Oct. 29, 2024 — NVIDIA has announced that xAI’s Colossus supercomputer cluster comprising 100,000 NVIDIA Hopper GPUs in Memphis, Tennessee, achieved this massive scale by using the NVIDIA Spectrum-X Ethernet […]

The post NVIDIA Ethernet Networking Accelerates xAI’s Colossus AI Supercomputer appeared first on HPCwire.

We hear a lot about quantum computers – sometimes too much – but not as much about quantum networking which will also be a critical component in making widespread use […]

The post EPB Offers Commercial Quantum Network for Quantum Developers appeared first on HPCwire.

COLLEGE PARK, Md. and VISTA, Calif., Nov. 8, 2024 — IonQ has announced that it has reached a definitive agreement to acquire substantially all of the operating assets of Qubitekk, […]

The post IonQ to Expand Quantum Networking Portfolio with Qubitekk Acquisition appeared first on HPCwire.

BOSTON, Dec. 12, 2023 — Aliro Quantum today announced the controlled availability of Aliro Simulator, a versatile, modular quantum network simulator equipped to model all portions of a quantum network from […]

The post Aliro Quantum Debuts Aliro Simulator, Enhancing Quantum Network Simulation and Visualization appeared first on HPCwire.

Networking doesn’t always have to feel like a self-serving transaction, says executive coach Daniel Hallak. Highlighting the importance of focusing on giving rather than taking when it comes to making connections, he outlines a mindset shift to help you build better relationships — in a way that doesn't feel gross.

Laura Medlock
Apr 13, 2022; 42:3133-3149
Systems/Circuits

Prithviraj Rajebhosale
Oct 23, 2024; 44:e0063242024-e0063242024
Cellular

William W. Seeley
Dec 11, 2019; 39:9878-9882
Progressions

Kong-Fatt Wong
Jan 25, 2006; 26:1314-1328
BehavioralSystemsCognitive

Umut Güçlü
Jul 8, 2015; 35:10005-10014
BehavioralSystemsCognitive

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by -secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V₃₂₁L) in the Nrg1 transmembrane domain that disrupts nuclear back signaling with minimal effects on forward signaling or local back signaling and was previously found to be associated with psychosis (Walss-Bass et al., 2006). We combined RNA sequencing, retroviral fate mapping of neural stem cells, behavioral analyses, and various network analyses of transcriptomic data to investigate the effect of disrupting Nrg1 nuclear back signaling in the dentate gyrus (DG) of male and female mice. The V₃₂₁L mutation impairs nuclear translocation of the Nrg1 ICD and alters gene expression in the DG. V₃₂₁L mice show reduced stem cell proliferation, altered cell cycle dynamics, fate specification defects, and dendritic dysmorphogenesis. Orthologs of known schizophrenia (SCZ)-susceptibility genes were dysregulated in the V₃₂₁L DG. These genes coordinated a larger network with other dysregulated genes. Weighted gene correlation network analysis and protein interaction network analyses revealed striking similarity between DG transcriptomes of V₃₂₁L mouse and humans with SCZ.

Words offer a unique opportunity to separate the processing mechanisms of object subcomponents from those of the whole object, because the phonological or semantic information provided by the word subcomponents (i.e., sublexical information) can conflict with that provided by the whole word (i.e., lexical information). Previous studies have revealed some of the specific brain regions and temporal information involved in sublexical information processing. However, a comprehensive spatiotemporal neural network for sublexical processing remains to be fully elucidated due to the low temporal or spatial resolutions of previous neuroimaging studies. In this study, we recorded stereoelectroencephalography signals with high spatial and temporal resolutions from a large sample of 39 epilepsy patients (both sexes) during a Chinese character oral reading task. We explored the activated brain regions and their connectivity related to three sublexical effects: phonological regularity (whether the whole character's pronunciation aligns with its phonetic radical), phonological consistency (whether characters with the same phonetic radical share the same pronunciation), and semantic transparency (whether the whole character's meaning aligns with its semantic radical). The results revealed that sublexical effects existed in the inferior frontal gyrus, precentral and postcentral gyri, temporal lobe, and middle occipital gyrus. Additionally, connectivity from the middle occipital gyrus to the postcentral gyrus and from postcentral gyrus to the fusiform gyrus was associated with the sublexical effects. These findings provide valuable insights into the spatiotemporal dynamics of sublexical processing and object recognition in the brain.

Italian police have uncovered a large-scale pan-European forgery network making and selling fake artworks attributed to some of the biggest names in modern and contemporary art including Banksy, Pablo Picasso and Andy Warhol.

Leading elevator components supplier implements 550 licenses of the SolidWorks PDM solution

In this week's episode of SA Money Report, we explore government's plans to allow private operators to use Transnet’s rail network, which is expected to instantly move some 58 million tons of cargo off South Africa’s battered roads.

The Penn State College of IST Distinguished Lecture Series will host Wenke Lee from Georgia Tech at noon on Nov. 18 in E202 Westgate Building at University Park.

Reliance Jio’s True 5G network can improve the smartphone’s battery life by up to 40 percent, a company official highlighted during the company’s earnings call for the second quarter (Q2) of FY25. The telecommunications provider leverages a standalone (SA) architecture along with other technical features for its 5G services in India and assigns the spectrum bandwidth as per the application.

Delaware’s agricultural industry looks forward to attending the annual Delaware Ag Week at the Delaware State Fairgrounds in Harrington from January 8 – 11, 2024. “Ag Week is the largest venue where Delaware farmers, agribusinesses, and subject matter experts can network and learn about the latest innovations and research that will impact them in the upcoming growing season,” said Secretary of Agriculture Michael T. Scuse.

In a network containing multiple nodes, the need for synchronization between the various nodes is not just instrumental but also a complicated and highly complex process. This process becomes even more tricky if we synchronize the clocks between the Manager and the Peripheral. As we know, in a real-time network, some of the nodes would behave like Managers while some would be a Peripheral. If we must make the communication process smooth, then the local clocks of these nodes must be synchronized. 

The problem with this synchronization is that we have the clock running in the Manager as well. If we send the value of the Manager clock to the Peripheral, the synchronization doesn’t happen as we have a propagation delay of the messages, along with the propagation delay of the electronic circuits of Manager and the Peripheral.  

The cherry on the cake is that these electronic circuit propagation delays are not random and remain constant, so we can add a time offset to it to match the clock. To tackle this challenge, IEEE has come up with a protocol named “Precision Timing Protocol.” 

Operation of PTP: 

To synchronize the clocks, a Sync message is sent by the Manager to the Peripheral, which then timestamps the receiving time of the same. Following this, a ‘Follow up’ message is issued by the Manager stating the timestamp at which the Sync message was sent. 

The Peripheral then finds the difference between the two values and adds this to its current time. After this, the time difference between the Manager and the Peripheral narrows down to only the propagation delay of the messages.  

To overcome this, the Peripheral issues a ‘Delay Request’ to the Manager, and the Manager, in turn, issues a ‘Delay Response.’ Both these messages have the timestamp of when they were issued. The time at which they are received is then noted. Since two messages are sent, one from the Peripheral and the other from the Manager, there are two propagation delays. Then half of this value is our propagation delay. 

The Peripheral then adds this propagation delay to its clock, and hence the clock gets synchronized. 

Advantages of PTP: 

1. It provides accurate time stamping. 
2. It is a well-known clock synchronization protocol. 
3. It provides intensified security inside the premises. 
4. It provides the possibility of setting coordinated actions and synchronized communication. 

There are various versions of PTP that have been developed over time, namely PTPv1, PTPv2, PTPv2_1, and the latest PTP-AS. 

Cadence Verification IP for Ethernet is available to support the newer version of PTP, allowing simulation of the device for efficient IP, SoC, and system-level design verification. Semiconductor companies can start using it to fully verify their controller design and achieve functional verification closure on it within no time. 

Hi all, I've trained a device model with the approach of an artificial neural network, and it shows well fit. 

May I know how to transfer the trained model to Verilog-A, so that, we can use this model to do circuit simulation?

And I've searched for some lectures that provide the Verilog-A code in the appendix, but I'm freshman in the field of Verilog-A, 

could anyone tell me each statement? such as

real hlayer-w[0:(NI*NNHL)-1   

How can Khamenei's "shadow empire" deteriorate?

7410 setup and network guide

The investment project is aligned with the following impact: Adequate, quality, sustainable, resilient, and safe transport infrastructure provided in the Greater Capital Region for the economic transformation of the country. The investment project will have the following outcome: Efficiency of road travel improved and the following outputs: (i) Output 1: Climate-resilient expressway along Laguna Lakeshore built; and (ii) Output 2: Institutional capacity of the Department of Public Works and Highways strengthened.

In the Laguna area, the government has prioritized improvement of public transport and is developing the South Commuter Rail Project, connecting Manila and Calamba. The government also released the Public Utility Vehicle Modernization Program in 2017 to improve the efficiency of road-based public transport operations, and started to establish bus terminals, such as the Paranaque Integrated Terminal Exchange, for more efficient and convenient bus operations.

Ancient stone goods found across France may have been made by skilled craftspeople in what is now Paris, who traded along vast networks

Title: Study: Young Adults Who Had Depression Have 'Hyper-Connected' Brain Networks
Category: Health News
Created: 8/27/2014 2:36:00 PM
Last Editorial Review: 8/28/2014 12:00:00 AM

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

ABSTRACTThe private health care sector is an important source of service delivery in low- and middle-income countries (LMICs). Yet, the private sector remains fragmented, making it difficult for health system actors to support and ensure the availability of quality health care services. In global health programs, social franchising is one model used to engage and organize the private health care sector. Two social franchise networks, ProFam in West Africa and Tunza in East and Central Africa, provide health care through branded networks of facilities. However, these social franchise networks include a limited number of private health care facilities, and in fragile contexts, like Burundi and Mali, they have faced challenges in integrating with national health systems. The MOMENTUM Private Healthcare Delivery (MPHD) project in Burundi and Mali sought to expand the number of health facilities it engaged beyond the existing ProFam and Tunza networks. The expansion aimed to help improve service quality in more private facilities while advancing localization and reducing fragmentation for improved stewardship by health system actors. MPHD achieved this expansion by removing barriers for private health facilities to join inclusive, nonbranded networks and engaging local partners to build and maintain these networks. We share lessons learned regarding the growing role of local organizations as actors within mixed health systems and provide insights on strengthening stewardship of the increasingly heterogeneous private health care delivery sector in LMICs, particularly in fragile settings.

ABSTRACTWe describe the development, implementation, and evaluation of a novel twinning approach: the Twinning Partnership Network (TPN). Twinning is a well-known approach to peer learning that has been used in a variety of settings to build organizational capacity. Although twinning takes many forms, the heart of the approach is that institutions with shared characteristics collaborate via sharing information and experiences to achieve a specific goal. We adapted a twinning partnership strategy developed by the World Health Organization to create a network of like-minded health institutions. The key innovation of the TPN is the network, which ensures that an institution always has a high-performing peer with whom to partner on a specific topic area of interest. We identified 10 hospitals and 30 districts in Rwanda to participate in the TPN. These districts and hospitals participated in a kickoff workshop in which they identified capacity gaps, clarified goals, and selected twinning partners. After the workshop, districts and hospitals participated in exchange visits, coaching visits, and virtual and in-person learning events. We found that districts and hospitals that selected specific areas and worked on them throughout the duration of the TPN with their peers improved their performance significantly when compared with those that selected and worked on other areas. Accreditation scores improved by 5.6% more in hospitals selecting accreditation than those that did not. Districts that selected improving community-based health insurance coverage improved by 4.8% more than districts that did not select this topic area. We hypothesize that these results are due to senior management’s interest and motivation to improve in these specific areas, the motivation gained by learning from high-performing peers with similar resources, and context-specific knowledge sharing from peer hospitals and districts.

Next-generation phone networks could dramatically outperform current ones thanks to a new technique for transmitting multiple streams of data over a wide range of frequencies

With a macrotrend/backdrop of platformization and convergence, the industry is exploring places where identity security, endpoint security, and network security naturally meet.

The post Identity, Endpoint, and Network Security Walk into a Bar appeared first on Gigaom.

Vanilla Reload Swipe Load is a quick, safe and easy way to load cash on to your prepaid card.

CCFA Partners is an innovative network where patients and researchers work together. Become a part of groundbreaking research: www.ccfapartners.org.

Ask About the Curve Public Service Announcement

Reliance Jio's ambitious rollout of its True 5G network across India is not just about faster internet speeds or improved connectivity. One of the less talked about, yet significant benefits is the potential enhancement of smartphone battery life. During the company's

Ancient stone goods found across France may have been made by skilled craftspeople in what is now Paris, who traded along vast networks

training for marten's future barista job

SreenivasaRao Jagarlamudi illustrates how Kafka and secure proxies are vital to the future of IoT security, addressing key challenges like data throughput, real-time analytics, and compliance.

As Ariana Grande would say, god is a woman. So it should come as no surprise that Chief, the network designed to develop the leadership skills of women, has hit a $1.1 billion valuation in a matter of three years. The startup, led by founders Carolyn Childers and Lindsay Kaplan, just raised a $100 million […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Late last year, Twitter CEO Jack Dorsey stepped down from his position in order to give his full attention to his other company, Square (now called Block), which had become increasingly invested in blockchain technology and cryptocurrency — just like Dorsey himself. Now we’re starting to see the results of Block’s embrace of crypto, as […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Since it was founded in 2015, Cato Networks has evangelized the concept of a Secure Access Service Edge (SASE) platform that combines many of the features of software-defined networking, modern network security tools, and endpoint protection into a single service backed by a global private network. The promise here is that instead of managing dozens […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Luggage storage as a vector for piling into convenience-based revenue opportunities in the business of global travel continues to put a spring in San Francisco-based Bounce‘s step. The startup has just tucked $19 million in Series B funding into its suitcase, with a plan to keep rolling revenue that’s grown 20x since its $12M Series […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Streaming has become a staple in our daily lives, offering endless entertainment at our fingertips. However, buffering and lag can ruin the experience. Optimising your home network is crucial for seamless streaming. This guide explores advanced techniques to enhance your network's