For clean-room technologies such as isolators and restricted access barrier systems (RABS), decontamination using hydrogen peroxide (H₂O₂) is increasingly attractive to fulfill regulatory requirements. Several approaches are currently used, ranging from manual wipe disinfection to vapor phase hydrogen peroxide (VPHP) or automated nebulization sanitization. Although the residual airborne H₂O₂ concentration can be easily monitored, detection of trace H₂O₂ residues in filled products is rather challenging. To simulate the filling process in a specific clean room, technical runs with water for injection (WfI) are popular. Thus, the ability to detect traces of H₂O₂ in water is an important prerequisite to ensure a safe and reliable use of H₂O₂ for isolator or clean room decontamination. The objective of this study was to provide a validated quantitative, fluorometric Amplex UltraRed assay, which satisfies the analytical target profile of quantifying H₂O₂ in WfI at low nanomolar to low micromolar concentrations (ppb range) with high accuracy and high precision. The Amplex UltraRed technology provides a solid basis for this purpose; however, no commercial assay kit that fulfills these requirements is available. Therefore, a customized Amplex UltraRed assay was developed, optimized, and validated. This approach resulted in an assay that is capable of quantifying H₂O₂ in WfI selectively, sensitively, accurately, precisely, and robustly. This assay is used in process development and qualification approaches using WfI in H₂O₂-decontaminated clean rooms and isolators.

BACKGROUND AND PURPOSE:

Physician-industry relationships can be useful for driving innovation and technologic progress, though little is known about the scale or impact of industry involvement in neuroradiology. The purpose of this study was to assess the trends and distributions of industry payments to neuroradiologists.

Practicing family medicine is really hard; the emotional toll of sharing patients’ distress, vulnerability, and trauma can build up and become overwhelming. A family physician experienced such a moment during one particularly complex morning. Feeling nearly ready to walk out of patient care, she reached out to the team nurse, who helped her get through the moment and re-engage with the waiting patients. Sharing vulnerability in the moment, and later reflecting and deciding to write about it shows the power of prioritizing teamwork in practice.

PURPOSE

We undertook a trial to test the efficacy of a technology-assisted health coaching intervention for weight management, called Goals for Eating and Moving (GEM), within primary care.

COPD is a heterogeneous condition, with tobacco smoking being the main environmental risk factor. The presence of type 2 (T2) inflammation is a well-recognised feature of asthma; however, it is now apparent that a subset of COPD patients also displays evidence of T2 inflammation with respect to elevated eosinophil counts and altered gene and protein expression of several T2 inflammatory mediators. T2 inflammatory mediators represent an attractive therapeutic target in both COPD and asthma; however, the efficacy of pharmaceutical interventions varies between diseases. Furthermore, the nature of some shared clinical features also differs. We provide a narrative review of differences in the nature of T2 inflammation between COPD and asthma, which may partly explain phenotypic differences between diseases. We focus on evidence from studies of pulmonary histopathology, sputum and epithelial gene and protein expression, and response to pharmacological interventions targeted at T2 inflammation.

Robert Eggers' re-imagining of the legendary vampire has his fangs out for prey in a very unusual manner.

Danielle Smith says she is “100 per cent committed” to a leaked plan to replace Alberta Health Services with new health boards, agencies, bureaucracy, all directed out of her office.

The post UCP set to announce plan to bust up AHS appeared first on rabble.ca.

Ministers must follow the UK Government and extend rates relief for businesses in Scotland, Anas Sarwar has said.

Anna Marie briefly stops by to tell us about what she's been playing while recovering. The Series X has a price now, will the PS5 get one this week? Also, PAX is happening!

The post RPG Cast – Episode 555: “Kelley Just Wants to Fight You” appeared first on RPGamer.

Alex looks so good he must be rendered. Robert rickrolls all the things. Kelley is our Neptunian Angel. Chris is getting ready to Rise, but first he must Ryza.

The post RPG Cast – Episode 578: “Sorry, I Just Don’t Care” appeared first on RPGamer.

The podcast trio is not at all ready for the flood of September releases. Anna Marie is kind of sick of the trigger, Chris insists Eclipse is owed an apology, and Kelley wants to know what is this garbage and how she can get more of it.

The post RPG Cast – Episode 599: “Serious Health Issues? No, Just a Cat” appeared first on RPGamer.

Josh demands justice for Jorts. Chris is deployed to the circus wars. And Kelley assures us that Fang sniper is real. We'll see you in 2022. Don't butter your cats!

The post RPG Cast – Episode 612: “He Must Have Put Skill Points Into Broom Handle” appeared first on RPGamer.

On this week's show, Chris gets run over by a wheat thresher, Robert throws his phone at a car, Kelley's cat gets offended at being a prop for gaming, and Josh goes kart racing in Horizon Forbidden West.

The post RPG Cast – Episode 620: “I Just Got Barbecued in a Grave Pit” appeared first on RPGamer.

Kelley thinks like a cat. Chris experiments with broccoli. Josh sells weed with Snoop Dogg. Don't tempt the mouse.

The post RPG Cast – Episode 639: “Can We Just Kill This Guy and Get a New Hero” appeared first on RPGamer.

Chris has a picnic with Emet-Selch. Kelley gets kicked out of the guild by her husband. Vahn drowns in gacha games. And everyone is honking. What is going on?

The post RPG Cast – Episode 662: “That’s Just a Skill Issue” appeared first on RPGamer.

Kelley risks her life trimming her cat's nails. Chris optimizes Eiyuden Chronicle live on stream. Robert plays dental roulette.

The post RPG Cast – Episode 722: “They’re Just a Stack of Rocks” appeared first on RPGamer.

More than a billion passengers flew with budget airlines last year, helping lift total passengers to 3.7 billion.

Call of Duty: Black Ops 6 has remained in first place on the Australian charts, according to IGEA for the week ending November 3, 2024.

There were three new releases in the top 10 this week with Dragon Age: The Veilguard debuting in second place, Horizon Zero Dawn Remastered in fourth place, and Life Is Strange: Double Exposure in ninth place.

Hogwarts Legacy is up one spot to third place, EA Sports FC 25 remained in fifth place, and Super Mario Party Jamboree dropped from second to sixth place.

Red Dead Redemption is in seventh place, NBA 2K25 is in eight place, and Battlefield 2042 rounds out the top 10.

Here are the top 10 best-selling titles in Australia for the week:

1. Call of Duty: Black Ops 6
2. Dragon Age: The Veilguard - NEW
3. Hogwarts Legacy
4. Horizon Zero Dawn Remastered - NEW
5. EA Sports FC 25 
6. Super Mario Party Jamboree
7. Red Dead Redemption
8. NBA 2K25
9. Life Is Strange: Double Exposure - NEW
10. Battlefield 2042

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463028/dragon-age-the-veilguard-debuts-in-2nd-on-the-australian-charts/

One of my favourite satires is the Screwtape Letters, an epistolary novel by Narnia scribe C.S. Lewis. It consists of messages from an oily elder demon to his nephew about how to correctly groom the soul of an unsuspecting human being. It's a claustrophobic send-up of managerial politics and nepotism, with World War 1 unfolding in the background. A real pick-me-up. Sintopia is the Two Point incarnation of that premise - in other words, brighter and breezier and definitely more slapstick than Christian. It puts you in charge of a world divided between Earth and hell, and challenges you to ensure a steady movement of optimally sinful souls between one and the other. Say your prayers and watch the trailer.

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Today in "person you already like says something you already agree with, but it’s still good to hear them say it" news, Arkane founder and im-simmy RPG studio WolfEye head Raphael Colantonio has spoken on Microsoft’s decision to shutter Prey (2017) studio Arkane Austin - alongside a handful of others - back in May.

Colantonio, who founded Arkane in 1999 and departed in 2017 to form Weird West studio WolfEye, recently chatted to Jeremy Peel for PC Gamer about Arkane’s closure, saying:

I think if you look a little bit, it's obvious that Arkane Austin was a very special group of people that have made some cool things and that could pull it off again. I think it was a decision that just came down to, 'We need to cut something.' Was it to please the investors, the stock market? They're playing a different game.

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Inflexion Games are closing their UK office, laying off staff and restructuring their main Canadian studio after failing to find commercial success with their Victorian fantasy survival game Nightingale. Reportedly, at least 22 people have been let go.

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Twitch have introduced a new "Politics and Sensitive Social Issues" label for streams that "focus" on topics like "elections, civic integrity, and war or military conflict". As with the streaming giant's existing labels for M-rated material, sexual themes or depictions of gambling, the idea is that viewers can filter out such streams in advance by altering their settings.

Advertisers, similarly, can "make better choices about the content they want to advertise next to" - in other words, pull their ads from a whole swathe of material if they don't want to be associated with anything controversial. Twitch's hope is that "the labels will allow advertisers to have more context to inform which types of streams they show their ads alongside, which we expect to increase brands’ confidence in running ads on Twitch, and could bring new advertisers to our service."

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It was the 20-year anniversary of Halo 2 at the weekend, which saw the shooter's modern counterparts celebrating with classic multiplayer maps and long-lost levels. But also emerging from the dust of time are insights to the sequel's development back in 2004. Rolling Stone interviewed two key designers of the game and made a fun discovery. The Flood (the sickly pale alien infestation that briefly turns Halo into sci-fi horror) was partly inspired by a colourful and innocent children's book about a nice elephant.

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After nearly a year of public beta honing, the Nvidia App – Team Green’s new one-stop shop for desktop GPU management – is out in full. Not alongside the upcoming RTX 50 series, as rumoured, but right-now-today-this-minute. I’ve been testing out the launch version and while it’s not without some dud features, it does agreeably achieve its stated goal of combining the functions within Nvidia Control Panel and GeForce Experience. And if installing it means never having to use the latter again, well, that’s 149MB well spent.

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It is nearly time for one of astronomy's top annual sights – the Perseid meteor shower. This year is a bit special, says Abigail Beall

The Milky Way may be home to strange black holes from the first moments of the universe, and the best candidates are the three closest black holes to Earth

Nearly imperceptible quantum flickers used to limit how precisely we could detect the way space-time ripples, but squeezing the laser light used in detectors overcomes this and doubles the number of gravitational waves we can see

Astronomers have detected an exoplanet around Barnard’s star, one of the sun’s closest neighbours, but it is too hot for liquid water or life

SpaceX is preparing for the sixth test flight of Starship, the world's most powerful rocket. Next week's launch – if successful – will be the fastest turnaround yet

You might have heard about plans to establish a self‑sustaining city on Mars. Here’s what life would really be like on the Red Planet

‘Battle of Technologies’ sees electric vehicles and combustion cars compete at the highest level. Who will win?

A powerful new AI called o1 is the most dangerous that OpenAI has ever released, the firm claims – but who are these warnings for, asks Chris Stokel-Walker

The US Census Bureau processes data before publishing it in order to keep personal information private – but a new approach could maintain the same privacy while improving accuracy

Former FIA race director Niels Wittich has rejected the motorsport governing body's version regarding his departure.

The water column is hazy as an unusual remotely operated vehicle glides over the seafloor in search of a delicate tilt meter deployed three years ago off the west side of Vancouver Island. The sensor measures shaking and shifting in continental plates that will eventually unleash another of the region’s 9.0-scale earthquakes (the last was in 1700). Dwindling charge in the instruments’ loggers threatens the continuity of the data.

The 4-metric-ton, C$8-million (US $5.8-million) remotely operated vehicle (ROV) is 50 meters from its target when one of the seismic science platforms appears on its sonar imaging system, the platform’s hard edges crystallizing from the grainy background like a surgical implant jumping out of an ultrasound image. After easing the ROV to the platform, operators 2,575 meters up at the Pacific’s surface instruct its electromechanical arms and pincer hands to deftly unplug a data logger, then plug in a replacement with a fresh battery.

This mission, executed in early October, marked an exciting moment for Josh Tetarenko, director of ROV operations at North Vancouver-based Canpac Marine Services. Tetarenko is the lead designer behind the new science submersible and recently dubbed it Jenny in homage to Forrest Gump, because the fictional character named all of his boats Jenny. Swapping out the data loggers west of Vancouver Island’s Clayoquot Sound was part of a weeklong shakedown to test Jenny’s unique combination of dexterity, visualization chops, power, and pressure resistance.

Jenny is only the third science ROV designed for subsea work to a depth of 6,000 meters.

By all accounts Jenny sailed through. Tetarenko says the worst they saw was a leaky O-ring and the need to add some spring to a few bumpers. “Usually you see more things come up the first time you dive a vehicle to those depths,” says Tetarenko.

Jenny’s successful maiden cruise is just as important for Victoria, B.C.–based Ocean Networks Canada (ONC), which operates the NEPTUNE undersea observatory. The North-East Pacific Time-series Undersea Networked Experiments array boasts thousands of sensors and instruments, including deep-sea video cameras, seismometers, and robotic rovers sprawled across this corner of Pacific. Most of these are connected to shore via an 812-kilometer power and communications cable. Jenny was custom-designed to perform the annual maintenance and equipment swaps that have kept live data streaming from that cabled observatory nearly continuously for the past 15 years, despite trawler strikes, a fault on its backbone cable, and insults from corrosion, crushing pressures, and fouling.

NEPTUNE remains one of the world’s largest installations for oceanographic science despite a proliferation of such cabled observatories since it went live in 2009. ONC’s open data portal has over 37,000 registered users tapping over 1.5 petabytes of ocean data—information that’s growing in importance with the intensification of climate change and the collapse of marine ecosystems.

Over the course of Jenny’s maiden cruise, her operators swapped devices in and out at half a dozen ONC sites, including at several of NEPTUNE’s five nodes and at one of NEPTUNE’s smaller sister observatories closer to Vancouver.

Inside Jenny

ROV Jenny aboard the Valour, Canpac’s 50-meter offshore workhorse, ahead of October’s NEPTUNE observatory maintenance cruise.Ocean Networks Canada

What makes Jenny so special?

• Jenny is only the third science ROV designed for subsea work to a depth of 6,000 meters.
• Motion sensors actively adjust her 7,000-meter-long umbilical cable to counteract topside wave action that would otherwise yank the ROV around at depth and, in rough seas, could damage or snap the cable.
• Dual high-dexterity manipulator arms are controlled by topside operators via a pair of replica mini-manipulators that mirror the movements.
• Each arm is capable of picking up objects weighing about 275 kilograms, and the ROV itself can transport equipment weighing up to 3,000 kg.
• 11 high-resolution cameras deliver 4K video, supported by 300,000 lumens of lighting that can be tuned to deliver the soft red light needed to observe bioluminescence.
• Dual multibeam sonar systems maximize visibility in turbid water.

Meghan Paulson, ONC’s executive director for observatory operations, says the sonar imaging system will be particularly invaluable during dives to shallower sites where sediments stirred up by waves and weather can cut visibility from meters to centimeters. “It really reduces the risk of running into things accidentally,” says Paulson.

To experience the visibility conditions for yourself, check out recordings of the live video broadcast from the NEPTUNE maintenance cruise. Tetarenko says that next year they hope to broadcast not only the main camera feed but also one of the sonar images.

3D video could be next, according to Canpac ROV pilot and Jenny codesigner, James Barnett. He says they would need to boost the computing power installed topside, to process that “firehose of data,” but insists that real-time 3D is “definitely not impossible.” Tetarenko says the science ROV community is collaborating on software to help make that workable: “3D imagining is kind of the very latest thing that’s being tested on lots of ROV systems right now, but nobody’s really there yet.”

More Than Science

Expansion of the cabled observatory concept is the more certain technological legacy for ONC and NEPTUNE. In fact, the technology has evolved beyond just oceanography applications.

ONC tapped Alcatel Submarine Networks (ASN) to design and build the Neptune backbone and the French firm delivered a system that has reliably delivered multigigabit Ethernet plus 10 kilovolts of direct-current electricity to the deep sea. Today ASN deploys a second-generation subsea power and communications networking solution, developed with the Norwegian international energy company Equinor.

ASN’s “Direct Current/Fiber Optic” or DC/FO system provides the 100-km backbone for the ARCA subsea neutrino observatory near Sicily, in addition to providing control systems for a growing number of offshore oil and gas installations. The latter include projects led by Equinor and BP where DC/FO networks drive the subsea injection of captured carbon dioxide and monitor its storage below the seabed. Future oil and gas projects will increasingly rely on the cables’ power supply to replace the hydraulic lines that have traditionally been used to operate machinery on the seafloor, according to Ronan Michel, ASN’s product line manager for oil and gas solutions.

Michel says DC/FO incorporates important lessons learned from the Neptune installation. And the latter’s existence was a crucial prerequisite. “The DC/FO solution would probably not exist if Neptune Canada would not have been developed,” says Michel. “It probably gave confidence to Equinor that ASN was capable to develop subsea power and coms infrastructure.”

Eliminating this pernicious policy should be on the Trump administration's first week to-do list.

The election is over and the economy had a huge impact. An AP analysis said 96% of those surveyed admitted that prices of gas and groceries had an influence on their vote.

Just got a PS5 or want to know what to prioritise in your backlog? We've got you covered with the best PlayStation 5 games for your console that you can play right now.

Scientists say geoengineering, or doing things like intentionally increasing Earth’s reflectivity or blocking the sun, is a “really big deal” in slowing down climate change. Here are the ideas they are proposing.

Cement is ubiquitous, but the process of making it emits carbon into the atmosphere. The industry says there's no easy way to avoid that, which is why it's turning to carbon capture and storage technology as a way to decarbonize.

A new Government Accountability Office report says that the Justice Department kept FBI employees in the dark for seven years after Congress updated whistleblower protections for bureau personnel in 2016.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents

The Massimo Modular E9 is a sleek, smart and comfy tiny home in 409 square feet. Tech expert Kurt “CyberGuy" Knutsson takes a closer look at what the future of housing might look like.

Tech expert Kurt “CyberGuy" Knutsson says opening emails is safe, but risks arise from interacting with links, attachments or HTML content.

The Portuguese midfielder is settling into life in east London well after his loan move.

… the opening round of the Davis Cup World Group on hard court … . Kyrgios led Australia to the Davis Cup semi-finals this year, while Zverev ….

Arsenal and England midfielder Jordan Nobbs will be a columnist for 90min & BBC Sport pundit at the Women's World Cup in France this summer, as Phil Neville's Lionesses' look to secure a maiden World Cup triumph. Two wins from our first two games is obviously what we were all hoping for. The first game of a World Cup, or any other major tournament, is never going to be one where you're playing at your absolute best. But the 2-1 win over was Scotland was great given the pre-match hype, the..