Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition, causing progressive decline in lung function leading to premature death. Acute exacerbations in COPD patients are predominantly associated with respiratory viruses. Ribavirin is a generic broad-spectrum antiviral agent that could be used for treatment of viral respiratory infections in COPD. Using the Particle Replication In Nonwetting Templates (PRINT) technology, which produces dry-powder particles of uniform shape and size, two new inhaled formulations of ribavirin (ribavirin-PRINT-CFI and ribavirin-PRINT-IP) were developed for efficient delivery to the lung and to minimize bystander exposure. Ribavirin-PRINT-CFI was well tolerated in healthy participants after single dosing and ribavirin-PRINT-IP was well tolerated in healthy and COPD participants after single and repeat dosing. Ribavirin-PRINT-CFI was replaced with ribavirin-PRINT-IP since the latter formulation was found to have improved physicochemical properties and it had a higher ratio of active drug to excipient per unit dose. Ribavirin concentrations were measured in lung epithelial lining fluid in both healthy and COPD participants and achieved target concentrations. Both formulations were rapidly absorbed with approximately dose proportional pharmacokinetics in plasma. Exposure to bystanders was negligible based on both the plasma and airborne ribavirin concentrations with the ribavirin-PRINT-IP formulation. Thus, ribavirin-PRINT-IP allowed for an efficient and convenient delivery of ribavirin to the lungs while minimizing systemic exposure. Further clinical investigations would be required to demonstrate ribavirin-PRINT-IP antiviral characteristics and impact on COPD viral-induced exacerbations. (The clinical trials discussed in this study have been registered at ClinicalTrials.gov under identifiers NCT03243760 and NCT03235726.)

The asking prices of apartments in both central and non-central districts of Hanoi are 20-40% lower than ones in Ho Chi Minh City (HCMC), according to data by Batdongsan.com.vn.

Publisher Wired Productions and developer Camel 101 have delayed psychological horror game, Those Who Remain, from May 15 to May 28 for the PlayStation 4, Xbox One and Windows PC via Steam. 

View the official release date trailer below:

Here is an overview of the game:

As the lights go out, the embers of darkness are stoked in the sleepy town of Dormont.

Whispers of disappearances carry through the town as a burgeoning, uneasy and irrational fear begins to spread and darkness comes to be an unwelcome reflection to Those Who Remain.

Some mistakes should never happen, not when your life is complete – and yet they do. Edward had the good life, a beautiful wife and the perfect little girl, yet finds himself several whiskeys down and driving through the night of Dormont to end his secret affair – in a bid to fix his mistakes.

As Edward pulls into the Golden Oak Motel, he is unaware just how much this night will change his life…

Key Features:

The horrors and darkness that thrive in the corner of every eye are torn loose…

Those Who Remain places you in an up-close, psychological horror story set in the sleepy town of Dormont – a town in a spiralling split from the fabric of reality, warped by darkness and the deeds of the Citizens who reside.

Confront the uncomfortable horrors reflected by the darkness and survive the night of Dormont as Edward is confronted with a test of his sanity, morality and the shadows of evil that lurks below.

• Darkness Has Eyes -Navigate and survive the encroaching darkness and stay in the protection of the light by any means[br]
• Worlds Torn Asunder – Pave your way ahead by moving between Dormont and its dark otherworldly counterpart to further solve the mysteries held within the dark
• Conscience of Choice – Choose to help any surviving citizens of Dormont you encounter or leave them to the darkness. Innocence cannot always be assumed, and the township of Dormont hides a cursed trove of secrets
• Savor your Sanity – Keep your sanity in check as you delve deeper into the darkness of Dormont – expected rules of the real world have been torn apart
• Follow your Path – Your decisions and choices will determine the fate of Edward, through multiple different branching outcomes

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443413/those-who-remain-delayed-to-may-28-for-ps4-xbox-one-and-steam/

After more than three long years, the Justice Department has finally lived up to its name by dropping charges against my former boss, former National Security Adviser and retired Army Lt. Gen. Michael Flynn. He should have never been prosecuted.

Bethesda challenges our hipster fashion instincts. Nintendo is doing something with that NFC sensor. Square Enix is faring pretty well, actually. And then there’s EA…who...

From a veteran fire chief to a 93-year-old Holocaust survivor, over 71,000 people have died in the United States from the ongoing novel coronavirus pandemic.Those we've lost come from all backgrounds and walks of life and include the very people -- first responders and medical staff, who are working so diligently to stem the tide of the infection and care for the sick. Variously described as heroes, caring educators and loving family members, they will never be forgotten. ...

Trial is notable for highlighting land and nature defender murders that ordinarily go unpunished

The sentencing on Thursday of seven men accused of murdering the Honduran environmentalist Berta Cáceres is only partial justice, but it should inspire anyone committed to ending the slaughter of land and nature defenders around the globe.

A court in Tegucigalpa handed down guilty verdicts on all but one of the eight accused, including two employees of the hydro-electric dam company that the indigenous Lenca woman had been campaigning against before her assassination on 2 March 2016.

Follow our live coronavirus updates HERE Coronavirus: The symptoms

Donald Trump has said his new US immigration ban would last for 60 days and apply to those seeking "green cards" for permanent residency.

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Shadow justice secretary David Lammy responded to the figures by calling for an urgent investigation into the disproportionate number of deaths.

Tomorrow marks 75 since the nation celebrated VE day - the end of fighting against Nazi Germany in Europe.

Many people will get coronavirus at some point during this pandemic and in the majority of cases will be able to manage the illness themselves. Emma Hammett, a nurse and founder of First Aid for Life, offers some advice on how to look after people who have mild or moderate symptoms at home.

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The Kraftwerk co-founder remained a mystery even after death, but there is no doubting the impact he made with his group’s sublime, visionary music

• News: Florian Schneider, Kraftwerk co-founder, dies aged 73

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It had apparently been taken in 2016 – a decade and a half after Schneider and fellow founder member Ralf Hütter had served Flür with a lawsuit provoked by his autobiography I Was a Robot – and was subsequently deleted from Flür’s Facebook page. Then, a week later, another electronic musician based in Germany, the Manchester-born Mark Reeder, posted a brief eulogy; one commenter claimed that Schneider had died “several days ago”.

The cardinal maintains he didn’t know about the Victorian town’s notorious paedophile priests, a claim the royal commission found ‘implausible’

“Why isn’t all of Australia talking about what happened here in Ballarat?”

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The brand behind Barbie has released a new line of toys inspired by emergency care workers to honour those fighting coronavirus.

Mamadou Sakho has revealed how he turned down approaches from Arsenal, Barcelona and Bayern Munich in order to secure a "dream" move to Liverpool.

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From making their own toothpaste to foraging locally for edible plants, more and more people are learning to cut the amount of rubbish they throw out. Here’s how they do it

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Newcastle's Anglican Dean calls for unity and respect as the diocese prepares to vote on blessing same-sex marriages.

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Dr Aluvihare

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[To be published in the Gazette of India, Extraordinary, Part II, Section 3, Sub-section (i)] Government of India Ministry of Finance

Dear Susan,

You were one of the caretakers of my life. The moment you saw me, you recognized me as one of yours and brought me under your wing. What a big wing it was—you brought so many people under there. I found some of my best friends under your wing, where you were sheltering them, as you sheltered me. We were all lovers of that “impractical” thing, children's literature. Until I came to Simmons and met you, I didn't know there was a place where people like us could go.

I think—I hope—I told you, before you died, that I have the best job in the world for me. It's not possible to be happier about one's daily work than I am about mine. Do you know who held the lantern and lit my way to this work? I would not be here without you. You changed my life, enormously. Do you have any idea how many women and men are thinking about you right now and saying to themselves, “She changed my life?”

You were so unique. You were a person who could never, ever be mistaken for anyone else. If faced with a line of your clones, it would’ve take me the briefest glance into your expressive, thoughtful face, the slightest sound of your careful grasping for the right words, for me to know which one was you. I would recognize your hug, too. I would certainly recognize your skirts and your earrings. I think I would recognize your perfume. After I got married last summer, you surprised me at tea. (Thank you, Cathie, for arranging that marvelous surprise.) You and Cathie gave me a bouquet that contained a beautiful flower and a beautiful umbrella (because you knew how much I love umbrellas). I brought them home to Kevin. As I showed the umbrella to him, trying so hard to express how much it meant to me, I exclaimed, “It smells like Susan!”

Last weekend, I was in Vermont by myself when I got the news that you’d died. I spent the day sitting on the porch of the cabin, looking out over the mountains, watching for hummingbirds, and reading a mystery novel by A. A. Milne. But really, I was thinking about you. I wondered if you knew that A. A. Milne wrote mysteries. I bet you did know that. I would've liked to talk to you about it. The story I read was just exactly the smart, funny (and annoyingly man-centered) sort of mystery you would expect A. A. Milne to have written, though Pooh is better. I wanted to know what you would have thought of it. You would’ve offered some perspective it wouldn’t have occurred to me to have. I would’ve gone to my friends, the ones I found under your wing, and told them, “Listen to what Susan said about this mystery by A. A. Milne.” And they would've laughed, delighted, then said, “That's so Susan.”

While I was thinking about you, a hummingbird landed on my foot. It's less surprising than it sounds; I was wearing pink and red socks with flowers on them. I thought to myself, “I hate that I can't show this gift to Susan. It would have delighted her.” Like Edna St. Vincent Millay in her poem “Dirge Without Music” that was read at your service yesterday, I am not resigned to your death, and I do not approve. The best was lost when you died. “More precious was the light in your eyes than all the roses in the world.”

And now I'm writing this letter because you are gone, and I don't know what else to do. How else can I express what you meant to me? I'm writing it to myself, and for all the people who loved you. I think—I hope—it helps to share grief, and to hear one's own gratitude expressed. There's no tidy way to wrap things up when someone dies, so I'm not going to try. I'll just say thank you, Susan, for that place under your wing. I love you, I miss you, and I'm not resigned. I will never, ever forget you.

Susan Parker Bloom, 1938-2019