magi Correction: Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer By pubs.rsc.org Published On :: Nanoscale, 2024, 16,20354-20355DOI: 10.1039/D4NR90194K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ziwei Li, Fan Yang, Di Wu, Yanhong Liu, Yang Gao, Haichen Lian, Hongxin Zhang, Zhibin Yin, Aiguo Wu, Leyong ZengThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
magi Applications of nanotheranostics in the second near-infrared window in bioimaging and cancer treatment By pubs.rsc.org Published On :: Nanoscale, 2024, Advance ArticleDOI: 10.1039/D4NR03058C, Review ArticleHuimin Li, Pengju Li, Jiarui Zhang, Ziyi Lin, Lintao Bai, Heyun ShenThis review summarized the application of the second near-infrared nano-platform in the field of nano-agents design, optical imaging and cancer treatment, aiming at providing profound insights into its development status and future challenges.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
magi Tailored peptide nanomaterials for receptor targeted prostate cancer imaging By pubs.rsc.org Published On :: Nanoscale, 2024, Advance ArticleDOI: 10.1039/D4NR03273J, PaperFátima Santillán, Carlie L. Charron, Betty C. Galarreta, Leonard G. LuytThis study reports on a cancer targeted nanomaterial created from cyclic octapeptides that is tailored for the optical imaging of prostate cancer. The strategy focuses on the co-assembly of four specific templates into cyclic peptide nanotubes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
magi Aptamer-functionalized Nucleic Acid Nanotechnology for Biosensing, Bioimaging and Cancer Therapy By pubs.rsc.org Published On :: Nanoscale, 2024, Accepted ManuscriptDOI: 10.1039/D4NR04360J, Review ArticleXiaofang Zheng, Zhiyong Huang, Qiang Zhang, Guoli Li, Minghui Song, Ruizi PengNucleic acids have enabled to fabricate self-assemblies and perform dynamic operations. Among different functional nucleic acids, aptamers can specifically bind to wide range of targets including proteins, viral antigens, living...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
magi PS-1: Mani Ratnam's Magic Works, Yet... By www.rediff.com Published On :: Mon, 03 Oct 2022 16:54:26 +0530 Ponniyin Selvan has everything going for it, yet, there is something missing for a wholesome film experience, observes N Sathiya Moorthy. Full Article
magi Honor unveils Magic V2: A foldable phone competing against Apple’s flagships By www.thehindubusinessline.com Published On :: Thu, 13 Jul 2023 17:59:23 +0530 With a foldable OLED screen and a competitive price, it aims to challenge iPhone’s dominance in the market. Full Article Mobiles & Tablets
magi Imagine By www.thehindubusinessline.com Published On :: Sat, 11 Apr 2020 16:55:37 +0530 Surviving Self-Distancing – Day 14 Full Article Poornima Joshi
magi Honor Magic 7 Series with AI features running on Snapdragon 8 Elite launched By www.thehindu.com Published On :: Fri, 01 Nov 2024 14:24:46 +0530 Snapdragon and Honor announced the launch of the AI-powered Honor Magic 7 Series Full Article Technology
magi Polarized light and the magic angle: Scientists making art By cen.acs.org Published On :: 17 Jun 2018 23:07:04 +0000 Full Article
magi L’Oréal launches AI-based Brow Magic. Here’s how it works By www.thehindubusinessline.com Published On :: Thu, 05 Jan 2023 17:47:55 +0530 L’Oréal confirms that the Brow Magic eyebrow applicator will launch in 2023 Full Article Other Gadgets
magi Imagicaa launches indoor trampoline park in theme park expansion By www.thehindubusinessline.com Published On :: Fri, 08 Nov 2024 15:11:24 +0530 Full Article Stocks
magi 'Magizhchi' at the box-office By www.thehindu.com Published On :: Sat, 30 Jul 2016 15:54:34 +0530 Kabali has had the biggest-ever opening for a Tamil film Full Article Cinema
magi Kareena Looks Simply Magical By www.rediff.com Published On :: Mon, 11 Nov 2024 13:22:49 +0530 She does not hesitate when it comes to experimenting with her makeup. Full Article
magi 'Couldn't Imagine Chatting With Kamal' By www.rediff.com Published On :: Thu, 07 Nov 2024 09:54:53 +0530 'I was completely in awe of him. After the shot was okayed, I would quickly run back to my chair and sit quietly till I was called again.' Full Article
magi BJP, MVA manifestoes and the woman vote: More needs to be imagined and offered to her By indianexpress.com Published On :: Mon, 11 Nov 2024 22:42:40 +0000 Full Article Editorials Opinion
magi Beyond Fingal's cave: Ossian in the musical imagination / James Porter By library.mit.edu Published On :: Sun, 10 May 2020 07:43:52 EDT Lewis Library - ML196.P67 2019 Full Article
magi Time Zones Are a Magical Thing By feedproxy.google.com Published On :: Wed, 01 Apr 2015 11:00:00 -0700 Full Article facepalm calendar time failbook g rated
magi 'They Can Talk' Is a Funny Web Comic That Imagines What Animals Would Say If They Could Speak Our Language By feedproxy.google.com Published On :: Sat, 24 Aug 2019 02:30:00 -0700 You can see more comics over here. Full Article talking wildlife funny animals web comics cat comics speech meow Cats
magi Re: Prognosis of unrecognised myocardial infarction determined by electrocardiography or cardiac magnetic resonance imaging: systematic review and meta-analysis By feeds.bmj.com Published On :: Saturday, May 9, 2020 - 18:01 Full Article
magi Grid cells come into play when the imagination runs away By www.theguardian.com Published On :: 2016-03-10T17:15:09Z New research suggests that neurons which track our movements are also involved in imaginary navigationBrain cells involved in spatial navigation and mapping the environment also fire when we merely imagine moving through familiar surroundings, according to a new study by researchers at University College London. The research, published today in the journal Current Biology, shows that memory and imagination are intimately linked in the brain at the cellular level, and could help to explain some of the changes that occur in the early stages of Alzheimer’s Disease. Related: The fly's neural compass works just like a mammal's Related: 3D compass cells found in the bat brain Continue reading... Full Article Science Neuroscience
magi Live imaging of synapse density in the human brain By www.theguardian.com Published On :: 2016-08-10T12:00:55Z A new imaging technique may give researchers fresh insights into brain development, function, and diseaseThe human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions. Related: Brain’s immune cells hyperactive in schizophrenia Related: 3D model of a nerve terminal in atomic detail | Mo Costandi Continue reading... Full Article Science Neuroscience
magi Across The Aisle: Imagination is everything in war against reality By www.financialexpress.com Published On :: 2020-05-03T05:05:00+05:30 On May 3, the governments would have got 40 days time to do those things; the question is, do governments need more time? Full Article Opinion
magi The Chinese chameleon reimagined in the age of Covid-19 By mg.co.za Published On :: Sat, 09 May 2020 18:58:00 +0000 The West’s perceptions of China hold up a mirror to its own preoccupations. More nuanced analysis is much-needed The post The Chinese chameleon reimagined in the age of Covid-19 appeared first on The Mail & Guardian. Full Article Coronavirus Opinion blame-game China Chinese Communist Party coronavirus Covid-19 Donald Trump Fox Butterfield Ideology John Fitzgerald Laurie Garrett openaccess Pandemic Richard Dawson Richard McGregor The Chinese Chameleon Xi Jinping
magi Curtain falls on man smitten with John F Kennedy magic By www.nation.co.ke Published On :: 2020-05-10T07:10:00Z He was a beneficiary of the Kennedy Airlifts, a project in the late 1950s and early 60s. Full Article
magi Imagine Being Pulled Off Death Row and Then Being Put Back on It By www.motherjones.com Published On :: Mon, 05 Jun 2017 10:00:09 +0000 In 1994, Marcus Robinson, who is black, was convicted of murder and sentenced to death for the 1991 killing of Erik Tornblom, a white teenager, in Cumberland County, North Carolina. He spent nearly 20 years on death row, but in 2012 his sentence was changed to life without a chance of parole. He was one of four death row inmates whose sentences were commuted by a judge who found that racial discrimination had played a role in their trials. The reason their cases were reviewed at all was because of a 2009 North Carolina law known as the Racial Justice Act, which allowed judges to reduce death sentences to life in prison without parole when defendants were able to prove racial bias in their charge, jury selection, or sentence. "The Racial Justice Act ensures that when North Carolina hands down our state's harshest punishment to our most heinous criminals," former Gov. Bev Perdue said when she signed the bill into law, "the decision is based on the facts and the law, not racial prejudice." At 21, Robinson was the youngest person sentenced to death in North Carolina. When he was three, he was hospitalized with severe seizures after being physically abused by his father and was diagnosed with permanent brain dysfunction. However, those weren't the only troubling aspects of his case. Racial discrimination in jury selection has been prohibited since it was banned by the Supreme Court in its 1986 Supreme Court decision Batson v. Kentucky, but Robinson's trial was infected with it. The prosecutor in the case, John Dickson, disproportionately refused eligible black potential jurors. For example, he struck one black potential juror because the man had been once charged with public drunkenness. However, he accepted two "nonblack" people with DWI convictions. Of the eligible members of the pool, he struck half the black people and only 14 percent of the nonblack members. In the end, Robinson was tried by a 12-person jury that included only three people of color—one Native American individual and two black people. Racial discrimination in jury selection was not uncommon in the North Carolina criminal justice system. A comprehensive Michigan State University study looked at more than 7,400 potential jurors in 173 cases from 1990 to 2010. Researchers found that statewide prosecutors struck 52.6 percent of eligible potential black jurors and only 25.7 percent of all other potential jurors. This bias was reflected on death row. Of the 147 people on North Carolina's death row, 35 inmates were sentenced by all-white juries; 38 by juries with just one black member. Under the Racial Justice Act, death row inmates had one year from when the bill became law to file a motion. Nearly all the state's 145 death row inmates filed claims, but only Robison and three others—Quintel Augustine, Tilmon Golphin, and Christina Walters—obtained hearings. In 2012, Robinson's was the first. At the Superior Court of Cumberland County, Judge Gregory Weeks ruled that race had played a significant role in the trial and Robinson was resentenced to life without parole. North Carolina appealed the decision to the state's Supreme Court. An immediate outcry followed the decision. The North Carolina Conference of District Attorneys issued a statement saying, "Capital cases reflect the most brutal and heinous offenders in our society. Whether the death penalty is an appropriate sentence for murderers should be addressed by our lawmakers in the General Assembly, not masked as claims (of) racism in our courts." The ruling attracted lots of publicity from across the country and North Carolina lawmakers were outraged. "There are definitely signs in the legislative record that there were some [lawmakers] that really wanted to see executions move forward," Cassandra Stubbs, the director of the ACLU Capital Punishment Project who also represents Robinson, says. Legislative staffers circulated talking points for lawmakers with arguments that the RJA turns "district attorneys into racists and convicted murderers into victims," describing the law as "an end-run around the death penalty and an indefinite moratorium on capital punishment." The day Judge Weeks resentenced Robinson, the Senate president pro tempore for the state Legislature, Phillip Berger, expressed concern that Robinson could be eligible for parole. He suggested Robinson—who had just turned 18 when he committed the crime and would not have been considered a juvenile—would be ineligible for life in prison without a chance of parole, citing a US Supreme Court ruling that prohibited juveniles from receiving life sentences without parole. "We cannot allow cold-blooded killers to be released into our community, and I expect the state to appeal this decision," he said. "Regardless of the outcome, we continue to believe the Racial Justice Act is an ill-conceived law that has very little to do with race and absolutely nothing to do with justice." The state Legislature took on the challenge and voted to repeal the Racial Justice Act in 2013. This made it impossible for those on death row to even attempt to have their sentences reviewed for racial bias, but it left the fates of the four who had been moved to life imprisonment unclear. "The state's district attorneys are nearly unanimous in their bipartisan conclusion that the Racial Justice Act created a judicial loophole to avoid the death penalty and not a path to justice," Gov. Pat McCrory said in a statement at the time. Even though the law was still in effect when the four inmates' sentences were reduced, they weren't safe from death row just yet. Robinson's sentenced had been legally reduced, but the legal battle was just beginning. In 2015, after nearly two years from the initial hearing, the North Carolina Supreme Court ordered the Superior Court to reconsider the reduced sentences for Robinson, Augustine, Golphin, and Walters, saying the judge failed to give the state enough time to prepare for the "complex" proceedings. This past January, Superior Court Judge Erwin Spainhour ruled that because the RJA had been repealed, the four defendants could no longer use the law to reduce their sentences. "North Carolina vowed to undertake an unprecedented look at the role of racial bias in capital sentencing," says Stubbs. But now, "the state Legislature explicitly turned from its commitment and repealed the law." Robinson is back on death row at Central Prison in the state's capital of Raleigh. In the petition to the state Supreme Court, Robinson's lawyers point out that the Double Jeopardy Clause—the law that prevents someone from being tried twice for the same crime—bars North Carolina from trying to reimpose the death penalty because the 2012 RJA hearing acquitted him of capital punishment. "He's never been resentenced to death," Stubbs says. "They have no basis to hold him on death row." Full Article Politics Crime and Justice Race and Ethnicity
magi Imagine if we beat Kaizer Chiefs twice in those two matches - Bidvest Wits' Alexander eyes PSL title By in.news.yahoo.com Published On :: Sun, 10 May 2020 03:16:49 -0500 The experienced midfielder believes they can clinch the title right under the noses of favourites Amakhosi and Masandawana Full Article
magi Patience: George Papadopoulos says the Durham investigation 'is far more along than anyone can imagine' By twitchy.com Published On :: Sat, 09 May 2020 16:57:32 Z Full Article <![CDATA[CIA]]> <![CDATA[investigation]]> <![CDATA[George Papadopoulos]]> <![CDATA[John Durham]]>
magi Close your eyes and imagine seeing the art world's treasures as if for the first time | Laura Cumming By www.theguardian.com Published On :: 2020-05-09T18:00:03Z The museums of Europe have begun reopening their doors to art lovers desperate to see old favourites and new worksI am cursing my bad luck not to be stuck in lockdown in the Prado. A friend wishes she had stowed away in a closet before they bolted the doors of the National Gallery. Others would give anything for a week in the Rijksmuseum, a day in the Uffizi, an hour with Rembrandt or Vermeer, even just a few minutes with a Samuel Palmer moonscape in the Ashmolean or a Turner sunrise at Tate Britain. Museums are places of the heart.We see art in time and place; we cannot see it otherwise. Of course there are other whereabouts of the works we most long to set eyes on again, during this evil pandemic: the cave paintings at Chaumet in France, Fra Angelico’s Annunciation in a Florentine monastery, Robert Smithson’s Spiral Jetty coiled in the glistening waters of the Great Salt Lake in Utah. These were all chosen in an unofficial and entirely self-selecting Twitter survey (mine), along with Leonardo’s The Last Supper and James Turrell’s Deer Shelter Skyspace, framing the blue heavens above Yorkshire Sculpture Park. Continue reading... Full Article Museums Coronavirus outbreak Culture Art UK news Art and design Europe Germany World news
magi The Magic of Christmas By www.medindia.net Published On :: It's that time of the year when magic fills the air - a magic that heralds the beautiful month of December - and Christm Full Article
magi The Business Climate Has Changed: Imagining New Approaches for Our Climate By www.oecd.org Published On :: Wed, 20 May 2015 15:26:00 GMT In his remarks to the Business & Climate Summit, the Secretary-General said that business lies at the heart of what we need to achieve on climate action. If Governments produce clear, credible and coherent national policies and clear messages and signals, the full transformative power of business, markets and human ingenuity will be unleashed. Full Article
magi The Business Climate Has Changed: Imagining New Approaches for Our Climate By www.oecd.org Published On :: Wed, 20 May 2015 15:26:00 GMT In his remarks to the Business & Climate Summit, the Secretary-General said that business lies at the heart of what we need to achieve on climate action. If Governments produce clear, credible and coherent national policies and clear messages and signals, the full transformative power of business, markets and human ingenuity will be unleashed. Full Article
magi Awarding – and imagining – teaching excellence (OECD Education Today Blog) By oecdeducationtoday.blogspot.fr Published On :: Mon, 04 Sep 2017 12:40:00 GMT Tertiary qualifications have become the entrance ticket for modern societies. Never before have those with advanced qualifications had the life chances they enjoy today, and never before have those who struggled to acquire a good education paid the price they pay today. Full Article
magi The life-changing magic of a roast chicken dinner By www.dailymail.co.uk Published On :: Sat, 24 Aug 2019 23:02:16 GMT Isabel Vincent's marriage was falling apart. Her elderly neighbour was grief-stricken. Little did they know that a supper invitation would heal them both Full Article
magi Re-imagining India with new data By indiatogether.org Published On :: Tue, 26 Mar 2013 00:00:00 +0000 A quiet but steady revolution seems to be underway as both government and private individuals and organizations increasingly explore ways to make more data available to the people and in various innovative ways to facilitate application. Shamala Kittane reports. Full Article
magi Wilde imagination: Oscar as Holmes By timesofindia.indiatimes.com Published On :: Sun, 05 Jun 2011 14:55:39 IST Imagine Oscar Wilde, the famed playwright and poet, in the mold of a Sherlock Holmes or a Hercules Poirot. That’s precisely what author Gyles Brandreth does - make a convincing detective out of Wilde even as he remains faithful in his portrayal of him as an aesthete and a bohemian with his flamboyant style and acerbic wit. Full Article
magi Delhi Govt Asks District Magistrates to Release 2,446 Tablighi Jamaat Members By www.news18.com Published On :: Sun, 10 May 2020 10:48:59 +0530 As many as 567 foreign attendees of the congregation held in Delhi's Nizamuddin area in March, will be handed over to the police. Full Article
magi Historical Fiction: Imagining—and WRITING—the PAST! By www.nyhistory.org Published On :: Tue, 17 Jul 2012 13:29:53 +0000 July 23–27. Registration requiredMon, 07/23/2012 - 10:00 to 16:00Mon, July 23rd, 2012 | 11:00 am to 5:00 pmTue, July 24th, 2012 | 11:00 am to 5:00 pmWed, July 25th, 2012 | 11:00 am to 5:00 pmThu, July 26th, 2012 | 11:00 am to 5:00 pmFri, July 27th, 2012 | 11:00 am to 5:00 pmJuly 23–27Price: $850Family Programs: CampsSold out: 0 Full Article
magi Historical Fiction: Imagining—and WRITING—the PAST! By www.nyhistory.org Published On :: Tue, 01 May 2012 16:14:33 +0000 Summer Writing Camps with the DiMenna Children’s History Museum and Writopia Lab! Pre-registration required.Sat, 06/23/2012 - 09:00 to Wed, 06/27/2012 - 16:00Sat, June 23rd, 2012 | 10:00 am to Wed, June 27th, 2012 | 5:00 pmAges 8–18Price: $850Family Programs: CampsSold out: 0 Full Article
magi Historical Fiction: Imagining—and WRITING—the PAST! By www.nyhistory.org Published On :: Tue, 01 May 2012 16:11:22 +0000 Summer Writing Camps with the DiMenna Children’s History Museum and Writopia Lab! Pre-registration required. Mon, 06/11/2012 - 09:00 to Thu, 06/14/2012 - 16:00Mon, June 11th, 2012 | 10:00 am to Thu, June 14th, 2012 | 5:00 pmFor ages 8–18Price: $700Family Programs: CampsSold out: 0 Full Article
magi Ex ordinis philosophorum mandato renuntiantur philosophiae doctores: et artium liberalium magistri rectore magnifico Ioanne Adolpho Overbeck ... decano Gustavo Henrico Wiedemann ... procancellario Ludovico Lange ... inde a die primo mensis Novembris a. MD By library.mit.edu Published On :: Sun, 7 Sep 2014 08:12:53 EDT Archives, Room Use Only - QC761.W54 1876 Full Article
magi Magician Roy Horn of 'Siegfried and Roy' dead at 75 from coronavirus By www.newkerala.com Published On :: Sun, 10 May 2020 01:45:01 +0530 Full Article
magi Keynote, Magic Move, and You By feedproxy.google.com Published On :: 2013-11-07T15:52:47+00:00 A confession: I love working in Keynote. Love it. (I’m speaking, of course, of Keynote ’09. Not the feature-stripped version that was released last month. Still, I’m hopeful it’ll improve over time, since it is so very pretty.) It’s not perfect, mind you—after four or five years of use, the program’s got some not-insignificant stability issues, crashing way more often than I’d like. But after all that time it’s still one of my favorite visual editors: it’s great for quickly prototyping UI components, sketching out ideas for animation timing, and, yes, making slides. Anyway: over the years, folks have said some very kind things about the visual design of my presentations. I don’t have any special knowledge about Keynote, mind, but thought I’d share a couple things I use in my presentations, in case anyone else finds them helpful. First up: Magic Move. Basically, Magic Move is a transition you can apply between two slides. If the second slide shares any objects—images, text boxes, or what-have-you—with the first slide, those objects will be, well, magically moved from one position to the next. Here’s a very, very simple example: As you can see, there’s just one object on both slides: a picture of my good friend Dwayne. The image is the same on both slides—you can duplicate the slide, or copy/paste the object to the second slide—but since its position changed, Magic Move kinda tweens the photo to its new position. Now, I don’t use Magic Move a lot, usually preferring to just lean on simple dissolves between slides. But it’s great for managing more complex animations, like this one: This animation requires a bit more setup, but the principle is basically the same: In the first slide, the “screenshots” you see are basically a lot of tiny little screencaps, each containing just one element of the interface. (So there’s an image for the toolbar in Editorially’s editor, another for the discussion panel, another for the account menu avatar, and so on.) When I’m arranging complex flyouts like this, I’ll usually have a reference screenshot on the canvas as a base layer, and place the smaller screencaps atop it. Just to make sure everything’s aligned, that is. Then, in the second slide, I move all those small images where I’d like them to end up. Turn on Magic Move, and you’re left with a neat little flyout cross-section of an interface. As with most things Keynote-related, Magic Move is pretty reliable…but the more you use it, you’ll probably run up against a couple idiosyncrasies. You can’t magicmove (oh god i’m so sorry) an object if it has any builds or actions on it; animated objects (YES MOM, I’M TALKING ABOUT GIFs) will just blink to their new position; and some objects might move completely counter to what you’d expect. And as with anything animation-driven, it’s very, very easy to overuse and abuse: try to consider marrying the animation with what you’re actually saying, and ensure the visuals don’t outwhelm your words as you’re presenting. That said, Magic Move is a fantastic tool to keep near at hand—when used just right I think it can be, well, kinda magical. Full Article
magi Punjab CM orders magisterial probe into school van fire incident at Longowal By www.newkerala.com Published On :: Sun, 16 Feb 2020 12:00:01 +0530 Full Article
magi Gazetted officers in Chandigarh get magistrate powers By www.newkerala.com Published On :: Sun, 05 Apr 2020 07:36:02 +0530 Full Article
magi Inebriated man held for creatingruckus, damaging police vehicle By www.thehindu.com Published On :: Sat, 09 May 2020 23:37:24 +0530 A man was arrested for allegedly creating ruckus and damaging a police vehicle in an inebriated state in east Delhi’s Kalyanpuri, the police said on S Full Article Delhi
magi Coherent Bragg imaging of 60 nm Au nanoparticles under electrochemical control at the NanoMAX beamline By scripts.iucr.org Published On :: 2019-08-27 Nanoparticles are essential electrocatalysts in chemical production, water treatment and energy conversion, but engineering efficient and specific catalysts requires understanding complex structure–reactivity relations. Recent experiments have shown that Bragg coherent diffraction imaging might be a powerful tool in this regard. The technique provides three-dimensional lattice strain fields from which surface reactivity maps can be inferred. However, all experiments published so far have investigated particles an order of magnitude larger than those used in practical applications. Studying smaller particles quickly becomes demanding as the diffracted intensity falls. Here, in situ nanodiffraction data from 60 nm Au nanoparticles under electrochemical control collected at the hard X-ray nanoprobe beamline of MAX IV, NanoMAX, are presented. Two-dimensional image reconstructions of these particles are produced, and it is estimated that NanoMAX, which is now open for general users, has the requisites for three-dimensional imaging of particles of a size relevant for catalytic applications. This represents the first demonstration of coherent X-ray diffraction experiments performed at a diffraction-limited storage ring, and illustrates the importance of these new sources for experiments where coherence properties become crucial. Full Article text
magi Progress in HAXPES performance combining full-field k-imaging with time-of-flight recording By scripts.iucr.org Published On :: 2019-11-01 An alternative approach to hard-X-ray photoelectron spectroscopy (HAXPES) has been established. The instrumental key feature is an increase of the dimensionality of the recording scheme from 2D to 3D. A high-energy momentum microscope detects electrons with initial kinetic energies up to 8 keV with a k-resolution of 0.025 Å−1, equivalent to an angular resolution of 0.034°. A special objective lens with k-space acceptance up to 25 Å−1 allows for simultaneous full-field imaging of many Brillouin zones. Combined with time-of-flight (ToF) parallel energy recording this yields maximum parallelization. Thanks to the high brilliance (1013 hν s−1 in a spot of <20 µm diameter) of beamline P22 at PETRA III (Hamburg, Germany), the microscope set a benchmark in HAXPES recording speed, i.e. several million counts per second for core-level signals and one million for d-bands of transition metals. The concept of tomographic k-space mapping established using soft X-rays works equally well in the hard X-ray range. Sharp valence band k-patterns of Re, collected at an excitation energy of 6 keV, correspond to direct transitions to the 28th repeated Brillouin zone. Measured total energy resolutions (photon bandwidth plus ToF-resolution) are 62 meV and 180 meV FWHM at 5.977 keV for monochromator crystals Si(333) and Si(311) and 450 meV at 4.0 keV for Si(111). Hard X-ray photoelectron diffraction (hXPD) patterns with rich fine structure are recorded within minutes. The short photoelectron wavelength (10% of the interatomic distance) `amplifies' phase differences, making full-field hXPD a sensitive structural tool. Full Article text
magi Methods for dynamic synchrotron X-ray respiratory imaging in live animals By scripts.iucr.org Published On :: 2020-01-01 Small-animal physiology studies are typically complicated, but the level of complexity is greatly increased when performing live-animal X-ray imaging studies at synchrotron and compact light sources. This group has extensive experience in these types of studies at the SPring-8 and Australian synchrotrons, as well as the Munich Compact Light Source. These experimental settings produce unique challenges. Experiments are always performed in an isolated radiation enclosure not specifically designed for live-animal imaging. This requires equipment adapted to physiological monitoring and test-substance delivery, as well as shuttering to reduce the radiation dose. Experiment designs must also take into account the fixed location, size and orientation of the X-ray beam. This article describes the techniques developed to overcome the challenges involved in respiratory X-ray imaging of live animals at synchrotrons, now enabling increasingly sophisticated imaging protocols. Full Article text
magi Formation of a highly dense tetra-rhenium cluster in a protein crystal and its implications in medical imaging By scripts.iucr.org Published On :: 2019-06-13 The fact that a protein crystal can serve as a chemical reaction vessel is intrinsically fascinating. That it can produce an electron-dense tetranuclear rhenium cluster compound from a rhenium tricarbonyl tribromo starting compound adds to the fascination. Such a cluster has been synthesized previously in vitro, where it formed under basic conditions. Therefore, its synthesis in a protein crystal grown at pH 4.5 is even more unexpected. The X-ray crystal structures presented here are for the protein hen egg-white lysozyme incubated with a rhenium tricarbonyl tribromo compound for periods of one and two years. These reveal a completed, very well resolved, tetra-rhenium cluster after two years and an intermediate state, where the carbonyl ligands to the rhenium cluster are not yet clearly resolved, after one year. A dense tetranuclear rhenium cluster, and its technetium form, offer enhanced contrast in medical imaging. Stimulated by these crystallography results, the unusual formation of such a species directly in an in vivo situation has been considered. It offers a new option for medical imaging compounds, particularly when considering the application of the pre-formed tetranuclear cluster, suggesting that it may be suitable for medical diagnosis because of its stability, preference of formation and biological compatibility. Full Article text
magi The achievable resolution for X-ray imaging of cells and other soft biological material By scripts.iucr.org Published On :: 2020-03-07 X-ray imaging of soft materials is often difficult because of the low contrast of the components. This particularly applies to frozen hydrated biological cells where the feature of interest can have a similar density to the surroundings. As a consequence, a high dose is often required to achieve the desired resolution. However, the maximum dose that a specimen can tolerate is limited by radiation damage. Results from 3D coherent diffraction imaging (CDI) of frozen hydrated specimens have given resolutions of ∼80 nm compared with the expected resolution of 10 nm predicted from theoretical considerations for identifying a protein embedded in water. Possible explanations for this include the inapplicability of the dose-fractionation theorem, the difficulty of phase determination, an overall object-size dependence on the required fluence and dose, a low contrast within the biological cell, insufficient exposure, and a variety of practical difficulties such as scattering from surrounding material. A recent article [Villaneuva-Perez et al. (2018), Optica, 5, 450–457] concluded that imaging by Compton scattering gave a large dose advantage compared with CDI because of the object-size dependence for CDI. An object-size dependence would severely limit the applicability of CDI and perhaps related coherence-based methods for structural studies. This article specifically includes the overall object size in the analysis of the fluence and dose requirements for coherent imaging in order to investigate whether there is a dependence on object size. The applicability of the dose-fractionation theorem is also discussed. The analysis is extended to absorption-based imaging and imaging by incoherent scattering (Compton) and fluorescence. This article includes analysis of the dose required for imaging specific low-contrast cellular organelles as well as for protein against water. This article concludes that for both absorption-based and coherent diffraction imaging, the dose-fractionation theorem applies and the required dose is independent of the overall size of the object. For incoherent-imaging methods such as Compton scattering, the required dose depends on the X-ray path length through the specimen. For all three types of imaging, the dependence of fluence and dose on a resolution d goes as 1/d4 when imaging uniform-density voxels. The independence of CDI on object size means that there is no advantage for Compton scattering over coherent-based imaging methods. The most optimistic estimate of achievable resolution is 3 nm for imaging protein molecules in water/ice using lensless imaging methods in the water window. However, the attainable resolution depends on a variety of assumptions including the model for radiation damage as a function of resolution, the efficiency of any phase-retrieval process, the actual contrast of the feature of interest within the cell and the definition of resolution itself. There is insufficient observational information available regarding the most appropriate model for radiation damage in frozen hydrated biological material. It is advocated that, in order to compare theory with experiment, standard methods of reporting results covering parameters such as the feature examined (e.g. which cellular organelle), resolution, contrast, depth of the material (for 2D), estimate of noise and dose should be adopted. Full Article text