The expanded relationship between the two long-time partners brings NTT DATA’s Managed Extended Detection Response Service onto the Palo Alto Networks XSIAM Cortex platform, to add additional AI capabilities to threat monitoring, detection and rapid response.

Celona reacts to the growing maturity of its channel by moving from a single-tier organization to a more diverse three tiered one, while complementing the channel announcement with new Aerloc security improvements for industrial IoT.

In this podcast, we speak to Brian Mayo of Dynamic Alliance who is well known in Technibble Forums as YeOldeStoneCat. We talked about on how to get started as a Managed Service Provider and how he gets client contracts with recurring revenue.

Source: How to Gain Managed Service Clients using Old School Networking with Brian Mayo - Technibble.com

Location: Electronic Resource- 

Location: Electronic Resource- 

Location: Engineering Library- TK5105.5.L667 2016

Location: Engineering Library- TK5103.2.D47 2016

Location: Engineering Library- TK5103.2.M49 2016

He tried to find a therapist who would take his insurance. He did not succeed.

analytica USA picks up on analytica's unique selling point by covering the entire spectrum of laboratories in industry and research, from laboratory planning to final equipment.

In this episode, Majid Almaadeed gives us a demonstration of Cisco Packet Tracer for Mac, a versatile network simulation and visualization tool designed for learning and practicing networking concepts. It provides a virtual environment where users can create, configure, and simulate network topologies and devices, enabling them to gain hands-on experience with networking technologies without the need for physical hardware.

Cisco Packet Tracer for Mac allows individuals to design and simulate complex network setups. It supports a wide range of Cisco devices, such as routers, switches, and wireless access points, enabling users to configure and interconnect them to create functional networks. You can explore various networking concepts, including routing, switching, wireless communications, and network security. It facilitates the simulation of network protocols and their behaviors, allowing users to understand how data flows through different network layers and devices.

In addition to its simulation capabilities, Cisco Packet Tracer for Mac offers a range of learning resources and activities, making it an ideal tool for educational institutions and self-paced learning. It allows users to test their network configurations, troubleshoot issues, and visualize the impact of changes before implementing them in real-world scenarios.

A Year 13 student from Birmingham Ormiston Academy (BOA) has secured a role with international news network, Russia Today.

Updated at 4 p.m. ET Months after approving some limited involvement by the Chinese technology giant Huawei in constructing the U.K.'s next-generation wireless data network, British regulators reversed course Tuesday. Beginning in January, U.K. regulators will implement a ban on telecom operators buying Huawei equipment. Existing Huawei 5G equipment will need to be removed from the U.K.'s 5G network by 2027. The decision comes after relations between the U.K. and China declined sharply over China's actions in Hong Kong, and in the face of a potential rebellion by parliamentarians from the U.K.'s ruling Conservative party who are concerned about the security implications of Chinese involvement in the 5G rollout. But it also follows sustained U.S. pressure on the U.K. and other European countries to exclude Huawei from 5G development. The U.S. says Huawei's equipment can be used for espionage by Beijing, and it has threatened to withhold intelligence from its allies that continued to use

EVE-NG PRO platform is ready for today’s IT-world requirements. It allows enterprises, e-learning providers/centers, individuals and group collaborators to create virtual proof of concepts, solutions and training environments. EVE-NG PRO is the first clientless multivendor network emulation software that empowers network and security professionals with huge opportunities in the networking world. Clientless management options will allow EVE-NG PRO to be as the best choice for Enterprise engineers without influence of corporate security policies as it can be run in a completely isolated environment.

The implications for some of Kaiser’s other hospital partnerships remain unclear.

The Government of Bermuda London Office invites Bermudian students and recent graduates in the UK to a networking dinner with Premier David Burt in Central London on Wednesday, November 20th. A Government spokesperson said, “The Government of Bermuda London Office invites Bermudian students and recent graduates’ resident in the United Kingdom to a networking dinner […]

Making use of Twitter I have spent hours on end gaining contacts for Twitter. You may become discouraged when you first get started trying to establish contacts/followers but persistence will pay for itself eventually. Like any good search engine optimization you must maintain a constant campaign to prove to be effective. Social media marketing is […]

The Personal Outcomes Network is made up of several organisations working towards the development and implementation of a personal outcomes approach. This site has been developed to bring together a range of resources to support the development and implementation of a personal outcomes approach in health and social care, as well as other human services.

Social networks are a great way to introduce people to the power of Sociology. In my Intro class, I make a point to show students the way their social networks shape the spread of divorce, how people ask for help, and the surprisingly tangled world of dating. Now there’s a new take on networks – […]

The U.S. Cybersecurity and Infrastructure Security Agency (CISA) on Thursday added a now-patched critical security flaw impacting Palo Alto Networks Expedition to its Known Exploited Vulnerabilities (KEV) catalog, citing evidence of active exploitation. The vulnerability, tracked as CVE-2024-5910 (CVSS score: 9.3), concerns a case of missing authentication in the Expedition migration tool that

Cybersecurity researchers have flagged a new ransomware family called Ymir that was deployed in an attack two days after systems were compromised by a stealer malware called RustyStealer. "Ymir ransomware introduces a unique combination of technical features and tactics that enhance its effectiveness," Russian cybersecurity vendor Kaspersky said. "Threat actors leveraged an unconventional blend

Twenty years ago the first edition of The Practice of System and Network Administration shipped! Since then there has been a 2nd and 3rd edition (2006 and 2014), plus a sequel book The Practice of Cloud System Administration, and many printings. (see the timeline here)

When we started the project we had no idea if it would be a success. There was a real chance it could be a flop. Many people told us that our proposal was illogical: How could you have a book about system administration that is vendor agnostic and talks about process and people instead of specific tools and operating systems? Well, to be honest, we took a deep breath and started writing anyway. It took 2+ years but in Sept/Oct 2001 the book finally shipped!

Instead of a flop, the reaction we got was very positive! It has sold tens of thousands of copies. Many universities have used the book and its future editions as text books. It received the Usenix LISA Outstanding Achievement Award. One DevOps pundit told me she considers it to be "the first devops book" which was quite humbling.

When I visited Google in 2004 (a year before I considered joining) I was told everyone in the "systems operations" team was given a copy on their first day. The person giving me a tour then took me to a supply closet with 30 copies awaiting to be distributed to new hires.

However the real satisfaction comes from how it has helped others. Fans have related many heartwarming stories. Many fans have told us they felt like reading the book was a turning point in their life, that the book "turned me into a professional system administrator".

To thank our readers, our publisher is offering a special deal: 45% off the latest editions now until Oct 31, 2021 What? You still have the 2nd edition and haven't seen the dozens of chapters of new material in the 3rd edition? Or maybe you haven't heard of our Cloud book? Now is your chance to get the 3rd edition or the cloud sequel!

• Use this link: https://informit.com/tposa
• Use this coupon code: TPOSA

Thank you to everyone that gave us feedback on the early drafts! Thank you to all our readers! This book changed our lives and we hope it changed yours too!

P.S. We would love to hear from you! Please post a comment with reflections on the book.

Juston Gordon-Montgomery's action-packed series with a lot of big ideas will debut this weekend on Adult Swim and Max.

Israel says its targets are legitimate, but critics say it is aiming at Hezbollah's social base.

It’s time to hang your winter jacket in the closet and change your wardrobe to warmer clothes, because “Spring Is Coming” to the Avangate Affiliate Network. Our spring contest will make your sales bloom and may even fulfill your Amazon wishlist. (Feel free to think “beyond the wall” with creative promotions!)

Three years ago, Chris Wallace walked away from Fox News over concerns that those at the “Fair and Balanced” network were beginning to, as he put it, “question the truth.” […]

The post CNN Host Reportedly Leaving Network After Short-Lived Stay: His Career Change Is Completely Absurd appeared first on The Western Journal.

Labour Party Conference – International affairs networking brunch 24 September 2024 — 11:00AM TO 12:00PM Anonymous (not verified) 16 September 2024 Labour – Grace 1 Suite, Hilton Hotel, Liverpool

Hosted by Sir Simon Fraser, Chairman of Chatham House.

This event is taking place at the Hilton Hotel, Grace 1 Suite, Liverpool.

You are warmly invited to join us for an exclusive networking brunch at the 2024 Labour Party Conference.

Sir Simon Fraser, Chairman of Chatham House, and Olivia O’Sullivan, Director of Chatham House’s UK in the World Programme, will deliver opening remarks, followed by an interactive networking session where you will have the chance to engage with a wide range of stakeholders. Join us to connect with key senior parliamentary, corporate and media attendees at the Labour Party Conference.

This event will be taking place outside of the secure zone.

Network Power in the Asia-Pacific: Making Sense of the New Regionalism and Opportunities for Cooperation 7 February 2020 — 9:45AM TO 5:30PM Anonymous (not verified) 17 January 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

The Asia-Pacific region continues to increase in geopolitical and geoeconomic importance. The rise of China and tensions with the US are affecting bilateral relationships and traditional alliances in the region. Whether seen from the perspective of the Quad – Australia, India, Japan and the US – or the Indo-Pacific concept embraced by a wide range of countries but with no shared consensus on scope and objectives or with ASEAN who insists on the importance of its own centrality, the region is redefining and reconceptualising itself.

With a diverse range of initiatives – including the Regional Comprehensive Economic Partnership (RCEP) and Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) – there are a plethora of regional agreements and institutional groupings that add further complexity.

As the Bretton Woods architecture continues to be dominated by Western powers, China is also spearheading parallel governance initiatives such as the Asian Infrastructure Investment Bank (AIIB), the Belt and Road Initiative and the Shanghai Cooperation Organization (SCO) as a means of enhancing its geopolitical and geoeconomic influence.

This one-day conference will focus on how such networks and alliances have been built, and sustained, in the Asia-Pacific region. In order to understand how new regional initiatives might open up opportunities for new forms of international cooperation, the conference will focus on the themes of cyber-technology and innovation, sustainable development and mitigating the impacts of climate change and new infrastructure initiatives. It will assess whether there is a zero-sum conflict between competing networks and agendas or whether a common approach can be developed.

Yi Zhang
Sep 1, 2005; 4:1240-1250
Research

T. De Ryck and S. Mishra
Math. Comp. 93 (), 2643-2677.
Abstract, references and article information

Sylwia Struk
Dec 28, 2020; 0:RA119.001766v1-mcp.RA119.001766
Research

R. Greg Stacey
Nov 4, 2020; 0:RA120.002275v1-mcp.RA120.002275
Research

Montgomery Blencowe
Dec 23, 2020; 0:jlr.RA120000713v1-jlr.RA120000713
Research Articles

Genome-wide association studies (GWAS) have implicated ~380 genetic loci for plasma lipid regulation. However, these loci only explain 17-27% of the trait variance and a comprehensive understanding of the molecular mechanisms has not been achieved. In this study, we utilized an integrative genomics approach leveraging diverse genomic data from human populations to investigate whether genetic variants associated with various plasma lipid traits, namely total cholesterol (TC), high and low density lipoprotein cholesterol (HDL and LDL), and triglycerides (TG), from GWAS were concentrated on specific parts of tissue-specific gene regulatory networks. In addition to the expected lipid metabolism pathways, gene subnetworks involved in ‘interferon signaling’, ‘autoimmune/immune activation’, ‘visual transduction’, and ‘protein catabolism’ were significantly associated with all lipid traits. Additionally, we detected trait-specific subnetworks, including cadherin-associated subnetworks for LDL, glutathione metabolism for HDL, valine, leucine and isoleucine biosynthesis for TC, and insulin signaling and complement pathways for TG. Finally, utilizing gene-gene relations revealed by tissue-specific gene regulatory networks, we detected both known (e.g. APOH, APOA4, and ABCA1) and novel (e.g. F2 in adipose tissue) key regulator genes in these lipid-associated subnetworks. Knockdown of the F2 gene (Coagulation Factor II, Thrombin) in 3T3-L1 and C3H10T1/2 adipocytes reduced gene expression of Abcb11, Apoa5, Apof, Fabp1, Lipc, and Cd36, reduced intracellular adipocyte lipid content, and increased extracellular lipid content, supporting a link between adipose thrombin and lipid regulation. Our results shed light on the complex mechanisms underlying lipid metabolism and highlight potential novel targets for lipid regulation and lipid-associated diseases.

During Drosophila oogenesis, the localization and translational regulation of maternal transcripts relies on RNA-binding proteins (RBPs). Many of these RBPs localize several mRNAs and may have additional direct interaction partners to regulate their functions. Using immunoprecipitation from whole Drosophila ovaries coupled to mass spectrometry, we examined protein-protein associations of 6 GFP-tagged RBPs expressed at physiological levels. Analysis of the interaction network and further validation in human cells allowed us to identify 26 previously unknown associations, besides recovering several well characterized interactions. We identified interactions between RBPs and several splicing factors, providing links between nuclear and cytoplasmic events of mRNA regulation. Additionally, components of the translational and RNA decay machineries were selectively co-purified with some baits, suggesting a mechanism for how RBPs may regulate maternal transcripts. Given the evolutionary conservation of the studied RBPs, the interaction network presented here provides the foundation for future functional and structural studies of mRNA localization across metazoans.

Despite the continued analysis of HDAC inhibitors in clinical trials, the heterogeneous nature of the protein complexes they target limits our understanding of the beneficial and off-target effects associated with their application. Among the many HDAC protein complexes found within the cell, Sin3 complexes are conserved from yeast to humans and likely play important roles as regulators of transcriptional activity. The presence of two Sin3 paralogs in humans, SIN3A and SIN3B, may result in a heterogeneous population of Sin3 complexes and contributes to our poor understanding of the functional attributes of these complexes. Here, we profile the interaction networks of SIN3A and SIN3B to gain insight into complex composition and organization. In accordance with existing data, we show that Sin3 paralog identity influences complex composition. Additionally, chemical cross-linking MS identifies domains that mediate interactions between Sin3 proteins and binding partners. The characterization of rare SIN3B proteoforms provides additional evidence for the existence of conserved and divergent elements within human Sin3 proteins. Together, these findings shed light on both the shared and divergent properties of human Sin3 proteins and highlight the heterogeneous nature of the complexes they organize.

The Discoidin, CUB, and LCCL domain-containing protein (DCBLD) family consists of two type-I transmembrane scaffolding receptors, DCBLD1 and DCBLD2, which play important roles in development and cancer. The nonreceptor tyrosine kinases FYN and ABL are known to drive phosphorylation of tyrosine residues in YXXP motifs within the intracellular domains of DCBLD family members, which leads to the recruitment of the Src homology 2 (SH2) domain of the adaptors CT10 regulator of kinase (CRK) and CRK-like (CRKL). We previously characterized the FYN- and ABL-driven phosphorylation of DCBLD family YXXP motifs. However, we have identified additional FYN- and ABL-dependent phosphorylation sites on DCBLD1 and DCBLD2. This suggests that beyond CRK and CRKL, additional DCBLD interactors may be regulated by FYN and ABL activity. Here, we report a quantitative proteomics approach in which we map the FYN- and ABL-regulated interactomes of DCBLD family members. We found FYN and ABL regulated the binding of several signaling molecules to DCBLD1 and DCBLD2, including members of the 14-3-3 family of adaptors. Biochemical investigation of the DCBLD2/14-3-3 interaction revealed ABL-induced binding of 14-3-3 family members directly to DCBLD2.

The EGFR tyrosine kinase inhibitor gefitinib is commonly used for lung cancer patients. However, some patients eventually become resistant to gefitinib and develop progressive disease. Here, we indicate that ecto-ATP synthase, which ectopically translocated from mitochondrial inner membrane to plasma membrane, is considered as a potential therapeutic target for drug-resistant cells. Quantitative multi-omics profiling reveals that ecto-ATP synthase inhibitor mediates CK2-dependent phosphorylation of DNA topoisomerase IIα (topo IIα) at serine 1106 and subsequently increases the expression of long noncoding RNA, GAS5. Additionally, we also determine that downstream of GAS5, p53 pathway, is activated by ecto-ATP synthase inhibitor for regulation of programed cell death. Interestingly, GAS5-proteins interactomic profiling elucidates that GAS5 associates with topo IIα and subsequently enhancing the phosphorylation level of topo IIα. Taken together, our findings suggest that ecto-ATP synthase blockade is an effective therapeutic strategy via regulation of CK2/phospho-topo IIα/GAS5 network in gefitinib-resistant lung cancer cells.

none

Biological functions emerge from complex and dynamic networks of protein-protein interactions. Because these protein-protein interaction networks, or interactomes, represent pairwise connections within a hierarchically organized system, it is often useful to identify higher-order associations embedded within them, such as multi-member protein complexes. Graph-based clustering techniques are widely used to accomplish this goal, and dozens of field-specific and general clustering algorithms exist. However, interactomes can be prone to errors, especially when inferred from high-throughput biochemical assays. Therefore, robustness to network-level noise is an important criterion for any clustering algorithm that aims to generate robust, reproducible clusters. Here, we tested the robustness of a range of graph-based clustering algorithms in the presence of noise, including algorithms common across domains and those specific to protein networks. Strikingly, we found that all of the clustering algorithms tested here markedly amplified noise within the underlying protein interaction network. Randomly rewiring only 1% of network edges yielded more than a 50% change in clustering results, indicating that clustering markedly amplified network-level noise. Moreover, we found the impact of network noise on individual clusters was not uniform: some clusters were consistently robust to injected noise while others were not. To assist in assessing this, we developed the clust.perturb R package and Shiny web application to measure the reproducibility of clusters by randomly perturbing the network. We show that clust.perturb results are predictive of real-world cluster stability: poorly reproducible clusters as identified by clust.perturb are significantly less likely to be reclustered across experiments. We conclude that graph-based clustering amplifies noise in protein interaction networks, but quantifying the robustness of a cluster to network noise can separate stable protein complexes from spurious associations.

The F-box protein MORE AXILLARY GROWTH 2 (MAX2) is a central component in the signaling cascade of strigolactones (SLs) as well as of the smoke derived karrikins (KARs) and the so far unknown endogenous KAI2 ligand (KL). The two groups of molecules are involved in overlapping and unique developmental processes, and signal-specific outcomes are attributed to perception by the paralogous α/β-hydrolases DWARF14 (D14) for SL and KARRIKIN INSENSITIVE 2/ HYPOSENSITIVE TO LIGHT (KAI2/HTL) for KAR/KL. Additionally, depending on which receptor is activated, specific members of the SUPPRESSOR OF MAX2 1 (SMAX1) – LIKE (SMXL) family control KAR/KL and SL responses. As proteins that function in the same signal transduction pathway often occur in large protein complexes, we aimed at discovering new players of the MAX2, D14 and KAI2 protein network by tandem affinity purification using Arabidopsis cell cultures. When using MAX2 as a bait, various proteins were co-purified among which general components of the Skp1-Cullin-F-box complex and members of the CONSTITUTIVE PHOTOMORPHOGENIC 9 signalosome. Here, we report the identification of a novel interactor of MAX2, a type 5 serine/threonine protein phosphatase, designated PHYTOCHROME-ASSOCIATED PROTEIN PHOSPHATASE 5 (PAPP5). Quantitative affinity purification pointed at PAPP5 as being more present in KAI2 rather than D14 protein complexes. In agreement, mutant analysis suggests that PAPP5 modulates KAR/KL-dependent seed germination in suboptimal conditions and seedling development. Additionally, a phosphopeptide enrichment experiment revealed that PAPP5 might dephosphorylate MAX2 in vivo independently of the synthetic strigolactone analog, rac-GR24. Together, by analyzing the protein complexes to which MAX2, D14 and KAI2 belong, we revealed a new MAX2 interactor, PAPP5, that might act through dephosphorylation of MAX2 to control mainly KAR/KL- related phenotypes and, hence, provide another link with the light pathway.

MLB Network's countdown of baseball's best players at each position came to a conclusion with the final installment of the "Top 10 Right Now!" series, featuring the game's top relief pitchers and shortstops.

CAMBRIDGE, England, Oct. 15, 2024 — Nu Quantum has announced a proof-of-principle prototype that advances the development of modular, distributed quantum computers by enabling connections across different qubit modalities and […]

The post Nu Quantum Unveils Qubit-Photon Interface to Enable Distributed Quantum Computing Networks appeared first on HPCwire.

Oct. 24, 2024 — The San Diego Supercomputer Center (SDSC), part of the School of Computing, Information and Data Sciences at UC San Diego, has been leading the Open Storage Network (OSN) program for years, and along […]

The post SDSC Leads Expansion of Open Storage Network to More Campus Computing Sites appeared first on HPCwire.

SANTA CLARA, Calif., Aug. 13, 2024 — Pure Storage today announced that it joined Ultra Ethernet Consortium (UEC), a Linux Foundation initiative dedicated to building a complete, open, and accessible Ethernet-based […]

The post Pure Storage Embraces Next-Gen Networking for AI with Ultra Ethernet Consortium Membership appeared first on HPCwire.

Aug. 19, 2024 — SURF’s innovation department recently collaborated with Cornelis Networks to advance networking capabilities for high-performance computing (HPC) clusters. The collaboration marks a new step forward for SURF […]

The post Cornelis Networks Partners with SURF to Enhance HPC Cluster Networking Capabilities appeared first on HPCwire.