DOVER, Del. (May 2, 2023) – On the morning of Saturday, April 29, the Delaware Forest Service celebrated Arbor Day with an extensive tree planting surrounding the Peters Scout Camp/Peters Tract at Blackbird State Forest, along with our 2023 Arbor Day Poster Contest winners and their families. With support from the Forest Initiative Fund (FIF), […]

DOVER, Del. (May 11, 2023) – The Delaware Department of Transportation (DelDOT) is partnering with the Delaware Department of Agriculture’s Delaware Forest Service (DFS) to plant over 12,100 trees in support of the Forest Initiative Fund (FIF). FIF was created by the DFS to help address water quality, air quality, and overall life for all […]

DOVER, Del. (May 19, 2023) – The Delaware Tree Stewards, housed under the Delaware Forest Service’s Urban and Community Program, is offering a four-session training, geared toward participants living in both New Castle County and Sussex County, Delaware. Participants will be equipped with skills to be able to work with neighbors, organizations and local public […]

The Tree for Every Delawarean Initiative (TEDI) is making significant progress toward the goal of planting 1 million trees by 2030. The initiative has awarded funding to seven new projects, which will push the total count beyond 200,000 trees this year.

Comparing Logistic Regression and Decision Tree - Which of our models is better at predicting our outcome? Learn how to compare models using misclassification, area under the curve (ROC) charts, and lift charts with validation data. In part 6 and part 7 of this series we fit a logistic regression [...]

Getting Started with Python Integration to SAS Viya for Predictive Modeling - Comparing Logistic Regression and Decision Tree was published on SAS Users.

The 7th Street Boating and Fishing Area on the Christina River has officially reopened to Wilmington's Eastside community, with DNREC, in partnership with the city, celebrating the $2.9 million project with a ribbon-cutting ceremony in John Barbiarz Park, where the popular facility is located.

The United States Department of Agriculture’s Animal and Plant Health Inspection Service (USDA-APHIS) has confirmed a find of box tree moth (BTM; Cydalima perspectalis) at a private residence in Kent County, Delaware. The box tree moth is a federally regulated pest that primarily feeds on boxwood species (Buxus spp.). If left unchecked, it causes significant damage and can potentially kill the plants. Boxwoods are a popular ornamental evergreen shrub common to many landscape environments in the United States.

The Tree for Every Delawarean Initiative (TEDI) is seeking funding requests for tree-planting projects that will be completed in 2025.

Ten projects will receive a combined $234,000 in funding from the Tree for Every Delawarean Initiative to plant more than 4,600 trees.

I want to create sub tree of sub trees how can i do that?

I want to create another tree for the Sub parameter also.

In the era of Artificial Intelligence, front-end designers need a magical key to empower them with technology that enables fully optimized RTL for implementation handoff and provides RTL designers with capabilities to accurately assist in the implementation convergence process.

The magic lies with Cadence Joules RTL Design Studio, an expert system that leverages generative AI for RTL design exploration, triages possible causes of violations, and additional insights that empower designers to understand how to address issues in their RTL, leading to smarter and more efficient chip design.

This unlocks the immense debugging and design analysis capabilities from a single, unified cockpit, enabling fully optimized RTL design prior to implementation handoff for the front-end designers and addresses all aspects of physical design by adding visibility into power, performance, area, and congestion (PPAC)

One critical component is the clock tree, which distributes the clock signal to all sequential elements, such as flip-flops and latches. Designers need the right techniques in the beginning stage to optimize the clock tree structure, ensuring that their designs meet the required timing specifications, reduce power consumption, maintain signal integrity, and increase reliability.

 This incredible feature is part of the Joules RTL Design Studio.

How do you efficiently explore the clock tree structure to optimize the results using Joules RTL Design Studio?

Joules Studio allows viewing a simplified version of the clock structure. This feature is primarily designed to help display clock frequency scaling through clock dividers. You can customize colors, symbols, and design elements using an input file. Additionally, you can cross-probe the custom clock tree structure to other widgets and the main schematic view in Joules Studio.

Moreover, with the clock tree preference features of the ideal clock tree wizard in Joules Studio GUI, you can highlight clock path, generate clocks and master clock, set case analysis, fold and unfold instances, undo and redo, set sense and disable timing, color preference, etc.

You can binge on these features through the channel videos posted on the support portal, which covers the Joules RTL Design Studio GUI Clock Tree Structure and Features of Ideal Clock Tree Wizard.

You can refer to the videos on Cadence Online Support (Cadence login required).

​Video Links:
Viewing Custom Clock Tree Structure in Joules RTL Design Studio (Video) 

Exploring Clock Tree Preference Widget of Ideal Clock Tree Wizard in Joules RTL Design Studio (Video) 

Want to learn more?

Explore the one-stop solution Joules RTL Design Studio Product Page on Cadence Online Support (Cadence login required).

Related Resources 

Related Training Bytes:

Understanding Prototype Design Flow in Joules RTL Design Studio (Video)

Running Prototype Implementation Flow in Joules RTL Design Studio (Video)

Understanding Analyze Timing By Hierarchy In Joules RTL Design Studio (Video)

Related Courses:

• Joules Power Calculator

Want to Enroll in this Course?

We organize this training for you as a "Blended" or "Live" training. Please reach out to Cadence Training for further information.

Please don't forget to obtain your Digital Badge after completing the training.

Related Blogs:

Let's Discover the Secret to Enhance Design's PPAC in a Single Cockpit! - Digital Design - Cadence Blogs - Cadence Community

Joules RTL Design Studio: Accelerating Fully Optimized RTL - Digital Design - Cadence Blogs - Cadence Community

Let's Replay the Process of Power Estimation with the Power of 'x'! - Digital Design - Cadence Blogs - Cadence Community

Is Design Power Estimation Lowering Your Power? Delegate and Relax! - Digital Design - Cadence Blogs - Cadence Community

The quantum computing era is coming, and it will change everything about how the world connects online. While quantum computing will yield tremendous benefits, it will also create new risks, so it’s essential that we prepare our critical internet infrastructure for what’s to come. That’s why we’re so pleased to share our latest efforts in […]

The post Verisign Provides Open Source Implementation of Merkle Tree Ladder Mode appeared first on Verisign Blog.

Anonymous (not verified) Tue, 05/21/2019 - 12:44

ferrard Wed, 08/17/2022 - 14:24

Dutch police disperse people from streets after Amsterdam tram set on fire

Margot Robbie uses the ultimate emotionally packed movie to cry in movies, and that’s what she did in the Wolf of Wall Street.In a yet-to-be-released episode of the Talking Pictures: A Movie Memories Podcast, which premiers on Nov. 26, the actress was recently questioned how she...

The act of planting trees offers more than shade and fruit. It symbolizes a deeper mission—restoring soil, preserving water, and, for these students, living in Tanzania’s northern Rorya district, delivering a form of climate justice. The reforestation efforts are in step with Tanzania's broader plans to fortify its agriculture and water systems against the advancing climate crisis.

Wall Street firms are expected to pay heftier bonuses for this year, the first increase since a bumper year in 2021, according to a report by compensation consultancy Johnson Associates. Payouts will probably rise after financiers benefited from several factors in recent months: a recovery in dealmaking, the Federal Reserve cutting interest rates and equity […]

to wire your street rod

DNA analysis suggests Pando, a quaking aspen in Utah with thousands of stems connected by their roots, is between 16,000 and 81,000 years old

DNA analysis suggests Pando, a quaking aspen in Utah with thousands of stems connected by their roots, is between 16,000 and 81,000 years old

AI and Google Street View have created 'digital twins' of living trees in North American cities – part of a huge simulation that could help make urban tree planting and trimming decisions

Ancient humans are said to have evolved to leave the trees, where our primate ancestors lived, in favour of open grassy savannahs – but we may have this idea wrong

Title: California Trees Harbor Fungus Deadly to People With HIV
Category: Health News
Created: 8/28/2014 9:35:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM

The flats are described as the first new homes on the Scottish town's High Street 'in living memory'

Got an email about this. Looks cool. Is free. “I’ll write about that,” I thought. “I’ll write about that for Rock Paper Shotgun, a place that semi-regularly posts articles about cool and free games.” So here we are. If you’re waiting for the other shoe to drop, assuming the only reason I’d open an article in a superfluous and straightforward manner is because I’m about to deliver some sort of third sentence twist, you’re completely wrong! There’s no twist at all. I’m simply going to deliver some information about the game in a neutral tone. You can find VED: Purification, a free prologue demo to RPG VED, here.

Read more

Sega are delisting several bundles of 'classic' games from digital stores, along with "select individual" games. On Steam specifically, this adds up to over 60 games in total, including several actual classics including the original Streets Of Rage trilogy, Crazy Taxi, and Jet Set Radio.

The games will be removed on December 6th but will remain playable to those who already own them.

Read more

AI and Google Street View have created 'digital twins' of living trees in North American cities – part of a huge simulation that could help make urban tree planting and trimming decisions

At ICRA 2024, Spectrum editor Evan Ackerman sat down with Unitree founder and CEO Xingxing Wang and Tony Yang, VP of Business Development, to talk about the company’s newest humanoid, the G1 model.

Smaller, more flexible, and elegant, the G1 robot is designed for general use in service and industry, and is one of the cheapest—if not the cheapest—of a new wave of advanced AI humanoid robots.

By inoculating greenhouse na’u seedlings with mycorrhizal fungi, researchers hope to boost survival odds when the plants are returned to the wild

Help scientists protect and nurture forests.

A review of 47,282 tree species by the International Union for Conservation of Nature found that more than one third are at risk of extinction

It is a surprisingly common peril among analysts: we don’t have the data to answer the question we’re interested in, so we answer a related question where we do have data. Unfortunately, the new answer turns out to shed no light on the original interesting question.

This is sometimes referred to as the Streetlight Effect – a phenomenon aptly illustrated by Mutt and Jeff over half a century ago:

This is the situation that the Tufts Center for the Study of Drug Development seems to have gotten itself into in its latest "Impact Report".  It’s worth walking through the process of how an interesting question ends up in an uninteresting answer.

So, here’s an interesting question:

My company owns a drug that may be approvable through FDA’s 505(b)(2) pathway. What is the estimated time and cost difference between pursuing 505(b)(2) approval and conventional approval?

That’s "interesting", I suppose I should add, for a certain subset of folks working in drug development and commercialization. It’s only interesting to that peculiar niche, but for those people I suspect it’s extremely interesting - because it is a real situation that a drug company may find itself in, and there are concrete consequences to the decision.

Unfortunately, this is also a really difficult question to answer. As phrased, you'd almost need a randomized trial to answer it. Let’s create a version which is less interesting but easier to answer:

What are the overall development time and cost differences between drugs seeking approval via 505(b)(2) and conventional pathways?

This is much easier to answer, as pharmaceutical companies could look back on development times and costs of all their compounds, and directly compare the different types. It is, however, a much less useful question. Many new drugs are simply not eligible for 505(b)(2) approval. If those drugs

Extreme qualitative differences of 505(b)(2) drugs. Source: Thomson Reuters analysis via RAPS

are substantially different in any way (riskier, more novel, etc.), then they will change the comparison in highly non-useful ways. In fact, in 2014, only 1 drug classified as a New Molecular Entity (NME) went through 505(b)(2) approval, versus 32 that went through conventional approval. And in fact, there are many qualities that set 505(b)(2) drugs apart.

So we’re likely to get a lot of confounding factors in our comparison, and it’s unclear how the answer would (or should) guide us if we were truly trying to decide which route to take for a particular new drug. It might help us if we were trying to evaluate a large-scale shift to prioritizing 505(b)(2) eligible drugs, however.

Unfortunately, even this question is apparently too difficult to answer. Instead, the Tufts CSDD chose to ask and answer yet another variant:

What is the difference in time that it takes the FDA for its internal review process between 505(b)(2) and conventionally-approved drugs?

This question has the supreme virtue of being answerable. In fact, I believe that all of the data you’d need is contained within the approval letter that FDA posts publishes for each new approved drug.

But at the same time, it isn’t a particularly interesting question anymore. The promise of the 505(b)(2) pathway is that it should reduce total development time and cost, but on both those dimensions, the report appears to fall flat.

• Cost: This analysis says nothing about reduced costs – those savings would mostly come in the form of fewer clinical trials, and this focuses entirely on the FDA review process.
• Time: FDA review and approval is only a fraction of a drug’s journey from patent to market. In fact, it often takes up less than 10% of the time from initial IND to approval. So any differences in approval times will likely easily be overshadowed by differences in time spent in development. 

But even more fundamentally, the problem here is that this study gives the appearance of providing an answer to our original question, but in fact is entirely uninformative in this regard. The accompanying press release states:

The 505(b)(2) approval pathway for new drug applications in the United States, aimed at avoiding unnecessary duplication of studies performed on a previously approved drug, has not led to shorter approval times.

This is more than a bit misleading. The 505(b)(2) statute does not in any way address approval timelines – that’s not it’s intent. So showing that it hasn’t led to shorter approval times is less of an insight than it is a natural consequence of the law as written.

Most importantly, showing that 505(b)(2) drugs had a longer average approval time than conventionally-approved drugs in no way should be interpreted as adding any evidence to the idea that those drugs were slowed down by the 505(b)(2) process itself. Because 505(b)(2) drugs are qualitatively different from other new molecules, this study can’t claim that they would have been developed faster had their owners initially chosen to go the route of conventional approval. In fact, such a decision might have resulted in both increased time in trials and increased approval time.

This study simply is not designed to provide an answer to the truly interesting underlying question.

[Disclosure: the above review is based entirely on a CSDD press release and summary page. The actual report costs $125, which is well in excess of this blog’s expense limit. It is entirely possible that the report itself contains more-informative insights, and I’ll happily update that post if that should come to my attention.]

The New Wall Street & Technology

Every bottle of Bellucci starts in a family grove.

New Amsterdam Vodka presents "It's Your Town"

DNA analysis suggests Pando, a quaking aspen in Utah with thousands of stems connected by their roots, is between 16,000 and 81,000 years old

AI and Google Street View have created 'digital twins' of living trees in North American cities – part of a huge simulation that could help make urban tree planting and trimming decisions

Andrés Bracamonte, known as Pillín, was gunned down near his club's stadium in Rosario.

Trainer Malcolm Jefferson believes bigger fences at the Grand National could have saved his horse According to Pete.

medlinkHimalaya/medlink Wellness Company, a prominent wellness brand in India, proudly announces its landmark achievement of planting over one million trees across the country.

The corrupting cricket tree

The monster of corruption has not spared even the games being enjoyed by the...

The Karnataka Forest Department has filed an FIR against the producers of Yash's 'Toxic' and officials from Canara Bank and HMT for allegedly cutting down trees on forest land during the film's shoot in Bengaluru.

Hero Motocorp has revealed the all-new Xtreme 250R at EICMA 2024. The Hero Xtreme 250R is the production version of the 2.5R Xtunt unveiled at last year's EICMA show and is the naked streetfighter sibling of the newly unveiled Karizma XMR

Italian motorcycle manufacturer Ducati has revealed the new Streetfighter V2 and V2 S. The new Ducati Streetfighter V2 sports the firm's brand-new Superquadro 890cc V-twin Superquadro engine and has undergone a big diet, making it the lightest Streetfighter from the Bologna