“Upload” feels like a slight, funny show — until you realize that without the jokes, the story would be unwatchably bleak. The Amazon Prime Video series (created by Greg Daniels of “The Office,” “Parks & Recreation” and the upcoming “Space Force”) takes place in a near future where people can upload digital copies of themselves […]

A specific type of small startup has a window to raise crowdfunding in a somewhat less regulated way than normally required in the US based on a temporary set of rule changes by the SEC announced this week. Excited yet?

Shares of Hindustan Unilever Limited (HUL) gained over 3 percent on Friday after foreign portfolio investor Societe General picked up 1.29 crore shares of the 5.69 percent stake off-loaded by GSK on Thursday. British drugmaker GlaxoSmithKline Pte (GSK) and Horlicks sold

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The Trump administration is working on placing a temporary ban on the issuance of some work-based visas like H-1B, which are popular among highly-skilled Indian IT professionals, as well as students visas and work authorisation that accompanies them, as unemployment levels

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The Trump administration is working on placing a temporary ban on the issuance of some work-based visas like H-1B, which are popular among highly-skilled Indian IT professionals, as well as students visas and work authorisation that accompanies them, as unemployment levels

Bollywood actress Tara Sutaria has absolutely impressed us with her multiple talent. Her brilliant acting prowess has definitely left the audience stunned and with her melodious voice, she has won millions of hearts too. Apart from it, the diva

Karisma Kapoor has been sharing a lot of throwback pictures these days. The latest one she shared was from a movie and even Karisma Kapoor doesn't know which movie the picture is from. She captioned her image as, "I

  Sridevi and Chiranjeevi starrer Telugu film, Jagadeka Veerudu Athiloka Sundari was released on 9 May 1990 and it turned out to be a blockbuster. In the film, veteran actress Sridevi portrayed the role of Indraja, who was a celestial being

K Raghavendra Rao's cult-classic Jagadeka Veerudu Athiloka Sundari starring Chiranjeevi and Sridevi, is all set to complete 30 years on May 9. On the occasion, Vyjayanthi Movies released a set of videos of Nani explaining the story behind the making of

He requested state governments to cooperate with railways in running of more Shramik special trains.

Lewis Library - ML418.P266 H39 2018

Rotch Library - ML189.M87 2019

Lewis Library - ML410.M382 A3 2018

At the first sign of trouble, one should exit credit risk funds: Arvind Chari, Head - Fixed Income and Alternatives, Quantum Advisors

Production from PSCs now stands around 30% share of domestic oil, 20% of natural gas

Eminent historian Hari Shankar Vasudevan died at a private hospital here on Sunday. He was 68. Vasudevan had tested positive for novel coronavirus o

Supriyo has shared the picture on May 8, claiming that if Sinha and Banerjee are together then it "raises many questions".

Coronavirus: China threat to put tariffs on Australian barley ‘concerning’  The AustralianView Full coverage on Google News

As I predicted, Kelly showed none of the tenacious questioning of the accuser’s story she so successfully leveraged in the Duke lacrosse case. In that case, she was clearly fed talking points from the defendants. In this one, she was clearly working on behalf of the accuser. And her own ambitions to get back into right-wing media.

Kelly never bothered to ask, much less explore, many of the disturbing contradictions in Reade’s story that have stymied reporters. Instead, we got a melodramatic and, I must say, compelling recitation of Reade's accusation. Throughout, Kelly did her utmost to make Reade sympathetic and credible and only pretended to ask tough questions.

For example, early on, Reade hinted at a spotty work history. Kelly neatly summarized Reade’s resumé for her, with details provided by someone unnamed. On Thursday, high-profile attorney Douglas Wigdor announced that he is representing Reade.

As Arizona's cities are laying off and furloughing workers because of cratering revenues as a result of the coronavirus pandemic, their Republican senator is telling them to toughen up. She isn't going to help them by voting for any financial support for state local government, citing that "blue state bailout" bullshit.

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Havasu Falls @ Arizona

Check out travel recommendations at Wanderfly!

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PHOENIX – Today, the U.S.

For Immediate Release No. 20-OPA-042

thank u, next husband.

There was certainly was stress in the air when health and economic consqeuences of COVID-19 bore down on Brooklyn and the rest of America. But as these pressures grew, constructive hearts and minds prevailed at the BKLYN Commons (BKC) shared workspace operation at 495 Flatbush Ave., in the Prospect-Lefferts Gardens area, which creatively and passionately morphed to adapt to the new normal.

With regulations urging residents statewide to wear masks when in public, here is how Southern Utahsn have fared following the recommended guidelines

Pasquale "Patrick" Amore, 88, had an infectious laugh and a zest for life. He died of COVID-19 at the age of 88.

Comparing “Likes” with “Tweets” of the Most Shared Stories

Ontario's provincial parks and conservation areas will reopen this week but campgrounds and beaches will continue to be off-limits for now.

How coping with OCD prepared one man for the challenges of the coronavirus pandemic.

Filed under: Europe, North America, France, United Kingdom, United States

Continue reading London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List

London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List originally appeared on Gadling on Tue, 17 Dec 2013 14:11:00 EST. Please see our terms for use of feeds.

The following article, Professor Who Mocked Barron Trump During Senate Hearings Gets Censorship Position at Facebook, was first published on 100PercentFedUp.com.

Facebook just announced a 20 person board of oversight that will assist with content moderation. One of the people selected for the board, a professor at Stanford Law School, was announced as a member of the board and is raising eyebrows because of her snarky comment about Barron Trump during Senate Impeachment Hearings. Pamela Karlan, […]

Continue reading: Professor Who Mocked Barron Trump During Senate Hearings Gets Censorship Position at Facebook ...

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.

This report finds that the 813,000 U.S. children under the age of 10 who have Black immigrant parents from Africa or the Caribbean generally fall in the middle of multiple well-being indicators, faring less well than Asian and white children but better than their native-born Black and Hispanic peers. Citizenship status, English proficiency, parental characteristics, poverty, housing, and access to social supports are examined.

Immigration from the Caribbean to the United States is a relatively recent phenomenon, beginning largely after 1965. This report provides a demographic profile of the 1.7 million Caribbean immigrants in the United States: their geographic settlement, education and workforce characteristics, earnings, modes of entry, and more.

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.

With maritime migration the subject of significant policy and public focus in Europe, Australia, and beyond, this timely volume reviews the policy responses to irregular maritime arrivals at regional, national, and international levels. The book includes case studies of the major global hotspots—the Mediterranean, Gulf of Aden, Bay of Bengal/Andaman Sea, Australia, and the Caribbean—and examines trends and policy responses.

This report assesses how new immigrants to Spain fare in the country's labor market, evaluating the conditions under which they are able to find employment, and their progress out of unskilled work into middle-skilled jobs. The report is part of a series of six case studies on labor market outcomes among immigrants to European Union countries.

Ravi Zacharias (date: 5/10/2020 - Rank: 6)

Kartik Aaryan has been quite active on social media in raising awareness about the pandemic and at the same time requesting all his fans to stay indoors. Not only that but the talented star has also come out in support of the government and contributed...

1. Happy Mother's Day: Karisma to Sushmita, a look at Bollywood's single mum's who have paved their own way  PINKVILLA
2. Mother’s Day 2020: From Aishwarya Rai to Kareena Kapoor, check out pics of these Bollywood moms and...  Hindustan Times
3. Happy Mother's Day 2020: Kareena Kapoor, Shilpa Shetty lead B-Town stars celebrate motherhood, wish mothers on this precious day | In Pics  Jagran English
4. When Aishwarya Rai Bachchan was asked to pick between Kareena Kapoor Khan & Rani Mukerji; Here’s what she said  PINKVILLA
5. Mother’s Day 2020: Single Mothers of Bollywood  News18
6. View Full coverage on Google News