Hagai Yodan premieres a daring piano-tech concerto at Jerusalem’s 2024 Piano Festival.

Malta ESG Alliance holds ISIMGħUNA conference to bring children and national leaders together to talk about the country's future

The 15 August 2021 Taliban takeover of Afghanistan devastated the lives of millions of Afghans. But the rights and freedoms of women and girls in particular have been progressively trampled by a series of edicts that have created a virtual system of gender apartheid.

Philippine institutions and governance structures must be strengthened as part of any effort to reform the country's financial supervisory structure.

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Title: Eye Pigment May Help Vision in Hazy Conditions
Category: Health News
Created: 8/28/2014 9:35:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM

Title: Health Tip: Exercise While Watching Television
Category: Health News
Created: 8/29/2014 7:35:00 AM
Last Editorial Review: 8/29/2014 12:00:00 AM

Title: School Kids Need Supervision After Classes End
Category: Health News
Created: 8/26/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

ABSTRACTIntroduction:Emergency contraceptive pills (ECPs) are effective and can be used safely at any age repeatedly within the same cycle. They are often favored by youth yet are underutilized. Private facilities can increase ECP access but present barriers including cost. Identifying effective public-sector ECP distribution models can help ensure equitable access. The Malawi Ministry of Health developed a strategy to improve ECP access in 2020. We documented ECP provision through select public, youth-serving channels recommended by the strategy: general and youth-specific outreach, paid and unpaid community health workers (CHWs), and youth clubs.Methods:We conducted this mixed methods study from November 2022–March 2023 in 2 rural districts (Mchinji and Phalombe) implementing the strategy. We conducted qualitative interviews with 10 national stakeholders, 46 providers, and 24 clients aged 15–24 years about ECP service delivery. Additionally, 25 providers collected quantitative tally data about clients seeking ECPs. We analyzed qualitative data using grounded theory and quantitative data descriptively.Results:Stakeholders and providers reported ECP uptake increased in geographies where the strategy was implemented, especially among youth. Providers documented 3,988 client visits for ECPs over 3 months. Of these visits, 26% were from male clients, 36% were from clients aged younger than 20 years, and 64% received ECPs for the first time. Across channels, youth club leaders and unpaid CHWs reported the most client visits per provider and served the youngest clients. However, no ECPs were dispensed during 29% of visits due to stock-outs. While many providers were supportive of youth accessing ECPs, most held unfavorable attitudes toward repeat use.Conclusion:ECP access should be expanded through provision in the studied channels, especially youth clubs and CHWs. However, to meet demand, the supply chain must be strengthened. We recommend addressing providers’ attitudes about repeat use to ensure informed method choice.

The phase 3 VISION trial demonstrated that [¹⁷⁷Lu]Lu-PSMA-617 prolonged progression-free survival and overall survival (OS) in prostate-specific membrane antigen [PSMA]–positive metastatic castration-resistant prostate cancer (mCRPC) patients who progressed on taxane-based chemotherapy and androgen receptor–signaling inhibitors (ARSIs). The U.S. expanded-access program (EAP; NCT04825652) was opened to provide access to [¹⁷⁷Lu]Lu-PSMA-617 for eligible patients until regulatory approval was obtained. This study aimed to evaluate the efficacy and safety profile of [¹⁷⁷Lu]Lu-PSMA-617 within the EAP and compare the results with those from the VISION trial. Methods: Patients enrolled in the EAP at 4 institutions in the United States with available toxicity and outcome data were included. Outcome measures included OS, a prostate-specific antigen (PSA) response rate (RR) of at least 50%, and incidences of toxicity according to Common Terminology Criteria for Adverse Events version 5.0. Differences in baseline characteristics, outcome data, and toxicity between the EAP and VISION were evaluated using t testing of proportions and survival analyses. Results: In total, 117 patients with mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP between May 2021 and March 2022 were eligible and included in this analysis. Patients enrolled in the EAP were more heavily pretreated with ARSI (≥2 ARSI regimens: 70% vs. 46%; P < 0.001) and had worse performance status at baseline (Eastern Cooperative Oncology Group score ≥ 2: 19% vs. 7%; P < 0.001) than VISION patients. EAP and VISION patients had similar levels of grade 3 or higher anemia (18% vs. 13%; P = 0.15), thrombocytopenia (13% vs. 8%; P = 0.13), and neutropenia (3% vs. 3%; P = 0.85) and similar PSA RRs (42% vs. 46%; P = 0.50) and OS (median: 15.1 vs. 15.3 mo; P > 0.05). Conclusion: Patients with PSMA-positive mCRPC who received [¹⁷⁷Lu]Lu-PSMA-617 within the EAP were later in their disease trajectory than VISION patients. Patients enrolled in the EAP achieved similar PSA RRs and OS and had a safety profile similar to that of the VISION trial patients.

Rare genetic conditions are challenging for the primary care provider to manage without proper guidelines. This clinical review is designed to assist the pediatrician, family physician, or internist in the primary care setting to manage the complexities of 16p11.2 deletion syndrome. A multidisciplinary medical home with the primary care provider leading the care and armed with up-to-date guidelines will prove most helpful to the rare genetic patient population. A special focus on technology to fill gaps in deficits, review of case studies on novel medical treatments, and involvement with the educational system for advocacy with an emphasis on celebrating diversity will serve the rare genetic syndrome population well.

BackgroundLong-term health conditions are major challenges for care systems. Social prescribing link workers have been introduced via primary care networks (PCNs) across England since 2019 to address the wider determinants of health by connecting individuals to activities, groups, or services within their local community.AimTo assess whether the rollout of social prescribing link workers was in areas with the highest need.Design and settingA retrospective study of social prescribing link workers in England from 2019 to 2023.MethodWorkforce, population, survey, and area-level data at the PCN-level from April 2020 to October 2023 were combined. Population need before the rollout of link workers was measured using reported lack of support from local services in the 2019 General Practice Patient Survey. To assess if rollout reflected need, linear regression was used to relate provision of link workers (measured by full-time equivalent [FTE] per 10 000 patients) in each quarter to population need for support.ResultsPopulations in urban, more deprived areas and with higher proportions of people from minority ethnic groups had the highest reported lack of support. Geographically these were in the North West and London. Initially, there was no association between need and provision; then from July 2022, this became negative and significant. By October 2023, a 10-percentage point higher need for support was associated with a 0.035 (95% confidence interval = −0.634 to −0.066) lower FTE per 10 000 patients.ConclusionRollout of link workers has not been sufficiently targeted at areas with the highest need. Future deployments should be targeted at those areas.

Netflix's mega-violent mega-hit series returns December 26.

Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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The Adison Vein Locator gives medical professionals Superman-like X-ray vision for finding patients' veins for easy insertion of needles.

Significant visual and comfort compromises make last year's Quest 3 a better VR investment.

This week, Apple Arcade sees a major game update for Apple Vision Pro and a few notable updates. Castle Crumble …

Continue reading "Castle Crumble for Apple Vision Pro Is Now Available on Apple Arcade Alongside Big Updates for Puyo Puyo Puzzle Pop, Crayola Adventures, and More"

Welcome to this week’s edition of the Steam Deck Weekly. If you missed my Gundam Breaker 4 Steam Deck review, …

Continue reading "Steam Deck Weekly: Visions of Mana and More Reviews, Reynatis Preview, Age of Mythology Retold Steam Deck Impressions, News, and More"

An activist investor with a $5 billion stake in Honeywell International is calling for the company to separate its Phoenix-based aerospace division into a separate business.

The initial buzz for Apple’s mixed-reality headset has died down, but new apps and experiences are still arriving for consumers who plunked down $3,500. The UK broadcaster Channel 4 just dropped a dedicated streaming app for the headset, which lets users watch stuff in “ground-breaking cinema-style.”

Channel 4 is the first UK broadcaster to take this step. The app leverages the tech inside the headset to overlay streaming content on the real world, which allows for a “full-screen viewing experience” of stuff like The Great British Bake Off and Taskmaster, in addition to multi-screen view.

Speaking of Taskmaster, the broadcaster also announced an environment based on the comedy game show. Environments on the AVP transform the world around the user, so people can watch Taskmaster while sitting in a room inspired by Taskmaster (cue that Xzibit Yo Dawg meme.) Other streaming apps have their own environments. Paramount+ offers one based on SpongeBob Squarepants and Disney+ now includes one set in Iceland.

This app doesn’t feature access to the recently-released Taskmaster VR experience. That one’s still tied to Steam VR and Meta Quest. By most accounts, it’s a pretty bad game, so the Vision Pro isn’t missing much.

Nvision Biomedical Technologies and Invibio Biomaterial Solutions have announced that the FDA has granted clearance of the first 3D-Printed PEEK Interbody System made from PEEK-OPTIMA.

Feb 29, 2024

Former U.S. Ambassador to Israel Ed Djerejian says Israeli Prime Minister Yitzak Rabin once told him, “There is no military solution to this conflict, only a political one.” Rabin was assassinated a few years later, and today bullets are flying, bombs are falling, and 1,200 Israelis are dead after the Hamas terrorist attacks of October 7 and nearly 30,000 Gazans have been killed in the Israeli response. Yet Djerejain still believes that a breakthrough is possible even in the current moment, as horrible as it is. Djerejian, a senior fellow at Harvard Kennedy School’s Belfer Center for Science and International Relations, says the crisis has shaken the regional status quo to the point where—if the United States pursues diplomacy that includes principled pragmatism, coalition-building, and good old-fashioned backbone—a breakthrough may finally be possible. But in a recent paper he argues that any breakthrough will have to be built around a two-state solution, which he says is the only path to peace and stability not only in Israel and Palestine, but the wider Middle East. Djerejian’s career as a diplomat spanned eight U.S. presidential administrations beginning with John F. Kennedy’s, and he also served as U.S. Ambassador to Syria and Assistant Secretary of State for Near Eastern Affairs.  

Matt Snow

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Years ago, NASA�s Hubble Space Telescope launched with an error in the telescope�s mirror, which blurred its images for its first years in orbit. For NASA�s upcoming James Webb Space Telescope that is traveling much farther out in space, there can�t be a mistake. Abbott scientists created a technology to calibrate the mirrors on NASA�s new James Webb Space Telescope, which is now the same technology used in the iDesign System that allows ophthalmologists to map the human eye with great precision for a highly personalized LASIK treatment.

If we talk about the frequency, the TDS return may be revised multiple times, which allows taxpayers to make corrections as and when needed. However, it is advisable to avoid excessive revisions to prevent complexities in record-keeping.

GOVERNMENT OF INDIAMINISTRY OF FINANCE (DEPARTMENT OF REVENUE)Notification No.27/2024-Central ExciseNew Delhi, the 28th October, 2024G.S.R.(E)...–In exercise of the powers conferred by sub-section(1) o

Learn about Google's four-pillar health strategy aimed at improving global health.

The Hon'ble Delhi High Court in the case of JV Creatives (P.) Ltd. v. Principal Additional Director General, DGGI, Gurugram Zonal Unit [W.P. (C) No. 10042 of 2024 dated July 23, 2024] dismissed the writ petition filed against the order of provisional attachment passed under Section 83 of the Central

The release of Apple’s mixed-reality headset raises questions about hours spent in a virtual replacement of our world

Russia's Ministry of Finance has said it is prepared to terminate the Dutch tax agreement if ongoing negotiations fail.

The Netherlands and Poland have agreed to make changes to their tax treaty, to add provisions to prevent tax base erosion and profit shifting (BEPS), and amend provisions relating to the taxation of pensions income.

Switzerland has signed protocols to its double taxation agreements with Cyprus, Liechtenstein, and Malta to implement minimum standards developed as part of the OECD's BEPS project.

Russia's Ministry of Finance has said it is prepared to terminate the Dutch tax agreement if ongoing negotiations fail.

On August 26, 2020, the Swiss Federal Council ratified a new double taxation agreement with Bahrain and a Protocol to revise its DTA with Kuwait.

Switzerland has signed protocols to its double taxation agreements with Cyprus, Liechtenstein, and Malta to implement minimum standards developed as part of the OECD's BEPS project.

On August 26, 2020, the Swiss Federal Council ratified a new double taxation agreement with Bahrain and a Protocol to revise its DTA with Kuwait.

A surprisingly diverse ecosystem exists right in your mouth, housing more than 500 species of medlinkbacteria/medlink in organized communities known as biofilms.

bHighlights:/bul class="group-list punch-points"li The world's first-ever complete eye transplant coupled with a partial face transplant conducted

Patients born with genetic medlinkblindness/medlink experienced significant visual improvements after a single treatment with gene therapy developed

Patrick Soon-Shiong, M.D. and Michele B. Chan Join Prestigious List of Recipients of KCET Visionary Award at 10th Gala H

Despite being enrolled in Medicare Advantage plans, lower-income adults face more difficulty paying for dental, vision, and hearing services than higher-income

Jeevan Sreerama's career exemplifies excellence in AI and data science. From his BCS Fellowship to his roles in academia and industry, Jeevan embodies visionary leadership in AI.

In a bid to boost the Bharat 6G Vision, the government is working towards the development of a multi-port switch for a single broadband antenna that can cover all 2G, 3G, 4G and 5G bands.

Ultrasound is perhaps best known as the technology that enables noninvasive body scans and underwater communication and can help us park our cars. A young startup called Sonair out of Norway wants to employ it for something else: 3D computer vision used in autonomous hardware applications.  Sonair’s founder and CEO Knut Sandven believes the company’s […]

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Last week’s Vision Pro release shed some fascinating light on Apple’s generally top secret development process. A Vanity Fair interview with Tim Cook detailed — in part — what a long and heavy lift it took to get the company’s first headset off the ground. The Apple CEO gave an early iteration of the device […]

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Call of Duty is one of the biggest franchises in the world of gaming, and we’re just a few short weeks from the debut of the next title. Welcome to the era of Modern Warfare II. Today at CoD Next, Activision is giving us our first look at live gameplay from MWII courtesy of more […]

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Beating the street and its own guidance, Zynga reported record third-quarter revenue of $705 million, up 40% from the same period last year and reaching its largest mobile audience ever of 183 million monthly active users, up 120% year over year. Despite warning in the second quarter of a material impact from Apple’s privacy policy […]

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Apple’s Vision Pro hasn’t exactly reshaped the market, but the company isn’t giving up on headsets that combine the digital and real worlds. A new report from Bloomberg’s Mark Gurman says that Apple’s next big mixed reality release could come as early as next year, with the launch of a Vision headset costing around $2,000 […]

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