Nick Wright reveals who climbs up and down his Week 11 QB Tiers, including Kyler Murray and Brock Purdy, who will face each other in the final game of the regular season with playoffs on the line. Watch as Nick explains why Caleb Williams is not off Mahomes Mountain yet despite a change in the Chicago Bears coaching staff.

Chipotle’s new chief executive is Scott Boatwright, a familiar face and name, given that he’s served as the interim CEO since August following former CEO Brian Niccol’s surprise decision to lead a turnaround at Starbucks. And while Boatwright, 52, will get a significant pay boost in his new…

« N-complex number, N-dimensional polar coordinate and 4D Klein bottle with 4-complex number» “A concrete representation of a 4D Klein bottle has been desired by many but has never been presented. So, I decided to dive into the Klein bottle. Working with the Klein bottle was my first opportunity to practice with this system. To...

I have only seen a hydrothermal vent once, during Dive 73 aboard the Monterey Bay Aquarium Research Institute’s Doc Ricketts. Unlike many deep-sea biologists, I…

The post A Journey to the Hottest Place on Earth: Hydrothermal Vents and the Resilient Pompeii Worm first appeared on Deep Sea News.

This research was undertaken by Stuart Fordyce as part of an MSc in Integrated Service Improvement (Health and Social Care) at the University of Edinburgh. It considers the impact of a rapidly ageing population on a Scottish local authority and its attempt to shift the focus to a more contemporary service provision. The aim is to explore what factors are inhibiting the effectiveness of enablement. Using a case study approach the research explored whether: (i) enablement is wholly effective in addressing the increase in current service demands; (ii) the approach adopted by the local authority is undermined as services are now over extended and are attempting to address competing objectives, and; (iii) the paradigmatic change across the sector in the future will materialise if organisations cannot create the capacity and infrastructure to enable change to occur

The core purpose of the Scottish Centre for Crime and Justice Research (SCCJR) is to carry out high quality, internationally recognised research in relation to crime and criminal justice.

SCLD brings together some of the most respected practitioners and thinkers from across the learning disability sector who work alongside people who have learning disabilities and their families and carers.The team at SCLD is focused on delivering real change through influencing policy, identifying and sharing evidence and good practice and challenging public attitudes. SCLD aims to be a knowledge hub – offering support, information and new ideas about learning disability in Scotland.

The Scottish Council for Voluntary Organisations (SCVO) is the membership organisation for Scotland's charities, voluntary organisations and social enterprises.

See the full video at ChaosMen

The post QuickClips: ChaosMen – Scott DeMarco Fucks Brody Meyer appeared first on QueerClick.

Photo courtesy of Colin W. Spotted in Japan. 

By Carly Tennes Published: November 12th, 2024

By JM McNab Published: November 12th, 2024

I couldn’t believe my eyes as I wandered through IKEA’s soft toy section. There, perched among the bins was Hedwig from Harry Potter. It was then I realized I was staring at IKEA’s new SKOGSDUVA snowy owl hand puppet. The resemblance to Harry’s faithful feathered companion was uncanny. While it might not deliver Hogwarts acceptance letters, it certainly brought a touch of magic to my shopping trip. With its fluffy white feathers and expressive eyes, this soft, cuddly version of […]

The post This Must-Have IKEA Item Completes Your Kid’s Harry Potter Costume appeared first on IKEA Hackers.

The new 2024-25 COVID vaccines are available, so FunkyPlaid and I got ours on Friday. Because we went to a pharmacy, my health insurance didn’t cover them, so I had to use funds from my HRA. (We could have waited until our medical provider had appointments, but that would have been late September or early October — and with travel coming up soon, I was unwilling to wait.)

It is bizarre and enraging to see how agencies supposedly dedicated to public health are flailing in this moment. I’m extremely fortunate to have a job that provides health insurance, an HRA, and sick leave, and I can afford KN95 masks and rapid antigen tests. What about people who are uninsured or underinsured?

I know it’s a bummer to read this, but it’s a bigger bummer to try to survive during yet another COVID surge. Let’s take care of our health, for ourselves and for our communities.

Concentrating on

This time of year is Planner Season, when the 2025 planners are released and people like me (and maybe you too) gobble them up and then spend the rest of this year hoping that next year we have lives exciting enough to plan.

Ever the optimist, my planner line-up for 2025 is:

• For my personal planner, daily log, habit tracker, reading journal, and commonplace book, I’ll be trying the Sterling Ink Common Planner in their new N1 size, which fits inside a Traveler’s Notebook. I’m currently using a Hobonichi Weeks, which is 95mm x 186mm; the N1 size is 110mm x 210mm.
• For my work planner, the Wonderland 222 A5 Weekly Planner has been working well for me this year, so I’ll try it again in 2025.

Cultivating

✍???? Drafting two stories, one for performance (I hope ????????) and one for a collection.

???? Still knitting that gift for someone.

???? Food I made that was yummy:

• Peperonata with peppers from a coworker’s CSA box, plus peppers from our own CSA box. CSA boxes are great!
• Gluten-free vegan apple crisp. I am not a huge fan of apples in their primary form; I prefer them as a cinnamon delivery device. So this recipe from Minimalist Baker, apples chopped up and baked with oats and sugar? That works.
• Sliced heirloom tomatoes on toast spread thinly with mayonnaise. Truffle salt if you’re feeling fancy. (I was.)

???????? Learning Italian with Duolingo.

???? The workweek was short because of the holiday on Monday, but also long because of everything. I’m still trying to create better boundaries around that.

Consuming

????️ One of my planner pals shared a sample of Bungukan Kobayashi’s Yagentoshiro Reflex Violet, a dusky blue with iridescent purple shimmer.

???? “girlfriend” by Hemlocke Springs is on repeat on my brain radio.

???? You don’t need to be a Rolling Stones fan to enjoy the “I Can’t Get No Legal Action” episode of the Judge John Hodgman podcast.

???? Still working my way through the crossword puzzle books I’ve hoarded and enjoying the daily Cross|word on Puzzmo. Also, Minute Cryptic is quite humbling.

???? One last episode of “Fargo” to go, then we’ll start the latest season of “Slow Horses”.

???? What I’m reading and quoting:

• “The Mountain in the Sea” by Ray Nayler: “The great and terrible thing about humankind is simply this: we will always do what we are capable of.”

Some links

From “What would an adequate COVID response look like?” by Julia Doubleday:

Right now, state representatives are deliberately avoiding mention of COVID, while propagandizing the safety of infection and/or the end of the pandemic by refusing to mask. It is hard to imagine how successful a pandemic response might be if public officials were actually trying to end the pandemic. We quite literally have public health and political and media figures working to hide three pieces of critical information: public knowledge of the virus, public knowledge of mitigation measures that would reduce viral spread, and public knowledge of the severity of the virus (which would motivate desire to reduce viral spread).

Other links:

• NaNoWriMo Shits The Bed On Artificial Intelligence (Chuck Wendig)
• Why Goblin Mode Is the New Self-Care Routine (Cleveland Clinic)
• 2024 Winners of the 17th Annual iPhone Photography Awards

One more thing

Today I’m journaling about this quote from Seneca: “Life, if well lived, is long enough.”

The hepatitis E virus protein ORF1 contains a region that scientists have struggled to characterize, making the structure and function of this region the subject of much debate. Now, Princeton scientists show that this region of the protein does not behave as a protease, as has been previously suggested, but instead serves as a molecular scaffold to stabilize the rest of the ORF1 protein.

Hale Freeman Trotter, an emeritus professor of mathematics, died at 91 at his home in Princeton, New Jersey.

PivotTables are a powerful tool to calculate, summarize, and analyze data that lets you see comparisons, patterns, and trends in your data. This session will introduce participants PivotTables and their functionality. We will also discuss creating PivotCharts, a graphical representation of a data summary displayed in a PivotTable.

Gemma Peacocke’s ‘A Strange Power’ is a 45-minute cantata about the tangled web of romance, free love, creation, and death in the early lives of Mary Wollstonecraft Godwin Shelley and her step-sister, Claire Clairmont. Scored for two sopranos, clarinet, piano, percussion, and cello, the work will be performed by Sputter Box with guest vocalist Charlotte Mundy. The program also features new works for the performers by other Princeton University graduate student composers Aliayta Foon-Dancoes, Devin Greenwood, Gemma Peacocke, and Onche Rajesh Ugbabe.

Another next-level build from Mr. Dangerholm.
( Photos: 31, Comments: 126 )

No sex? No problem. At least not for Charlotte the stingray.

Vistors to the North Coast 500 are being asked to sign a pledge amin concerns of speeding drivers

Ibiza, a stunning island in the Mediterranean Sea, is globally renowned for its electric nightlife and vibrant party scene. This picturesque island has become the epitome of summer party destinations. It attracts visitors from all corners of the world with its beautiful beaches, mesmerizing sunsets, and, most notably, its unparalleled nightlife. Clubs in Ibiza are not just venues; they are the beating heart of the island’s culture as they showcase world-class DJs, groundbreaking music, and unforgettable experiences to define the essence of a perfect summer getaway. The purpose of this article is to guide you through the exhilarating nightlife of Ibiza. Whether you’re a seasoned club-goer or a first-time visitor, this comprehensive guide to the top 10 must-visit nightclubs will ensure you hit the hottest spots and make the most of your nights in Ibiza. From iconic institutions to cutting-edge clubs, we’ve curated a list that captures the diversity and vibrancy of Ibiza’s nightlife. These places promise unforgettable nights filled with music, dance, and celebration. Why Ibiza? Ibiza stands as a beacon for nightlife enthusiasts from around the globe. It’s celebrated for its unmatched party scene and vibrant atmosphere. But what exactly catapults this Balearic Island into the spotlight as a world-renowned destination for nightlife? Diverse Music Scene: Ibiza’s music landscape is as varied as it is electrifying. From techno and house to EDM and indie rock, the island offers something for every taste, hosted across an array of clubs and venues. Vibrant Atmosphere: There’s an infectious energy that permeates Ibiza’s nightlife. Whether you’re dancing under the stars at an outdoor beach club or losing yourself in the immersive environment of an underground venue, the atmosphere is always charged with excitement. Stunning Venues: Ibiza’s nightclubs are more than just places to dance; they’re architectural wonders and sensory experiences. From clubs with breathtaking views of the Mediterranean to venues that push the boundaries of interior design, Ibiza offers stunning settings that elevate the party experience to new heights. Criteria for Selection When it comes to pinpointing the top 10 nightclubs in Ibiza, our selection is driven by a carefully considered set of criteria. We aim to showcase venues that not only dominate the nightlife scene but also offer unique experiences that leave a lasting impression. The following factors play a crucial role in our selection: Music Genres: A club’s musical offerings are pivotal. We look for diversity and quality, favoring venues that host world-renowned DJs to suit a wide range of musical tastes. Atmosphere: The vibe of a nightclub is its soul. We seek out places that offer more than just a dance floor. In fact, we prioritize those who create an immersive experience through their energy, design, and crowd.  Reputation: A club’s reputation is built on years of delivering exceptional nights out. We consider the esteem in which venues are held by both locals and international visitors, as well as their recognition within the global nightlife community. Overall Experience: Finally, we factor in the overall experience, including the quality of sound and lighting systems, the presence of unique features (like outdoor terraces or poolside dance floors), and the level of service provided. A club that offers an unforgettable night out, from entry to exit, makes our list.  Club 1: Amnesia Ibiza Location San Rafael, Ibiza Music Genres Techno House EDM Atmosphere Amnesia Ibiza stands out for its high-energy ambiance which makes it a sanctuary for dance music enthusiasts. The club’s iconic terrace offers an immersive experience that draws partygoers into a world of euphoric beats and rhythms. Notable Features Famous Foam Parties: These unique and wildly entertaining parties are a signature Amnesia experience. State-of-the-Art Sound System: Delivers crystal-clear audio that enhances the musical journey. Spectacular Light Shows: Visually stunning displays complement the sonic experience, creating unforgettable moments.  Highlights Legends of the electronic music scene, such as Carl Cox and Marco Carola, are regulars here, guaranteeing an unmatched lineup of performances. Club 2: Pacha Ibiza Location Ibiza Town, Ibiza Music Genres House Techno EDM Atmosphere Pacha Ibiza exudes a glamorous and chic vibe and offers a luxurious nightclub experience. Its atmosphere attracts a stylish crowd to dance the night away in one of the island’s most iconic settings. Notable Features Iconic Cherry Logo: A symbol of the club’s heritage and prestige. VIP Sections: For those seeking a more exclusive experience, with stunning views of Ibiza Town. Elegant Decor: Pacha’s interior design combines style with comfort, creating a uniquely sophisticated environment. Highlights Hosting world-renowned DJs like David Guetta and Martin Solveig, Pacha remains at the forefront of Ibiza’s nightlife scene. Club 3: DC-10 Location Sant Josep de sa Talaia, Ibiza Music Genres Techno House Atmosphere DC-10 is celebrated for its raw and underground atmosphere. This club offers an intimate setting where the focus is squarely on the music and the communal experience of dance. Notable Features Open-Air Terrace: Provides a unique outdoor clubbing experience. Industrial Vibe: The club’s minimalist, warehouse-style setup enhances its gritty, authentic feel. Immersive Experiences: DC-10’s events are designed to create a deep connection between the DJs and the crowd. Highlights Home to the legendary Circoloco parties, DC-10 attracts top DJs such as Seth Troxler and The Martinez Brothers to ensure an unparalleled lineup and vibe. Club 4: Ushuaïa Ibiza Beach Club Location Playa d’en Bossa, Ibiza Music Genres EDM House Atmosphere Ushuaïa Ibiza Beach Club is the epitome of an extravagant outdoor party experience. With its poolside setting, it invites guests to dance under the sun and stars in one of the most breathtaking venues on the island. Notable Features Massive Stage: Hosts some of the biggest names in the music industry. Stunning Visuals: Offers a sensory feast with its impressive light shows and stage productions. Celebrity Appearances: A hotspot for celebrities, adding to the club’s allure. Highlights Iconic pool parties featuring world-class performances by artists like Calvin Harris and Avicii are the heart of Ushuaïa’s appeal. Club 5: Hï Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House EDM Atmosphere Hï Ibiza offers a sophisticated and futuristic nightclub experience. Its immersive atmosphere is crafted through cutting-edge sound and stunning visuals that make every night a journey into the future of nightlife. Notable Features Cutting-Edge Sound System: Delivers unparalleled audio quality. Immersive Production: Engages all senses for a complete clubbing experience. Stunning Visuals: The club’s design and lighting create a mesmerizing environment. Highlights Glitterbox parties at Hï Ibiza shine with disco and house music vibes, featuring top DJs and a vibrant, inclusive atmosphere. Club 6: Privilege Ibiza Location San Rafael, Ibiza Music Genres House Techno EDM Atmosphere Privilege Ibiza is recognized for its massive scale and extravagant atmosphere. Holding the Guinness World Record for the world’s largest club, it offers an immersive experience with panoramic views of Ibiza. Notable Features World’s Largest Club: A title that adds to its legendary status. Panoramic Views: The club’s location and design provide breathtaking views of the island. Highlights Resistance parties at Privilege are a highlight, featuring top techno and house DJs like Adam Beyer and Charlotte de Witte to create unforgettable nights. Club 7: Eden Ibiza Location San Antonio, Ibiza Music Genres House Techno EDM Atmosphere Eden Ibiza strikes a perfect balance between lively and intimate as it creates an energetic atmosphere for music lovers to enjoy themselves up close with the performers. Notable Features Renovated Venue: A recent makeover has injected new life into Eden, enhancing its appeal. Impressive LED Screens: Add to the visual experience, complementing the beats with captivating displays. Intimate Dance Floor: Despite its size, Eden maintains an intimate feel, making every night more personal. Highlights Toolroom parties at Eden are a standout, with house music legends like Mark Knight behind the decks. Club 8: Heart Ibiza Location Ibiza Town, Ibiza Music Genres Eclectic Avant-garde Live performances Atmosphere Heart Ibiza offers an artistic and immersive experience with a blend of music, art, and gastronomy into a unique nightlife adventure to tantalize all senses. Notable Features Fusion of Music, Art, and Gastronomy: A unique concept that stands out in Ibiza’s nightlife. Stunning Interior Design: Adds to the immersive experience with its beauty and creativity. Highlights Heart Factory events are particularly notable for their live performances and DJ sets by international artists, making each night a unique journey. Club 9: Ibiza Rocks Hotel Location San Antonio, Ibiza Music Genres Indie Rock EDM Atmosphere Ibiza Rocks Hotel is known for its lively and vibrant environment, where the poolside setting adds a refreshing twist to the traditional nightclub experience. Notable Features Outdoor Stage: Offers a unique venue for live music under the Ibiza sun and stars. Pool Parties: Bring an energetic and fun atmosphere, perfect for daytime reveling. Live Music Events: Unlike many other clubs focusing solely on DJs, Ibiza Rocks hosts live bands and performances. Highlights The Ibiza Rocks Pool Party series is a summer highlight, featuring an eclectic mix of live performances by indie bands and DJs. It offers something different from the typical club scene. Club 10: Octan Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House Atmosphere Octan Ibiza brings a raw and underground vibe to the forefront of Ibiza’s nightlife. Its intimate setting allows for an immersive clubbing experience that’s both intense and personal. Notable Features Intimate Dance Floors: Designed to create a close connection between the DJs and the crowd. Immersive Experiences: Focused on delivering cutting-edge underground parties. Legacy: Carrying the torch from the famed Sankeys Ibiza, Octan continues to push the boundaries of the electronic music scene. Highlights The club is a haven for enthusiasts of techno and house music, and it hosts cutting-edge underground parties with leading DJs in the genre. Frequently Asked Questions (FAQ) What is the legal drinking age in Ibiza? The legal drinking age in Ibiza is 18 years old. Is there a dress code for Ibiza nightclubs? Dress codes can vary. While some clubs are more relaxed, others might require a more upscale attire. It’s best to check the specific club’s policy before going. How much does it cost to enter Ibiza nightclubs? Entrance fees can range widely from club to club and depending on the event or DJ playing. Prices can vary from €20 to over €50. VIP services and tables will cost significantly more. Are there any age restrictions for entry into nightclubs? Yes, most nightclubs in Ibiza have an age restriction of 18 years and above. Is it necessary to book tickets in advance for Ibiza nightclubs? It’s highly recommended to book tickets in advance, especially for popular events, to ensure entry and often at a lower price. What are the typical opening hours for Ibiza nightclubs? Nightclubs usually open around midnight and can go on till dawn, with peak hours from 1 AM to 4 AM. Are there any safety tips for clubbing in Ibiza? Stay hydrated, especially if dancing for long periods. Keep an eye on your belongings. Never accept drinks from strangers. Stick with your friends and plan how to get back to your accommodation safely. Conclusion We’ve explored the top 10 must-visit nightclubs in Ibiza, and each offers its unique vibe. From the extravagant and glamorous to the raw and underground, Ibiza’s nightlife is unparalleled. Its diverse music scenes and world-renowned DJs provide an unforgettable experience for every partygoer. Whether you’re drawn to the legendary foam parties of Amnesia, the sophisticated atmosphere of Hï Ibiza, or the intimate underground vibes of Octan, the island caters to all. We encourage you to dive into the vibrant energy of Ibiza’s nightlife scene and experience the magic of these iconic clubs firsthand.  

The post Top 10 Must-Visit Ibiza Nightclubs: Your Ultimate Guide to the Island’s Hottest Spots appeared first on Geeky Traveller.

“A huge fish in the Mekong River thought to be extinct has been spotted three times in recent years,” reports the Associated Press: “The giant salmon carp is like a symbol of the Mekong region,” said Chheana Chhut, a researcher at the Inland Fisheries Research Institute in Cambodia. The predatory fish can grow up to […]

The post Giant fish believed to be extinct is spotted in the Mekong River appeared first on Liberty Unyielding.

Tottenham boss Ange Postecoglou says their inconsistent start is down to him rather than his players after a fifth Premier League defeat.

We discuss the Scotland men’s squad, promoting young talent and Celtic v Chelsea.

Scottish League 2 club Bonnyrigg Rose are deducted six points - because of the slope on their New Dundas Park pitch.

East Kilbride stun Ayr United to reach the semi-finals of the SPFL Trust Trophy as Dunfermline Athletic and Livingston progress.

America and Americans must decide what the US' place in the world is and then accept what comes with that, writes Lisa Otto.

velocityconf: RT @courtneynash: Bill Scott's #fluentconf keynote theme also rings true re #velocityconf: tech change is really about people/culture change

Lesotho's national assembly has passed a motion to ban the importation of bottled water into the country as part of measures to promote the local industry.

News24 brings you the top stories of the day, summarised into neat little packages. Read through quickly or listen to the articles via our customised text-to-speech feature.

The World Meteorological Organisation (WMO) has raised the alarm over climate change, reporting 2024 is the world's hottest year yet.

You know it's bad when you give the Democrats a whoopin and the corprate media clowns have no choice but to concede your point.

The post GLORIOUS: Scott Jennings Gets Van Jones To Cry ‘Uncle’ Live On CNN appeared first on Clash Daily.

Weixian Deng
Dec 22, 2020; 0:RA120.002411v1-mcp.RA120.002411
Research

Deep proteome coverage in bottom-up proteomics requires peptide-level fractionation to simplify the complex peptide mixture before analysis by tandem mass spectrometry. By decreasing the number of co-eluting precursor peptide ions, fractionation effectively reduces the complexity of the sample leading to higher sample coverage and reduced bias towards high abundance precursors that are preferentially identified in data-dependent acquisition strategies. To achieve this goal, we report a bead-based off-line peptide fractionation method termed CIF or Carboxylate modified magnetic bead-based isopropanol gradient peptide fractionation. CIF is an extension of the SP3 (single-pot solid-phase-enhanced sample preparation) strategy and provides an effective but complementary approach to other commonly used fractionation methods including strong cation exchange (SCX) and reversed phase (RP)-based chromatography. We demonstrate that CIF is an effective offline separation strategy capable of increasing the depth of peptide analyte coverage both when used alone or as a second dimension of peptide fractionation in conjunction with high pH RP. These features make it ideally suited for a wide range of proteomic applications including the affinity purification of low abundance bait proteins.

Veteran quarterback Dak Prescott will undergo season-ending surgery to repair his injured hamstring, Dallas Cowboys owner Jerry Jones announced Tuesday.

A Maryland Lottery player said following a friend's advice led to her winning a $30,000 prize from a Fast Play game.

A North Carolina man's age turned out to be a lucky number when it inspired him to buy a scratch-off lottery ticket worth $200,000.

A North Carolina woman made a stop for orange juice and ended up winning $250,000 from a scratch-off lottery ticket.

An Illinois woman tucked a Lucky Day Lotto ticket into her purse and forgot about it before discovering it was a $1 million winner.

A Maryland man found some loose cash in his back pocket and ended up using it to buy a lottery ticket worth more than $45,000.

A boom in AI has created a problem for the organizers of the NeurIPS conference, which is considered an essential machine-learning research conference. The sheer number of registrations has overwhelmed […]

The post Lottery to Determine Major AI Conference Attendees Amid Registration Boom appeared first on HPCwire.

Animal behavior expert Philip Johns introduces us to the vibrant urban environments of Singapore, where city dwellers and skyscrapers coexist with a rich array of other species, including otters, hornbills and lizards — prompting the question: Can we design cities to be wildlife refuges?

What if you could take something as tiny as a grain of sand — and as common as a glass bottle — and use it to tackle the climate crisis? Waste alchemist Franziska Trautmann shares how the spark of an idea turned into a large-scale operation helping restore the eroded shores of Louisiana and beyond. (Created in collaboration with Ignite Talks)

Controversy over a proposal to admit students by lottery to a highly selective school in Virginia echoes a nationwide debate over how to include more Blacks, Latinos, and low-income students in advanced academic programs.

Teacher-evaluation reforms in places like New Mexico, Tennessee, Denver, and the District of Columbia have paid off, says the National Council on Teacher Quality.

Parents Unified for Local School Education New Jersey is calling for community-driven schools and opposes the One Newark reorganization plan.

Kenzie Lalonde will become the first woman play-by-play announcer for an NHL team's TV broadcasts in Canada. Reactions and endorsements have poured in.

Zack Ostapchuk returns to Belleville after posting one assist in six games with the big club.

Chance Gray scored 14 of her career-high 31 points in the third quarter and she tied a program-best with nine 3-pointers to help No. 12 Ohio State beat Charlotte 94-53 on Tuesday night. Gray finished 9 of 14 from 3-point range to top her previous best of six makes. Gray scored 11 points in the first half after making all three of her 3-pointers to help Ohio State build a 43-17 lead.