HydroEvent.com, the one-stop location for all things related to the world’s largest hydro event, is up and running for HydroVision International 2016. The conference and events are scheduled for July 26-29 in Minneapolis, Minn. at the Minneapolis Convention Center. 

The U.S. Department of Energy released the long-awaited Hydropower Vision report -- alongside $9.8 million in funding for hydroelectric power -- earlier today at HydroVision International 2016 in Minneapolis.

The U.S. Department of Energy released the long-awaited Hydropower Vision report -- alongside $9.8 million in funding for hydroelectric power -- earlier today at HydroVision International 2016 in Minneapolis.

This weekend at its “Earth Day Every Day Fair,” Green Mountain Power announced an energy vision to have a 100 percent carbon free energy supply by 2025 and 100 percent renewable energy by 2030. The utility said the move is among the most aggressive carbon targets for a utility of GMP’s size in the country.

The HydroVision International event is now under way in the Oregon Convention Center in Portland, with more than 3,000 hydropower professionals from around the world coming together for four days of learning and networking.

Freyr AS, a startup planning to build one of Europe’s first battery gigafactories in Norway, has a bigger vision for the region: a “Nordic Battery Belt.”

New York State is pushing its utility industry to shift away from a century-old business model into a system that can accommodate more power from solar and wind.

If all energy production channels were employed, the United States has sufficient resources to eliminate all coal, gasoline and diesel combustion in all demand sectors and replace them with natural gas, wind and solar electricity firmed and shaped with both grid-scale and distributed energy storage. I believe that we can reach a zero-air-pollution, coal-free, crude-import free, all-electric low-cost energy future. We have energy rhetoric and technology to get there; do we have leadership and will?

This weekend at its “Earth Day Every Day Fair,” Green Mountain Power announced an energy vision to have a 100 percent carbon free energy supply by 2025 and 100 percent renewable energy by 2030. The utility said the move is among the most aggressive carbon targets for a utility of GMP’s size in the country.

On Tuesday, July 23 at the HydroVision International keynote, Vice President Marla Barnes asked the audience to close their eyes and envision their next vacation. “Are you sitting on a beach? Are you packing your family into the car for a wild adventure? What do you see,” she asked.

Guidance on establishing processes to rapidly detect and respond to cyber incidents.

As Bruce Dear writes, “COVID-19 poses a threat of unparalleled potency to our real estate markets and economy. So our industry and government must unite behind a grand, generous and visionary response to match the scale of this once in a cent...

At the same time he delivered his (final) Autumn Statement the Chancellor also issued a strategy document to advance one of his predecessor’s key policy aims - the Northern Powerhouse. For those who support the notion of the North providin...

In preparation for the forthcoming withdrawal of the UK from the EU, the Government has been amending legislation and regulations relevant to town and country planning, infrastructure planning, environmental protection, air quality, environmental im...

In preparation for the forthcoming withdrawal of the UK from the EU, Scottish Ministers have been amending legislation and associated regulations controlling the requirements and processes of town and country planning and environmental matters. The ...

The Climate Change Act 2008 (2050 Target Amendment) Order 2019 requires the UK to bring all greenhouse gas emissions to net zero by 2050 (compared with the previous target of at least 80% reduction from 1990 levels). Developing or enhancing the nece...

TBD (Owen Holland) Ltd v Simons & Ors [2020] EWHC 30 (Ch) Background A search order is one of the most draconian orders that the English courts can make, allowing an applicant – where there is a real possibility that a respondent may destroy o...

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Introduction There has been significant debate amongst key stakeholders including government, mining companies, and environmental lobbyists regarding how mining companies should not only be held accountable for mine closure but also how the often va...

With the delivery of the Medium Term Budget Policy Statement on 30 October 2019, updated and amended draft tax bills have been released highlighting the latest proposed amendments to the relevant tax acts.  The amended bills contain the le...

No support in the Corona crisis... The measures already initiated by the German Federal Government and the EU Commission to support and secure liquidity in the Corona crisis are focused on the industries directly affected by Corona/ COVID 19. They ...

Since the 2007 decision of the Reading Employment Tribunal in the case of Hunt v (1) Storm Communications Ltd (2) Wild Card Public Relations Ltd and (3) Brown Brothers Wines (Europe) Limited it has been understood that the provision of professional ...

Introduciton On 5 December 2017, the Financial Reporting Council (FRC) published its proposals for a revised UK Corporate Governance Code. The Code is shorter, building on the FRC’s...

Alger -Le projet de r�vision de la Constitution dont les...

Alger -L'avant-projet de r�vision de la...

From a planning perspective the Bill does not envisage major regime change, but rather concentrates on refinements to the nationally significant infrastructure projects (NSIP) system and includes a measure aimed at accelerating decisions at a local ...

A weekly selection of opinions and analyses from the Arab media around the world.

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

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ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ADB has a vacancy for the position of Intern - Urban Development and Water Division, SERD - 2008 in the Southeast Asia Department. The deadline for submitting applications is on 15 September 2019.

ADB has a vacancy for the position of Intern - Solutions Delivery Division, OIST - 2012 in the Office of Information Systems and Technology. The deadline for submitting applications is on 15 September 2019.

Dentons has advised TSXV listed Bragg Gaming Group Inc., a next generation gaming group, on the sale of its online media division to SN&CK Media Limited. The sale follows a strategic review initiated by CEO, Dominic Mansour, and will allow Bragg to focus its efforts and resources on Oryx,  the group's rapidly growing B2B online gaming business.

HARMAN International, sussidiaria di Samsung Electronics Co., Ltd., focalizzata sulle tecnologie per il mercato automotive, per quello consumer ed enterprise, ha commissionato una nuova e approfondita ricerca1 sulle abitudini di ascolto contemporanee degli utenti e cosa aspettarci dal futuro.

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Last Editorial Review: 4/29/2010 10:28:50 AM

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ABSTRACT

Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria. However, the cotransfer of large gene clusters encoding RND-type pumps from the chromosome to a plasmid appears infrequent, and no plasmid-mediated RND efflux pump gene cluster has yet been found to confer resistance to tigecycline. Here, we identified a novel RND efflux pump gene cluster, designated tmexCD1-toprJ1, on plasmids from five pandrug-resistant Klebsiella pneumoniae isolates of animal origin. TMexCD1-TOprJ1 increased (by 4- to 32-fold) the MICs of tetracyclines (including tigecycline and eravacycline), quinolones, cephalosporins, and aminoglycosides for K. pneumoniae, Escherichia coli, and Salmonella. TMexCD1-TOprJ1 is closely related (64.5% to 77.8% amino acid identity) to the MexCD-OprJ efflux pump encoded on the chromosome of Pseudomonas aeruginosa. In an IncFIA plasmid, pHNAH8I, the tmexCD1-toprJ1 gene cluster lies adjacent to two genes encoding site-specific integrases, which may have been responsible for its acquisition. Expression of TMexCD1-TOprJ1 in E. coli resulted in increased tigecycline efflux and in K. pneumoniae negated the efficacy of tigecycline in an in vivo infection model. Expression of TMexCD1-TOprJ1 reduced the growth of E. coli and Salmonella but not K. pneumoniae. tmexCD1-toprJ1-positive Enterobacteriaceae isolates were rare in humans (0.08%) but more common in chicken fecal (14.3%) and retail meat (3.4%) samples. Plasmid-borne tmexCD1-toprJ1-like gene clusters were identified in sequences in GenBank from Enterobacteriaceae and Pseudomonas strains from multiple continents. The possibility of further global dissemination of the tmexCD1-toprJ1 gene cluster and its analogues in Enterobacteriaceae via plasmids may be an important consideration for public health planning.

IMPORTANCE In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment of carbapenem-resistant Enterobacteriaceae, the most problematic pathogens in human clinical settings—especially carbapenem-resistant K. pneumoniae. Here, we identified a new plasmid-borne RND-type tigecycline resistance determinant, TMexCD1-TOprJ1, which is widespread among K. pneumoniae isolates from food animals. tmexCD1-toprJ1 appears to have originated from the chromosome of a Pseudomonas species and may have been transferred onto plasmids by adjacent site-specific integrases. Although tmexCD1-toprJ1 still appears to be rare in human clinical isolates, considering the transferability of the tmexCD1-toprJ1 gene cluster and the broad substrate spectrum of TMexCD1-TOprJ1, further dissemination of this mobile tigecycline resistance determinant is possible. Therefore, from a "One Health" perspective, measures are urgently needed to monitor and control its further spread. The current low prevalence in human clinical isolates provides a precious time window to design and implement measures to tackle this.

Annette E. Allen, Joshua W. Mouland, Jessica Rodgers, Beatriz Bano-Otalora, Ronald H. Douglas, Glen Jeffery, Anthony A. Vugler, Timothy M. Brown, and Robert J. Lucas

An animal's temporal niche – the time of day at which it is active – is known to drive a variety of adaptations in the visual system. This includes variations in the topography, spectral sensitivity and density of retinal photoreceptors, and changes in the eye's gross anatomy and spectral transmission characteristics. We have characterised visual spectral sensitivity in the murid rodent Rhabdomys pumilio (‘the four-striped grass mouse’), which is the same family as (nocturnal) mice and rats, but exhibits a strong diurnal niche. As is common in diurnal species, the Rhabdomys lens acts as a long-pass spectral filter, providing limited transmission of light <400nm. Conversely, we found strong sequence homologies with the Rhabdomys SWS and MWS opsins and those of related nocturnal species (mice and rats) whose SWS opsins are maximally sensitive in the near UV. We continued to assess in vivo spectral sensitivity of cone vision using electroretinography and multi-channel recordings from the visual thalamus. These revealed that responses across the human visible range could be adequately described by those of a single pigment (assumed to be MWS opsin) maximally sensitive ~500nm, but that sensitivity in the near UV required inclusion of a second pigment whose peak sensitivity lay well into the UV range (_max <400nm, likely ~360nm). We therefore conclude that, despite the UV-filtering effects of the lens, the Rhabdomys retains an SWS pigment with a UV-A _max. In effect, this somewhat paradoxical combination of long-pass lens and UV-A _max results in narrow-band sensitivity for SWS cone pathways in the UV-A range.

Cone photoreceptors in the retina enable vision over a wide range of light intensities. However, the processes enabling cone vision in bright light (i.e. photopic vision) are not adequately understood. Chromophore regeneration of cone photopigments may require the retinal pigment epithelium (RPE) and/or retinal Müller glia. In the RPE, isomerization of all-trans-retinyl esters to 11-cis-retinol is mediated by the retinoid isomerohydrolase Rpe65. A putative alternative retinoid isomerase, dihydroceramide desaturase-1 (DES1), is expressed in RPE and Müller cells. The retinol-isomerase activities of Rpe65 and Des1 are inhibited by emixustat and fenretinide, respectively. Here, we tested the effects of these visual cycle inhibitors on immediate, early, and late phases of cone photopic vision. In zebrafish larvae raised under cyclic light conditions, fenretinide impaired late cone photopic vision, while the emixustat-treated zebrafish unexpectedly had normal vision. In contrast, emixustat-treated larvae raised under extensive dark-adaptation displayed significantly attenuated immediate photopic vision concomitant with significantly reduced 11-cis-retinaldehyde (11cRAL). Following 30 min of light, early photopic vision was recovered, despite 11cRAL levels remaining significantly reduced. Defects in immediate cone photopic vision were rescued in emixustat- or fenretinide-treated larvae following exogenous 9-cis-retinaldehyde supplementation. Genetic knockout of Des1 (degs1) or retinaldehyde-binding protein 1b (rlbp1b) did not eliminate photopic vision in zebrafish. Our findings define molecular and temporal requirements of the nonphotopic or photopic visual cycles for mediating vision in bright light.

The first Biograph Vision PET/CT system (Siemens Healthineers) was installed at the University Medical Center Groningen. Improved performance of this system could allow for a reduction in activity administration or scan duration. This study evaluated the effects of reduced scan duration in oncologic ¹⁸F-FDG PET imaging on quantitative and subjective imaging parameters and its influence on clinical image interpretation. Methods: Patients referred for a clinical PET/CT scan were enrolled in this study, received a weight-based ¹⁸F-FDG injected activity, and underwent list-mode PET acquisition at 180 s per bed position (s/bp). Acquired PET data were reconstructed using the vendor-recommended clinical reconstruction protocol (hereafter referred to as "clinical"), using the clinical protocol with additional 2-mm gaussian filtering (hereafter referred to as "clinical+G2"), and—in conformance with European Association of Nuclear Medicine Research Ltd. (EARL) specifications—using different scan durations per bed position (180, 120, 60, 30, and 10 s). Reconstructed images were quantitatively assessed for comparison of SUVs and noise. In addition, clinically reconstructed images were qualitatively evaluated by 3 nuclear medicine physicians. Results: In total, 30 oncologic patients (22 men, 8 women; age: 48–88 y [range], 67 ± 9.6 y [mean ± SD]) received a single weight-based (3 MBq/kg) ¹⁸F-FDG injected activity (weight: 45–123 kg [range], 81 ± 15 kg [mean ± SD]; activity: 135–380 MBq [range], 241 ± 47.3 MBq [mean ± SD]). Significant differences in lesion SUV_max were found between the 180-s/bp images and the 30- and 10-s/bp images reconstructed using the clinical protocols, whereas no differences were found in lesion SUV_peak. EARL-compliant images did not show differences in lesion SUV_max or SUV_peak between scan durations. Quantitative parameters showed minimal deviation (~5%) in the 60-s/bp images. Therefore, further subjective image quality assessment was conducted using the 60-s/bp images. Qualitative assessment revealed the influence of personal preference on physicians’ willingness to adopt the 60-s/bp images in clinical practice. Although quantitative PET parameters differed minimally, an increase in noise was observed. Conclusion: With the Biograph Vision PET/CT system for oncologic ¹⁸F-FDG imaging, scan duration or activity administration could be reduced by a factor of 3 or more with the use of the clinical+G2 or the EARL-compliant reconstruction protocol.

Symmetric division of stem cells positive for gastrin receptor CCK2R is linked to gastric cancer.

A new contest aims to help first responders leverage computer vision algorithms and drone imagery during a search

Stay home, keep gaming

TD also said it will have about $600 million of set-asides tied to U.S. credit cards