pee EPIC: The ‘Songify’ Trend Of Clipping Speeches To Music Is Back… And AWESOME! By clashdaily.com Published On :: Mon, 11 Nov 2024 11:00:46 +0000 Kamala was right about one thing: this election really DID deliver 'joy'... just not the way she expected. The post EPIC: The ‘Songify’ Trend Of Clipping Speeches To Music Is Back… And AWESOME! appeared first on Clash Daily. Full Article Videos
pee Nuclear stability for all put at risk by Putin's speech By www.chathamhouse.org Published On :: Wed, 22 Feb 2023 21:14:31 +0000 Nuclear stability for all put at risk by Putin's speech Explainer NCapeling 22 February 2023 Explaining the risks of Russia’s decision to suspend the New START nuclear treaty with the US, and the wider implications for international relations. Why is New START important? Following the collapse of the Intermediate-range Nuclear Forces treaty (INF), New START is the only remaining nuclear arms control treaty between the US and Russia. This means that without it there would be no limits on numbers or the type of Russian and US deployed nuclear warheads. The limits set under New START are lower than those set under its predecessor, the Strategic Arms Reduction Treaty (START). It is also important for maintaining some form of strategic arms control between Russia and the US. The treaty provides the US and Russia with mechanisms for transparency and confidence-building, for instance through regular biannual data exchanges, as well as measures for verification. What is Russia able to do next after suspending participation? President Vladimir Putin’s decision to suspend its participation could pave the way for Russia to increase the number of deployed warheads, delivery vehicles and launchers, potentially exceeding the limits placed on numbers under the new START. Putin stated he would resume testing of nuclear weapons if the US resumed – Russia is a full state party to the nuclear Comprehensive Test Ban Treaty (CTBT) negotiated in 1996, as is the UK and France. The US has signed, as has China, but neither state has yet ratified the treaty. This is likely to have wider implications for progress on nuclear non-proliferation under the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), as well as the wider international security treaty regime. Other countries required to ratify the treaty for it to enter into force include Egypt, India, Iran, Israel, North Korea, and Pakistan. Although the US is modernizing its nuclear weapons forces, there is no need – or plan – for the US to test nuclear warheads, and it is the same for the UK and France. Concerns are now rising that Russia could point to no-fissionable yield experiments – which are allowed under the treaty and which the US and other nuclear weapons possessors conduct primarily for safety purposes – and then falsely declare those to be nuclear weapons tests, thus paving the way for a narrative to justify the resumption of nuclear testing by Russia. Conducting a nuclear weapons test would be seen clearly as a further step on the escalation scale towards nuclear use for Russia. While inspections of nuclear weapons sites had not resumed since COVID-19, Russia’s suspension of its participation could result in the further halting of other transparency and verification measures under New START, including the regular mutual data exchanges between the US and Russia – for example on warhead numbers, locations, and technical information on weapons systems and their sites – which are conducted through the Bilateral Consultative Commission (BCC). What is the difference between withdrawing from New START and ‘suspending’ participation? In his speech, Putin announced the suspension of Russian participation in New START. While this does not mean Russia has formally withdrawn from the treaty, the suspension could enable Russia to continue preventing the US from inspecting its nuclear weapons sites and halt Russia’s participation in other obligations, such as the routine reporting and data exchanges on nuclear weapons as well as meetings of the BCC. The decision to suspend participation rather than withdraw from the treaty means Russia retains the option to return to compliance at a later point. However, it is not yet clear under what conditions Russia would opt to return to compliance with the treaty, or whether this means the US will, in turn, suspend their own obligations. The treaty text itself does not provide for a suspension of participation by parties to the treaty. However, the Vienna Convention on the Law of Treaties does address the mechanisms for suspension of participation in a treaty. Russia is a full state party to the Vienna Convention, but the US has remained a signatory without ratification since 1970. There is a precedent of Russia suspending its membership in arms control treaties rather than withdrawing, which is when Russia suspended its participation in the original Treaty on Conventional Armed Forces in Europe (CFE) in 2007. The US does not recognize Russia’s suspension of its participation in the CFE treaty, but this does not make a material difference to Russian actions. What does the suspension mean for the wider international treaty regime? Russia’s suspension of the New START could signal the end of strategic arms control between the two countries. There is now virtually no regular scheduled arms control communication between the two countries bilaterally – this is a dangerous position to be in, especially in times of crisis. By announcing Russia’s suspension of the treaty in his main address on the anniversary of the invasion of Ukraine, Putin is sending a signal about Russia’s intent for the future The suspension of New START further erodes limited recourse for communication between the two countries, by suspending information exchange and meetings of the BCC under the treaty. This is likely to have wider implications for progress on nuclear non-proliferation under the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), as well as the wider international security treaty regime. Will this increase the nuclear threat or the likelihood of nuclear use? New START provides both the US and Russia with a degree of transparency surrounding nuclear weapons systems. Without an avenue for regular data exchange and notification, and mechanisms for verification through mutual nuclear weapons site inspections, the risk of misperception or misunderstanding could increase and fuel uncertainty which could increases the perception of threat between Russia and the US. What are Putin’s reasons for suspending Russia’s participation? Putin and various members of his government have been linking the future of New START to the war in Ukraine rhetorically for several months now, threatening that Russia may not be willing to negotiate a follow-on treaty for when New START expires in Feb 2026 because of US support for Ukraine. By announcing Russia’s suspension of the treaty in his main address on the anniversary of the invasion of Ukraine, Putin is sending a signal about Russia’s intent for the future. Russia’s new hypersonic glide vehicle Avangard was already counted under New START and it is likely follow-on negotiations would have focused on some of Russia’s other hypersonic capabilities or other new nuclear systems. Without the treaty, Russia might be less inhibited in its development of new nuclear systems. Have both the US and Russia been compliant with the treaty until now? Both the US and Russia have remained within the central limits of the treaty since its entry into force in 2011. Following the outbreak of COVID-19, both sides agreed to suspend in-person inspections due to restrictions on travel, and attempts to recommence in-person inspections in 2022 were unsuccessful. In August 2022, Russia prevented US on-site inspections under New START and a November 2022 meeting of the BCC was called off by Russian officials. Russia has blamed both the ongoing COVID-19 pandemic and the sanctions burden on Russia as reasons for not wanting to resume inspections. Full Article
pee Who Should Regulate Free Speech Online? By f1.media.brightcove.com Published On :: Thu, 27 Jun 2019 00:00:00 +0100 Full Article
pee Undercurrents: Episode 51 - Preparing for Pandemics, and Gandhi's Chatham House Speech By brightcove.hs.llnwd.net Published On :: Thu, 30 Apr 2020 00:00:00 +0100 Full Article
pee SAS Notes for SAS®9 - 66492: FILENAME FTP(FTP/TLS) fails with "ERROR: The connection was reset by a peer" due to using implicit FTP/TLS By Published On :: Wed, 26 Aug 2020 13:59:34 EST If you connect to a FTP/TLS server that is configured to use implicit FTP/TLS, FILENAME FTP/TLS might fail with the following error: ERRO Full Article BASE+Base+SAS
pee High-speed Analysis of Large Sample Sets - How Can This Key Aspect of the Omics Be Achieved? [Perspective] By www.mcponline.org Published On :: 2020-11-01T00:05:37-07:00 High-speed analysis of large (prote)omics sample sets at the rate of thousands or millions of samples per day on a single platform has been a challenge since the beginning of proteomics. For many years, ESI-based MS methods have dominated proteomics because of their high sensitivity and great depth in analyzing complex proteomes. However, despite improvements in speed, ESI-based MS methods are fundamentally limited by their sample introduction, which excludes off-line sample preparation/fractionation because of the time required to switch between individual samples/sample fractions, and therefore being dependent on the speed of on-line sample preparation methods such as liquid chromatography. Laser-based ionization methods have the advantage of moving from one sample to the next without these limitations, being mainly restricted by the speed of modern sample stages, i.e. 10 ms or less between samples. This speed matches the data acquisition speed of modern high-performing mass spectrometers whereas the pulse repetition rate of the lasers (>1 kHz) provides a sufficient number of desorption/ionization events for successful ion signal detection from each sample at the above speed of the sample stages. Other advantages of laser-based ionization methods include the generally higher tolerance to sample additives and contamination compared with ESI MS, and the contact-less and pulsed nature of the laser used for desorption, reducing the risk of cross-contamination. Furthermore, new developments in MALDI have expanded its analytical capabilities, now being able to fully exploit high-performing hybrid mass analyzers and their strengths in sensitivity and MS/MS analysis by generating an ESI-like stable yield of multiply charged analyte ions. Thus, these new developments and the intrinsically high speed of laser-based methods now provide a good basis for tackling extreme sample analysis speed in the omics. Full Article
pee Ciena Powers SC24’s SCinet with High-Speed Connectivity and Advanced Optical Solutions By www.hpcwire.com Published On :: Tue, 05 Nov 2024 14:47:50 +0000 HANOVER, Md., Nov. 5, 2024 — Ciena has announced that its optical and routing and switching innovations will once again support the SCinet network at SC24, taking place November 17–22 […] The post Ciena Powers SC24’s SCinet with High-Speed Connectivity and Advanced Optical Solutions appeared first on HPCwire. Full Article
pee Speed up Innovation with performance gains of up to 42% on the most powerful HPC Cloud By www.hpcwire.com Published On :: Thu, 20 May 2021 12:00:33 +0000 About This Webinar Oracle’s next generation HPC architecture with Intel compute instance based on 3rd Generation Intel® Xeon® Scalable processors, code named “Ice Lake”, changes the game for HPC in […] The post Speed up Innovation with performance gains of up to 42% on the most powerful HPC Cloud appeared first on HPCwire. Full Article
pee Collaboration Speeds Complex Chemical Modeling By www.hpcwire.com Published On :: Mon, 04 Nov 2024 18:41:38 +0000 A recent collaboration among researchers from HUN-REN Wigner Research Centre for Physics in Hungary and the Department of Energy’s Pacific Northwest National Laboratory (PNNL), along with industry collaborators SandboxAQ and […] The post Collaboration Speeds Complex Chemical Modeling appeared first on HPCwire. Full Article Features GPU PNNL Schrödinger equation
pee Hacked websites, hate speech hit suburban Chicago schools By www.teachermagazine.org Published On :: 2020-11-13T21:03:02-05:00 Full Article Education
pee Getting New School Board Members Up to Speed By www.teachermagazine.org Published On :: 2020-11-18T00:00:00-05:00 One way to train newly elected school board members for the job ahead is to start before they even run for office. Full Article Education
pee Peeps in a Microwave: A Peep Jousting Experiment By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Read more at http://blogs.smithsonianmag.com/science/2010/04/01/a-peep-experiment/ Our Surprising Science blogger tests whether stale peeps or fresh peeps are better for the spring tradition of peep jousting. Full Article
pee Virginia State Parks Install Viewfinders for People With Colorblindness, Just in Time for Leaf-Peeping Season By www.smithsonianmag.com Published On :: Mon, 23 Sep 2024 20:40:01 +0000 The viewfinders are outfitted with special lenses that help people with red-green colorblindness distinguish between hues Full Article
pee How to Watch the Bright and Speedy Orionid Meteor Shower By www.smithsonianmag.com Published On :: Thu, 17 Oct 2024 18:57:50 +0000 While the Orionids, peaking early Sunday and Monday, might be hard to see because of the waning gibbous moon, these zippy meteors can produce long "trains" that last up to several minutes Full Article
pee Oilers captain Connor McDavid makes speedy recovery, returns to action against Vegas By www.cbc.ca Published On :: Wed, 06 Nov 2024 13:24:19 EST Connor McDavid retured from injury — well ahead of schedule. The Oilers captain re-entered the lineup when Edmonton hosted the Vegas Golden Knights on Wednesday. Full Article Sports/Hockey/NHL
pee SolidWorks Customer BUB Racing Recaptures Motorcycle World Land Speed Record By www.solidworks.com Published On :: Mon, 30 Nov 2009 00:00:00 -0500 367.382 mph in a Two-Wheeled Missile Full Article
pee SolidWorks 2009 Delivers Dramatic Speed Increase Plus More Than 260 Customer-Driven Enhancements By www.solidworks.com Published On :: Thu, 18 Sep 2008 00:00:00 -0500 Newest Version of Leading 3D CAD Software Eliminates Traditional Performance/Functionality Tradeoffs Full Article
pee ROLLON speeds time to market, enhances global marketing with SolidWorks software By www.solidworks.com Published On :: Tue, 21 Feb 2006 00:00:00 -0500 Italian linear motion systems provider standardizes on SolidWorks 3D CAD and COSMOS design analysis software; deploys interactive online catalog using 3D PartStream.NET Full Article
pee Dyco doubles design speed and eases large-assembly handling by switching to SOLIDWORKS software By www.solidworks.com Published On :: Mon, 11 Dec 2006 00:00:00 -0500 New 3D CAD software increases productivity, quality, and efficiency Full Article
pee Burlington Technologies speeds engine component design with SOLIDWORKS, PDMWorks By www.solidworks.com Published On :: Mon, 20 Aug 2007 00:00:00 -0500 Canadian aluminum die casting company cuts development time in half, reduces errors with 3D CAD and product data management software Full Article
pee Dassault Systèmes’ SOLIDWORKS Drives TEAM USA Bobsled to New Speeds in Sochi By www.solidworks.com Published On :: Tue, 28 Jan 2014 00:00:00 -0500 SOLIDWORKS 3D Design Software Delivers the Precision Needed to Shave Milliseconds off Bobsled Finish Times Full Article
pee Undergraduate students provided speech and audiology support to youth in Belize By www.psu.edu Published On :: Thu, 24 Oct 2024 11:06:21 -0400 Undergraduate students in the Penn State Department of Communication Sciences and Disorders traveled to Belize during spring break 2024 to help provide speech and audiology support to children and teens in the middle-income nation. Full Article
pee OWC Thunderbolt 5 Hub offers high-speed port expansion for Apple's newest Macs By appleinsider.com Published On :: Tue, 12 Nov 2024 13:26:01 +0000 OWC's new Thunderbolt 5 Hub aims to provide even more access to the fastest ports, by splitting one off into three more.OWC Thunderbolt 5 Hub - Image credit: OWCIn 2021, OWC introduced the Thunderbolt Hub, a dock that provided three additional Thunderbolt 4 ports when it was plugged into a Mac's Thunderbolt 4 connections. Three years later, it's doing it again, but for the newest Mac models.The OWC Thunderbolt 5 Hub is the same concept as before, with one Thunderbolt 5 cable connecting to the host Mac while providing three more Thunderbolt 5 ports to plug devices into. The hub also adds a single USB-A port to the equation too. Continue Reading on AppleInsider | Discuss on our Forums Full Article
pee Getting New School Board Members Up to Speed By www.edweek.org Published On :: Tue, 17 Nov 2020 00:00:00 +0000 One way to train newly elected school board members for the job ahead is to start before they even run for office. Full Article School+boards
pee WATCH: Watch this 15-year-old boxer's unbelievable tricks on the speed bag By abcnews.go.com Published On :: Tue, 12 Nov 2024 03:17:49 -0500 Amateur boxing champion Marley "Baby Bug" McNealy shows off her masterful skills and signature tricks with her speed bag training videos. Full Article GMA
pee Rupee At All-Time Low Of Rs 84.40 Against US Dollar In Early Trade By www.ndtv.com Published On :: Wed, 13 Nov 2024 09:30:47 +0530 The rupee slipped 1 paisa to an all-time low of 84.40 against the US dollar in early trade on Wednesday, as persistent foreign fund outflows and a muted trend in domestic equities weighed on the local unit. Full Article
pee Rupee At All-Time Low Of Rs 84.40 Against US Dollar In Early Trade By www.ndtv.com Published On :: Wed, 13 Nov 2024 10:13:53 +0530 The rupee slipped 1 paisa to an all-time low of 84.40 against the US dollar in early trade on Wednesday, as persistent foreign fund outflows and a muted trend in domestic equities weighed on the local unit. Full Article
pee Ultra-Processed Foods Might Be Speeding Up Your Body's Ageing - Here's How To Avoid These Risky Foods By food.ndtv.com Published On :: Mon, 11 Nov 2024 17:38:17 +0530 Spotting ultra-processed foods in your pantry and understanding their impact can be a game-changer for your health and well-being. Full Article
pee Electronic Speed Safety Program to Begin in I-95 Restore the Corridor Construction Zone By news.delaware.gov Published On :: Mon, 10 Jan 2022 21:08:40 +0000 The Delaware Department of Transportation (DelDOT) in partnership with the Delaware State Police announce that beginning Monday, January 17, 2022, the pilot Electronic Speed Safety Program will be active only in the I-95 construction zone in Wilmington and will last until the end of the project. The goal of the pilot program is to reduce […] Full Article Delaware State Police Department of Transportation Kent County New Castle County News Office of Highway Safety Sussex County delaware state police DelDOT DelDOT -- News I-95 Restore the Corridor speeding
pee Electronic Speed Safety Program in I-95 Restore the Corridor Construction Zone to Begin Issuing Violations By news.delaware.gov Published On :: Thu, 14 Apr 2022 23:16:25 +0000 The Delaware Department of Transportation (DelDOT) in partnership with the Delaware State Police announce the warning period for the Electronic Speed Safety Program in the I-95 construction zone in Wilmington ends on Sunday, April 17, 2022. Beginning Monday, April 18, 2022, first-time offenders will receive a warning and all subsequent violations will result in a […] Full Article Delaware State Police Department of Transportation Kent County New Castle County Speed Awareness Sussex County delaware state police DelDOT DelDOT -- News DelDOT Secretary Nicole Majeski dsp Electronic Speed Safety Program ESSP I-95 I-95 Restore the Corridor
pee Electronic Speed Safety Program to begin in I-95/Route 896 Construction Zone By news.delaware.gov Published On :: Tue, 18 Jun 2024 21:11:41 +0000 The Delaware Department of Transportation (DelDOT) in partnership with the Delaware State Police announce that beginning Monday, July 8, 2024, the Electronic Speed Safety Program (ESSP) will be active in the I-95/Route 896 construction zone in Newark and will last until the end of the project. Full Article Department of Safety and Homeland Security Department of Transportation New Castle County News Office of Highway Safety DelDOT DelDOT -- News ESSP I-95 Newark
pee 3700 Board of Examiners of Speech/Language Pathologists, Audiologists & Hearing Aid Dispensers By regulations.delaware.gov Published On :: Thu, 03 Oct 2024 11:37:59 EDT DEPARTMENT OF STATE: Division of Professional Regulation Full Article proposed
pee Logitech G435 LIGHTSPEED Wireless Gaming Headset Review By www.digit.in Published On :: 2023-09-22T13:09:00+05:30 Read the in depth Review of Logitech G435 LIGHTSPEED Wireless Gaming Headset Gaming. Know detailed info about Logitech G435 LIGHTSPEED Wireless Gaming Headset configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback. Full Article Gaming
pee AMD Ryzen™ 6000 series offers exceptional speed and long battery life for thin and light laptops By www.digit.in Published On :: 2022-12-28T13:09+05:30 Full Article videoDefault
pee 5 Killed As Speeding Car Rams Truck On Greater Noida Expressway By www.ndtv.com Published On :: Sun, 10 Nov 2024 14:19:27 +0530 At least five people were killed this morning after their speeding car rammed a truck that had broken down and was parked on the roadside in Noida. Full Article
pee NVIDIA and Global Consulting Leaders Speed AI Adoption Across Japan’s Industries By blogs.nvidia.com Published On :: Wed, 13 Nov 2024 02:08:04 +0000 Consulting giants including Accenture, Deloitte, EY Strategy and Consulting Co., Ltd. (or EY Japan), FPT, Kyndryl and Tata Consultancy Services Japan (TCS Japan) are working with NVIDIA to establish innovation centers in Japan to accelerate the nation’s goal of embracing enterprise AI and physical AI across its industrial landscape. The centers will use NVIDIA AI Read Article Full Article Cloud Generative AI Digital Twin Events NVIDIA AI Enterprise NVIDIA Hopper Architecture NVIDIA NIM Omniverse
pee Police sergeant trying to evade arrest caught with an unlicensed firearm after a high speed chase in a Toyota Fortuner By www.iol.co.za Published On :: Mon, 11 Nov 2024 10:00:20 GMT Full Article
pee Ghana: Ghanaians Urged To Avoid Hate Speech Ahead Of Polls By allafrica.com Published On :: Tue, 12 Nov 2024 13:11:43 GMT [Ghanaian Times] The Chairperson of the National Commission for Civic Education (NCCE), Ms Kathleen Addy, has cautioned Ghanaians against hate speech as it could cause conflict in the lead-up to the General Election. Full Article Ghana Governance Legal and Judicial Affairs Press and Media West Africa
pee Aliyev criticises Western nations' stance on fossil fuels at COP29 opening speech By www.euronews.com Published On :: Tue, 12 Nov 2024 22:27:57 +0100 Aliyev criticises Western nations' stance on fossil fuels at COP29 opening speech Full Article
pee to give a damn good speech By english.al-akhbar.com Published On :: to give a damn good speech Full Article
pee The Nexus of Peer-to-Peer Lending and Monetary Policy Transmission: Evidence from the People’s Republic of China By www.adb.org Published On :: 2024-11-05 This paper examines how booms and busts in peer-to-peer (P2P) lending in the People’s Republic of China (PRC) affect monetary policy transmission to inflation and output. Full Article
pee There may be a cosmic speed limit on how fast anything can grow By www.newscientist.com Published On :: Fri, 01 Nov 2024 14:28:25 +0000 Alan Turing's theories about computation seem to have a startling consequence, placing hard limits on how fast or slow any physical process in the universe can grow Full Article
pee Part of the Atlantic is cooling at record speed and nobody knows why By www.newscientist.com Published On :: Mon, 19 Aug 2024 23:24:41 +0100 After over a year of record-high global sea temperatures, the equatorial Atlantic is cooling off more quickly than ever recorded, which could impact weather around the world Full Article
pee There may be a cosmic speed limit on how fast anything can grow By www.newscientist.com Published On :: Fri, 01 Nov 2024 14:28:25 +0000 Alan Turing's theories about computation seem to have a startling consequence, placing hard limits on how fast or slow any physical process in the universe can grow Full Article
pee Financial Incentives May Speed Radiology Test Results By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Financial Incentives May Speed Radiology Test ResultsCategory: Health NewsCreated: 8/20/2010 2:10:00 PMLast Editorial Review: 8/23/2010 12:00:00 AM Full Article
pee Encouraging Your Baby's Babbling May Speed Language Development By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Encouraging Your Baby's Babbling May Speed Language DevelopmentCategory: Health NewsCreated: 8/29/2014 9:36:00 AMLast Editorial Review: 8/29/2014 12:00:00 AM Full Article
pee Secret Tunnels Between Skull, Brain Speed Immune Cells After Stroke in Mice By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Secret Tunnels Between Skull, Brain Speed Immune Cells After Stroke in MiceCategory: Health NewsCreated: 8/27/2018 12:00:00 AMLast Editorial Review: 8/28/2018 12:00:00 AM Full Article
pee Teen's Democratic Convention Speech Brings Awareness to Stuttering By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Teen's Democratic Convention Speech Brings Awareness to StutteringCategory: Health NewsCreated: 8/28/2020 12:00:00 AMLast Editorial Review: 8/28/2020 12:00:00 AM Full Article
pee Space Travel Speeds Up Aging, Weakening of Bones By www.medicinenet.com Published On :: Thu, 4 Aug 2022 00:00:00 PDT Title: Space Travel Speeds Up Aging, Weakening of BonesCategory: Health NewsCreated: 8/4/2022 12:00:00 AMLast Editorial Review: 8/4/2022 12:00:00 AM Full Article
pee The Impact of Increased PEEP on Hemodynamics, Respiratory Mechanics, and Oxygenation in Pediatric ARDS By rc.rcjournal.com Published On :: 2024-10-25T05:44:12-07:00 BACKGROUND:PEEP is a cornerstone treatment for children with pediatric ARDS. Unfortunately, its titration is often performed solely by evaluating oxygen saturation, which can lead to inadequate PEEP level settings and consequent adverse effects. This study aimed to assess the impact of increasing PEEP on hemodynamics, respiratory system mechanics, and oxygenation in children with ARDS.METHODS:Children receiving mechanical ventilation and on pressure-controlled volume-guaranteed mode were prospectively assessed for inclusion. PEEP was sequentially changed to 5, 12, 10, 8 cm H2O, and again to 5 cm H2O. After 10 min at each PEEP level, hemodynamic, ventilatory, and oxygenation variables were collected.RESULTS:A total of 31 subjects were included, with median age and weight of 6 months and 6.3 kg, respectively. The main reasons for pediatric ICU admission were respiratory failure caused by acute viral bronchiolitis (45%) and community-acquired pneumonia (32%). Most subjects had mild or moderate ARDS (45% and 42%, respectively), with a median (interquartile range) oxygenation index of 8.4 (5.8–12.7). Oxygen saturation improved significantly when PEEP was increased. However, although no significant changes in blood pressure were observed, the median cardiac index at PEEP of 12 cm H2O was significantly lower than that observed at any other PEEP level (P = .001). Fourteen participants (45%) experienced a reduction in cardiac index of > 10% when PEEP was increased to 12 cm H2O. Also, the estimated oxygen delivery was significantly lower, at 12 cm H2O PEEP. Finally, respiratory system compliance significantly reduced when PEEP was increased. At a PEEP of 12 cm H2O, static compliance had a median reduction of 25% in relation to the initial assessment (PEEP of 5 cm H2O).CONCLUSIONS:Although it may improve arterial oxygen saturation, inappropriately high PEEP levels may reduce cardiac output, oxygen delivery, and respiratory system compliance in pediatric subjects with ARDS with low potential for lung recruitability. Full Article