C-X-C motif chemokine receptor 4 (CXCR4)–directed imaging has gained clinical interest in aiding clinical diagnostics in primary aldosteronism (PA). We retrospectively evaluated the feasibility of CXCR4-directed scintigraphy using the novel CXCR-4 ligand [^99mTc]Tc-pentixatec in patients with PA. Methods: Six patients (mean age ± SD, 49 ± 15 y) underwent CXCR4-directed scintigraphy (including planar imaging and SPECT/CT) 30, 120, and 240 min after injection of 435 ± 50 MBq of [^99mTc]Tc-pentixatec. Adrenal CXCR4 expression was analyzed by calculating lesion-to-contralateral ratios (LCRs). Imaging results were correlated to clinical information. Histopathology and clinical follow-up served as the standard of reference. Results: Three subjects showed lateralization of adrenal tracer accumulation, with a mean maximum lesion-to-contralateral ratio of 1.65 (range, 1.52–1.70), which correlated with morphologic findings on CT. One individual underwent adrenalectomy and presented with complete biochemical and clinical remission at follow-up. Histopathologic workup confirmed unilateral aldosterone-producing adenoma. Conclusion: [^99mTc]Tc-pentixatec scintigraphy with SPECT in patients with PA is feasible and might offer a valuable alternative to CXCR4-directed imaging with [⁶⁸Ga]Ga-pentixafor PET.

Did you grow up in a world void of social media platforms? Then, you’re probably the last ‘lucky’ generation. A part of Generation Y and most of Generation Z have been raised alongside the internet and social media. Individuals belonging to the latter have practically been raised by such platforms, as they interact with strangers […]

The post Sacrificing the Human Psyche at the Altar of Social Media? 4 Concerning Ill-Effects to Know first appeared on What is Psychology?.

New report on Oregon's tribal students show they start out behind, miss more school, and are more likely to drop out.

New Jersey leads the states on Quality Counts 2020’s summative rankings based on previous years’ data. But the annual report card shows plenty of work needed all around as the pressure mounts.

Several school districts have been forced to close due to a large number of teachers calling out sick in protest of a pension-reform bill.

A Kentucky teen who became the subject of a viral video after a class field trip warned viewers of the Republican National Convention of an "outrage mob" that threatens to silence conservative viewpoints.

Tupac Mosley overcame homelessness to graduate as valedictorian, writes Jonathan E. Collins, but there’s an overlooked part of his inspirational story: policy.

New Jersey leads the states on Quality Counts 2020’s summative rankings based on previous years’ data. But the annual report card shows plenty of work needed all around as the pressure mounts.

The bill would have given public school teachers at least six weeks of paid maternity leave.

The Indiana state teachers' union is pushing to protect student and staff safety during active-shooter trainings.

Sabres coach Lindy Ruff provided a concerning update about Ukko-Pekka Luukkonen following the game.

Members of 30 different state and national advocacy groups and unions are meeting in Washington, D.C., for the Grassroots Assembly for Child Care and Early Education.

Teachers in the nation's third-largest school system are fighting for salary increases, class-size caps, and a written commitment for more nurses, social workers, and librarians—as well as investments some say are outside the scope of collective bargaining.

Bruce S. McEwen
Jan 2, 2020; 40:12-21
Viewpoints

Different people listening to the same story may converge upon a largely shared interpretation while still developing idiosyncratic experiences atop that shared foundation. What linguistic properties support this individualized experience of natural language? Here, we investigate how the "concrete–abstract" axis—the extent to which a word is grounded in sensory experience—relates to within- and across-subject variability in the neural representations of language. Leveraging a dataset of human participants of both sexes who each listened to four auditory stories while undergoing functional magnetic resonance imaging, we demonstrate that neural representations of "concreteness" are both reliable across stories and relatively unique to individuals, while neural representations of "abstractness" are variable both within individuals and across the population. Using natural language processing tools, we show that concrete words exhibit similar neural representations despite spanning larger distances within a high-dimensional semantic space, which potentially reflects an underlying representational signature of sensory experience—namely, imageability—shared by concrete words but absent from abstract words. Our findings situate the concrete–abstract axis as a core dimension that supports both shared and individualized representations of natural language.

A ring could explain a mysterious arrangement of impact craters near the equator and might even have caused an ice age, according to a new study

Using sound recordings, the team identified the largest known population of the night parrot, a secretive species known as the "Holy Grail of birdwatching"

A recurrent nova, known as the Blaze Star or T Coronae Borealis, is predicted to soon appear in the night sky. But the exact timing of the rare eruption remains unknown

Ashley Hickey, a parent of a kid with celiac disease, is concerned that Nova Scotia's new school program does not offer any 100 per cent guaranteed gluten-free options.

A candidate for the Nova Scotia NDP has apologized and is no longer running for the party in the provincial election after her comments on Israel and the Holocaust drew concern from the Jewish organizations. 

Newspaper editor Horace Greeley unsuccessfully ran against incumbent Ulysses S. Grant in November 1872. Twenty-four days later, he died of unknown causes at a private mental health facility

There have been three separate reports of pellet gun attacks in the past seven days in Guelph, Ont. Police have made an arrest in one case and continue to investigate the other two.

Concerns are mounting over the potential environmental impact on fish populations following the destruction of Kamloops' historic Red Bridge, which collapsed into the South Thompson River during a fire.

OM Montenegro has discovered that if they are faithful and patient, they can eventually walk through doors that had once seemed closed.

New Conceptual, Instinctive, Social, Connected Design Application Introduced at SOLIDWORKS World 2014

First SOLIDWORKS Application on the 3DEXPERIENCE Platform Accelerates Product Innovation on the Cloud

Oxana works with OM Moldova to change the fate of girls facing neglect and exploitation, sharing their past and offering hope for their future.

In the lawsuit, the Chicago-based team's parents allege Little League was aware of potential residency issues, "but chose to ignore and/or deliberately conceal these facts in order to garner higher ratings, publicity, and money."

Zimbabwe sought to assure citizens that its gold-backed currency would not suffer another steep devaluation and steps were being taken to assure its defence.

Jack Saint Clair will bring his 17-piece jazz orchestra to Penn State Abington for a free concert at 7 p.m. Nov. 13 in Sutherland Auditorium.

The Penn State School of Music's annual "Mosaic" concert will return to Eisenhower Auditorium on Sunday, Dec. 8 at 4 p.m. 

Sandton was a place to be before the pandemic. But footfall in Africa's richest square mile refuses to go back to pre-pandemic levels. Restaurants and hotels around the area are struggling.

Blue Ribbon and Snowflake owner Premier's interim earnings rose by almost a third on Tuesday as the group benefited from a focus on margin management, cost savings and continued investment in its assets.

All principals are dealing with COVID-19, and some are dealing with wildfires or hurricanes at the same time. Those issues, on top of increasing job demands, are pushing principals to the breaking point. We need to do something about that.

The Penn State School of Music will present three choir concerts on Sunday, Nov. 17, in the Recital Hall on the University Park campus. Featuring world premieres, folk traditions and themes of community and aspiration, these concerts will make for a lovely Sunday afternoon of music for audiences of all ages. 

Donald Trump's impending White House return poses questions once again about conflicts of interest related to his business empire, with new cryptocurrency and other ventures raising fresh concerns.

Kyle Singler's videos have left the NBA fraternity concerned with many of his former teammates offering support.

The lower-end Xbox Series S has run into hardware bottlenecks in the past when it comes to new releases, and concerns have been raised about whether the console would be able to run GTA 6 without problems. Take-Two Interactive CEO Strauss Zelnick has now downplayed those concerns, saying he is “not worried” about GTA 6 performance on Xbox Series S.

Suriya said, "I realised I had to pull my socks"

Donald Trump's impending White House return poses questions once again about conflicts of interest related to his business empire, with new cryptocurrency and other ventures raising fresh concerns.

DOVER, DE (OCT. 28, 2022) – The Delaware Division of Public Health (DPH) is concerned about increases in respiratory viruses in the state, particularly influenza (flu) and respiratory syncytial virus (RSV). For the week of Oct. 16, 2022, through Oct. 22, 2022, there were 44 laboratory-confirmed cases of the flu, compared to 19 cases the week […]

In 2021, anonymous reports helped protect 2,184 vulnerable adults from potential abuse; new hotline makes reporting neglect, abuse and exploitation easy and confidential   NEWARK (Nov. 30, 2022) – The Delaware Division of Services for Aging and Adults with Physical Disabilities (DSAAPD) today announced the launch of the new Adult Protective Services (APS) hotline – 888-APS-4302. With one simple […]

[COSATU] The Congress of South African Trade Unions (COSATU) is deeply concerned by the Minister for Communications and Digital Technologies, Mr. S. Malatsi's sudden withdrawal of the South African Broadcasting Corporation (SABC) SOC Ltd Bill from Parliament where it was being engaged upon by the National Assembly's Portfolio Committee: Communications and Digital Technologies.

Power efficiency is a critical factor in the fast-evolving world of semiconductor design.

The IEEE 1801 standard, also known as UPF (Unified Power Format), was developed by the IEEE to address the intricate challenges associated with power management in contemporary semiconductor designs. This standard offers a uniform framework for defining power domains, power states, and power intent, ensuring consistency across diverse tools and phases of the design process. By utilizing UPF, you can precisely model and regulate power consumption, a critical aspect for battery-operated devices, high-performance computing, and energy-efficient designs.

The key concepts of IEEE 1801 are:

1. Power domains
2. Power states
3. Power gating and isolation
4. Power switches
5. Level shifters, isolation, and retention cells
6. Macro model

Based on these building blocks, you write the power intent of the design.

The power intent for the design includes identifying/implementing low-power strategies that provide a clear description of the power architecture of a design.

The power definitions can effectively manage power consumption and ensure the chip meets its power and performance requirements.

You can start by creating the Power Supply Network, which defines how power is supplied to the design's various power domains and logic cells.

What's the next step to build the file? How do you understand the various concepts related to IEEE 1801? How do you complete the rest of the power intent file?

Relax!

Gear up to attend the training class created just for you to dive deep into the entire format and explore this exciting power specification method/format with hands-on labs in one day!

Training

Fundamentals of IEEE 1801 Low-Power Specification Format Training

This course is a complete tutorial for understanding the fundamentals of IEEE 1801 low-power specification format concepts. You learn about IEEE 1801 power supply networks, ground ports and nets, creating and connecting supply ports/nets, power domain, power switch, power states, defining isolation and level shifter strategies, hierarchical IEEE 1801, and various versions of the IEEE 1801. You also explore how power intent information can be used for a design across various flow stages, such as functional verification, synthesis, logic equivalency checking, place-and-route, test, timing signoff, power integrity, and so forth, using Cadence^® tools.

Labs

We ensure that your learning journey is smooth with hands-on labs covering various design scenarios.

Lab Videos

Now, the exciting part is that to help you further, we have created engaging videos of the training labs. You can refer to the lab module's instructions in demo format at https://support.cadence.com.

Lab Demo: Checking Power Supply Network in IEEE 1801 format and Running IEEE 1801 Quality Checks using Conformal Low Power

Lab Demo: Checking Power Intent for The Macro Connections in IEEE 1801 Format And Running IEEE 1801 Quality Checks using Conformal Low Power 

Online Class

Here is the course link.

Get ready for the most thrilling experience with Accelerated Learning!

The more you know, the faster you go!

Grab the cycle  or hike it, based on your existing knowledge.

Take the quiz and increase your learning pace!!

What's Next?

Grab your Badge after finishing the training and flaunt the expertise you have built up. 😊

Ready to take a tour of this power specification world? Let's help you enroll in this course.

We organize this training for you as a "Blended" or "Live" training. Please reach out to Cadence Training for further information. If you want to ensure you are always the first to know about anything new in training, you can use the SUBSCRIBE button on the landing page to sign up for our regular training newsletters.

Related Short Training Bytes/Videos

Enhance the learning experience with short videos:

Genus Synthesis Solution: Video Library

 Joules RTL Power Solution: Video Library

Related Training

 Low-Power Synthesis Flow with Genus Synthesis Solution

Genus Low-Power Synthesis Flow with IEEE 1801

Related Blogs

It's the Digital Era; Why Not Showcase Your Brand Through a Digital Badge! - Digital Design - Cadence Blogs - Cadence Community

Relax in Summer with Cooler IC chips and Ice-Cream! Do you want to Explore the Recipe? - Digital Design - Cadence Blogs - Cadence Community

Power Is HOT and Touches Everything and Everybody! But the Challenge Is To Deal With Low Power During Design Synthesis; How? - Digital Design - Cadence Blogs - Cadence Community

Binge on Chip Design Concepts this Weekend! - Digital Design - Cadence Blogs - Cadence Community

Tanzania's economy is booming and its tourism sector is thriving. However, concerns about the president's strong-arm tactics and delays in the completion of key infrastructure projects are threatening this growth.

Severe threats to the environment accounted for all of the five most likely long-term risks in the WEF’s Global Risks Report 2020.

FDI project numbers from China into the EU are on a downward trend, but Europe is still a popular destination for Chinese investment.