The gaming console uses Wi-Fi 7, a wireless standard that uses the 6GHz band for connecting to the internet. However, the band itself is embroiled under controversy with telecom operators pushing for it to be reserved for mobile internet services.

Manos Nikolakis, GM, BIC Cello, said, "While e-commerce is growing significantly across the country, the landscape of the Indian market is still heavily reliant on traditional trade. Accordingly, this remains our main sales driver. The lack of digital penetration in semi-urban and rural areas can sometimes create a challenge in the e-commerce space, which means that e-commerce is mostly relevant in bigger cities with a more mature infrastructure."

Shree Vallabh Metals in October 2023 had secured an injunction from Delhi HC against the use of the MAX FRESH trademark by Cello Plastic Industrial Works.

The term sheet indicates an indicative issue price of Rs 852 per share and a floor price of Rs 896 per share. Cello World’s stock closed at Rs 961 on July 3, indicating that the QIP is being launched at an 11% discount to the last closing price.

Château Palmer is a wine estate in Margaux, in south-west France. Those that know about these things rate their wines as among the best anywhere in Bordeaux. If you are going to record a jazz album outside of the recording studio, then a light and airy wood-paneled salon at the château with French windows overlooking the serene estate seems to be an inspired choice... [ read more ]

Climate change and insects, and designing Canada’s lunar rover

Bocelli’s delivery is irresistible, and these arrangements can be intoxicating.

It's unclear why.

All the colors of jazz!

All the colors of jazz!

All the colors of jazz!

All the colors of jazz!

All the colors of jazz!

Joni Mitchell, Arturo Sandoval, Gladys Knight, Freddie Hubbard and Horace Silver!

Russell Malone, Lizz Wright, Patricia Barber, Duke Ellington and Wynton Marsalis!

Houston Person, Lou Rawls, Red Garland, Jazzmeia Horn and Miles Davis!

Mose Allison

All the colors of jazz!

Black athletes continued to set standards at the games.

Following weather-related cancellations of the City Hall All-White Ball and the Tasting Village, the City of Hamilton said they are “working with PTix to provide full refunds to all patrons who purchased tickets or tokens for the events.” A spokesperson said, “Initially, the City decided on Friday to proceed with Saturday’s dining experience, as forecasts indicated […]

The Marc of Excellence Memorial Football Kick, in honour of the late Marco Warren, was held at TN Tatem Middle School in Warwick yesterday [June 2]. It was organised by Warren’s family and marked the first anniversary of his funeral after being killed in a hit-and-run incident in Hamilton Parish aged 29. Warren was respected […]

Removed From Troubles – Problem Resolved (Not open for application): Gothic Subculture (Lifestyles); Goths (People) Troubled People Miscellany (Not open for application) The following fanlistings are scheduled for removal on November 13, 2024. If your fanlisting is listed below, please fix the problem/send in a finished form and reply to the troubles email! Pending Removal: […]

RetroStyle Games, a company specializing in game development and visual design, congratulates Space Age Games on Supercell's acquisition of the remaining 38% of their shares, making Space Ape Games fully owned by Supercell.... Tagged as:

In the wake of the devastation rendered by Hurricane Helene, Carolina Furfare released a newsletter on October 1 stating the cancellation of the event that was to occur this weekend, and indicating that the hotels and facilities were needed in order to assist with rescue and sheltering efforts after the Hurricane hit the mountainous region.

This weather event hit the top ten most fatal and costly hurricanes in the United States even before full recovery efforts could be finalized. People who pre-registered have been given the option to roll over to next year, or to Bewhiskered 2025; due to the cancellation being so close to event day they cannot guarantee refunds for now.

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The Israeli Defense Forces (IDF) said on Wednesday that it eliminated a militant cell member, Yasser Ghandi, in Gaza's Shejaiya area who allegedly participated in the October 7 attack in Israel that l...

Flagstaff, Arizona draws outdoorsy folks and is known as one of Arizona’s more progressive and laidback towns — which bodes well for vegans. I spent a few days in Flagstaff and didn’t run out of delicious, plant-based places to eat. It’s an attractive town to visit in its own right, though many people find themselves here on their way to the Grand Canyon, which is an hour and a half away. Here are some of the top places for vegans to get a good meal.[...]

Daniel Osherson, Princeton’s Henry R. Luce Professor in Information Technology, Consciousness, and Culture, Emeritus, known for his  creative scientific explorations with collaborators in many disciplines, died at home on Sept. 4. 

Virgin Atlantic and British Airways have announced further suspension of routes

Over a dozen flights cancelled or delayed between Bali and Australia

Elizabeth line, Great Western Railway and Heathrow Express services are all being affected.

Australian airlines say it is unsafe to fly after Mount Lewotobi Laki-laki spewed ash.

Tamar Geiger
Mar 1, 2012; 11:M111.014050-M111.014050
Special Issue: Prospects in Space and Time

Qiang Tian
Oct 1, 2004; 3:960-969
Research

Shao-En Ong
May 1, 2002; 1:376-386
Research

Staphylococcus aureus adhesion to the host's skin and mucosae enables asymptomatic colonization and the establishment of infection. This process is facilitated by cell wall-anchored adhesins that bind to host ligands. Therapeutics targeting this process could provide significant clinical benefits; however, the development of anti-adhesives requires an in-depth knowledge of adhesion-associated factors and an assay amenable to high-throughput applications. Here, we describe the development of a sensitive and robust whole cell assay to enable the large-scale profiling of S. aureus adhesion to host ligands. To validate the assay, and to gain insight into cellular factors contributing to adhesion, we profiled a sequence-defined S. aureus transposon mutant library, identifying mutants with attenuated adhesion to human-derived fibronectin, keratin, and fibrinogen. Our screening approach was validated by the identification of known adhesion-related proteins, such as the housekeeping sortase responsible for covalently linking adhesins to the cell wall. In addition, we also identified genetic loci that could represent undescribed anti-adhesive targets. To compare and contrast the genetic requirements of adhesion to each host ligand, we generated a S. aureus Genetic Adhesion Network, which identified a core gene set involved in adhesion to all three host ligands, and unique genetic signatures. In summary, this assay will enable high-throughput chemical screens to identify anti-adhesives and our findings provide insight into the target space of such an approach.

MS Brown
Jul 1, 1980; 21:505-517
Reviews

W Gamble
Nov 1, 1978; 19:1068-1070
Articles

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles

CJ Fielding
Aug 1, 1997; 38:1503-1521
Reviews

JL Dixon
Feb 1, 1993; 34:167-179
Reviews

EJ Blanchette-Mackie
Jun 1, 1995; 36:1211-1226
Articles

Linda J. Pike
Jul 1, 2006; 47:1597-1598
Report

JF Oram
Dec 1, 1996; 37:2473-2491
Reviews

George H. Rothblat
May 1, 1999; 40:781-796
Reviews

Robert W. Mahley
Jan 1, 1999; 40:1-16
Reviews

AE Christian
Nov 1, 1997; 38:2264-2272
Articles

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands and preventing T cell–mediated anti-tumor responses. Consequently, therapeutic blockade of PD-1 enhances T cell–mediated anti-tumor immunity, but many patients do not respond and a significant proportion develop inflammatory toxicities. To improve anti-cancer therapy, it is critical to reveal the mechanisms by which PD-1 regulates T cell responses. We performed global quantitative phosphoproteomic interrogation of PD-1 signaling in T cells. By complementing our analysis with functional validation assays, we show that PD-1 targets tyrosine phosphosites that mediate proximal T cell receptor signaling, cytoskeletal organization, and immune synapse formation. PD-1 ligation also led to differential phosphorylation of serine and threonine sites within proteins regulating T cell activation, gene expression, and protein translation. In silico predictions revealed that kinase/substrate relationships engaged downstream of PD-1 ligation. These insights uncover the phosphoproteomic landscape of PD-1–triggered pathways and reveal novel PD-1 substrates that modulate diverse T cell functions and may serve as future therapeutic targets. These data are a useful resource in the design of future PD-1–targeting therapeutic approaches.

Distinct cell types emerge from embryonic stem cells through a precise and coordinated execution of gene expression programs during lineage commitment. This is established by the action of lineage specific transcription factors along with chromatin complexes. Numerous studies have focused on epigenetic factors that affect embryonic stem cells (ESC) self-renewal and pluripotency. However, the contribution of chromatin to lineage decisions at the exit from pluripotency has not been as extensively studied. Using a pooled epigenetic shRNA screen strategy, we identified chromatin-related factors critical for differentiation toward mesodermal and endodermal lineages. Here we reveal a critical role for the chromatin protein, ARID4B. Arid4b-deficient mESCs are similar to WT mESCs in the expression of pluripotency factors and their self-renewal. However, ARID4B loss results in defects in up-regulation of the meso/endodermal gene expression program. It was previously shown that Arid4b resides in a complex with SIN3A and HDACS 1 and 2. We identified a physical and functional interaction of ARID4B with HDAC1 rather than HDAC2, suggesting functionally distinct Sin3a subcomplexes might regulate cell fate decisions Finally, we observed that ARID4B deficiency leads to increased H3K27me3 and a reduced H3K27Ac level in key developmental gene loci, whereas a subset of genomic regions gain H3K27Ac marks. Our results demonstrate that epigenetic control through ARID4B plays a key role in the execution of lineage-specific gene expression programs at pluripotency exit.