Vampire bats have complex social relationships.

Autistic children exhibited significantly decreased sympathetic activity and increased relaxation in a sensory-adapted dental environment (SADE) during

Forest managers are seeking practical guidance on how to adapt their current practices and, if necessary, their management goals, in response to climate change. Science-management collaboration was initiated on national forests in eastern Washington where resource managers showed a keen interest in science-based options for adapting to climate change at a 2-day workshop. Scientists and managers reviewed current climate change science and identified resources vulnerable to expected climate change. Vulnerabilities related to vegetation and habitat management included potential reductions in forest biodiversity and low forest resilience to changing disturbance regimes. The vulnerabilities related to aquatic and infrastructure resources included changing water quality and quantity, the risk to roads and other facilities from changes to hydrologic regimes, and the potential loss of at-risk aquatic species and habitats. Managers then worked in facilitated groups to identify adaptations that could be implemented through management and planning to reduce the vulnerability of key resources to climate change. The identified adaptations were grouped under two major headings: Increasing Ecological Resiliency to Climate Change, and Increasing Social and Economic Resiliency to Climate Change. The information generated from the science-management collaborative represents an initial and important step in identifying and prioritizing tangible steps to address climate change in forest management. Next would be the development of detailed implementation strategies that address the identified management adaptations..

Systemic infection and proliferation of intracellular pathogens require the biogenesis of a growth-stimulating compartment. The gastrointestinal pathogen Salmonella enterica commonly forms highly dynamic and extensive tubular membrane compartments built from Salmonella-modified membranes (SMMs) in diverse host cells. Although the general mechanism involved in the formation of replication-permissive compartments of S. enterica is well researched, much less is known regarding specific adaptations to different host cell types. Using an affinity-based proteome approach, we explored the composition of SMMs in murine macrophages. The systematic characterization provides a broader landscape of host players to the maturation of Salmonella-containing compartments and reveals core host elements targeted by Salmonella in macrophages as well as epithelial cells. However, we also identified subtle host specific adaptations. Some of these observations, such as the differential involvement of the COPII system, Rab GTPases 2A, 8B, 11 and ER transport proteins Sec61 and Sec22B may explain cell line-dependent variations in the pathophysiology of Salmonella infections. In summary, our system-wide approach demonstrates a hitherto underappreciated impact of the host cell type in the formation of intracellular compartments by Salmonella.

Systemic infection and proliferation of intracellular pathogens require the biogenesis of a growth-stimulating compartment. The gastrointestinal pathogen Salmonella enterica commonly forms highly dynamic and extensive tubular membrane compartments built from Salmonella-modified membranes (SMMs) in diverse host cells. Although the general mechanism involved in the formation of replication-permissive compartments of S. enterica is well researched, much less is known regarding specific adaptations to different host cell types. Using an affinity-based proteome approach, we explored the composition of SMMs in murine macrophages. The systematic characterization provides a broader landscape of host players to the maturation of Salmonella-containing compartments and reveals core host elements targeted by Salmonella in macrophages as well as epithelial cells. However, we also identified subtle host specific adaptations. Some of these observations, such as the differential involvement of the COPII system, Rab GTPases 2A, 8B, 11 and ER transport proteins Sec61 and Sec22B may explain cell line-dependent variations in the pathophysiology of Salmonella infections. In summary, our system-wide approach demonstrates a hitherto underappreciated impact of the host cell type in the formation of intracellular compartments by Salmonella.

Host Matt Egan is joined by producer Chris to talk about the raft of announcements coming out of the Google I/O developer conference this week, including Android N, Google assistant and Allo. Techworld.com editor Charlotte Jee joins in to discuss driverless cars (17:00) following the Queen's speech this week. Finally, acting editor at Macworld.co.uk David Price talks about terrible film adaptations of video games, from Angry Birds to World of Warcraft (29:00). Don't forget to like, share and tell your friends!  

See acast.com/privacy for privacy and opt-out information.

Jungle Cruise's Dwayne Johnson and Emily Blunt to star in Ball and Chain, Marc Guggenheim to script Prophet.

Hayden Library - PN1997.85.N68 2018

Hayden Library - PN1995.9.I42 H65 2018

When it comes to film adaptations of comic-books, the source material should always be treated as gospel, right? Wrong. Angry Nerd explains why, and shares his concerns for Frank Miller's upcoming Sin City: A Dame to Kill For—which could end up being too faithful for its own good.

Hayden Library - BF371.M87 2017

This week, viruses as remnants of a fourth domain of life, a scan of many Tibetan genomes reveals seven new genes potentially related to high-altitude life, and doubts about dark energy with Online News Editor David Grimm. Danielle Li joins Sarah Crespi to discuss her study quantifying the impact of government funding on innovation by linking patents to U.S. National Institutes of Health grants. Listen to previous podcasts. Download the show transcript. Transcripts courtesy of Scribie.com. [Image: artubo/iStockphoto; Music: Jeffrey Cook]

STACK BOOKS PN1995.9.M86 O94 2019