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Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Impact of the COVID-19 lockdown on basic science research in ophthalmology: the experience of a highly specialized research facility in France




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Do malocclusions affect oral health related quality of life?




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The Political Power of Proxies: Why Nonstate Actors Use Local Surrogates

Unlike state sponsors, which value proxies primarily for their military utility, nonstate sponsors use proxies mainly for their perceived political value. An analysis of three case studies—al-Qaida in the Arabian Peninsula, the People’s Protection Units in Syria, and Hezbollah in Lebanon—illustrates this argument.




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Anti-obesity therapy with peripheral CB1 blockers: from promise to safe(?) practice




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The Political Power of Proxies: Why Nonstate Actors Use Local Surrogates

Unlike state sponsors, which value proxies primarily for their military utility, nonstate sponsors use proxies mainly for their perceived political value. An analysis of three case studies—al-Qaida in the Arabian Peninsula, the People’s Protection Units in Syria, and Hezbollah in Lebanon—illustrates this argument.




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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation




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HIF1α blockade reduces kidney injury in lupus nephritis




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




loc

Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.









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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Designing Thoughtful Minimum Wage Policy at the State and Local Levels


Rising wage inequality and stagnant real wages have contributed to inequality in family incomes during the past three decades. While the expansion of the Earned Income Tax Credit (EITC) and the Supplemental Nutrition Assistance Program (SNAP) have helped mitigate the impact on low-income families (Bitler and Hoynes 2010), federal minimum wage policy has not contributed to the solution. The federal minimum wage has failed to keep pace with both the cost of living and the median wage in the labor market. As a consequence, working full-time at the minimum wage does not allow many families to escape poverty, or to attain economic self-sufficiency.

State and local governments can set minimum wages in excess of the statutory federal minimum wage. Indeed, state and local governments have played an important role in establishing minimum wages across the country; as a result, thirty-seven states had state minimum wages exceeding the federal level in 2007 prior to the most recent federal increase. Cities, too, have begun setting higher minimum wages, as evidenced by city-level wage minimums in Albuquerque, San Francisco, San Jose, Santa Fe, Seattle, and Washington, DC; other cities are actively exploring possibilities of raising minimum wages. 

In this policy memo, I propose a framework for effective state and local minimum wage policy. First, I propose using half the local-area median wage as an important gauge for setting an appropriate level of the minimum wage. Second, I propose that state and local governments take into account the local cost of living as a relevant consideration in setting a minimum wage, and I provide estimates of how state minimum wages would vary if they reflected cost-of-living differences. I also recommend the use of regional consumer price indexes (CPIs) to index the local minimum wage. Finally, I propose that cities and counties coordinate regional wage setting to mitigate possible negative effects of local mandates. 

The implementation of the state and local framework does not override the need for reform at the federal level. Thoughtful reforms to the federal minimum wage can help reduce poverty and mitigate inequality. The federal minimum wage has been the focus of substantial debate by academics and policymakers; this proposal focuses on state and local reforms that have received substantially less attention. These state and local reforms can be an important part of the policy portfolio for reducing the incidence of poverty and for helping low-income families support themselves as they strive toward the middle class. In particular, although the federal minimum wage serves as a floor in the labor market, there is some room for additional increases in higher-wage areas.

Downloads

Authors

  • Arindrajit Dube
Publication: The Hamilton Project
Image Source: Hero Images
     
 
 




loc

The Political Power of Proxies: Why Nonstate Actors Use Local Surrogates

Unlike state sponsors, which value proxies primarily for their military utility, nonstate sponsors use proxies mainly for their perceived political value. An analysis of three case studies—al-Qaida in the Arabian Peninsula, the People’s Protection Units in Syria, and Hezbollah in Lebanon—illustrates this argument.




loc

Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




loc

The Political Power of Proxies: Why Nonstate Actors Use Local Surrogates

Unlike state sponsors, which value proxies primarily for their military utility, nonstate sponsors use proxies mainly for their perceived political value. An analysis of three case studies—al-Qaida in the Arabian Peninsula, the People’s Protection Units in Syria, and Hezbollah in Lebanon—illustrates this argument.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Vettel leads dominant Red Bull front-row lock out

Red Bull's Sebastian Vettel and Mark Webber silenced rivals' claims that the car was gaining an unfair advantage this season by locking out the front row of the grid in qualifying for the Chinese Grand Prix.




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Hamilton blocked from novelty helmet change

Lewis Hamilton appears to be the first victim of the FIA's controversial helmet ban after being blocked from wearing a novelty lid in Malaysia




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Africa in the news: Nagy visits Africa, locust outbreak threatens East Africa, and Burundi update

Security and youth top agenda during US Assistant Secretary of State Nagy’s visit to Africa On January 15, U.S. Assistant Secretary of State for African Affairs Tibor Nagy headed to Africa for a six-nation tour that included stops in the Central African Republic, Ethiopia, Kenya, South Sudan, Sudan, and Somalia. Security was on the top of the agenda…

       




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Dealing with coronavirus: A not-so-serious take on surviving the lockdown

Coronavirus
Do all the things you always wished you had the time to do, like working on a script that will be picked up by Leonardo DiCaprio or perfecting the pincha mayurasana.
Pixabay
Corona or not, it sucks to be cooped up like chickens with our loved ones without the comfortable distance required to make the heart grow fonder. In a bid to do my part to save the world from this crippling pandemic without actually moving my backside for fear of stepping over the Lakshman Rekha, I decided to draw up a survival guide of Dos and Don’ts to weather the tsunami of trouble stirred up by this nasty critter. Trust me, preliminary studies conducted by the reputed folks at WhatsApp University have confirmed their efficacy beyond a shadow of doubt. The first step is to make soap and water your most intimate acquaintances. They have proven themselves good friends to humanity long before diamonds and dogs usurped their rightful spot and will continue to prove their worth long after corona has shrunk back into the bowels of hell from which it has erupted like a particularly foul effluent. It would also help if one were to make personal hygiene a priority and public hygiene an even bigger one if only as a preventive measure against the spread of communicable diseases and related hazards that could prove to have epic stakes in the survival game. Roughly translated, that means not ever dumping your trash outside the sparkling interiors of your home into the streets, using the great outdoors as a spittoon or latrine, defacing public property by scratching your lover’s name, throwing up pornographic sketches on every available surface or blowing your nose and allowing the discharge to fly every which way. Steer clear of social media if you value your sanity or at least use it in moderation especially if you lack the balancing power of a monkey on stilts to take the better while leaving out the bitter, barf – inducing garbage out there. Ever since some wiseacre got word out that democracy works best when your voice is heard out loud, people have been screaming themselves hoarse to make sure that their endless torrent of nonsense is amplified to the furthest reaches of the internet, bolstered by twitchy fingers compulsively hitting like and share in the desperate hope that they will be rewarded in kind. Therefore we have internet idiots and savants with interchangeable attributes raving and ranting fit to burst. The insufferably self-righteous and superior types tend to drip scorn for everyone and everything from the admitted showmanship of the supreme leader and inadequacy of the ruling party to the extreme foolishness of the folks who tentatively stepped out of their homes to find a bite to eat or medicine for an ailing grandmother only to be sneakily photographed or recorded so that they may be viciously trolled, endlessly abused and publicly shamed for putting millions at risk. Then there are the fanatical religious nuts who swear that India need not be subjected to a lockdown because Indians practise the downward facing dog regularly on their balconies with their rear ends strategically raised towards the benign sun which unleashes the Kundalini Shakti with all its serpentine strength which is more than sufficient to slay corona, sharona and whatever else have you or something equally ludicrous about the virus killing power of pots and pans banged in unison. Relatively innocuous Instagram must also be avoided at all costs too. According to the illustrious professors of WhatsApp University, those pretty pictures have great envy-inducing powers which can corrupt the best and brightest till they are reduced to gibbering, glass-eyed cyber stalkers who can spend years staring at pics and videos of Janhvi Kapoor sexily pretending to eat a slice of pizza, giving her puppy a bath or showing you the correct technique for applying lipstick to the exclusion of all things useful or worthy. Avoid fake news like the plague. Fear and panic cause a lot more damage than pandemics. Be sure to verify the credentials and reliability of all purveyors of information and check the facts. Even if you can’t be bothered, be sure to think thrice before you join hands with the mob to tear apart the hapless medical personnel getting off a gruelling nightshift because they are suspected to be carriers of COVID-16 (or is it COVID-17?). And believing self-proclaimed experts who have declared that the only country in the world that is currently corona free is Kailasa and you are considering applying for permanent citizenship under the benevolent rule of HDH Nithyananda even if you run a far higher risk of contracting HIV, do yourself a favour and check yourself into the nearest hospital for a lobotomy. While many endorse vegetating in front of Netflix, it is advisable to take time out to work out, read a book, cook a meal, take the dog for a walk, play with the kids or teach them something useful that does not involve staring at a screen, converse with the spouse about something other than whose turn it is to do the dishes or swab the floors and do whatever it takes to tough things out as long as it is legal and non-fattening. Do all the things you always wished you had the time to do, even if it is something impracticable like working on a script that will be picked up by Leonardo DiCaprio at an exorbitant price or perfecting the pincha mayurasana in the hopes that a video of you executing the same or at least the blooper version will go viral on the internet. If you are inclined to feel that this survival guide is lacking in scientific detail, didn’t once mention social distancing, testing, gaumutra, masks, sanitiser and is somewhat on the rambling side not unlike the supreme leader’s impassioned addresses to the nation, allow me to stress that if the buzz on WhatsApp is to be believed I am a shoo-in for the Noble Prize thanks to this priceless contribution towards the greater good, entirely free of cost. If that doesn’t convince you to take every word put down here as the gospel truth which deserves to be liked and shared till it has spread to the furthest corners of civilized society like a contagion, I don’t know what will.
Body 2: 




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Liuzzi penalised five grid positions for blocking

Tonio Liuzzi has been slapped with a five-place grid penalty for impeding Nico Hulkenberg, meaning the Force India driver will start the British Grand Prix from 20th




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




loc

Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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Turning back the Poverty Clock: How will COVID-19 impact the world’s poorest people?

The release of the IMF’s World Economic Outlook provides an initial country-by-country assessment of what might happen to the world economy in 2020 and 2021. Using the methods described in the World Poverty Clock, we ask what will happen to the number of poor people in the world—those living in households with less than $1.90…

       




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Exit from coronavirus lockdowns – lessons from 6 countries

       




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Africa in the news: Nagy visits Africa, locust outbreak threatens East Africa, and Burundi update

Security and youth top agenda during US Assistant Secretary of State Nagy’s visit to Africa On January 15, U.S. Assistant Secretary of State for African Affairs Tibor Nagy headed to Africa for a six-nation tour that included stops in the Central African Republic, Ethiopia, Kenya, South Sudan, Sudan, and Somalia. Security was on the top of the agenda…

       




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Why local governments should prepare for the fiscal effects of a dwindling coal industry