el Telstra privacy breach leaves customer's voicemail exposed By www.smh.com.au Published On :: Fri, 22 Jan 2016 05:56:14 GMT Richard Thornton did a factory reset on his second-hand iPhone 5, but the buyer kept receiving his voicemail. Full Article
el Ricochet uses power of the dark web to help journalists, sources dodge metadata laws By www.smh.com.au Published On :: Fri, 19 Feb 2016 04:19:51 GMT A new internet messaging tool that sidesteps the federal government's metadata collection regime to help journalists protect whistle blowers and assists human rights activists has received a tick of approval from security experts. Full Article
el MyGov to feel the audit blowtorch By www.smh.com.au Published On :: Thu, 03 Mar 2016 06:23:08 GMT Human Service to face National Audit Office scrutiny. Again. Full Article
el Governments should hack less, deliver better online services: Harvard IT expert By www.smh.com.au Published On :: Sat, 30 Jul 2016 13:30:00 GMT Western governments have established the international norm of online hacking and should not be surprised when foreign governments do the same. Full Article
el Call for a cyber security reserve corps to help fight major attacks By www.smh.com.au Published On :: Mon, 15 Aug 2016 14:15:00 GMT Experienced volunteers would help fight major online threats to governments, private industry and civil institutions. Full Article
el Centrelink apologises for new privacy breach By www.smh.com.au Published On :: Sat, 05 Nov 2016 06:37:10 GMT Rookie email error shares hundred of email addresses – twice. Full Article
el Centrelink debt debacle shows government is unprepared for digital revolution By www.smh.com.au Published On :: Mon, 06 Feb 2017 13:15:00 GMT The public service needs to embrace partnerships if it's to harvest big data's massive yields. Full Article
el Quirk's integrity questioned over failure to release "secret" IT report By www.smh.com.au Published On :: Tue, 08 Aug 2017 07:26:04 GMT Opposition councillors have called Brisbane's Lord Mayor Graham Quirk secretive and accused him of putting his integrity at stake over the failure to release an external review into the now terminated $122 million IT contact with Technology One. Full Article
el Medical records exposed by flaw in Telstra Health's Argus software By www.smh.com.au Published On :: Wed, 21 Mar 2018 21:21:02 GMT Default static password allowed medical practitioners' computers and servers to be accessed remotely by hackers. Full Article
el Development Prospects in the Asia-Pacific: The Role of the Asian Development Bank By feedproxy.google.com Published On :: Wed, 04 Sep 2019 12:55:01 +0000 Research Event 25 September 2019 - 12:30pm to 1:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Takehiko Nakao, President, Asian Development BankChair: Champa Patel, Head, Asia-Pacific Programme, Chatham House The speaker will discuss development prospects in the Asia-Pacific and their implications for Europe and the UK. He will outline prospects for the region’s growth, the impact of the current US-China trade conflict as well as other challenges faced by the region. He will also discuss the future role of the Asian Development Bank and how it plans to support the further development of the region. Department/project Asia-Pacific Programme, Sustainable and Inclusive Growth, Trade, Investment and Economics Lucy Ridout Programme Administrator, Asia-Pacific Programme +44 (0) 207 314 2761 Email Full Article
el Intellectual Breakdown Has Led to Political Turmoil By feedproxy.google.com Published On :: Thu, 03 Oct 2019 08:17:48 +0000 3 October 2019 Jim O'Neill Chair, Chatham House At the root of growing discontent is a clear problem: the international capitalist model has stopped functioning as it should. 2019-10-03-GJ.jpg Gilets jaunes protestors march through the Place de la Concorde in Paris in November 2018. Photo: Getty Images. As the chair of the Royal Institute of International Affairs, I recently hosted an offsite event with some of the organization’s strongest supporters, research staff, and other leaders. I left with a clearer view of three of the biggest issues of our time: slowing productivity growth, anti-establishment politics, and the rise of China.Generally speaking, the reason that we have so many 'issues' is that the international capitalist model has stopped functioning as it should, particularly in the years since the 2008 financial crisis. This has become increasingly apparent to many Western voters, even as experts have struggled to understand the precise nature of the economic and political shifts underway.According to the economic textbooks that I grew up with in the 1970s, successful businesses within a market-based system should deliver profits to their equity owners, which in turn should lead to stronger investment and rising wages. At the same time, the potential for profits should attract new market entrants, which in turn should erode the incumbents’ profitability, fuel competition, and spur innovation.This pattern no longer holds. Incumbents’ reported profits seem to rise persistently – often with the help of extremely efficient balance-sheet and financial management – but there is scarce evidence of rising investment or wages. As a result, productivity across many advanced economies appears to be trending lower.In these circumstances, it is little wonder that Western voters have been attracted to anti-establishment political parties. But this does not mean that liberal democracy is breaking down, as one often hears. In fact, a forthcoming Chatham House report casts substantial doubt on the credibility of that alarmist claim.Between the 1970s and the start of the new millennium, politics in many Western countries moved rightward – a trend epitomized by New Labour in the United Kingdom and the Democratic Leadership Council in the United States. For a while, this mode of politics seemed to work fine. Under conditions of persistent growth, low inflation, and a rising tide that lifted all (or most) boats, a neoliberal consensus crystallized, and alternative views were marginalized.Everything changed after 2008. Over the past decade, markets seemed to have stopped delivering widely shared growth, and mainstream parties have not come up with any new ideas. Voters have thus turned to the once-sidelined voices on the left and right.The far-left policies being proposed by UK Labour leader Jeremy Corbyn almost certainly would not work. But that is beside the point. What matters to disadvantaged voters is that Corbyn’s proposals seem to offer something that the current system does not. Similarly, those on the right are unlikely to deliver greater prosperity, but their ideas have the virtue of sounding different. Blaming immigration, 'globalists', and China for everything can make for a powerful sales pitch.In order to offer voters a better choice, the centre must do much more to ensure that market forces are delivering the same results as they did in previous decades. And here, throwing around sweeping accusations of 'populism' and the end of democracy won’t help.In trying to explain the current moment, too many of my liberal colleagues are relying on a mistaken narrative. The problem is not that scary new populist forces are destroying the post-war economic model; rather, it is the other way around. The rise of new political movements is the logical result of the earlier period of neoliberal consolidation, and of the failure of centrist thinking to deliver the same results it once did.To be sure, there is some merit to the argument that social media have facilitated the spread of heterodox – and sometimes toxic – points of view. The leading social-media companies clearly have not spent enough on protecting their users from sophisticated propaganda, scams, and the like. But the real question is why those messages have found so many receptive ears. After all, the same technologies that allow marginal voices to reach a much larger audience are also available to centrists. Barack Obama’s 2008 US presidential campaign harnessed the power of these platforms to great effect.Finally, the Sino-American dispute over trade and technology may be more dramatic for involving a non-liberal, non-Western rising power. But the essence of the conflict is economic. Within the next decade or so, China’s economy will likely surpass that of the US as the largest in the world.To my mind, Western policymakers should be countering Sinophobia and encouraging their societies to live comfortably with China. Economic progress in China will not prevent America’s 327 million people from becoming individually wealthier themselves. If the West adopts sensible policies, its own firms and consumers stand to benefit substantially from China’s growth.As for think tanks like Chatham House, it is clear that we must play a more active role in setting the facts straight on all of these issues. It would be a tragedy to sacrifice our collective prosperity as a result of unclear thinking.This article was originally published by Project Syndicate. Full Article
el UK General Election 2019: What the Political Party Manifestos Imply for Future UK Trade By feedproxy.google.com Published On :: Mon, 25 Nov 2019 15:50:01 +0000 Research Event 4 December 2019 - 12:30pm to 1:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Michael Gasiorek, Professor of Economics, University of Sussex; Director, Interanalysis; Fellow, UK Trade Policy Observatory, University of SussexJulia Magntorn Garrett, Research Officer, UK Trade Policy Observatory, University of SussexProf Jim Rollo, Deputy Director, UK Trade Policy Observatory, University of Sussex; Associate Fellow, Global Economy and Finance Department, Chatham HouseNicolo Tamberi, Research Officer in the Economics of Brexit, University of SussexL. Alan Winters, Professor of Economics, Director, UK Trade Policy Observatory, University of Sussex The upcoming UK general election is arguably a 'Brexit election', and as such, whoever wins the election will have little time to get their strategy for Brexit up and running to meet the new Brexit deadline of 31 January 2020. But what are the political parties’ policies for the UK's future trade? This event will present and discuss what the five main parties’ manifestos imply for future UK trade. Each manifesto will be presented and analysed by a fellow of the UK Trade Policy Observatory (UKTPO) and will be followed by a Q&A session. Department/project Global Economy and Finance Programme, UK Trade Policy Observatory Michela Gariboldi Research Assistant, Global Economy and Finance Programme 02073143692 Email Full Article
el Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden By feedproxy.google.com Published On :: Wed, 15 Jan 2020 09:23:12 +0000 20 January 2020 How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Jamie Gaskarth explores how intelligence professionals view accountability in the context of 21st century politics. Jamie Gaskarth Senior Lecturer, University of Birmingham Secrets and Spies (cover image) Using the UK as a case study, this book provides the first systematic exploration of how accountability is understood inside the secret world. It is based on new interviews with current and former UK intelligence practitioners, as well as extensive research into the performance and scrutiny of the UK intelligence machinery.The result is the first detailed analysis of how intelligence professionals view their role, what they feel keeps them honest, and how far external overseers impact on their work.The UK gathers material that helps inform global decisions on such issues as nuclear proliferation, terrorism, transnational crime, and breaches of international humanitarian law. On the flip side, the UK was a major contributor to the intelligence failures leading to the Iraq war in 2003, and its agencies were complicit in the widely discredited U.S. practices of torture and 'rendition' of terrorism suspects. UK agencies have come under greater scrutiny since those actions, but it is clear that problems remain.Secrets and Spies is the result of a British Academy funded project (SG151249) on intelligence accountability.Open society is increasingly defended by secret means. For this reason, oversight has never been more important. This book offers a new exploration of the widening world of accountability for UK intelligence, encompassing informal as well as informal mechanisms. It substantiates its claims well, drawing on an impressive range of interviews with senior figures. This excellent book offers both new information and fresh interpretations. It will have a major impact.Richard Aldrich, Professor of International Security, University of Warwick, UKGaskarth’s novel approach, interpreting interviews with senior figures from the intelligence world, brings fresh insight on a significant yet contested topic. He offers an impressively holistic account of intelligence accountability—both formal and informal—and, most interestingly of all, of how those involved understand it. This is essential reading for those wanting to know what accountability means and how it is enacted.Rory Cormac, Professor of International Relations, University of NottinghamAbout the authorJamie Gaskarth is senior lecturer at the University of Birmingham, where he teaches strategy and decision-making. His research looks at the ethical dilemmas of leadership and accountability in intelligence, foreign policy, and defence. He is author/editor or co-editor of six books and served on the Academic Advisory panel for the 2015 UK National Security Strategy and Strategic Defence and Security Review.Available now: Buying optionsInsights: Critical Thinking on International Affairs Department/project Russia and Eurasia Programme Full Article
el A Credit-fuelled Economic Recovery Stores Up Trouble for Turkey By feedproxy.google.com Published On :: Mon, 17 Feb 2020 13:47:40 +0000 17 February 2020 Fadi Hakura Consulting Fellow, Europe Programme LinkedIn Turkey is repeating the mistakes that led to the 2018 lira crisis and another freefall for the currency may not be far off. 2020-02-17-TurCB.jpg Headquarters of the Central Bank of the Republic of Turkey. Photo: Getty Images. Since the 2018 economic crisis, when the value of the lira plummeted and borrowing costs soared, Turkey’s economy has achieved a miraculous ‘V-shaped’ economic recovery from a recession lasting three quarters to a return back to quarterly growth above 1 per cent in the first three months of 2019.But this quick turnaround has been built on vast amounts of cheap credit used to re-stimulate a consumption and construction boom. This so-called ‘triple C’ economy generated a rapid growth spurt akin to a modestly able professional sprinter injected with steroids.This has made the currency vulnerable. The lira has steadily depreciated by 11 per cent against the US dollar since the beginning of 2019 and crossed the rate of 6 lira versus the US dollar on 7 February. And there are further warning signs on the horizon.Credit bonanzaStatistics reveal that Turkish domestic credit grew by around 13 per cent on average throughout 2019. The credit bonanza is still ongoing. Mortgage-backed home sales jumped by a record high of 600 per cent last December alone and the 2019 budget deficit catapulted by 70 per cent due to higher government spending.Turkey’s central bank fuelled this credit expansion by cutting interest rates aggressively to below inflation and, since the start of this year, purchasing lira-denominated bonds equivalent to around one-third of total acquisitions last year to push yields lower.Equally, it has linked bank lending to reserve requirements – the money that banks have to keep at the central bank – to boost borrowings via state and private banks. Banks with a ‘real’ loan growth (including inflation) of between 5 and 15 per cent enjoy a 2 per cent reserve ratio on most lira deposits, which authorities adjusted from an earlier band of 10-20 per cent that did not consider double-digit inflation.Cumulatively, bond purchases (effectively quantitative easing) and reserve management policies have also contributed to eased credit conditions.Commercial banks have also reduced deposit rates on lira accounts to less than inflation to encourage consumption over saving. Together with low lending rates, the boost to the economy has flowed via mortgages, credit card loans, vehicle leasing transactions and general business borrowings.Accordingly, stimulus is at the forefront of the government’s economic approach, as it was in 2017 and 2018. It does not seem to be implementing structural change to re-orient growth away from consumption towards productivity. In addition, governance is, again, a central issue. President Recep Tayyip Erdogan’s near total monopolization of policymaking means he guides all domestic and external policies. He forced out the previous central bank governor, Murat Cetinkaya, in July 2019 because he did not share the president’s desire for an accelerated pace of interest rate reductions.New challengesDespite the similarities, the expected future financial turbulence will be materially different from its 2018 predecessor in four crucial respects. Firstly, foreign investors will only be marginally involved. Turkey has shut out foreign investors since 2018 from lira-denominated assets by restricting lira swap arrangements. Unsurprisingly, the non-resident holdings of lira bonds has plummeted from 20 per cent in 2018 to less than 10 per cent today.Secondly, the Turkish government has recently introduced indirect domestic capital controls by constraining most commercial transactions to the lira rather than to the US dollar or euro to reduce foreign currency demand in light of short-term external debt obligations of $191 billion.Thirdly, the Turkish state banks are intervening quite regularly to soften Lira volatility, thereby transitioning from a ‘free float’ to a ‘managed float’. So far, they have spent over $37 billion over the last two years in a futile effort to buttress the lira. This level of involvement in currency markets cannot be maintained.Fourthly, the Turkish state is being far more interventionist in the Turkish stock exchange and bond markets to keep asset prices elevated. Government-controlled local funds have participated in the Borsa Istanbul and state banks in sovereign debt to sustain rallies or reverse a bear market. All these measures have one running idea: exclude foreign investors and no crisis will recur. Yet, when the credit boom heads to a downturn sooner or later, Turks will probably escalate lira conversions to US dollars; 51 per cent of all Turkish bank deposits are already dollar-denominated and the figure is still rising.If Turkey’s limited foreign reserves cannot satisfy the domestic dollar demand, the government may have to impose comprehensive capital controls and allow for a double digit depreciation in the value of the lira to from its current level, with significant repercussions on Turkey’s political stability and economic climate.To avoid this scenario, it needs to restore fiscal and monetary prudence, deal the with the foreign debt overhang in the private sector and focus on productivity-improving economic and institutional reforms to gain the confidence of global financial markets and Turks alike. Full Article
el Coronavirus: Could a People’s Bailout Help? By feedproxy.google.com Published On :: Wed, 06 May 2020 12:42:49 +0000 7 May 2020 Jim O'Neill Chair, Chatham House Lyndsey Jefferson Digital Editor, Communications and Publishing Department @LyndseyLdn The coronavirus crisis has resulted in an unprecedented economic downturn. Conventional quantitative easing measures used after the 2008 financial crisis will not be enough this time. 2020-05-06-Coronavirus-Food-Bank-NYC.jpg Local residents line up outside a food pantry during the COVID-19 pandemic on 23 April 2020 in Brooklyn, New York. Due to increased levels of unemployment, the lines at the daily food pantry have been getting longer. Photo: Getty Images. What is quantitative easing? How was it used after the 2008 financial crisis?Quantitative easing (QE) has been in existence since the Japanese central bank introduced it at the turn of the millennium. The simplest way to think about it is this: when interest rates can't go down anymore and play their normal role of stimulating growth, central banks try to expand the money supply. So, they're expanding the quantitative amount of money they put into the system. Of course, after 2008 because of the scale of the financial and economic collapse, many Western countries resorted to QE. Some have never gotten rid of it. Others have started to, but as a result of this crisis, have gone straight back to that playbook.33 million Americans have now filed for unemployment and one in five American workers have lost their jobs due to COVID-19. These are levels not seen since the Great Depression. You recently called for G20 countries to provide income support for all citizens. Why is this so urgent to implement now?It is incredible to reflect back on the short time since I published that piece. I entitled it the need for a so-called people's QE, and in some ways a number of European countries, including the UK, have executed some aspects of what I was suggesting. The United States has not, even though the absolute amounts of money the US authorities have put through their fiscal system to try and support the economy is actually bigger as a percentage of GDP than many in Europe. What they haven't done is support ongoing employment through various schemes that many European countries have done, of which the UK has, to some degree, been one of the most ambitious.That’s partly why you see such enormous filing for unemployment claims in the US. There’s no direct support to encourage employers to keep their employees on, in complete contrast to what you see in many Scandinavian countries who were the first to do it in Europe, and something the UK has since done. On a practical level, what might a smart people’s QE look like? We are living in an extraordinary time. Like many others in my generation, it’s nothing that any of us have gone through. Perhaps economically, the only parallel one can find is from the 1920s and 1930s.It became obvious to me in early March that governments are going to have to essentially force as many of us as possible, if we weren't doing absolutely crucial necessities, to stop working or to work from home. It was pretty obvious that the consequences could be horrific. So, the idea of a people's QE that I suggested then, some would have regarded as quite audacious. The most dramatic thing that could be done was, to put it simply, governments effectively pay for every business and every employee to have a two month paid holiday. Obviously, this would cost a very large amount of money for governments, but it would be the least disruptive way of getting us all to stay home.And when the time is right to start letting us get back to anything vaguely like normality, there wouldn't be as much permanent disruption. I think about six weeks have passed since I wrote that piece. Actually, given the policies many governments have announced, I'm not sure undertaking the audacity in generosity of what I suggested would have cost any more. Over the long term, it might have actually turned out to be less. Of course, there are ethics issues around whether the system could be gamed or not, amongst other issues. But six weeks later, I still believe that would have been the smartest thing to do. It certainly would have been much better than trying to encourage many businesses, particularly smaller ones, to take out loans.A couple of countries got close to what I was suggesting – Germany and Switzerland were very quick to give 100% government guarantees to business, as well as generous wage support systems. But a number of other countries haven't, like the US, even though they wrote a $1200 check for each citizen. Should a people’s QE involve the purchase and write off of consumer debt and student debt by a central bank? I think these things might have to be considered. I remember being on a conference call to Chatham House members where we discussed what would be the likely economic consequences and what policymakers should do. One person on the call was talking about quite conventional forms of policy just through various forms of standard QE. During the Q&A, someone asked whether we thought the US Federal Reserve might end up buying equities. And I said, well, why not? Eventually, it might come to that. Actually, before that discussion was over, the Fed coincidentally announced they were going to buy high-yield corporate bonds, or very risky company debt. This is something that would have been unheard of even by the playbook of 2008. So, I don't think ideas like a kind of provision to help student debtors is entirely crazy. These are things that our policymakers are going to have to think about as we go forward in the challenging and unpredictable days and weeks ahead. Poorer countries like El Salvador have gone as far as cancelling rent and major utility bills for its citizens. Do you think countries like the US and UK have gone far enough to help people during the crisis?Going one step further than a people’s QE and postponing major payments is a pretty interesting concept. I think in reality, it would be very disruptive to the medium to long-term mechanism of our societies. It could be very, very complicated. But, of course, some parts of the G20 nations, including the UK, have moved significantly in these areas as it relates to rent payments or mortgage payments. There have been significant mortgage holidays being introduced for many sectors of our community. I think the British government has been quite thoughtful about it without doing the whole hog of potentially getting rid of our transaction system for two months or beyond.You know, this may well be something that has to be considered if, God forbid, there is a second peak of the virus. If countries come out of a lockdown and all that results in is a dramatic rise in infections and then death again, we're going to end up right back where we are. Policymakers may have to implement more generous versions of what we've done already, despite what the long term debt consequences could be.The Coronavirus Aid, Relief, and Economic Security (CARES) Act in the US has been criticized as a corporate bailout while offering little to the American people. It was recently reported that hedge fund managers are applying for bailouts as ‘small businesses.’ Do you think more oversight is needed in how the stimulus funds are allocated? The speed at which many countries have responded and introduced policies means that there's going to be some gaping holes which allow people to unfairly benefit from the system. And if indeed, that were to be the case, I cannot see why a hedge fund should benefit from government generosity.A true hedge fund is supposed to be a form of investment manager that thrives in times of great volatility, and knows how to better navigate such financial markets than more conventional funds. So this shouldn’t be an environment where hedge funds seek the same kind of help as small businesses. That is certainly something the government should be very careful about.Some economists argue that central banks are not independent as they finance fiscal spending through purchase of government bonds. Do the strong measures taken by central banks in response to the crisis undermine the argument for central bank independence? In my view, an effective central bank has to do whatever is necessary, including doing very unconventional things, when the society in which that central bank operates needs it. Most of the time, central banks are pretty boring places, but they really become crucial organizations when we go through times like the 1920s, 1930s, 2008, and of course, this current crisis. If they want to maintain their legitimacy, whatever the true parliamentary or congressional legal standing is, they have to do things quickly and as we've seen in this case, differently than the convention in order to do what our societies need. Somebody was asking me just last week whether the Fed buying high grade debt was legal or not. I think that’s a pretty irrelevant conversation because if it’s not legal now, it will be made legal tomorrow. So, I think central banks have to keep their legitimacy and they have to do what is necessary when the time requires it. In that sense, I think most central banks have handled this crisis so far pretty well. Full Article
el How images frame China's role in African development By feedproxy.google.com Published On :: Thu, 07 May 2020 09:21:23 +0000 7 May 2020 , Volume 96, Number 3 George Karavas Read online Political leaders, policy-makers and academics routinely refer to development as an objective process of social change through the use of technical, value-free terms. Images of poverty and inequality are regularly presented as evidence of a world that exists ‘out there’ where development unfolds. This way of seeing reflects the value of scientific forms of knowledge but also sits in tension with the normative foundations of development that take European modernization and industrialization as the benchmark for comparison. The role images play in this process is often overlooked. This article argues that a dominant mode of visuality based on a Cartesian separation between subject and object, underpinning the ascendance of European hegemony and colonialism, aligns with the core premises of orthodox development discourse. An example of how visual representations of development matter is presented through images of Africa–China relations in western media sources. Using widely circulated images depicting China's impact on African development in western news media sources as an example of why visual politics matters for policy-making, the article examines how images play a role in legitimizing development planning by rendering associated forms of epistemological and structural violence ‘invisible to the viewer’. Full Article
el Development of a sensitive and quantitative method for the identification of two major furan fatty acids in human plasma By feedproxy.google.com Published On :: 2020-04-01 Long XuApr 1, 2020; 61:560-569Methods Full Article
el Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study By feedproxy.google.com Published On :: 2020-04-01 Gemma CadbyApr 1, 2020; 61:537-545Patient-Oriented and Epidemiological Research Full Article
el HDL and pancreatic {beta} cells: a SMO-king gun? By feedproxy.google.com Published On :: 2020-04-01 Liam R. BrunhamApr 1, 2020; 61:468-469Commentary Full Article
el Phosphatidylinositol Metabolism, Phospholipases, Lipidomics, and Cancer:In Memoriam of Michael J. O. Wakelam (1955-2020) By feedproxy.google.com Published On :: 2020-04-28 Edward A DennisApr 28, 2020; 0:jlr.T120000868v1-jlr.T120000868Tribute Full Article
el HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic {beta}-cells in vitro by activation of Smoothened By feedproxy.google.com Published On :: 2020-04-01 Mustafa YalcinkayaApr 1, 2020; 61:492-504Research Articles Full Article
el Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination By feedproxy.google.com Published On :: 2020-04-01 Deanna L. DavisApr 1, 2020; 61:505-522Research Articles Full Article
el Hexacosenoyl-CoA is the most abundant very long-chain acyl-CoA in ATP binding cassette transporter D1-deficient cells By feedproxy.google.com Published On :: 2020-04-01 Kotaro HamaApr 1, 2020; 61:523-536Patient-Oriented and Epidemiological Research Full Article
el Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice By feedproxy.google.com Published On :: 2020-05-01 Yipeng SuiMay 1, 2020; 61:696-706Research Articles Full Article
el A novel NanoBiT-based assay monitors the interaction between lipoprotein lipase and GPIHBP1 in real time By feedproxy.google.com Published On :: 2020-04-01 Shwetha K. ShettyApr 1, 2020; 61:546-559Methods Full Article
el Roles of endogenous ether lipids and associated PUFA in the regulation of ion channels and their relevance for disease By feedproxy.google.com Published On :: 2020-04-07 Delphine FontaineApr 7, 2020; 0:jlr.RA120000634v1-jlr.RA120000634Research Articles Full Article
el Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease. By feedproxy.google.com Published On :: 2020-04-14 Inês Magro dos ReisApr 14, 2020; 0:jlr.RA120000632v1-jlr.RA120000632Research Articles Full Article
el Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes By feedproxy.google.com Published On :: 2020-03-10 Inga NilssonMar 10, 2020; 0:jlr.RA120000654v1-jlr.RA120000654Research Articles Full Article
el Commentary on SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect fatty acid translocation By feedproxy.google.com Published On :: 2020-05-01 Henry J. PownallMay 1, 2020; 61:595-597Commentary Full Article
el A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice By feedproxy.google.com Published On :: 2020-05-01 Chelsea DeLeonMay 1, 2020; 61:767-777Research Articles Full Article
el Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro By feedproxy.google.com Published On :: 2020-03-10 Eyad NaserMar 10, 2020; 0:jlr.RA120000682v1-jlr.RA120000682Research Articles Full Article
el Ebola virus matrix protein VP40 hijacks the host plasma membrane to form the virus envelope By feedproxy.google.com Published On :: 2020-04-15 Souad AmiarApr 15, 2020; 0:jlr.ILR120000753v1-jlr.ILR120000753Images in Lipid Research Full Article
el Accessibility of cholesterol at cell surfaces By feedproxy.google.com Published On :: 2020-04-23 Kristen A. JohnsonApr 23, 2020; 0:jlr.ILR120000836v1-jlr.ILR120000836Images in Lipid Research Full Article
el GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells By feedproxy.google.com Published On :: 2020-05-01 Xia MengMay 1, 2020; 61:591-591Images in Lipid Research Full Article
el Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2016-12-30T00:06:37-08:00 Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how the high risk variant (Arg-325), which is also a higher frequency (>50%) allele, is correlated with zinc transport activity. Here, we compared the activity of Arg-325 with that of a low risk ZnT8 variant (Trp-325). The Arg-325 variant was found to be more active than the Trp-325 form following induced expression in HEK293 cells. We further examined the functional consequences of changing lipid conditions to mimic the impact of lipid remodeling on ZnT8 activity during insulin granule biogenesis. Purified ZnT8 variants in proteoliposomes exhibited more than 4-fold functional tunability by the anionic phospholipids, lysophosphatidylcholine and cholesterol. Over a broad range of permissive lipid compositions, the Arg-325 variant consistently exhibited accelerated zinc transport kinetics versus the Trp-form. In agreement with the human genetic finding that rare loss-of-function mutations in ZnT8 are associated with reduced T2D risk, our results suggested that the common high risk Arg-325 variant is hyperactive, and thus may be targeted for inhibition to reduce T2D risk in the general populations. Full Article
el Episode 29 - The Internet of Wildcats (IoW) Android Nougat, Deliveroo strikes & Playstation rumours By play.acast.com Published On :: Fri, 26 Aug 2016 12:30:46 GMT Henry Burrell is the master of ceremonies this week, dropping beats on the hottest tech topics. First up, producer Chris joins to chat about the latest Android OS: Nougat. Then staff writer at Techworld.com Scott Carey jumps in to chat about the Deliveroo strikes this week and what this means for sharing economy companies like Uber and Airbnb in general (15:30). Finally, staff writer at Tech Advisor Lewis Painter has some Playstation console rumours to discuss (27:00). See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 32 - The Internet of Natural Selection (IoNS) By play.acast.com Published On :: Fri, 16 Sep 2016 14:02:08 GMT In episode 32, Techworld's Scott Carey looks at Amazon's Echo and finds a dystopian future world in which our household appliances listen to us and talk back. Digital Arts editor Neil Bennett (15:06) explains why Tesla now has to design products for stupid people, and Macworld's David Price explains why mums don't like Apple's iOS 10 (28:00). We also discuss the beauty and lyricism of the German language. See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 52 - The Internet of Nostalgia (IoN) Nokia 3310, drone taxis and Apple on the telly By play.acast.com Published On :: Fri, 17 Feb 2017 13:58:54 GMT Matt Egan takes us where no other pod has dared gone before (September 2000) and asks Digital Arts Editor Neil Bennett if anyone cares that Nokia is rereleasing the famous 3310. Is it cool to rock one now? Then Techworld Audience Development Editor Christina Mercer lets us know that the future is already here with self driving drone taxis. Would you hitch a lift round Dubai on a massive quadcopter? Finally Deputy Editor at Macworld David Price ruminates on Apple's forecast foray into the world of snackable media content - will it challenge Netflix or try to buy it? See acast.com/privacy for privacy and opt-out information. Full Article podcast technology tech pod nokia nokia 3310 drones automotive Apple
el Episode 53 - The Internet of UberEATS Itself (IoUEI) Uber's mess, Apple's orchards and MWC's phones By play.acast.com Published On :: Fri, 24 Feb 2017 12:25:36 GMT Allow Matt Egan (and Shed7) to lull you into this week's pod as we tackle the big tech issues of the week. Staff Writer at Digital Arts Miriam Harris explains the latest HR and PR mess over at Uber. How long will consumers use a service when the company are clearly not treating its staff well? Then (16:30) Deputy Editor of Macworld UK David Price gets excited about Apple Park, the so-called 'spaceship campus' that has been under construction for years. May contain orchards. Finally (26:48) Senior Staff Writer at Tech Advisor Henry Burrell previews Mobile World Congress which gets underway on 26th February. Are any of the major handset launches worth your attention? See acast.com/privacy for privacy and opt-out information. Full Article pocast pod mobile world congress tech technology mwc 2017 apple uber sony huawei samsung LG blackberry motorola
el Episode 57 - The Internet of Apple press releases (IoAPR) iPads, red iPhones, black OnePlus phones and Android O By play.acast.com Published On :: Fri, 24 Mar 2017 11:24:07 GMT Gather round as three men spend 30 minutes talking about tech. Wait, what do you mean 'no thanks'?! Matt Egan shares the mic with David Price and Henry Burrell to thrash out why Apple deemed a press release adequate to announce the successor to 2014's iPad Air 2. There's also a slick new red iPhone, and a black OnePlus 3T. What's with the limited editions, eh? Or are they even limited? The gang also chat about the developer preview of Android O, out now while Android N is barely months old. Is it too early to say if it'll kick ass, and why do Google and Apple need such long public lead time with new OS builds? See acast.com/privacy for privacy and opt-out information. Full Article pod podcast technology tech chat apple funny humour funny podcast nerd nerds iphone ipad oneplus android google
el Episode 61 - The Internet of automated selfies (IoAS) Amazon Echo Look and job automation By play.acast.com Published On :: Fri, 28 Apr 2017 10:58:21 GMT Join host Henry Burrell in conversation with two editors, Karen Khan of Macworld UK in her debut pod along with pod regular Charlotte Jee of Techworld. We tackle the issues of privacy and self esteem, particularly in the young people that we are not, and ask who this product is for (because surely it will sell). Tech obviously plays a big part in the selfie phenomenon/epidemic. Second we discuss automation and how it is affecting the job market. Can a robot make an iPhone? Is Trump right about bringin' it all back home? What should politicians be doing to understand the technology involved? Thanks for listening, listener. See acast.com/privacy for privacy and opt-out information. Full Article pod podcast tech technology amazon amazon echo amazon echo look automation jobs apple iphone factory work work politics
el Episode 66 - The Internet of Monkeys (IoM) Amazon Prime Day and monkey selfies By play.acast.com Published On :: Fri, 14 Jul 2017 09:39:31 GMT We return like a nerdy phoenix for episode 66, where Henry Burrell leads David Price and Dominic Preston down the tech rabbit hole to discuss the week's news. Amazon Prime Day came and went, but what does it really mean for consumers and the media? Did you buy anything? Did you need it? The team then discuss the odd ongoing story of the man who lost copyright of an image of a monkey to... the monkey that allegedly took it. PETA got involved. It's weird. It's good to be back. See acast.com/privacy for privacy and opt-out information. Full Article pod podcast funny humour humor tech technology amazon monkeys
el Episode 72 - The Internet of Pixels (IoP) Google and Amazon events, Uber and the SNES Mini By play.acast.com Published On :: Fri, 06 Oct 2017 14:21:35 GMT We back. Google and Amazon introduced a raft of new products for us to drool over and, of course, apply a degree of scepticism. Jim Martin was on the ground to use all the new Google stuff and has the latest. Scott then talks us through Uber's mishaps, this time its London licence has been revoked. Will the company go public when it wants to? Finally we discuss the SNES Mini which we managed to get our hands on and why Nintendo has such low stock of all its great products. See acast.com/privacy for privacy and opt-out information. Full Article pod podcast humor humour funny tech technology google amazon echo dot pixel 2 pixel 2 xl
el Episode 73 - The Internet of Electric Sheep (IoES) Facebook's blunder, the new Kindle and Blade Runner 2049 By play.acast.com Published On :: Fri, 13 Oct 2017 11:48:50 GMT Episode 73 sees David Price lead Scott Carey, Miriam Harris and Henry Burrell into a critique of Mark Zuckerberg's decision to go into a VR tour of Puerto Rico. Disaster tourism at its finest/worst.Henry then discusses the new Kindle Oasis, which for the firs time is waterproof - but very expensive and quietly released.Finally we all chip in to ask why Blade Runner 2049 is quite so overtly sexist in its portrayal of women. There be spoilers. See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 74 - The Internet of KRACK (IoK) Wi-Fi flaws, Pixel 2 and Facebook vs cyberbullying By play.acast.com Published On :: Fri, 20 Oct 2017 09:50:29 GMT David Price is back to host this week, with Christina Mercer breaking down what all the fuss about KRACK is and why you should take precautions with your Wi-Fi. Henry Burrell reviewed the Google Pixel 2 this week so gives us his thoughts on the device. You might want to avoid the larger XL though. We then discuss Facebook's idea to counterattack cyberbullying. Charlotte Jee recently spoke with the company to see what they are doing, but will it work? See acast.com/privacy for privacy and opt-out information. Full Article technology podcast krack KRACK wifi wi-fi security google pixel 2 google pixel 2 android facebook cyberbullying
el Episode 76 - The Internet of Deals (IoD) Black Friday, Mac root bug, Pixel Buds and Animal Crossing By play.acast.com Published On :: Fri, 01 Dec 2017 15:49:36 GMT It's a bumper pod! David Price leads Ashleigh Macro and Henry Burrell down the topical rabbit hole to discuss why Black Friday largely sucks, but is an interesting venture for publishers as well as consumers. Who else bought a Switch?We then tackle the Mac root issue that hit headlines worldwide before tearing the Pixel Buds a new one. And we all downloaded Animal Crossing: Pocket Camp to see what the fuss is about. See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 79 - The Internet of New Year (IoNY) Meltdown & Spectre, iPhone batteries, iMac Pro and the VFX Bafta noms By play.acast.com Published On :: Mon, 15 Jan 2018 00:00:00 GMT 2018 lands with a distinct thud as Charlotte Jee tackles Meltdown and Spectre, David Price wrestles with Apple's batteries and its new iMac Pro, before Miriam Harris works through the Bafta nominations for visual effects. Henry Burrell leads us down the rabbit hole. See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 83 - The Internet of White Rings (IoWR) HomePod, Kingdom Come: Deliverance and no spoiler Black Panther chat By play.acast.com Published On :: Fri, 16 Feb 2018 00:00:00 GMT Scott Carey assembles half the Tech Advisor squad to chat about the HomePod's great audio and then all the things that make it a tabloid headline. Jim Martin lets us know if Apple ruined his oak and/or pine.Lewis Painter chats us through Kingdom Come: Deliverance and all the wacky things you can do in its slow paced but huge world. Dom Preston then lets us know - without spoilers - just how good Black Panther is, Marvel's latest marvel (hopefully). See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 89 - The Internet of Pirates (IoP) Hacker pirates, face recognition ethics and Elon Musk By play.acast.com Published On :: Wed, 16 May 2018 11:01:06 GMT Back once again like the Renegade Master, the UK Tech Weekly Podcast is coming to you from its new, earlier-in-the-week time slot.Host Scott Carey is joined by Tamlin Magee to talk about pirate-obsessed Nigerian hacking syndicates, and Charlotte Jee is on board to discuss the ethics of facial (and racial) recognition technology.We wrap things up with an Elon Musk news roundup, from his latest bae to building bricks. See acast.com/privacy for privacy and opt-out information. Full Article
el Episode 104 - The Internet of Circles (IoC) RIP Google+, Pixel 3 and new tech in films By play.acast.com Published On :: Fri, 12 Oct 2018 14:46:35 GMT This week our host Scott Carey catches up on the Google+ breach news and the final demise of the doomed social media network before being joined by consumer technology editor at Tech Advisor, Henry Burrell, to talk about Google's latest batch of smartphones: the Pixel 3 and Pixel 3 XL.Then Techworld reporter Tamlin Magee joins to talk about the technology-related films screening during the London Film Festival this month and his hopes for more utopian tech-flecked stories in the future. See acast.com/privacy for privacy and opt-out information. Full Article