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Western front: On the parties and their prospects in the Maharashtra polls

Granular factors can determine the outcome in Maharashtra 




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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article
Open Access
Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Railways using treated water from its STP for maintaining green spaces

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction




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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.




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600: Where Will The Web Be 12 Years from Now?

We've got your feedback as well as our thoughts on where we all think the web will be in 2036 - as we celebrate 12 years of ShopTalk Show history, we're looking forward to what's to come with ideas around cookie banners, undo, no more passwords, React, Deno, Node, and Mozilla's future, ChatGPT's thoughts, accessibility, blockchain, VR / AR, hoverboards, P3 color space, indie web, JS bundle sizes, and more!




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601: Brad Frost on A Global Design System + Frostapalooza

Brad Frost has got design systems on his mind—at a global scale. What is a global design system? Are two design systems ever the same? How would this slot inside atomic design? What has been the response from the web community to global design system as an idea? And what's Frostapalooza?




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624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch

On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024.




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630: Frostapalooza Recap, Follow Up, and Messy Codebases

Chris has a birthday today 🎉, we recap our Frostapalooza experience celebrating Brad Frost's birthday, do all codebases become a mess, Mermaid, TLDraw, and Figjam thoughts, making tiny games, where's the follow up in web and world news, and what's the current state of CMS' on the web?




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Power from wind and sun

Human activities are rapidly depleting non-renewable energy sources; therefore hybrid energy has emerged as a viable alternative




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Challenges on the water front

Weather anomalies, pollution, mindless exploitation… the problems are many but solutions are available.




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Style and substance, from waste

Many architects with green ideologies have converted waste to usable construction material, some of it in the most innovative manner.




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F1: Piastri on pole as McLaren in front

McLaren are leading the constructor's championship but are only 29 points ahead of Ferrari, with Leclerc an obvious threat and team mate Carlos Sainz qualifying fifth and Mercedes' George Russell sixth.




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A sporty knock from India Inc

A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too




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Unlocking renewable energy from industrial waste: Biogas production from spent wash

It is a sustainable solution for industrial waste management and renewable energy generation




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From agri waste to industrial raw material

altM is developing alternatives to mined materials and petrochemicals 




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Idukki project leapfrogs ‘endangered’ list

Local enthusiasts pitch in to bring amphibian species back from the brink of extinction




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New venture Zerofifty from ad veterans wants to simplify the agency model

ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model




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India seeks $70 million from Climate Investment Funds

India looks to accelerate proposed ‘renewable energy integration programme’




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Why power from Sri Lanka is a better option than offshore wind

Wind industry sources estimate island nation has 65 GW onshore potential




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Keeping track of Scope-3 emissions from supply chains

Gurgaon-based startup OnlyGood FutureTech helps companies measure emissions generated by supply partners




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Navigating the flood of healthcare information, with a little help from AI

A global survey maps how willing, and equipped clinicians are in using artificial intelligence to support their work 




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Time to embrace ‘re-sign’ from resign

Rehiring your ex-colleagues is no longer an emotional decision but the most logical one




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GalaxEye: A multi-sensor peek at earth from outer space

Startup sets out to fill a crucial gap in satellite imagery for real-world applications




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Campaign to discourage open burning from Nov 6, 588 teams to be deployed: Delhi Minister Rai

Mr. Rai said 588 teams from different civic agencies, including the Municipal Corporation of Delhi (MCD), will be deployed to report open burning incidents across the national capital




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CVC has sought report from CPWD over CM House renovation: Delhi LoP




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29-year-old woman arrested from Delhi’s Shakurpur for human trafficking minor




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Lawyer sent to jail for 4 months from Delhi HC for ‘derogatory’ remarks against judges

The court directed the police to take Sanjeev Kumar into custody directly from the court and sent him to jail




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Three arrested for raping intellectually disabled research scholar from Odisha




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Delhi cop Nidhin Valsan’s inspiring journey from arresting cancer to Ironman finish line

Diagnosed with stage 4 non-Hodgkin’s lymphoma in 2021, IPS officer Nidhin Valsan resurrected himself by competing the Ironman triathlon and writing his memoir because he hopes to be a good influence on other cancer patients




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Learning from US gig economy debate

What are the implications for India in terms of non-formal employment, labour laws and social security?




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Straight from the heart

Isher Judge Ahluwalia’s memoirs are also a tale of India’s socio-economic reforms trajectory




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From diplomacy to Raisina Hill

Diplomat, Vice-Chancellor, policy wonk and Vice-President, the many hats that Hamid Ansari wore




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Booming Digital Stars: 11 Inspiring Journeys from India’s Creator Economy 

Lessons from the exciting success stories of social media influencers




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A natural farm from wasteland at Andhra University in Visakhapatnam

The Andhra University Avani Organics Gardening Hub in Visakhapatnam has grown into a thriving natural farm and is building a community of urban dwellers that is transforming a wasteland into a patch of green




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From beauty parlours to farming, prisoners in India’s jails are channeling their time into creative new outlets

Some trivia from prisons across the country




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Centre aims seven-fold jump in wheat procurement from Uttar Pradesh, Rajasthan, Bihar this year

“Even as the ban on outbound shipments of wheat continues, “it will be a dream for us to export now”, Food Secretary Sanjeev Chopra said.




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How can small-scale farmers benefit from trees on farms?

The adoption of agroforestry at scale in India by smallholders is currently stymied by ecological and socio-economic factors




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First International Dairy Federation Asia-Pacific summit in Kochi from June 26 to 28




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In Assam, banks suffer from ‘militancy hangover’: experts

The absence of bank linkage is affecting optimum production by 25 lakh small and marginal farmers in the State, they said




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Onam 2024: Flowers and vegetables from Vattiyoorkavu set an example

MLA VK Prasanth encourages Krishi Bhavan at Vattiyoorkavu to cultivate vegetables and flowers on a vacant plot owned by the government



  • Life & Style

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UAS Dharwad to host Krishi Mela from September 21

UAS Vice-Chancellor P. L. Patil said that the main objective of this year’s Krishi Mela is to provide information on various aspects of climate change to farmers




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Tata Housing raises $25 m from CDC




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Delay in handover of units from Goa to Daman leaves investors in limbo




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Delay over handover of industrial estate from Goa to Daman and Diu leaves investors




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Greenko raises $230 million from ADIA, GIC