360°-Sounderlebnis mit dynamischen Lichtshows! Das ist der JBL Pulse, der ab sofort in der vierten Generation verfügbar ist. Ob Party-Modus oder einfach zu m Chillen, der JBL Pulse 4 schafft die perfekte Stimmung. Im Wohnzimmer oder am Strand (und überall dazwischen), der neue Lautsprecher garantiert unglaublichen Sound und die passende Atmosphäre.

360° JBL sound. Vibrant lightshow. JBL’s Pulse 4 is here; party time or chill, you create the mood. From living room to beach party (and everything in between), the new JBL Pulse 4 provides incredible sound, with visuals to match.

This follow-up study of a randomized, prospective trial included 192 patients with newly diagnosed severe aplastic anemia receiving antithymoglobulin and cyclosporine, with or without granulocyte colony-stimulating factor (G-CSF). We aimed to evaluate the long-term effect of G-CSF on overall survival, event-free survival, probability of secondary myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), clinical paroxysmal nocturnal hemoglobinuria, relapse, avascular osteonecrosis and chronic kidney disease. The median follow-up was 11.7 years (95% CI, 10.9-12.5). The overall survival rate at 15 years was 57±12% in the group given G-CSF and 63±12% in the group not given G-CSF (P=0.92); the corresponding event-free survival rates were 24±10% and 23±10%, respectively (P=0.36). In total, 9 patients developed MDS or AML, 10 only a clonal cytogenetic abnormality, 7 a solid cancer, 18 clinical paroxysmal nocturnal hemoglobinuria, 8 osteonecrosis, and 12 chronic kidney disease, without any difference between patients treated with or without G-CSF. The cumulative incidence of MDS, AML or isolated cytogenetic abnormality at 15 years was 8.5±3% for the G-CSF group and 8.2±3% for the non-G-CSF group (P=0.90). The cumulative incidence of any late event including myelodysplastic syndrome or acute myeloid leukemia, isolated cytogenetic abnormalities, solid cancer, clinical paroxysmal nocturnal hemoglobinuria, aseptic osteonecrosis, chronic kidney disease and relapse was 50±12% for the G-CSF group and 49±12% for the non-G-CSF group (P=0.65). Our results demonstrate that it is unlikely that G-CSF has an impact on the outcome of severe aplastic anemia; nevertheless, very late events are common and eventually affect the prognosis of these patients, irrespectively of their age at the time of immunosuppressive therapy (NCT01163942).

Epic will be hosting its latest in-game event in Fortnite this weekend, featuring the talents of Dillon Francis, Steve Aoki and deadmau5

The new Nightlife reactive skin is now live ahead of the Fortnite Party Royale event which starts later today.

Epic Games has issued a warning ahead of the Party Royale event, but it might not be the only problem facing players this evening.

Fortnite Party Royale event starts soon. Here's everything you need to know including start times for Deadmau5, Dillon Francis and Steve Aoki - PLUS how to claim the many live event rewards available from Epic Games as they celebrate 350 million players.

"Fortnite" Party Royale had another big show on May 8. Here's everything you need to know about the Dillion Francis, Steve Aoki and deadmau5 concert that just took place.

Sierra Leone's president Julius Maada Bio has accused the main opposition party of orchestrating a spate of violent incidents, deepening a political standoff that risks undermining the country's efforts to contain a coronavirus outbreak.

Joe Biden's campaign is gaining the support of key progressive groups to unite the party's factions.

Rep. Justin Amash believes his White House bid is bad for both President Trump and his Democratic challenger, the Michigan Libertarian indicated in a recent interview.

Mr. Amash, a former Republican who left the GOP last year, told Time that he expects his presence in the presidential race will not ...

Read our live coronavirus updates HERE Coronavirus: The symptoms

The Government is facing calls from cross-party MPs to urgently recall of parliament in "virtual" form so that their coronavirus response can be properly scrutinised.

Police in New York broke up a "4/20" marijuana party in Manhattan after receiving a tip that nearly 40 people were not practising social distancing during the coronavirus outbreak.

Elephants at Chester Zoo will be treated to a pool party in this week's virtual tour of the attraction which is currently closed to the public during the coronavirus lockdown.

Members of the Commander's crew were filmed dancing to techno music behind a DJ set on deck

Two 20-year-old men were arrested on suspicion of public order offences

A group of VE Day revellers have sparked fury by performing a conga dance in an apparent breach of social distancing rules.

Labour leader Sir Keir Starmer will hold virtual meetings with members of the public over Zoom as he tries to resuscitate the party after its historic electoral defeat.

Jennie Formby has resigned as Labour's general secretary as new leader Sir Keir Starmer reshapes the party.

US indie rock maverick Will Toledo is back with an experimental album that finds him collaborating with his own electronic side project

You cannot accuse Car Seat Headrest, AKA Will Toledo, of taking the easy route. Four years on from the release of breakthrough record Teens of Denial, Toledo is back with new album Making a Door Less Open, only now he is going under the name Trait and is wearing a gas mask in photos. Toledo’s restless and impassioned indie rock is looking a little different, too. The new album blends his classic songwriting chops with a bold exploration of electronic textures. This is the result of essentially making the album twice: once as Car Seat Headrest, and again alongside producer Andrew Katz as their jokey EDM side project 1 Trait Danger, before landing on a middle ground.

Related: The Guide: Staying In – sign up for our home entertainment tips

Is it all moot because of the deadly virus infecting Australia and no I don’t mean the National party ahahaha

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The designer is inviting us all to her Instagram party

Want to watch Netflix with your friends or have a virtual date? Kast is here to help

From Joshua Tree to Formentera, Ibiza legend Dawn Hindle shares her favourite travel memories

Why not try these easy, tasty recipes at home?

Everton say they are "appalled" and have strongly condemned the actions of Moise Kean as "completely unacceptable" after the player was reported to have flouted coronavirus lockdown measures.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

The Labor Party has walked out of the NSW Legislative Assembly after Opposition Leader Jody McKay is thrown out by the Speaker.

You can still experience prom doing the COVID-19 outbreak.

The all-day extravaganza is set for Saturday.

Hacienda Classical will perform at the second stay-at-home rave from the legendary club and United We Stream

The squabbling over an empty federal seat shows why the National Party remains a problem for Scott Morrison as he plots his post-coronavirus agenda, writes Laura Tingle.

A group of North Melbourne footballers apologises for throwing a party at a Melbourne home last night, with the club saying it was "inappropriate in the current climate".

Used in balloons and industry, gas is hard to capture and supplies are diminishing and its price rising. Researchers think it may be found under ground.

Joe Biden has tried to move past an allegation that he assaulted a female staffer decades ago by not talking about it. It isn't working. Some Democrats worry the story line will fester into a much bigger problem for him and the party if he keeps ignoring it.

The former chief of party in Baghdad for the United States Institute of Peace (USIP), Robert Nathan Boorda, pleaded guilty to an information unsealed today in the U.S. District Court for the District of Columbia for conspiring to enrich himself by having USIP award a security contract at a fraudulently inflated price in exchange for a purported monthly consulting fee of $20,000 paid by the contractor.

For the past three years the Republican Party leadership have stood by the president through thick and thin. Previous harsh critics and opponents in the race for the Republican nomination like Senator Lindsey Graham and Senator Ted Cruz fell in line, declining to say anything negative about the president even while, at times, taking action…

For the past three years the Republican Party leadership have stood by the president through thick and thin. Previous harsh critics and opponents in the race for the Republican nomination like Senator Lindsey Graham and Senator Ted Cruz fell in line, declining to say anything negative about the president even while, at times, taking action…

What happened in this year’s Democratic nominating contest? To the surprise of many, a relatively moderate establishment candidate, former Vice President Joe Biden, won. Why didn’t the Democratic primary process in 2020 follow the chaotic course that the Republican process took in 2016? Why did the party establishment prevail? An important new paper by the…

For the past three years the Republican Party leadership have stood by the president through thick and thin. Previous harsh critics and opponents in the race for the Republican nomination like Senator Lindsey Graham and Senator Ted Cruz fell in line, declining to say anything negative about the president even while, at times, taking action…

For the past three years the Republican Party leadership have stood by the president through thick and thin. Previous harsh critics and opponents in the race for the Republican nomination like Senator Lindsey Graham and Senator Ted Cruz fell in line, declining to say anything negative about the president even while, at times, taking action…

For the past three years the Republican Party leadership have stood by the president through thick and thin. Previous harsh critics and opponents in the race for the Republican nomination like Senator Lindsey Graham and Senator Ted Cruz fell in line, declining to say anything negative about the president even while, at times, taking action…