Chicago — Coal miners in Kentucky, Virginia and West Virginia may be more than eight times more likely than the general public to die from black lung disease and chronic obstructive pulmonary disease.

Atlanta – Among workers younger than 55, employees in service and blue-collar jobs are more likely to report a history of coronary heart disease or stroke, according to a report from the Centers for Disease Control and Prevention.

Research Triangle Park, NC – Outbreaks of viruses such as Ebola and Zika have prompted the National Institute of Environmental Health Sciences – together with the Centers for Disease Control and Prevention, OSHA, and the Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response – to launch an infectious disease safety training program for first responders and hazardous waste workers.

Washington — A new Government Accountability Office report recommends OSHA look at “available actions” – including developing a standard on infectious disease – to help protect workers in the meat and poultry processing industries.

Secaucus, NJ — Lyme disease is becoming more common outside the Northeast and more prevalent in the United States overall, a recent study by lab services provider Quest Diagnostics shows.

Adelaide, Australia — Open toilet lids, defective plumbing drains and uncovered trash cans may increase the risk of bacterial and viral disease transmission in public restrooms, according to a recent research review.

One serious risk of outdoor work is Lyme disease, which is spread when individuals are bitten by infected ticks. Initial symptoms of the disease include fever, headache, fatigue and skin rash.

Occupational skin diseases are the second-most common type of occupational disease. NIOSH estimates that more than 13 million U.S. workers are potentially exposed to chemicals that can be absorbed through their skin.

Washington — OSHA’s proposed rule on infectious diseases in “health care and other high-risk environments” has been submitted to the White House Office of Information and Regulatory Affairs for final review.

The use of flavored e-liquids in vaping devices may lead to the formation of nearly 300 different harmful substances, results of a recent study out of Ireland suggest.

Nanjing, China — A recent study highlighting the expected ties between exposure to cancer-causing per- and polyfluoroalkyl substances, or PFAS, and a risk factor for heart disease could impact workers.

The post Potential Schizophrenia Medications Point to New Disease Model was curated by information for practice.

The post Notice of Special Interest (NOSI): Analysis of Existing Linked Datasets to Understand the Relationship between Housing Program Participation and Risk for Chronic Diseases and Other Conditions (R01-Clinical Trial Not Allowed) [First Available Due Date: Oct 07] was curated by information for practice.

The post Notice of Special Interest (NOSI): Analysis of Existing Linked Datasets to Understand the Relationship between Housing Program Participation and Risk for Chronic Diseases and Other Conditions (R01-Clinical Trial Not Allowed) was curated by information for practice.

University of Coimbra Failure by immune cells worsens Alzheimer's disease, reveals study by the University of Coimbra A team from the Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC) in Portugal discovered how some cells of the immune system lose the ability to fight Alzheimer's disease. This new knowledge can help to find a definitive diagnosis. Ana Luísa Cardoso, the coordinator of the research group, explains that "We found that monocytes (the innate immune system cells) of Alzheimer's patients are unable to move when stimulated by substances produced in the brain, which may lead to reduction of cells that can be recruited to the nervous tissue and participate in fighting the disease."

University of Wisconsin-Madison researchers targeting a group of hereditary neurodegenerative diseases have found success using a gene therapy treatment in an animal model. The approach, which uses CRISPR-Cas9 genome editing technology, offers a unique and promising strategy that could one day treat rare but debilitating motor neuron diseases in humans.

The Korea Research Institute of Standards and Science (KRISS) announced that they have developed an advanced disease diagnosis and treatment system based on nanomaterials.

The Korea Research Institute of Standards and Science (KRISS) announced that they have developed an advanced disease diagnosis and treatment system based on nanomaterials.

[Science] :
The Animal and Plant Quarantine Agency says it has developed, for the first time in the world, a differential diagnosis technology for lumpy skin disease(LSD), a viral disease that affects cattle. With the technology, jointly developed with Median Diagnostics, it can be determined within eight hours if a ...

[more...]

Patrick Doherty volunteered for a new medical intervention of gene-editor infusions for the treatment of genetically-based diseases.; Credit: /Patrick Doherty

Patrick Doherty had always been very active. He trekked the Himalayas and hiked trails in Spain.

But about a year and a half ago, he noticed pins and needles in his fingers and toes. His feet got cold. And then he started getting out of breath any time he walked his dog up the hills of County Donegal in Ireland where he lives.

"I noticed on some of the larger hill climbs I was getting a bit breathless," says Doherty, 65. "So I realized something was wrong."

Doherty found out he had a rare, but devastating inherited disease — known as transthyretin amyloidosis — that had killed his father. A misshapen protein was building up in his body, destroying important tissues, such as nerves in his hands and feet and his heart.

Doherty had watched others get crippled and die difficult deaths from amyloidosis.

"It's terrible prognosis," Doherty says. "This is a condition that deteriorates very rapidly. It's just dreadful."

So Doherty was thrilled when he found out that doctors were testing a new way to try to treat amyloidosis. The approach used a revolutionary gene-editing technique called CRISPR, which allows scientists to make very precise changes in DNA.

"I thought: Fantastic. I jumped at the opportunity," Doherty says.

On Saturday, researchers reported the first data indicating that the experimental treatment worked, causing levels of the destructive protein to plummet in Doherty's body and the bodies of five other patients treated with the approach.

"I feel fantastic," Doherty says. "It's just phenomenal."

The advance is being hailed not just for amyloidosis patients but also as a proof-of-concept that CRISPR could be used to treat many other, much more common diseases. It's a new way of using the innovative technology.

"This is a major milestone for patients," says Jennifer Doudna of the University of California, Berkeley, who shared a Nobel Prize for her work helping develop CRISPR.

"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," Doudna says.

CRISPR has already been shown to help patients suffering from the devastating blood disorders sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer and to restore vision to people blinded by a rare genetic disorder.

But those experiments involve taking cells out of the body, editing them in the lab, and infusing them back in or injecting CRISPR directly into cells that need fixing.

The study Doherty volunteered for is the first in which doctors are simply infusing the gene-editor directly into patients and letting it find its own way to the right gene in the right cells. In this case, it's cells in the liver making the destructive protein.

"This is the first example in which CRISPR-Cas9 is injected directly into the bloodstream — in other words systemic administration — where we use it as a way to reach a tissue that's far away from the site of injection and very specifically use it to edit disease-causing genes," says John Leonard, the CEO of Intellia Therapeutics, which is sponsoring the study.

Doctors infused billions of microscopic structures known as nanoparticles carrying genetic instructions for the CRISPR gene-editor into four patients in London and two in New Zealand. The nanoparticles were absorbed by their livers, where they unleashed armies of CRISPR gene-editors. The CRISPR editor honed in on the target gene in the liver and sliced it, disabling production of the destructive protein.

Within weeks, the levels of protein causing the disease plummeted. Researchers reported at the Peripheral Nerve Society Annual Meeting and in a paper published in The New England Journal of Medicine.

"It really is exciting," says Dr. Julian Gillmore, who is leading the study at the University College London, Royal Free Hospital.

"This has the potential to completely revolutionize the outcome for these patients who have lived with this disease in their family for many generations. It's decimated some families that I've been looking after. So this is amazing," Gillmore says.

The patients will have to be followed longer, and more patients will have to be treated, to make sure the treatment's safe, and determine how much it's helping, Gillmore stresses. But the approach could help those struck by amyloidosis that isn't inherited, which is a far more common version of the disease, he says.

Moreover, the promising results potentially open the door for using the same approach to treatment of many other, more common diseases for which taking cells out of the body or directly injecting CRISPR isn't realistic, including heart disease, muscular dystrophy and brain diseases such as Alzheimer's.

"This is really opening a new era as we think about gene-editing where we can begin to think about accessing all kinds of different tissue in the body via systemic administration," Leonard says.

Other scientists who are not involved in the research agree.

"This is a wonderful day for the future of gene-editing as a medicine,"
agree Fyodor Urnov, a professor of genetics at the University of California, Berkeley. "We as a species are watching this remarkable new show called: our gene-edited future."

Doherty says he started feeling better within weeks of the treatment and has continued to improve in the weeks since then.

"I definitely feel better," he told NPR. "I'm speaking to you from upstairs in our house. I climbed stairs to get up here. I would have been feeling breathless. I'm thrilled."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Evidence exists linking three cancers and two other health problems with chemicals used in herbicides in the Vietnam War, a committee of the Institute of Medicine (IOM) has concluded.

A bold national initiative is needed to reduce the enormous health burden of sexually transmitted diseases (STDs) in the United States, according to a new report from a committee of the Institute of Medicine.

Insufficient evidence exists to support claims that taking megadoses of dietary antioxidants, such as selenium and vitamins C and E, or carotenoids, including beta-carotene, can prevent chronic diseases, says the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine of the National Academies.

To meet the bodys daily energy and nutritional needs while minimizing risk for chronic disease, adults should get 45 percent to 65 percent of their calories from carbohydrates, 20 percent to 35 percent from fat, and 10 percent to 35 percent from protein.

The vast majority of healthy people adequately meet their daily hydration needs by letting thirst be their guide, says the newest report on nutrient recommendations from the Institute of Medicine of the National Academies.

A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinsons disease for Vietnam veterans.

A new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of disease and ultimately enhance diagnosis and treatment, says a new report from the National Research Council.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome -- commonly referred to as ME/CFS -- is a legitimate, serious, and complex systemic disease that frequently and dramatically limits the activities of affected individuals, says a new report from the Institute of Medicine.

Joint statements from the national science academies of the G7 nations were delivered today to the Italian government in advance of the G7 Summit to be held in Taormina, Italy, at the end of May.

A new report from the National Academies of Sciences, Engineering, and Medicine outlines how to examine whether specific levels of nutrients or other food substances (NOFSs) can ameliorate the risk of chronic disease and recommends ways to develop dietary reference intakes (DRI) based on chronic disease outcomes.

A single breakthrough discovery for managing citrus greening in Florida in the future is unlikely, says a new report by the National Academies of Sciences, Engineering, and Medicine.

Black lung disease cases in coal miners have been increasing since 2000 for uncertain reasons.

The U.S. needs stronger policies and guidance to combat Legionnaires’ disease, a form of pneumonia caused by inhaling air contaminated with Legionella bacteria from water systems, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases — including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections — but workforce shortages, stigma, and financial and policy barriers are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine.

WASHINGTON — In response to the COVID-19 outbreak, the White House Office of Science and Technology Policy has asked the National Academies of Sciences, Engineering, and Medicine to establish a Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats.

Formed earlier this month, the National Academies’ Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats was assembled at the request of the White House Office of Science and Technology Policy and the Office of the Assistant Secretary for Preparedness and Response in response to the COVID-19 outbreak.

The recently formed National Academies Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats, assembled at the request of the White House Office of Science and Technology Policy and the U.S. Department of Health and Human Services’ Office of the Assistant Secretary for Preparedness and Response in response to the COVID-19 outbreak, has been providing rapid expert consultations on several topics, such as social distancing and severe illness in young adults.

The recently formed National Academies Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats, assembled at the request of the White House Office of Science and Technology Policy (OSTP) and the U.S. Department of Health and Human Services’ Office of the Assistant Secretary for Preparedness and Response in response to the COVID-19 outbreak, has been providing rapid expert consultations on several topics, such as social distancing and severe illness in young adults.

A new rapid expert consultation from a standing committee of the National Academies of Sciences, Engineering, and Medicine responds to questions from the White House Office of Science and Technology Policy (OSTP) regarding survival of the COVID-19 virus in relation to temperature and humidity and potential for seasonal reduction and resurgence of cases.

A new rapid expert consultation from a standing committee of the National Academies of Sciences, Engineering, and Medicine.

A new rapid expert consultation from a standing committee of the National Academies of Sciences, Engineering, and Medicine responds to questions from the White House Office of Science and Technology Policy (OSTP) regarding the effectiveness of homemade fabric masks to protect others from the viral spread of COVID-19 from potentially contagious asymptomatic or presymptomatic individuals.

Over the next five years, the U.S. Department of Defense’s Biological Threat Reduction Program (BTRP) should encourage and be among co-leaders in the federal government’s development of an enduring interagency mechanism to address an array of biological threats – including natural disease outbreaks, accidental releases, and intentional attacks -- to deployed U.S. forces and to the nation itself, says a new report from the National Academies of Sciences, Engineering, and Medicine

Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably without introducing undesired changes — a criterion that has not yet been met by any genome editing technology, says a new report by an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.’s Royal Society.

A new report from the National Academies of Sciences, Engineering, and Medicine provides a blueprint and eight overarching strategies for improving health care for the approximately 100,000 people in the United States living with sickle cell disease (SCD).

Disease surveillance, testing, and contact tracing are among the best public health tools available to protect ourselves and our communities during the COVID-19 pandemic, said panelists during a recent COVID-19 Conversations webinar, hosted by the National Academy of Medicine and American Public Health Association.

To enhance and coordinate its research on autoimmune diseases, the National Institutes of Health should create an Office of Autoimmune Disease/Autoimmunity Research and a plan that spans all institutes and centers to provide an overall NIH strategy for autoimmune disease research.

The CDC’s Division of Global Migration and Quarantine should create an effective and innovative quarantine station model to confront new challenges in preventing the spread of infectious diseases in the U.S., and requires new investment and regulatory reforms to do so.

Among the many parts of the U.S. public health system strained by the COVID-19 pandemic were the Centers for Disease Control and Prevention’s Division of Global Migration and Quarantine and its network of quarantine stations. A recent report explored how to improve these stations based on lessons learned during the pandemic.

Throughout the COVID-19 pandemic, wastewater surveillance has provided advance indications of community-level outbreaks, sometimes weeks before other indicators. A new report says that wastewater surveillance is worthy of investment and outlines a vision for the future of a national system.