Animal germline development and fertility rely on paralogs of general transcription factors that recruit RNA polymerase II to ensure cell type-specific gene expression. It remains unclear whether gene expression processes downstream from such paralog-based transcription is distinct from that of canonical RNA polymerase II genes. In Drosophila, the testis-specific TBP-associated factors (tTAFs) activate over a thousand spermatocyte-specific gene promoters to enable meiosis and germ cell differentiation. Here, we show that efficient termination of tTAF-activated transcription relies on testis-specific paralogs of canonical polymerase-associated factor 1 complex (PAF1C) proteins, which form a testis-specific PAF1C (tPAF). Consequently, tPAF mutants show aberrant expression of hundreds of downstream genes due to read-in transcription. Furthermore, tPAF facilitates expression of Y-linked male fertility factor genes and thus serves to maintain spermatocyte-specific gene expression. Consistently, tPAF is required for the segregation of meiotic chromosomes and male fertility. Supported by comparative in vivo protein interaction assays, we provide a mechanistic model for the functional divergence of tPAF and the PAF1C and identify transcription termination as a developmentally regulated process required for germline-specific gene expression.

C'était une nouvelle attendue.

Niels Wittich leaves his role as Formula 1's race director with immediate effect.

German luxury carmaker Mercedes has launched the Mercedes-AMG C 63 S E-Performance sedan in India. The Mercedes-AMG C 63 S E-Performance is priced at Rs 1.95 crore (ex-showroom) and is the 14th and final product launch for the German marque for

“The independent investigation into the allegations made against Mr. Horner is complete, and Red Bull can confirm that the grievance has been dismissed,” said Red Bull GmbH

Rain isn't a major concern in Bahrain so problem drains at two corners have simply been filled in with concrete.

Pérez remains convinced the team is united.

Four-time Formula 1 champion Sebastian Vettel is getting back behind the wheel

The 24-race season will commence on March 16 in Melbourne and end on Dec. 7 in Abu Dhabi as Formula One celebrates the 75th anniversary of its world championship.

Lando Norris needed 110 starts and a mistake by Max Verstappen to earn his first ever Formula 1 race and end Verstappen’s dominance at the Miami Grand Prix

In a highly complex sport, the 65-year-old design genius — F1’s foremost aerodynamicist — is the closest guarantee of success. And so while Lewis Hamilton’s Ferrari move is seismic, Newey’s departure is much more significant, in terms of its potential effect on the pecking order

Verstappen has won six of the nine races so far this season and recorded his 60th career win in Montreal two weeks ago.

Max Verstappen has steered his Red Bull to victory at the Spanish Grand Prix to increase his lead of the Formula 1 drivers championship

The sport’s fans have longed for a situation in which multiple constructors are in contention for victories, and out of nowhere in 2024, this compelling scenario has manifested. Moreover, the four teams that have tasted victory this year have top driver lineups, which allows for great racing

Lando Norris leads Oscar Piastri in McLaren qualifying one-two; Verstappen comes third

Max Verstappen celebrates 200 F1 races and hints at retirement before No. 400, keeping future options open

Verstappen came in second for Red Bull after a race that was largely uneventful after he held off Lewis Hamilton into the first corner at the start

The 35-year-old Ricciardo knew at the Singapore Grand Prix it was likely his final F1 race

The drivers’ championship appeared a foregone conclusion at one stage this season, but Norris and McLaren have changed the complexion of the title picture. While Verstappen still enjoys a 52-point lead, Norris is the in-form driver — the final run of races could well be the making of him

Max Verstappen delivered one of the best performances of his career to move up from 17th at the start and clinch victory

The win was a first for Ferrari in Mexico since 1990 and fourth of Carlos Sainz's career.

“In order to be a great Formula 1 driver, you need to have the cognitive capabilities of a chess grandmaster, the strength, stamina, and reactions of a fighter, and then you also have to have the endurance of a marathon runner.” Former F1 performance coach Clayton Green breaks down precisely why they average person would be unable to drive a Formula One car—and why the professionals are such unique athletes.

RB driver Liam Lawson apologised to Sergio Perez after the pair clashed at the Mexican Grand Prix but the New Zealand rookie said he would not change his aggressive approach to Formula One racing.

McLaren are leading the constructor's championship but are only 29 points ahead of Ferrari, with Leclerc an obvious threat and team mate Carlos Sainz qualifying fifth and Mercedes' George Russell sixth.

Red Bull's Max Verstappen dealt Lando Norris a shattering blow in their Formula One title battle by winning a wet and chaotic Sao Paulo Grand Prix from 17th on the grid.

India could finally have a driver on the F1 grid after 13 long years.

Two-time Formula One World Champion Fernando Alonso attended the event and emphasised the pivotal role of Cognizant’s technology in driving improvements on and off the track

“With many advanced technological features present in Formula One cars, Cognizant, the US-based IT company with a large presence in India, plays a critical role in improving the performance of the car”

India could finally have a driver on the F1 grid after 13 long years.

Few of these bikes hold the promise of performance that will excite college-going kids while some can be entertaining even for the mature riders.

Sergio Perez has revealed that the financial problems at the former Force India squad were evident on the first day he visited its factory before the 2014 Formula 1 season

Daniel Ricciardo says Formula 1’s return will see ‘chaos’ in the opening race as drivers get back in the car for the first time after the coronavirus-enforced break.

When watching Formula One, it can be easy to forget these drivers are taking their lives in their own hands.

Formula One world champion Lewis Hamilton admits the confusion of whether the Australian Grand Prix should have gone ahead was a huge “shock to the system”.

Lewis Hamilton says he's getting messages from fans desperate to see the return of Formula One, but the six-time world champion feels races without them will be "worse than a test day".

David Coulthard has pointed his finger at former FIA president Max Mosley after Sunday's processional start to the 2010 season in Bahrain

Jerome d'Ambrosio insists that has Formula One career is not over after Virgin announced that it will replace him with Charles Pic for the 2012 season

Nico Rosberg is hoping Mercedes' rivals can make a step up and start providing some competition this weekend in Malaysia and is particularly looking forward to Ferrari driver Sebastian Vettel joining in on his Friday debrief

The boss of the Australian Grand Prix Ron Walker has labelled Formula One drivers "lazy prima donnas" after they complained about low light levels at this year's race

Max Verstappen says his early elevation to Formula One feels perfectly normal after he received some pearls of wisdom ahead of his debut from some of the sport's most experienced drivers

Volunteers who help the British Grand Prix run smoothly want to get back trackside but questions remain on safety and testing

“We are like one big family,” says Carolyn Doyle of the bond between the marshals of the British Grand Prix. “We are there because we love it and we want to achieve the same thing – that’s what makes it really special.”

Much as it does bring great pleasure to this selfless collective, the sport knows their presence is invaluable. As Silverstone considers hosting two consecutive races behind closed doors in July, the volunteer marshals are having to consider the new realities imposed on Formula One by the coronavirus crisis.

Ahead of the 2020 F1 season, here's a look at what the racers would be driving if they had to pilot the best road cars made by their respective teams - and where they'd be on the grid.

Who do you think you are, sir? Stirling Moss? It was the disapproving question asked time and again - until police pulling over motorists grew too young to remember one of Britain's greatest racers.

Lewis Hamilton said racing without fans will be weird as they are the ones who really make that race.

Daniel Ricciardo cannot wait for Formula One to get back to racing in a COVID-19 blighted season, and when it does he reckons the first grand prix could be a recipe for chaos.

Six-times Formula One world champion Lewis Hamilton says the prospect of a home British Grand Prix without spectators leaves him empty inside but he is still raring to get going after months of waiting.