An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.

Methods and compositions are described for categorizing and treating autoimmune disease, using single cell network profiling (SCNP), where activation levels of one or more activatable elements are determined in single cells, with or without modulation, to categorize or determine treatment for the autoimmune disease.

This invention publicizes a chronic renal disease diagnostic kit, comprised of FGF23 monoclonal antibody, biotin labeling reagent Sulfo-NHS-LC-Biotin, PBS buffer solution (pH7.0, 0.1M), casein saline solution, streptomycin avidin and substrate TMB. The labeling condition is the weight ratio of FGF23 antibody and Sulfo-NHS-LC-Biotin, which is 1:5-1:12. The dilution ratio of streptomycin avidin is 1:3000. The lowest testing threshold limit value of FGF23 kit is 10 pg/ml, whose sensitivity is 10 times higher than that of common monoclonal antibody, which is very significant for early diagnose of chronic renal disease.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

The couple, who were married for 23 years, are among the hundreds of people in Washington state who have died after testing positive for coronavirus.

Petra Karr, who with her husband, Chris, founded what became the theater company ACT 1, died on April 7.

Editor’s note: The impact of the coronavirus pandemic is generally expressed in numbers of cases and deaths. But each data point represents a human life whose loss is felt by countless other people. We are chronicling some of them in an obituary series called Lives Remembered. If you know someone who has died of COVID-19, […]

The couple, who were married for 23 years, are among the hundreds of people in Washington state who have died after testing positive for coronavirus.

Editor’s note: The impact of the coronavirus pandemic is generally expressed in numbers of cases and deaths. But each data point represents a human life whose loss is felt by countless other people. We are chronicling some of them in an obituary series called Lives Remembered. If you know someone who has died of COVID-19, […]

The couple, who were married for 23 years, are among the hundreds of people in Washington state who have died after testing positive for coronavirus.

Steve Shulman, longtime grocer and community figure at Leschi Market along Lake Washington in Seattle, died Wednesday night from the effects of COVID-19, his family says. “We all mourn the passing of this generous man who has been a pillar of the Leschi community and beyond for many years,” his nephew Yousef Shulman, co-owner of […]

Immigration Minister David Coleman overturns a department ruling based on Rajasegaran Manikam's kidney disease diagnosis that would have seen the Manikam family deported to Singapore.

Research continues to point to blue-green algae toxins as a trigger for neurological diseases, with motor neurone disease under increased investigation.

As the global death toll from coronavirus continues to climb, a sizeable minority remains intent on downplaying the seriousness of the threat — with potentially dangerous consequences.

The Templeton family, fourth-generation farmers who almost lost everything to a pest called pythium, turn to extreme cleaning — with the help of a $250,000 washing machine from Italy — and are recognised for their efforts.

Forty experts from the Asia-Pacific will train animal workers to spot virus outbreaks before they even begin, in a new government-funded scheme to reduce the risk of another virus crisis.

One of three peregrine falcon chicks that hatched, in front of thousands of online fans, has died in a nest perched high on a Melbourne skyscraper, marking the third year in a row the nest has suffered such a loss.

Do you suffer from an indescribable feeling of vertigo, constant dizziness and motion sickness? Chances are you could have Mal de Debarquement Syndrome.

The Health Department confirms a massive spike in the number of influenza cases in Western Australia this year, with 3,000 extra notifications and 14 deaths in the past week alone.

Residents against a controversial abattoir take their fight to the Victorian Civil and Administrative Tribunal in a final attempt to stop the plan going ahead.

Port Macquarie resident Kim Dahler was diagnosed with Parkinson's disease in her 40s and wants others to know life can still be fulfilling.

Following the recent Hendra virus outbreak, an equine vet is encouraging horse owners to vaccinate their animals against the deadly bat-borne disease.

Australian woolgrowers are set to benefit from the suspension of wool exports from South Africa to China due to an outbreak of foot-and-mouth disease.

A disease is wreaking havoc on Australian beehives, and one PhD student and beekeeper is trying to find out why.

An autoimmune disease that has robbed textile artist Annemieke Mein of her sense of touch will not stop the ecologist, collector, researcher, and activist.

The land of the Alyawarr people in Central Australia has become the unlikely ground zero in the global fight against a crippling medical condition with wicked genetic links.

The deadly march of pig-killing African swine fever is continuing, with one quarter of the world's pigs now dead, according to meat and livestock analysts.

Pregnant Aboriginal women in the Northern Territory are three times less likely to go to a clinic for their first antenatal visit, and the consequences can be devastating. But these healthcare workers are making a difference.

African swine fever is believed to have first emerged early last century, but due to a lack of commercial interest no vaccine was developed. Now the world is racing to find a way to stop the spread of the disease.

Australias largest barramundi farm is calling for a halt in whole-fish imports from Asia not because around 60 per cent is imported, but for biosecurity reasons.

Di White says her son Anthony, 36, needed a ventilator to breathe after his diagnosis and "really didn't have a life" in the 16 months before he died in the bathroom at the local tavern.

A 19-year-old university student from the New South Wales Central Coast dies from meningococcal disease, the region's second death from the illness in as many months, prompting authorities to issue a warning.

A disease that could potentially wipe out Australia's multi-billion-dollar livestock industry has been detected at Australian airports.

AFL great Neale Daniher is named the 2019 Victorian of the Year in recognition of his advocacy to find a cure for the fatal motor neurone disease he was diagnosed with six years ago.

Communication Toolkit for Transportation Partners to Inform Road Travelers , released by the U.S. Centers for Disease Control and Prevention

The risk of disease transmission at airports and on aircraft is similar to the risks associated with other densely populated places. There are also unique factors related to the interaction of individuals from geographically diverse regions with differing immunity and endemic diseases. The TRB Airport Cooperative Research Program's ACRP Report 91: Infectious Disease Mitigation in Airports and on Aircraft offers guidance for mitigating the risk of disease spread via droplet, airborne, and contact at airpo...

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy.

The IBM Research findings achieve the highest recorded accuracy of 86 percent by using deep learning and pathology insights to identify the severity of diabetic retinopathy.

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

The beloved 49-year-old priest, born in Mexico City, passed away Friday evening at the Wyckoff Medical Center in Brooklyn, the diocese said. Father Jorge, as he was known to worshippers, served as the diocesan coordinator of the ministry for Mexican-Americans among his other duties.

Mathematical modeling and AI can pick out patterns preceding epidemics that human brains can’t readily discern.

Collecting and analyzing real-time data on the number of cases and deaths during a disease outbreak is crucial. Here's why we've failed.

Research has been paused on everything but COVID-19, which could have serious consequences on cures for other diseases for generations to come.

When we arrived in China to pick up our adopted daughter, we found out she had chickenpox. The days of waiting were the most anxious of our lives.

Epidemiologists and government officials agree that large-scale concerts and festivals can't be safely held until 2021, a crushing blow.