I CAN'T help feeling that this is all a long-delayed return to normal. I know the lockdown feels abnormal, and I suppose it is, in that we've never seen anything like it before. But beyond that, I have a powerful sense that normal relations have merely been resumed; the age-old see-saw relationship between man and planet re-established.

Built around an Arts & Crafts theme, this year's Centerpiece Home shows off natural tones and details from Japan and the American late 1800s.

People who want to know if they were infected with coronavirus in the past can now get antibody testing to check.

America relies on both legal and undocumented immigrant labor to ensure that food and other goods continue flowing across the country, Hackney writes.

President Trump has made several claims about coronavirus testing in the US - is he right?

A Canadian grocery chain says its introducing a fleet of intelligent grocery carts that scan and weigh products as customers place them in the cart.

Strong Customer Authentication (SCA) came into effect on September the 14th 2019 as part of the latest General Data Protection Regulation. This new regulation affects many online merchants who sell to those within Europe and other businesses that operate within the region. This regulation was devised to limit the amount of online fraudulent activity and […]

The post Check if Your Stripe Checkout is SCA Compliant appeared first on Tips and Tricks HQ.

If you are just starting up your website, perhaps you are selling tangible items, or you have a hit single that you’ll be offering digital copies of, one of your pressing questions may be: “Which payment gateway should I use to accept payments from my customers?“. While there are pros and cons of using any […]

The post Benefits of Adding Multiple Payment Gateways to Your Website’s Checkout appeared first on Tips and Tricks HQ.

oscon: RT @mmmpork: If you're going to #oscon and you're into #perl check out my talk on contributing http://t.co/HEJaPF5JbY

I’m excited to speak with Pavel Cherkashin in today’s episode of the How To CEO podcast!. Pavel is a co-founder and managing partner at Mindrock Capital. Pavel is also a managing partner at GVA Capital. I spoke with him about what founders and CEOs need to know about raising early checks. When Should Founders Try […]

The post How Founders and CEOs Can Raise Early Checks (With Pavel Cherkashin) appeared first on ReadWrite.

If you’re a big business and you abused the Small Business Association’s new Paycheck Protection Program, you’re getting very close to the deadline for you to pay the government back. If you don’t, that means the government is going to be coming after you — and you can definitely be ready for an audit. That’s…

The post Big Businesses That Abused Paycheck Protection Program Should Get Ready for an Audit appeared first on The Western Journal.

Striso is a digital instrument with pressure-sensitive buttons that plays a variety of acoustic-like sounds.  Read more...

The budget carrier will begin conducting temperature checks via touchless thermometers on June 1. Passengers have to start wearing masks Friday.

Alma L. Burlingame
Apr 1, 2020; 19:571-571
Editorial

Introduction: A new pattern of response, so-called hyper-progressive disease (HPD), is emerging during treatment with immune checkpoint inhibitors (ICI). Our aim was to investigate the prevalence of such phenomenon and to assess its association with clinical variables and metabolic parameters by ¹⁸F-fludeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT). Methods: Data from 50 patients (34 male, 16 female, median age 73) with non-small cell lung carcinoma (NSCLC) and treated with ICI were prospectively collected. All patients underwent contrast-enhanced CT, ¹⁸F-FDG PET/CT, and complete peripheral blood sample at baseline before ICI. HPD was defined according to clinical and radiologic criteria. Because of the rapid disease progression or worsening of clinic conditions, radiologic response assessment was available for 46 patients. OS were analyzed using the Kaplan–Meier method and the log-rank test. A Cox proportional hazards regression analysis was used to evaluate factors independently associated with OS. Median follow-up was 12.4 months (9.7-15.2 months). Results: We identified the following response categories: 10 cases as complete/partial response (CR/PR), 17 cases with stable disease (SD), 5 patients with progressive disease (PD), and 14 with HPD. Among metabolic parameters we observed a statistically significant association between HPD status and tumor burden, expressed by both MTV (756.1ml for HPD vs 475.6ml for non-HPD, P = 0.011) and TLG (287.3 for HPD vs 62.1 for non-HPD, P = 0.042). Among clinical variables, 12/14 patients (85.7%) within the HPD group compared with 8/32 patients (25%) in the non-HDP group had more than two metastatic sites (p<0.001). In addition, the derived neutrophil-to-lymphocyte ratio (dNLR) and platelet counts was significantly associated with HPD status (P = 0.038, P = 0.025, respectively). Survival analysis showed a median OS of 4 months for HPD group compared with 15 months within non-HPD patients (P = 0.003). Likewise, median OS was significantly different when we considered all the response categories: CR/PR, SD, PD, and HPD (P = 0.001). Finally, Multivariate analysis identified MTV and dNLR as independent predictors for OS. Conclusion: Our results suggest that the use of ICI might represent a concern in patients with high metabolic tumor burden and inflammatory indexes at baseline. However Additional studies are needed.

Immune checkpoint blockade represents a promising approach in oncology, showing anti-tumor activities in various cancers. However, although being generally far more well-tolerated than classical cytotoxic chemotherapy, this treatment, too, may be accompanied by considerable side effects and not all patients benefit equally. Therefore, careful patient selection and monitoring of the treatment response is mandatory. At present, checkpoint-specific molecular imaging is increasingly investigated as a tool for patient selection and response evaluation. Here, an overview of the current developments in immune checkpoint imaging is provided.

The gang returns with an eclectic mix of tech chat. Can Nectome really download your thoughts - while killing you - to preserve your memories forever in the cloud? We didn't make this up.

Then we discuss the brand new Samsung Galaxy S9, phone cameras and crap AR before discussing how the UK should go about contracting a company to age check porn site users.

See acast.com/privacy for privacy and opt-out information.

Helen Macdonald and Carl Heneghan are back again talking about what's happened in the world of evidence this month. (1.20) Carl grinds his gears over general health checks, with an update in the Cochrane Library. (9.15) Helen is surprised by new research which looks at over prescription of antibiotics - but this time because the courses...

The Association is waiting for clear guidance from the Small Business Administration on the best way to help dentists considering applying for Paycheck Protection Program 7(a) loans.

Dentists can apply for both Economic Injury Disaster Loans and Paycheck Protection Program 7(a) loans, the Small Business Administration told the American Dental Association on April 6.

The Small Business Administration said that as of April 16, the agency is unable to accept any new applications for the Paycheck Protection Program or the Economic Injury Disaster Loans due to a lack of funding.

The House of Representatives passed a new coronavirus relief bill April 23 that calls for additional funding for federal loan programs to help businesses nationwide, including dental practices, recover from the economic fallout of the pandemic.

The Small Business Administration will resume accepting Paycheck Protection Program loan applications at 10:30 a.m. EST on April 27 from “approved lenders on behalf of any eligible borrower,” the agency said.

The Organized Dentistry Coalition is asking Congress for flexibility in the Paycheck Protection Program to allow dentists to purchase personal protective equipment as states begin the reopening phase of the COVID-19 pandemic.

South Dakota Gov. Kristi Noem has ordered two Sioux tribes to remove checkpoints designed to curb the coronavirus on tribal lands.

The Internal Revenue Service said Wednesday is the last day for Americans to provide their direct deposit information to receive their stimulus checks directly to their bank accounts.

What do the war in Iraq, your Christmas shopping and this week's Thanksgiving dinner have in common?

If to do were as easy as to know what were good to do, chapels had been churches, and poor men's cottages princes' palaces.

Three horrors await Americans who get behind the wheel of a car for a family road trip this summer: the spiraling price of gas, the usual choruses of "are-we-there-yet?" -- and the road rage of fellow drivers.

Sexually transmitted infections (STIs) are on the rise, and many people are curious about the reasons why. While the cause is obviously multifactorial, some have suggested that at least part of the rise in STIs may be due to increasing rates of pubic hair grooming in men and women alike. Given that it’s not uncommon for people to experience cuts and skin irritation from genital grooming practices, it at least sounds plausible in theory that pubic hair shaving could potentially increase infection risk. But what does the research actually say?

Saint Paul schools are in the market for a vendor to provide background checks, while the Education Technology Joint Powers Authority is seeking media repositories. A Texas district wants quotes on technology for new campuses.

The post Calif. Ed-Tech Consortium Seeks Media Repository Solutions; Saint Paul District Needs Background Check Services appeared first on Market Brief.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

Brush up on hot topics with these five FAO titles. Browse through the language versions using the top right-hand language bar to discover different titles.

To keep up to date [...]

Authors, scientists and others are offering fun livestream lessons and performances to keep kids engaged during isolation

Green Lake’s mayor says he wants to see further measures introduced to prevent people who aren't from Saskatchewan from travelling through his community as the region deals with the COVID-19 pandemic. 

STYLE AND SUBSTANCE

A group of young people were filmed taunting a Native American man and military veteran who was participating in the Indigenous Peoples March.