drug

AIADMK cadre protest against DMK government for failing to curb illegal drug sales 




drug

The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
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drug

Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
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drug

Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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drug

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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drug

Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
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drug

Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
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drug

A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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drug

Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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drug

Students cautioned against drug addiction




drug

Outgunning fake drugmakers

Stringent steps needed to keep India label safe from fly-by-night operators




drug

Kejriwal gives clarion call to sarpanchs in Punjab to wipe out curse of drugs

Opposition says AAP government has ‘mishandled and mismanaged’ every aspect of State administration




drug

Vasan urges T.N. govt. to take steps to end illegal sale of narcotic drugs

He expressed concerns over the future of a section of students and youth who were allegedly involved in using and selling such banned substances




drug

Pickering emulsions for stimuli-responsive transdermal drug delivery: effect of rheology and microstructure on performance

Soft Matter, 2024, 20,8621-8637
DOI: 10.1039/D4SM00993B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Simona Migliozzi, Yiting He, Maryam Parhizkar, Yang Lan, Panagiota Angeli
Elucidating the impact of microgels attributes on the microstructure, rheology and functionality of Pickering emulsions.
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drug

Editorial. Clinical trials waiver for some drugs raises questions

The Centre should not relax its clinical trials norms unless the situation is exceptional or dire




drug

Editorial. More action needed against substandard, spurious drugs

Industry bodies should take the lead to protect the image of a sector that has at least 10,000 units and a market size of about $50 billion, growing in double digits




drug

Bevel Up - Drugs, Users and Outreach Nursing / directed by: Nettie Wild ; produced by: Fiona Gold, Juanita Maginley, Betsy Carson, Nettie Wild, Svend-Erik Eriksen, Rina Fraticelli ; production agencies: National Film Board of Canada (Montreal), British Co

Montreal : National Film Board of Canada, 2016




drug

Topics : Aboriginals & Drugs / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




drug

Topics : Drugs & the Brain / directed by: Nettie Wild ; production agencies: National Film Board of Canada (Montreal), British Columbia Centre for Disease Control. Street Nurse Program (Vancouver)

Montreal : National Film Board of Canada, 2019




drug

Topics : Mental Health & Drugs / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




drug

Topics : Pregnancy & Drugs / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




drug

Topics : Street Drugs 101 / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




drug

Topics : Sex Work & Drugs / directed by: Nettie Wild ; production agencies: National Film Board of Canada (Montreal), British Columbia Centre for Disease Control. Street Nurse Program (Vancouver)

Montreal : National Film Board of Canada, 2019




drug

Topics : Nurses Who Use Drugs / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




drug

Topics : Sex, Drugs & Gender / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




drug

Drugs menace inherited from previous ‘corrupt and criminal’ regime, says A.P. Deputy CM Pawan Kalyan  

Tagging his post on X to the office of the Union Home Minister, Pawan Kalyan calls for a special focus to check drug mafia, ganja cultivation, and related criminal activities in the State




drug

C–H acylation as an enabling tool to tag phenolic drugs

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01505C, Research Article
Open Access
Carlota Girón-Elola, Arkaitz Correa
A Pd-catalyzed directed C–H acylation of a collection of intricate phenol-containing compounds with ethanol and other alcohols and aldehydes is reported.
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drug

18F-labelling of nitrogen-containing aryl boronates – anti-cancer drug melflufen as a case study

Org. Chem. Front., 2024, 11,6411-6417
DOI: 10.1039/D4QO01594K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kevin Bajerke, Fredrik Lehmann, Gunnar Antoni, Kálmán J. Szabó
This study addresses the 18F-labelling of nitrogen-containing arenes via copper-mediated radiofluorination (CMRF). In this case study, derivatives/fragments of the anti-cancer drug melflufen were targeted.
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drug

Raid on hospitals in Hyderabad and Secunderabad leads to seizure of controlled drugs

The raiding teams found substances which are are classified as controlled drugs and their sale and possession are strictly regulated under the Narcotic Drugs and Psychotropic Substances (NDPS) Act




drug

Ugandan woman sentenced to 13 years RI for smuggling drugs to Hyderabad

The woman was caught attempting to smuggle 3,900 grams of heroin, worth ₹25 crore, to Hyderabad




drug

Telangana to set up four new drug testing labs




drug

Synthesis of F127-GA@ZnO nanogel as a cisplatin drug delivery pH-sensitive system

RSC Adv., 2024, 14,35005-35020
DOI: 10.1039/D4RA06514J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nguyen Ngoc Son, Vu Minh Thanh, Nguyen Thi Huong
In this study, a novel drug delivery system based on zinc oxide nanoparticles (ZnO NPs) was developed for the enhanced delivery of cisplatin (CPT) to improve cancer treatment.
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drug

Self-immolative polydisulfides and their use as nanoparticles for drug delivery systems

RSC Adv., 2024, 14,35568-35577
DOI: 10.1039/D4RA07228F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katharina Völlmecke, Maurice Kramer, Corinna Horky, Oliver Dückmann, Dennis Mulac, Klaus Langer, Dirk Kuckling
Polydisulfide based nanoparticles can be degraded by glutathione (GSH) to deliver hydrophobic drugs.
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drug

Retraction: Fabrication of novel quantum dots for the estimation of COVID-19 antiviral drug using green chemistry: application to real human plasma

RSC Adv., 2024, 14,35696-35696
DOI: 10.1039/D4RA90133A, Retraction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Baher I. Salman, Adel Ehab Ibrahim, Sami El Deeb, Roshdy E. Saraya
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Quantitative determination and subcellular mapping of Pt-based drugs in single breast tumour cells via laser ablation-ICP-mass spectrometry

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02467B, Paper
Open Access
Legna Colina-Vegas, Thibaut Van Acker, Wilmer Villarreal, Olivier De Wever, Alzir Azevedo Batista, Joaquim Araújo Nóbrega, Frank Vanhaecke
This study utilizes LA-ICP-MS to reveal the distribution and determine the concentration of Pt in MDA-MB-231 cells, providing insight into the mechanism and efficacy of Pt-based chemotherapeutic drugs.
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drug

A Zr-based metal–organic framework drug release system with long-lasting antibacterial behavior for accelerating wound healing

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02734E, Paper
Hui-Qian Zheng, Han-Xiao Feng, Bing-Xin Li, Yi-Fei Hui, Yi-Han Lin, Xian-Feng Su, Lai-Peng Yan, Zijie Zhou, Zu-Jin Lin, Faqiang Tang
A biocompatible Zr-based metal–organic framework drug release system, CIP@SU-102, was fabricated by the cation exchange method, which shows superior and long-lasting antibacterial activity as well as effective promotion of infected wound healing.
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drug

An acidity-triggered aggregation nanoplatform based on degradable mesoporous organosilica nanoparticles for precise drug delivery and phototherapy of focal bacterial infection

Dalton Trans., 2024, 53,17893-17901
DOI: 10.1039/D4DT02111H, Paper
Yunhan Huang, Wei Guo, Xinyu Wang, Jingrui Chang, Bo Lu
An acidity-triggered aggregation antibacterial nanoplatform based on biodegradable mesoporous organic silica nanoparticles, is reported. It enables precise drug release and spatial accuracy for photodynamic therapy and photothermal therapy.
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drug

India becoming part of global drug development operation of BMS: Samit Hirawat 

Samit Hirawat discussed India’s growing significance as a site for clinical trials, innovations in drug development, and how technology is poised to help bring new products to market faster




drug

To curb antimicrobial resistance, government may include antibiotics in definition of new drug

If brought into the new drug bracket, manufacturing, marketing and sale of antibiotics will be documented; patients will be able to buy antibiotics on prescription only




drug

IISc scientists find a way to break down ‘biofilm barriers’ by using cow’s gut enzyme to aid entry of drugs




drug

Kilitch Drugs (India) Ltd. - Board Meeting Intimation for To Consider And Approve The Un-Audited Financial Results Of The Company For The Quarter Ended June 30, 2019.




drug

Synergistic effect of ROS-generating polydopamine on drug-induced bone tissue regeneration

Nanoscale, 2024, 16,20118-20130
DOI: 10.1039/D4NR02887B, Paper
Hyeju Han, Bongkyun Kang, Shazid Md. Sharker, Tabassum Binte Kashem, Yuejin Kim, Jeehee Lee, Minok Park, Eunjeong Kim, YunJae Jung, Jinkyu Lim, Seungwon Ryu, Kyueui Lee
The combination of PDA NPs and 1,4-DPCA leads to a synergistic effect that enhances bone tissue regeneration in vivo.
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drug

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Biomater. Sci., 2024, 12,1662-1692
DOI: 10.1039/D3BM01451G, Review Article
Qiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu Xianjun
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
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drug

Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models

Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
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drug

Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00083H, Paper
Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao, Xintao Shuai
An ROS-labile nanodrug co-encapsulating Ce6 and a Bcl-2 inhibitor enabled PDT and reversed apoptotic resistance, demonstrating a potent inhibitory effect on tumor growth.
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drug

Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01055D, Review Article
Ziba Zakeri, Morteza Heiderzadeh, Azra Kocaarslan, Ecem Metin, Seyed Nasir Hosseini Karimi, Sepideh Saghati, Atay Vural, Göktuğ Akyoldaş, Kemal Baysal, Yusuf Yağcı, Yasemin Gürsoy-Özdemir, Savaş Taşoğlu, Reza Rahbarghazi, Emel Sokullu
The targeted delivery of pharmacologically active molecules, metabolites, and growth factors to the brain parenchyma has become one of the major challenges following the onset of neurodegeneration and pathological conditions.
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drug

Correction: A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer

Biomater. Sci., 2024, 12,2165-2166
DOI: 10.1039/D4BM90022G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yinjie Wang, Zhenqi Jiang, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li, Aiguo Wu
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drug

Beyond Nanoparticle-based Oral Drug Delivery: Transporter-mediated Absorption and Disease Targeting

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4BM00313F, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hana Cho, Kang Moo Huh, Hyun Ji Cho, Bogeon Kim, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Young Jik Kwon, Han Chang Kang
Various strategies in the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many...
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drug

Lipid sulfoxide polymers as potential inhalable drug delivery platforms with differential albumin binding affinity

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D3BM02020G, Paper
Gayathri Ediriweera, Neville Butcher, Ashok Kothapalli, Jiacheng Zhao, Joanne Therese Blanchfield, Christopher N. Subasic, James Lynden Grace, Changkui Fu, Xiao Tan, John F. Quinn, David Ascher, Michael R Whittaker, Andrew Whittaker, Lisa Kaminskas
Inhalable nanomedicines are increasingly being developed to optimise the pharmaceutical treatment of respiratory diseases. Large lipid-based nanosystems at the forefront of the inhalable nanomedicines development pipeline, though, have a number...
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drug

Actor Venkatesh releases ASR district police’s anti-drug campaign ‘Swachh Sankalpam’ brochure at Araku Valley