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Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases




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The effect of COVID-19 and disease suppression policies on labor markets: A preliminary analysis of the data

World leaders are deliberating when and how to re-open business operations amidst considerable uncertainty as to the economic consequences of the coronavirus. One pressing question is whether or not countries that have remained relatively open have managed to escape at least some of the economic harm, and whether that harm is related to the spread…

       




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Coupled Contagion Dynamics of Fear and Disease: Mathematical and Computational Explorations

Published version of the CSED October 2007 Working Paper

ABSTRACT

Background

In classical mathematical epidemiology, individuals do not adapt their contact behavior during epidemics. They do not endogenously engage, for example, in social distancing based on fear. Yet, adaptive behavior is well-documented in true epidemics. We explore the effect of including such behavior in models of epidemic dynamics.

Methodology/Principal Findings

Using both nonlinear dynamical systems and agent-based computation, we model two interacting contagion processes: one of disease and one of fear of the disease. Individuals can “contract” fear through contact with individuals who are infected with the disease (the sick), infected with fear only (the scared), and infected with both fear and disease (the sick and scared). Scared individuals–whether sick or not–may remove themselves from circulation with some probability, which affects the contact dynamic, and thus the disease epidemic proper. If we allow individuals to recover from fear and return to circulation, the coupled dynamics become quite rich, and can include multiple waves of infection. We also study flight as a behavioral response.

Conclusions/Significance

In a spatially extended setting, even relatively small levels of fear-inspired flight can have a dramatic impact on spatio-temporal epidemic dynamics. Self-isolation and spatial flight are only two of many possible actions that fear-infected individuals may take. Our main point is that behavioral adaptation of some sort must be considered.”

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Publication: PLoS One Journal
      
 
 




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On MNN: Water heaters and Legionnaires' Disease

And more blaming the millennials, robots and boomers and kitchens are exhuasting.




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How modern, minimalist design (and washing your hands) can fight disease

The modern movement started as a way of dealing with tuberculosis. The same rules apply today.




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Detecting Plant Diseases? There's an App for that

The Gene-Z app works with Apple and Android and can detect plant diseases in 10-30 minutes.




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Link Between BPA and Heart Disease Seen in Urine, New Study Reports

A new study finds those with heart disease had higher concentrations of BPA in their urine.




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Smartphones can now detect diseases in minutes

A new plug-in diagnostic tool could mean better healthcare around the world.




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Scientists Estimate Up to 6.7 Million Bats Dead From Disease

White nose syndrome has decimated bat populations on the East Coast. Now scientists believe the disease, which is spreading, may have been worse than previously imagined.




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National Sports Commentator, Dr. Jerry Punch, Together with Men's Health Network and Endo Pharmaceuticals, Encourages Men with Peyronie's Disease to Ask About the Curve - Ask About the Curve Public Service Announcement

Ask About the Curve Public Service Announcement




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International Survey Released for World Meningitis Day Shows Parents Feel They Don't Know Enough About the Disease and its Consequences - Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador

Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador





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One of the Top Infectious Diseases Among Children in the U.S. is Preventable - Help Kids Defeat the Mouth Monsters

Help Kids Defeat the Mouth Monsters




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National Sports Commentator, Dr. Jerry Punch, Together with Men's Health Network and Endo Pharmaceuticals, Encourages Men with Peyronie's Disease to Ask About the Curve - Ask About the Curve Public Service Announcement

Ask About the Curve Public Service Announcement




disease

International Survey Released for World Meningitis Day Shows Parents Feel They Don't Know Enough About the Disease and its Consequences - Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador

Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador




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Masimo CEO says its remote oxygen monitors were made to mitigate diseases like coronavirus

Masimo CEO Joe Kiani discussed how the medical device maker's telehealth systems can be useful in the fight against coronavirus.





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How a Warming Climate Could Affect the Spread of Diseases Similar to COVID-19

A hotter planet could change the relationship among infectious agents, their hosts and the human body’s defense mechanisms

-- Read more on ScientificAmerican.com




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China says it will update disease control measures in wake of coronavirus

Senior health official says virus exposed ‘weak links’ in way country manages epidemics

China will reform its disease prevention and control system to address weaknesses exposed by the coronavirus outbreak, a senior health official has said.

China has been criticised domestically and abroad for being initially slow to react to the outbreak, which started in Wuhan. The virus has now infected almost 4 million people around the world, and almost 250,0000 people have died from the Covid-19 disease it causes.

Continue reading...




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Inside a Greek coronavirus ward: how debt-ridden nation is beating the disease – video

Despite a decade-old financial crisis that has crippled its hospitals, Greece appears to be keeping its coronavirus outbreak under control, with a far lower death toll than many other European nations. Dr Yota Lourida, Infectious Diseases specialist at Sotiria hospital in Athens, explains how it dealt with the crisis, and the steps taken by the country to mitigate against potentially catastrophic outcomes

Continue reading...




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Transatlantic slavery introduced infectious diseases to the Americas

The remains of three slaves found in Mexico contain the earliest signs of the hepatitis B virus and yaws bacteria in the Americas, suggesting transatlantic slavery introduced these diseases




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Common herpes virus causes signs of Alzheimer's disease in brain cells

A study of brain cells in a dish adds to growing evidence that Alzheimer’s disease can be caused by herpes viruses, but antiviral treatment may help stop it




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Coronavirus: Disease meets deforestation at heart of Brazil's Amazon

Coronavirus has overwhelmed Manaus, the Amazon's biggest city, and the worst is yet to come.




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Antibacterial in toothpaste may combat severe lung disease: Study



Researchers have found that a common antibacterial substance found in toothpaste may combat life-threatening diseases such as cystic fibrosis (CF) when combined with a drug.

The study, published in the journal Antimicrobial Agents and Chemotherapy, found that when triclosan -- a substance that reduces or prevents bacteria from growing -- is combined with an antibiotic called tobramycin, it kills the cells that protect the CF bacteria, known as Pseudomonas aeruginosa, by up to 99.9 per cent.

CF is a common genetic disease with one in every 2,500 to 3,500 people diagnosed with it at an early age. It results in a thick mucus in the lungs, which becomes a magnet for bacteria.

These bacteria are notoriously difficult to kill because they are protected by a slimy barrier known as a biofilm, which allows the disease to thrive even when treated with antibiotics, the researcher said.

"The problem that we're really tackling is finding ways to kill these biofilms," said lead author Chris Waters, Professor at the Michigan State University.

According to the researcher, there are many common biofilm-related infections that people get such as ear infections and swollen, painful gums caused by gingivitis.

But more serious, potentially fatal diseases join the ranks of CF including endocarditis, or inflammation of the heart, as well as infections from artificial hip and pacemaker implants, the researcher added.

For the study, the researchers grew 6,000 biofilms in petri dishes, added in tobramycin along with many different compounds, to see what worked better at killing the bacteria.

Twenty-five potential compounds were effective, but one stood out, the researcher said.

"It's well known that triclosan, when used by itself, isn't effective at killing Pseudomonas aeruginosa. But when I saw it listed as a possible compound to use with tobramycin, I was intrigued. We found triclosan was the one that worked every time," said Alessandra Hunt from the Michigan State University.

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Dogs born in summers more likely to suffer heart disease

Representational Image

Owing to a higher level of outdoor air pollution during summers, dogs born during this time are more likely to be at higher risk of heart disease, according to a study.

For both dogs and humans, outside air pollution during pregnancy and at the time of birth appears to play a role in later development of heart disease.

Overall, dogs have a 0.3 to 2 per cent risk of developing heart disease depending on breed, but among those that are genetically predisposed to the heart disease, the birth month difference in risk was found to be marginal.

However, breeds not genetically predisposed to the disease, such as Norfolk terrier, Berger Picard, American Staffordshire terrier, English toy spaniel, Bouvier des flandres, Border terrier and Havanese were also found to be at highest risk.

This suggests that the effect supports an environmental mechanism, the researchers said, in a paper published in the journal Scientific Reports.

The study, published in the journal Scientific Reports, also supports earlier findings in humans pointing to the role of early gestational exposure to fine air particulates and increased risk of heart disease later in life.

"It's important to study dogs because the canine heart is a remarkably similar model to the human cardiovascular system," said Mary Regina Boland, Assistant Professor at the University of Pennsylvania in the US.

"Also, humans and dogs share their lives together and are exposed to similar environmental effects, so seeing this birth season-cardiovascular disease relationship in both species illuminates mechanisms behind this birth-season disease relationship," Boland added.

Because dogs' pregnancies are shorter than humans (lasting only 2 months), pollution as a possible mechanism is still thought to be through the mother's inhalation of air pollution effecting the uterine environment, which in turn affects the developing cardiovascular system of the baby or puppy, the study showed.

For the new study, the team examined 129,778 canines encompassing 253 different breeds.

The research team found that risk climbs to the greatest level in dogs born in July, who have a 74 per cent greater risk of heart disease than would typically be expected.

Catch up on all the latest Crime, National, International and Hatke news here. Also download the new mid-day Android and iOS apps to get latest updates

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.




disease

A repairable brain: cell reprogramming to halt neurodegenerative disease

EU-funded researchers have developed innovative genetic reprogramming techniques to replace and repair brain cells, opening up novel therapeutic pathways to combat debilitating disorders such as Parkinson's and Huntington's disease.




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Research Headlines - Biosensing test to transform disease diagnosis and monitoring

[Source: Research & Innovation] EU-funded researchers have developed an ultrasensitive test to rapidly, accurately and cost-effectively diagnose disease, underpinned by innovative biosensing technology that could help combat the COVID-19 pandemic, HIV and cancer.




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Dengue Cases on Rise in Madhya Pradesh, 277 People Test Positive for the Disease

The dengue virus kills an estimated 20,000 people each year and infects up to 100 million, suggested the World Health Organization (WHO). There is no vaccine for dengue.




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Prior Infection With Dengue Lowers Zika Disease Severity

People who are infected by Zika virus are less likely to fall ill if they had dengue fever before than individuals with Zika virus who never had dengue, reveals a new study.




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Possible New Therapeutic Strategy for Severe Dengue Disease

Nafamostat mesylate, a tryptase inhibitor, can treat severe dengue disease, according to the team of researchers from Duke-NUS Medical School. The




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Regular Tub Bathing can Reduce Heart Disease Death Risk

Highlights: Taking a tub bath every day can save your heart and make you live longer Regular tub bathing can




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Childhood Obesity and High Blood Pressure can Lead to Future Heart Disease

Highlights: Children who are obese are at higher risk of developing heart disease later Regular physical ac




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Berries, Apples and Tea can Help Fight Alzheimer's Disease

Highlights: Consuming flavonoid-rich foods can keep Alzheimer's disease at bay Foods rich in flavonoids a




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Investigational Drug to Prevent Heart Disease May Treat Ovarian Cancer

Ovarian cancer cells become detached from their point of origin and shift using fats as an energy source, according to Benjamin Bitler, PhD, and CU Cancer




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Diabetes Drugs Effective in Reducing Heart, Kidney Disease

Two types of diabetes drugs namely SGLT2 inhibitors and GLP-1 drugs were effective in reducing heart complications including stroke, heart attack, and




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Teprotumumab, First FDA-approved Drug for Thyroid Eye Disease Proves Effective

Regardless of patient gender, age or smoking status, teprotumumab, the first FDA-approved drug for thyroid eye disease, provides significant improvement




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Drug Saves Lives of Children Fighting Fatal Immune Disease

Emapalumab saved a child suffering from HLH. Although the 34-patient study wasn't large enough to show the efficacy of this new drug, doctors say their data are promising.




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Good Sleep Patterns Reduce Heart Disease Risk Despite Genetic Influences

Highlights: Healthy sleep patterns can reduce the risk of cardiovascular diseases (CVD) These sleep pat




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Intermittent Fasting Helps Prevent Disease

Intermittent fasting has worked on the liver to help prevent disease, stated researchers in Australia. The findings will help medical scientists working




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Diet can Impact the Multiple Sclerosis Disease Course

Propionic acid can serve as a potent immunomodulatory supplement to multiple sclerosis (MS) drugs, reports a new study. The findings of the study are published in the journal iCell/i.




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Study Leads to Improved Vaccinations Against Sexually Transmitted Diseases

Skin vaccination generates protective CD8 T-cells that are recruited to the genital tissues. Study conducted by King's College London scientists has revealed




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Alerting Patients to Their Risk of Gum Disease Improves Inflammation and Dental Hygiene, Says Study

Use of psychological techniques to communicate the risk of developing periodontal disease to patients improved their dental hygiene over a three month period.




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Respiratory Exposures in Dental Clinics May Up Occupational Lung Disease in Dentists

Frequent exposure to dangerous microscopic, airborne particulates, and gases during dental procedures may increase dental professionals' risk of developing




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Elite Athletes Have High Rates of Oral Disease Despite Brushing Twice Daily

Elite athletes have poor oral health despite brushing their teeth more regularly than most people, reports a new study. The findings of the study are published in the iBritish Dental Journal/i.




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Tooth Loss Tied to Higher Risk of Heart Disease

Individual's who have lost their teeth due to nontraumatic reasons may have a higher risk of developing heart disease. The causal association between




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Periodontal Disease: Patent for Biodegradable Rods

New biodegradable rods can effectively treat periodontal disease. Researchers of the Institute of Pharmacy at Martin Luther University Halle-Wittenberg




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Gum Disease Linked to Stroke Risk

Gum disease, inflammation, and hardened arteries were found to be associated with stroke risk, revealed preliminary research to be presented at the American




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Cause of Noise-associated Blood Vessel Damage, Heart Disease Identified

Potential mechanism underlying the reason for inflammation, blood vessel damage and heart disease due to long-term exposure to noise was identified by




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Pneumococcal Disease Susceptibility Linked to Exposure to Diesel Exhaust Particles

An individual's susceptibility to pneumococcal disease is increased when exposed to diesel exhaust particles (DEPs), revealed study published in the Journal of Allergy and Clinical Immunology.




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Air Pollution can Put You at Risk of Dementia and Heart Disease

People continuously exposed to air pollution are at a higher risk of developing dementia and heart disease. However, the risk is even higher in people