weight Mental Health of Extremely Low Birth Weight Survivors in Their 30s By pediatrics.aappublications.org Published On :: 2015-02-09T00:05:26-08:00 Little is known about the mental health of extremely low birth weight survivors in their 30s. It is also unclear whether being born small for gestational age or being exposed to antenatal corticosteroids increases risk in this group.In their 30s, extremely low birth weight survivors are less likely to have substance problems but are at elevated risk for other psychiatric disorders. Those born small for gestational age are at higher risk, but those exposed to antenatal corticosteroids are at the greatest risk of all. (Read the full article) Full Article
weight Antibiotic Exposure in Infancy and Risk of Being Overweight in the First 24 Months of Life By pediatrics.aappublications.org Published On :: 2015-03-30T00:05:22-07:00 Subtherapeutic doses of antibiotics have been used as growth promoters in animal farming since the 1950s. Antibiotic exposure during infancy is associated with increased body mass in humans.The weight-promoting effect of antibiotics is most pronounced when the exposure occurs at <6 months of age or repeatedly during infancy. Increased body mass is distinctly associated with exposure to cephalosporins and macrolides, especially in boys. (Read the full article) Full Article
weight Car Seat Screening for Low Birth Weight Term Neonates By pediatrics.aappublications.org Published On :: 2015-06-15T00:06:46-07:00 Almost half of NICUs include low birth weight (<2.5 kg) as an inclusion criterion for car seat tolerance screening (CSTS), formerly car seat challenges. However, little is known about incidence and risk factors for failure in this group.This is the largest study to date evaluating the incidence and predictors of CSTS failure in full-term low birth weight neonates. Epidemiologic data are provided to help guide future CSTS policies and protocol development for this group. (Read the full article) Full Article
weight Weight Growth Velocity and Postnatal Growth Failure in Infants 501 to 1500 Grams: 2000-2013 By pediatrics.aappublications.org Published On :: 2015-06-22T00:06:55-07:00 Postnatal growth failure is common for very low birth weight infants. Although many of the major morbidities experienced by these infants during their initial NICU stays have decreased in recent years, it is unclear whether growth has improved.For infants weighing 501 to 1500 g, average growth velocity increased and postnatal growth failure decreased from 2000 to 2013. Still, in 2013, half were discharged with a weight below the 10th percentile for postmenstrual age. (Read the full article) Full Article
weight Parent/Adolescent Weight Status Concordance and Parent Feeding Practices By pediatrics.aappublications.org Published On :: 2015-08-24T00:07:08-07:00 Research has shown that parent feeding practices are associated with adolescent weight status and dietary intake. It is unknown whether certain factors such as parent and child weight status concordance or discordance influence parents’ use of specific feeding practices.Findings from the current study suggest that parents use the highest levels of pressure-to-eat feeding practices when parents and adolescents are both nonoverweight and the highest levels of food restriction when parents and adolescents are both overweight/obese. (Read the full article) Full Article
weight Lung Function in Very Low Birth Weight Adults By pediatrics.aappublications.org Published On :: 2015-09-07T00:07:56-07:00 Children born preterm at very low birth weight have reduced lung function. Reduced lung function may extend to adult life, but to what extent this outcome is attributable to bronchopulmonary dysplasia and other prenatal and neonatal conditions is not known.Young adults born preterm at very low birth weight had impaired airflow. This finding suggests an increased risk of later obstructive airways disease and was observed also among those with no bronchopulmonary dysplasia, regardless of other prenatal and neonatal complications. (Read the full article) Full Article
weight Weight Gain, Executive Functioning, and Eating Behaviors Among Girls By pediatrics.aappublications.org Published On :: 2015-09-21T00:07:36-07:00 Executive functioning and excess weight have been associated in both cross-sectional and prospective studies, but mechanisms explaining this relationship are unclear.Impulsivity and planning at age 10 predicted age 10 to 16 BMI changes, and age 12 binge-eating tendencies mediated the relation between impulsivity at age 10 and changes in BMI change through age 16. (Read the full article) Full Article
weight Maternal Gestational and Postdelivery Weight Gain and Child Weight By pediatrics.aappublications.org Published On :: 2015-10-19T00:07:47-07:00 Maternal gestational weight gain is associated with childhood overweight. It is unknown whether gestational weight gain programs the child’s health or whether gestational weight gain is an indicator of postnatal behavioral factors.We disentangled these influences by studying the effect of gestational weight gain simultaneously with postdelivery maternal weight change as an indicator for shared family lifestyle on child’s weight development and found that both had an independent effect. (Read the full article) Full Article
weight Randomized Placebo-controlled Trial of a 42-Day Tapering Course of Dexamethasone to Reduce the Duration of Ventilator Dependency in Very Low Birth Weight Infants: Outcome of Study Participants at 1-Year Adjusted Age By pediatrics.aappublications.org Published On :: 1999-07-01 T. Michael O'SheaJul 1, 1999; 104:15-21ARTICLES Full Article
weight Delivery Room Management of Extremely Low Birth Weight Infants: Spontaneous Breathing or Intubation? By pediatrics.aappublications.org Published On :: 1999-05-01 Wolfgang LindnerMay 1, 1999; 103:961-967ARTICLES Full Article
weight Longitudinal Growth of Hospitalized Very Low Birth Weight Infants By pediatrics.aappublications.org Published On :: 1999-08-01 Richard A. EhrenkranzAug 1, 1999; 104:280-289ARTICLES Full Article
weight Poor Predictive Validity of the Bayley Scales of Infant Development for Cognitive Function of Extremely Low Birth Weight Children at School Age By pediatrics.aappublications.org Published On :: 2005-08-01 Maureen HackAug 1, 2005; 116:333-341ARTICLES Full Article
weight Trends in Mortality and Morbidity for Very Low Birth Weight Infants, 1991-1999 By pediatrics.aappublications.org Published On :: 2002-07-01 Jeffrey D. HorbarJul 1, 2002; 110:143-151ARTICLES Full Article
weight Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants By pediatrics.aappublications.org Published On :: 2009-01-01 C. Michael CottenJan 1, 2009; 123:58-66ARTICLES Full Article
weight Growth in the Neonatal Intensive Care Unit Influences Neurodevelopmental and Growth Outcomes of Extremely Low Birth Weight Infants By pediatrics.aappublications.org Published On :: 2006-04-01 Richard A. EhrenkranzApr 1, 2006; 117:1253-1261ARTICLES Full Article
weight Is Chronic Lung Disease in Low Birth Weight Infants Preventable? A Survey of Eight Centers By pediatrics.aappublications.org Published On :: 1987-01-01 Mary Ellen AveryJan 1, 1987; 79:26-30ARTICLES Full Article
weight The Relation of Overweight to Cardiovascular Risk Factors Among Children and Adolescents: The Bogalusa Heart Study By pediatrics.aappublications.org Published On :: 1999-06-01 David S. FreedmanJun 1, 1999; 103:1175-1182ARTICLES Full Article
weight Neurodevelopmental and Functional Outcomes of Extremely Low Birth Weight Infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994 By pediatrics.aappublications.org Published On :: 2000-06-01 Betty R. VohrJun 1, 2000; 105:1216-1226ARTICLES Full Article
weight Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network By pediatrics.aappublications.org Published On :: 2002-08-01 Barbara J. StollAug 1, 2002; 110:285-291ARTICLES Full Article
weight Blood Pressure Responses to Psychosocial Stress in Young Adults With Very Low Birth Weight: Helsinki Study of Very Low Birth Weight Adults By pediatrics.aappublications.org Published On :: 2009-01-26 Young adults born prematurely with very low birth weight (≤1500 g) have higher blood pressure than do their counterparts born at term. We tested whether they also have higher blood pressure reactivity to psychosocial stress, which may be a more-specific predictor of long-term cardiovascular morbidity. Systolic and diastolic blood pressure levels for 44 very low birth weight adults (mean age: 23.1 years; SD: 2.3 years) and 37 control subjects (mean age: 23.6 years; SD: 2.0 years) were measured through noninvasive finger photoplethysmography during a standardized psychosocial stress challenge (Trier Social Stress Test). Baseline and task values and their difference (ie, reactivity) served as outcome variables. In comparison with the control group, the very low birth weight group had 7.9 mm Hg higher diastolic blood pressure during the task and 4.8 mm Hg higher diastolic reactivity, with adjustment for gender and age, height, and BMI at testing. A similar trend was seen for systolic blood pressure during the baseline period and the task, but the group differences were not statistically significant. Our results indicate that very low birth weight is associated with elevated blood pressure reactivity to psychosocial stress and, therefore, may increase the risk of cardiovascular morbidity. Full Article
weight Fin24.com | Getting the cap out the weight By www.fin24.com Published On :: Thu, 28 Oct 2010 13:10:29 +0200 How to overcome enhanced index ETF data. Full Article
weight Delaware consumers protected by work of weights and measures inspectors By news.delaware.gov Published On :: Fri, 28 Feb 2020 16:57:16 +0000 DOVER, Del. – Every day, Delaware consumers are protected by the work of the Weights and Measures inspectors at the Delaware Department of Agriculture. When consumers purchase products based on a weight or measurement – like a gallon of gas or a pound of lunch meat – the Department’s Weights and Measures section is responsible […] Full Article Department of Agriculture count Delaware Department of Agriculture measure National Weights and Measures Week protecting consumers weight Weights and Measures
weight Champ sh*t only: UFC 249 headliner OFFICIAL as Ferguson & Gaethje make weight ahead of keenly-anticipated showdown (VIDEO) By www.rt.com Published On :: Fri, 08 May 2020 14:19:34 +0000 Tony Ferguson and Justin Gaethje have both successfully made weight ahead of the UFC's first fight card in nearly two months on Saturday night, in what promises to be a fiercely violent affair between the two lightweight stars. Read Full Article at RT.com Full Article
weight 'Let's make Curtis Blaydes mad!' Fans take dig at UFC heavyweight with Rachael Ostovich beach bikini post (PHOTOS) By www.rt.com Published On :: Fri, 08 May 2020 17:10:19 +0000 MMA fans have taken aim at UFC heavyweight Curtis Blaydes using Rachael Ostovich's new smoking beach snaps as ammunition after Blaydes questioned whether the women's flyweight was fighting in the organisation on merit or on looks. Read Full Article at RT.com Full Article
weight UFC 249: Dominick Cruz can cement legacy as bantamweight royalty with win against Henry Cejudo By www.rt.com Published On :: Fri, 08 May 2020 17:23:56 +0000 Injury-plagued former champ Dominick Cruz makes his return from another extended absence from the cage to challenge Henry Cejudo for bantamweight gold at UFC 249, knowing that a win will mark him out as the best of all time. Read Full Article at RT.com Full Article
weight Coronavirus analysis shows weight elevates risk of complications By www.smh.com.au Published On :: Sun, 19 Apr 2020 02:12:09 GMT An analysis of 15,100 patients across Britain hospitalised with COVID-19 finds carrying excess weight increases the likelihood of severe complications. Full Article
weight Adele's trainer lashes out at trolls questioning her weight loss: 'Appreciate the hard work' By feedproxy.google.com Published On :: Sat, 09 May 2020 02:47:14 +0500 Adele got accused of getting her weight reduced cosmetically Full Article
weight Men are worse than women at estimating their height and weight By www.newscientist.com Published On :: Fri, 01 May 2020 12:30:35 +0000 We tend to overestimate our height and underestimate our weight to fit society’s ideals, or because we think we're still the same as our younger selves Full Article
weight Weight-Loss Surgery Works, No Matter How Long Patient Was Obese By www.medicinenet.com Published On :: Mon, 2 Mar 2020 00:00:00 PDT Title: Weight-Loss Surgery Works, No Matter How Long Patient Was ObeseCategory: Health NewsCreated: 2/28/2020 12:00:00 AMLast Editorial Review: 3/2/2020 12:00:00 AM Full Article
weight Lose Weight, Lower Prostate Cancer Risk By www.medicinenet.com Published On :: Mon, 9 Mar 2020 00:00:00 PDT Title: Lose Weight, Lower Prostate Cancer RiskCategory: Health NewsCreated: 3/6/2020 12:00:00 AMLast Editorial Review: 3/9/2020 12:00:00 AM Full Article
weight Fitness Key to Long-Term Weight Loss Success By www.medicinenet.com Published On :: Wed, 1 Apr 2020 00:00:00 PDT Title: Fitness Key to Long-Term Weight Loss SuccessCategory: Health NewsCreated: 3/31/2020 12:00:00 AMLast Editorial Review: 4/1/2020 12:00:00 AM Full Article
weight Which Diets Help You Keep the Weight From Coming Back? By www.medicinenet.com Published On :: Fri, 3 Apr 2020 00:00:00 PDT Title: Which Diets Help You Keep the Weight From Coming Back?Category: Health NewsCreated: 4/2/2020 12:00:00 AMLast Editorial Review: 4/3/2020 12:00:00 AM Full Article
weight High Reps With Low Weights Builds Muscle, Too By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: High Reps With Low Weights Builds Muscle, TooCategory: Health NewsCreated: 4/28/2012 11:01:00 AMLast Editorial Review: 4/30/2012 12:00:00 AM Full Article
weight Losing Weight May Help Lower Cancer Risk By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Losing Weight May Help Lower Cancer RiskCategory: Health NewsCreated: 5/1/2012 11:00:00 AMLast Editorial Review: 5/1/2012 12:00:00 AM Full Article
weight Too Much Drinking, Weight May Harm Liver By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Too Much Drinking, Weight May Harm LiverCategory: Health NewsCreated: 4/26/2013 6:36:00 PMLast Editorial Review: 4/29/2013 12:00:00 AM Full Article
weight How Weight-Loss Surgery Improves Diabetes Control By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: How Weight-Loss Surgery Improves Diabetes ControlCategory: Health NewsCreated: 4/30/2013 4:35:00 PMLast Editorial Review: 5/1/2013 12:00:00 AM Full Article
weight Study Supports Broader Access to Lap-Band Weight-Loss Surgery By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Study Supports Broader Access to Lap-Band Weight-Loss SurgeryCategory: Health NewsCreated: 5/2/2013 10:35:00 AMLast Editorial Review: 5/2/2013 12:00:00 AM Full Article
weight Extreme Birth Weights Tied to Autism in Swedish Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Extreme Birth Weights Tied to Autism in Swedish StudyCategory: Health NewsCreated: 5/3/2013 10:35:00 AMLast Editorial Review: 5/3/2013 12:00:00 AM Full Article
weight Health Tip: Why Am I Overweight? By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Health Tip: Why Am I Overweight?Category: Health NewsCreated: 4/28/2014 7:35:00 AMLast Editorial Review: 4/28/2014 12:00:00 AM Full Article
weight Overweight Teens Feel Stigmatized, Bullied: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Overweight Teens Feel Stigmatized, Bullied: StudyCategory: Health NewsCreated: 5/1/2014 9:35:00 AMLast Editorial Review: 5/1/2014 12:00:00 AM Full Article
weight Beijing Olympics Study Hints at Smog's Impact on Birth Weights By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Beijing Olympics Study Hints at Smog's Impact on Birth WeightsCategory: Health NewsCreated: 4/28/2015 12:00:00 AMLast Editorial Review: 4/29/2015 12:00:00 AM Full Article
weight Mom's Pre-Pregnancy Weight May Help Predict Child's Size By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Mom's Pre-Pregnancy Weight May Help Predict Child's SizeCategory: Health NewsCreated: 4/27/2016 12:00:00 AMLast Editorial Review: 4/28/2016 12:00:00 AM Full Article
weight Can Dropping Some Weight Save Your Knees? By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Can Dropping Some Weight Save Your Knees?Category: Health NewsCreated: 5/2/2017 12:00:00 AMLast Editorial Review: 5/2/2017 12:00:00 AM Full Article
weight Could Fasting Every Other Day Help You Lose More Weight? By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Could Fasting Every Other Day Help You Lose More Weight?Category: Health NewsCreated: 5/1/2017 12:00:00 AMLast Editorial Review: 5/2/2017 12:00:00 AM Full Article
weight Too Much or Too Little Weight May Worsen Rheumatoid Arthritis By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Too Much or Too Little Weight May Worsen Rheumatoid ArthritisCategory: Health NewsCreated: 4/30/2018 12:00:00 AMLast Editorial Review: 4/30/2018 12:00:00 AM Full Article
weight Lowering Gestational Diabetes Risk by Prenatal Weight Gain Counseling By www.jabfm.org Published On :: 2020-03-16T09:31:37-07:00 Purpose: Excess weight gain during pregnancy is at epidemic proportions, and pregnancy complications are also on the rise. We sought to determine whether better weight gain counseling of expectant mothers will improve obstetric outcomes. Methods: Our historic control study design included 2 years of preintervention data, then 6 months of physician and staff training in prenatal weight gain counseling in accordance with 2009 Institute of Medicine guidelines, and finally, 2 more years of data collection for postintervention outcomes. Seven family medicine residency clinics monitored 1571 continuity prenatal cases. Counseling recommendations were noted and the following outcomes were analyzed: gestational age, birth weight, route of delivery, and the incidences of hypertension and gestational diabetes. Multiple logistic regression was used to control for demographic variables and body mass index at enrollment. Results: Institute of Medicine congruent counseling increased from 10% to 63% (P < .01). Excess weight gain decreased from 46.4% to 41.5% (adjusted odds ratio [AOR] = 0.85; 95% CI, 0.63–1.16; P = .10). Gestational diabetes decreased significantly from 11.5% to 7.3% (P = .008). The difference remained statistically significant even after adjusting for prepregnancy obesity and other clinical and demographic characteristics (AOR = 0.54; 95% CI, 0.32–0.91; P = .02). Differences in gestational age, birth weight, hypertension, primary cesarean, and shoulder dystocia were not statistically significant. Conclusions: Improved weight gain counseling of prenatal patients by physicians did reduce the pregnancy complication of gestational diabetes. This occurred even though the trend toward less excess weight gain was not statistically significant. Full Article
weight Dose Frequency Optimization of the Dual Amylin and Calcitonin Receptor Agonist KBP-088: Long-Lasting Improvement in Food Preference and Body Weight Loss [Behavioral Pharmacology] By jpet.aspetjournals.org Published On :: 2020-04-21T06:02:31-07:00 Dual amylin and calcitonin receptor agonists (DACRAs) are novel candidates for treatment of type 2 diabetes and obesity because of their beneficial effects on body weight, blood glucose, insulin sensitivity, and food preference, at least short-term. DACRAs activate the receptors for a prolonged time period, resulting in metabolic effects superior to those of amylin. Because of the prolonged receptor activation, different dosing intervals and, hence, less frequent receptor activation might change the efficacy of DACRA treatment in terms of weight loss and food preference. In this study, we compared daily dosing to dosing every other day with the aim of understanding the optimal balance between efficacy and tolerability. Obese and lean male Sprague-Dawley rats were treated with the DACRA KBP-088, applying two different dosing intervals (1.5 nmol/kg once daily and 3 nmol/kg every other day) to assess the effect on body weight, food intake, glucose tolerance, and food preference when given the choice between chow (13% fat) and a high-fat diet (60% fat). Treatment with KBP-088 induced significant weight loss, reduction in adiposity, improvement in glucose control, and altered food preference toward food that is less calorie-dense. KBP-088 dosed every other day (3 nmol/kg) was superior to KBP-088 once daily (1.5 nmol/kg) in terms of weight loss and improvement of food preference. The beneficial effects were evident in both lean and obese rats. Hence, dosing KBP-088 every other day positively affects overall efficacy on metabolic parameters regardless of the lean/obese state, suggesting that less-frequent dosing with KBP-088 could be feasible. SIGNIFICANCE STATEMENT Here, we show that food preference can be altered chronically toward choices that are less calorie-dense by pharmacological treatment. Further, pharmacological dosing regimens affect the efficacy differently, as dosing every other day improved body weight loss and alterations in food preference compared with daily dosing. This suggest that alterations of the dosing regimens could be feasible in the treatment of obesity. Full Article
weight Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009-2017 By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE There is a controversy over the association between obesity and end-stage renal disease (ESRD) in people with or without type 2 diabetes; therefore, we examined the effect of BMI on the risk of ESRD according to glycemic status in the Korean population. RESEARCH DESIGN AND METHODS The study monitored 9,969,848 participants who underwent a National Health Insurance Service health checkup in 2009 from baseline to the date of diagnosis of ESRD during a follow-up period of ~8.2 years. Obesity was categorized by World Health Organization recommendations for Asian populations, and glycemic status was categorized into the following five groups: normal, impaired fasting glucose (IFG), newly diagnosed diabetes, diabetes <5 years, and diabetes ≥5 years. RESULTS Underweight was associated with a higher risk of ESRD in all participants after adjustment for all covariates. In the groups with IFG, newly diagnosed type 2 diabetes, diabetes duration <5 years, and diabetes ≥5 years, the hazard ratio (HR) of the underweight group increased with worsening glycemic status (HR 1.431 for IFG, 2.114 for newly diagnosed diabetes, 4.351 for diabetes <5 years, and 6.397 for diabetes ≥5 years), using normal weight with normal fasting glucose as a reference. The adjusted HRs for ESRD were also the highest in the sustained underweight group regardless of the presence of type 2 diabetes (HR 1.606 for nondiabetes and 2.14 for diabetes). CONCLUSIONS Underweight showed more increased HR of ESRD according to glycemic status and diabetes duration in the Korean population. These associations also persisted in the group with sustained BMI during the study period. Full Article
weight Efficacy and Safety of Liraglutide 3.0 mg in Individuals With Overweight or Obesity and Type 2 Diabetes Treated With Basal Insulin: The SCALE Insulin Randomized Controlled Trial By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE Most individuals with type 2 diabetes also have obesity, and treatment with some diabetes medications, including insulin, can cause further weight gain. No approved chronic weight management medications have been prospectively investigated in individuals with overweight or obesity and insulin-treated type 2 diabetes. The primary objective of this study was to assess the effect of liraglutide 3.0 mg versus placebo on weight loss in this population. RESEARCH DESIGN AND METHODS Satiety and Clinical Adiposity—Liraglutide Evidence (SCALE) Insulin was a 56-week, randomized, double-blind, placebo-controlled, multinational, multicenter trial in individuals with overweight or obesity and type 2 diabetes treated with basal insulin and ≤2 oral antidiabetic drugs. RESULTS Individuals were randomized to liraglutide 3.0 mg (n = 198) or placebo (n = 198), combined with intensive behavioral therapy (IBT). At 56 weeks, mean weight change was –5.8% for liraglutide 3.0 mg versus –1.5% with placebo (estimated treatment difference –4.3% [95% CI –5.5; –3.2]; P < 0.0001). With liraglutide 3.0 mg, 51.8% of individuals achieved ≥5% weight loss versus 24.0% with placebo (odds ratio 3.41 [95% CI 2.19; 5.31]; P < 0.0001). Liraglutide 3.0 mg was associated with significantly greater reductions in mean HbA1c and mean daytime glucose values and less need for insulin versus placebo, despite a treat-to-glycemic-target protocol. More hypoglycemic events were observed with placebo than liraglutide 3.0 mg. No new safety or tolerability issues were observed. CONCLUSIONS In individuals with overweight or obesity and insulin-treated type 2 diabetes, liraglutide 3.0 mg as an adjunct to IBT was superior to placebo regarding weight loss and improved glycemic control despite lower doses of basal insulin and without increases in hypoglycemic events. Full Article
weight Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-04-20T12:00:32-07:00 OBJECTIVE We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association. RESEARCH DESIGN AND METHODS Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20–71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazards regressions and meta-analysis techniques. RESULTS Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls 5.04 [95% CI 3.92–6.48]; HRboys 3.78 [95% CI 2.68–5.33]). Individuals with a high BMI at 7 years but without adult obesity did not have a higher risk (HRgirls 0.74 [95% CI 0.52–1.06]; HRboys 0.93 [95% CI 0.65–1.33]). Education, smoking, and LTPA were associated with diabetes risks but did not modify or confound the associations with BMI changes. Results for 12 years of age were similar. CONCLUSIONS A high BMI in childhood was associated with higher type 2 diabetes risks only if individuals also had obesity in adulthood. These associations were not influenced by educational and lifestyle factors, indicating that BMI is similarly related to the risk across all levels of these factors. Full Article
