The company’s 83-year-old chairman, John Malone, will be the interim CEO.

The Formula 1 race director has one of the most crucial roles in the sport.

Formula 1 is to introduce a device to cool drivers when conditions become too extreme in hot weather, in response to scenes at last year’s Qatar Grand Prix.

President and chief executive officer of Formula 1 owner Liberty Media, Greg Maffei, is to step down from his role at the end of the year.

Canal+ a confirmé le départ de sa journaliste vedette. Cette dernière aurait été contactée par TF1 pour remplacer Patrick Poivre d'Arvor à la présentation du journal de 20h. Des commentateurs voient dans ce changement des "gages donnés" à Nicolas Sarkozy...

(Telecompaper) France's leading TV channel TF1 said that viewers of its TF1+ streaming service can now access over 2,000 hours of additional content following a distribution partnership with Franco-German TV network Arte. As part of the agreement, the entire offering within the Arte.tv platform will be available...

F1 has announced a new 2025 season launch event where all 10 teams will unveil their livery on February 18, marking the start of the championship’s 75th anniversary year. Tickets will be available for fans to attend the event, which will be held at London’s The O2.

1. F1 2025 launch event tickets go on sale on November 15
2. All 20 drivers will be present

F1 2025 season launch tickets, livestream

All 10 F1 teams will be unveiling their 2025 season liveries at the event. An official statement shared by F1 says the event will also feature interviews with key figures from the sport – including the drivers and team principals – as well as entertainment segments and special guest presenters.

The event will take place on February 18 from 8pm-10pm GMT (1:30am-3:30am IST) and ticket prices range from £58 to £113 (around Rs 6,200-12,000). Tickets go on sale on Friday, November 15.

For fans who can’t attend the event in person, there will also be a livestream. Further details on this will be revealed in the coming weeks.

“For the first time we will bring together our fans, all 20 superstars of our sport and some very special guests to officially kick off our new season and mark our 75th year of racing,” said Stefano Domenicali, president and CEO of Formula 1.

“With 2025 set to be a classic season following all the drama so far for 2024, this is a fantastic opportunity for fans of all ages to experience up-close the incredible entertainment spectacle that is Formula 1.”

Will teams show their real cars?

It is very unlikely that teams will showcase their final 2025 contenders at the event.

2025 F1 pre-season testing will take place from February 26-28 in Bahrain. Given that most teams will not want to give away any major secrets ahead of this, we can expect the launch event to largely feature show cars simply sporting the new liveries. But this has already been the case for several years now, with majority of the teams opting to share cleverly concealed renders or displaying show cars during their individual launch events.

What about traditional F1 launches?

This replaces the standard pre-season build-up where teams usually hold their own launch events across several weeks. However, F1 hasn’t confirmed whether this will be a permanent addition. For now, it’s simply been billed as a special event to celebrate the championship’s 75th anniversary.

Also see:

F1 2024: Verstappen wins Brazil GP from P17 on grid

F1 has announced a new 2025 season launch event where all 10 teams will unveil their livery on February 18, marking the start of the championship’s 75th anniversary year. Tickets will be available for fans to attend the event, which will be held at London’s The O2.

1. F1 2025 launch event tickets go on sale on November 15
2. All 20 drivers will be present

F1 2025 season launch tickets, livestream

All 10 F1 teams will be unveiling their 2025 season liveries at the event. An official statement shared by F1 says the event will also feature interviews with key figures from the sport – including the drivers and team principals – as well as entertainment segments and special guest presenters.

The event will take place on February 18 from 8pm-10pm GMT (1:30am-3:30am IST) and ticket prices range from £58 to £113 (around Rs 6,200-12,000). Tickets go on sale on Friday, November 15.

For fans who can’t attend the event in person, there will also be a livestream. Further details on this will be revealed in the coming weeks.

“For the first time we will bring together our fans, all 20 superstars of our sport and some very special guests to officially kick off our new season and mark our 75th year of racing,” said Stefano Domenicali, president and CEO of Formula 1.

“With 2025 set to be a classic season following all the drama so far for 2024, this is a fantastic opportunity for fans of all ages to experience up-close the incredible entertainment spectacle that is Formula 1.”

Will teams show their real cars?

It is very unlikely that teams will showcase their final 2025 contenders at the event.

2025 F1 pre-season testing will take place from February 26-28 in Bahrain. Given that most teams will not want to give away any major secrets ahead of this, we can expect the launch event to largely feature show cars simply sporting the new liveries. But this has already been the case for several years now, with majority of the teams opting to share cleverly concealed renders or displaying show cars during their individual launch events.

What about traditional F1 launches?

This replaces the standard pre-season build-up where teams usually hold their own launch events across several weeks. However, F1 hasn’t confirmed whether this will be a permanent addition. For now, it’s simply been billed as a special event to celebrate the championship’s 75th anniversary.

Also see:

F1 2024: Verstappen wins Brazil GP from P17 on grid

Formula 1 drivers urged the operators of the Interlagos circuit to improve the new surface they laid ahead of this year's event.

In the round-up: F1 hopes for South Americans "getting better" • Verschoor back to MP for fifth F2 season • Verstappen races in charity event

Gabriel Bortoleto said he was determined not to sit out a year of racing in 2025 after Sauber confirmed he will make his debut for them in Formula 1 next year.

Liam Lawson is unhappy the British national anthem is played when McLaren win. But would the New Zealand anthem really be more correct?

Alpine have officially announced they will use Mercedes power units when Formula 1 introduces its new engine regulations in 2026.

Niels Wittich has unexpectedly stood down from his role as Formula 1's race director. The FIA named Rui Marques as his replacement.

All 10 Formula 1 teams will participate in a new "season launch event" in February next year to reveal their liveries together.

Niels Wittich's unexpected departure as Formula 1's race director recreates the circumstances in which Michael Masi was thrown in at the deep end.

Max Verstappen suggests he won't change his aggressive driving this weekend at the Brazilian Grand Prix as he bids for a fourth successive Formula 1 title.

Sauber has signed 20-year-old Brazilian driver Gabriel Bortoleto to make his debut in Formula 1 next year as Nico Hulkenberg's teammate.

Formula 1 drivers have criticized the president of the sport's governing body, the FIA, and asked to be treated like adults in an escalating row over swearing in news conferences.

The struggling Alpine Formula 1 team will use engines and gearboxes from Mercedes starting in 2026 after parent company Renault cuts its in-house F1 engine program.

Formula 1 race director Niels Wittich will be replaced in a surprise move with three races to go and the title yet to be decided.

The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a small EDRK-rich factor 1a (SERF1a) in promoting Httex1 fibrillization through interactions with its N terminus. By establishing an integrated approach with size-exclusion-column-based small- and wide-angle X-ray scattering (SEC-SWAXS), NMR, and molecular simulations using Rosetta, the analysis here reveals a tight binding of two NT17 fragments of Httex1 (comprising the initial 17 amino acids at the N terminus) to the N-terminal region of SERF1a. In contrast, examination of the complex structure of SERF1a with a coiled NT17-polyQ peptide (33 amino acids in total) indicates sparse contacts of the NT17 and polyQ segments with the N-terminal side of SERF1a. Furthermore, the integrated SEC-SWAXS and molecular-simulation analysis suggests that the coiled NT17 segment can transform into a helical conformation when associated with a polyQ segment exhibiting high helical content. Intriguingly, NT17-polyQ peptides with enhanced secondary structures display diminished interactions with SERF1a. This insight into the conformation-dependent binding of NT17 provides clues to a catalytic association mechanism underlying SERF1a's facilitation of Httext1 fibrillization.

built for those who aspire to challenge the limit of the course

Engineered to deliver unparalleled energy efficiency and versatility, the GK-F16 is set to revolutionize lighting solutions for a variety of large-scale environments such as warehouses, supermarkets, and stadiums.

12 ноября на полках магазинов Великобритании появится новая книга о Формуле 1, которая обещает стать бестселлером. Называется она «Внутри Mercedes F1»...

В Alpine F1 подтвердили, что с 2026 года на машинах команды будут стоять двигатели и коробки передач производства Mercedes...

Good deals, just grabbed FF16, AC VI, and Jedi Survivor, don't forget to use the coupon for an extra 10% off!

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Britain's Oliver Bearman, 18, discusses his F1 debut and the prospect of working alongside seven-time world champion Lewis Hamilton at Ferrari.

Trying to find the balance between pure engineering and entertainment has been a very difficult balancing act over the years in Formula 1, but many in the sport think we seeing the signs of change as the cost cap takes effect on track.

McLaren's Lando Norris talks to BBC Sport about why he wants Formula One to retain the "sound and smell" that first sparked his love for the sport.

F1 in 10 Years is a new BBC Sport series that talks to the decision-makers in Formula One about the future they would like to see.

Drivers seen as gladiators are a thing of the past, according to motorsport's safety figurehead.

Honda and Alpine are fined by governing body the FIA after being found guilty of breaching Formula 1's cost-cap rules for engine manufacturers in 2023.

The 2024 title fight is getting heated between Max Verstappen and Lando Norris - here are eight other memorable championship battles.

In the latest 'F1 in 10 Years' video, BBC Sport asks young fans what changes they would like to see in the sport over the next decade.

Ayrton Senna, Michael Schumacher, Lewis Hamilton and Max Verstappen have all mastered treacherous conditions to win F1 races - but which was the best?

Formula 1 drivers urge the sport's governing body to treat them like adults after Max Verstappen and Charles Leclerc were punished for swearing.

BBC F1 correspondent Andrew Benson answers your questions as we approach the final three races of the 2024 season.

Litong Nie
Dec 1, 2020; 19:2015-2029
Research

Xinting Zhang
Dec 8, 2020; 0:RA120.002306v1-mcp.RA120.002306
Research

The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state.

Specific E3 ligases target tumor suppressors for degradation. Inhibition of such E3 ligases may be an important approach to cancer treatment. RNF146 is a RING domain and PARylation-dependent E3 ligase that functions as an activator of the β-catenin/Wnt and YAP/Hippo pathways by targeting the degradation of several tumor suppressors. Tankyrases 1 and 2 (TNKS1/2) are the only known poly-ADP-ribosyltransferases that require RNF146 to degrade their substrates. However, systematic identification of RNF146 substrates have not yet been performed. To uncover substrates of RNF146 that are targeted for degradation, we generated RNF146 knockout cells and TNKS1/2-double knockout cells and performed proteome profiling with label-free quantification as well as transcriptome analysis. We identified 160 potential substrates of RNF146, which included many known substrates of RNF146 and TNKS1/2 and 122 potential TNKS-independent substrates of RNF146. In addition, we validated OTU domain-containing protein 5 and Protein mono-ADP-ribosyltransferase PARP10 as TNKS1/2-independent substrates of RNF146 and SARDH as a novel substrate of TNKS1/2 and RNF146. Our study is the first proteome-wide analysis of potential RNF146 substrates. Together, these findings not only demonstrate that proteome profiling can be a useful general approach for the systemic identification of substrates of E3 ligases but also reveal new substrates of RNF146, which provides a resource for further functional studies.

Gonadal soma-derived factor (gsdf) has been demonstrated to be essential for testicular differentiation in medaka (Oryzias latipes). To understand the protein dynamics of Gsdf in spermatogenesis regulation, we used a His-tag "pull-down" assay coupled with shotgun LC-MS/MS to identify a group of potential interacting partners for Gsdf, which included cytoplasmic dynein light chain 2, eukaryotic polypeptide elongation factor 1 alpha (eEF1α), and actin filaments in mature medaka testis. As for the interaction with TGFβ-dynein being critical for spermatogonial division in Drosophila melanogaster, the physical interactions of Gsdf-dynein and Gsdf-eEF1α were identified through a yeast 2-hybrid (Y2H) screening of an adult testis cDNA library using Gsdf as bait, which were verified by a paired Y2H assay. Co-immunoprecipitation of Gsdf and eEF1α was defined in adult testes as supporting the requirement of a Gsdf and eEF1α interaction in testis development. Proteomics analysis (data are available via ProteomeXchange with identifier PXD022153) and ultrastrutural observations showed that Gsdf deficiency activated eEF1α-mediated protein synthesis and ribosomal biogenesis, which in turn led to the differentiation of undifferentiated germ cells. Thus, our results provide a framework and new insight into the coordination of a Gsdf (TGFβ and eEF1α complex in the basic processes of germ cell proliferation, transcriptional and translational control of sexual RNA which may be fundamentally conserved across phyla during sexual differentiation.

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Alpine F1 team will make switch to Mercedes-Benz AMG power units in 2026 Agreement lasts until at least 2030 Former supplier Renault is ending F1 power unit program to focus on EV technology The Alpine Formula 1 team on Tuesday announced plans to switch to power units and gearboxes from Mercedes-Benz AMG starting in 2026, when F1 is due to...