onsite at all times. Ampirical is one of those businesses.

The company will produce four new projects over the next two years.

Imagining the Indian explores the impact that stereotyping and marginalization of Native history have had on Native people. It chronicles the long social movement to eliminate mascoting. KC area interviews are included in the documentary.

Bringing Advanced Dental Sleep Medicine to North Miami Beach Residents

The cash-in payment network chooses iDenfy's AML services to ensure global compliance

Tampa residents and businesses looking for new ways to spice up their events in 2023 are in luck - a new outdoor LED screen event rentals company is coming to the city.

Academy Award-nominated actor Josh Brolin narrates "Ground Swell: The Other Side of Fear" feature documentary heading to movie theaters starring the best big wave surfers in the world, including the 100-foot wave from Nazare, Portugal!

Eagle Eye Screening Solution announces their ability to provide quality background check services

Local general contractor offers deck, patio and porch maintenance services

Eagle Eye Screening Solutions Breaks Down Various Searches Available to Los Angeles Clients