60,000 students participate virtually from 900 schools in Tirupati district

The startup raised $40 million to target a class of GPCRs called Mas-related G-protein receptors, to treat neuroimmune and inflammatory conditions

Unwanted crystals could adversely affect drug stability and shelf life

The start-up, based on the work of Broad Institute scientist Aviv Regev, has raised $65 million to develop therapies for cancer and autoimmune disease

New investor takes on a company trying to combine a range of pharmaceutical services

Diversity, drug prices, and 'right to try' permeated conversation at the drug industry meeting

New investor takes on a company trying to combine a range of pharmaceutical services

Listen to the latest Stereo Chemistry episode that explores why certain drug targets are so vexing, and the cutting edge approaches chemists are taking to finally crack them

Acasti picks CordenPharma to extract omega-3s from krill

Piramal sites on different continents have become involved in producing Theracos’s diabetes treatment

Skyhawk will receive $60 million up front to develop drug candidates that target RNA in neurological diseases

Study shows how stopping one enzyme could help drugs treat an important class of cancers more effectively

The French startup will develop an RNA-targeted therapy for the rare muscle disease centronuclear myopathy

The president deemed the price rollback a victory, but industry watchers say Pfizer could benefit in the long run

With purchase, manufacturer of active pharmaceutical ingredients will move downstream into finished drugs

New partnership is part of GSK’s R&D face-lift, which includes an increased focus on immune system targets

Type 2 diabetes drug metformin impedes glucose overproduction in a redox-dependent manner, researchers say

With purchase, manufacturer of active pharmaceutical ingredients will move downstream into finished drugs

Companies are hoping to use the vesicles to package small-molecule, protein, and RNA drugs or even use them as therapies themselves

Drug major Dr Reddy’s Laboratories is recalling 1,752 bottles of generic heartburn medicine in the US after the American health regulator found qual

Pharma major Dr Reddy’s Laboratories Ltd has initiated recall of 1m752 bottles of generic Esomeprazole Magnesium delayed release capsules in the US.A

1. Anti-viral drug trio found to shorten COVID-19 illness in mild cases: study  Yahoo News Australia
2. Triple antiviral drug shows early promise in COVID-19 trial  msnNOW
3. Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial  The Lancet
4. New triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial  Medical Xpress
5. Triple anti-viral drug shows COVID-19 promise in Hong Kong study  Al Jazeera English
6. View Full coverage on Google News

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Given the rapid spread of COVID-19 and its relatively high mortality, filling the gap for coronavirus-specific drugs is urgent.

After working with the needy on a Transform 2012 outreach to Greece, Anthony (UK) returned to Athens to continue in that ministry.

WHO’s Solidarity and Oxford’s RECOVERY trials can give a clearer picture on some drugs that showed early promise.

Coronavirus COVID 19 vaccine news, latest update, human trials: Sanofi's Pasteur division has an established track record in influenza vaccines. Last month it had teamed with its British rival GSK to produce a vaccine candidate hoping that it will be ready in 2021.

GHALLANAI: Local elders have demanded the government to take action against drug mafia in Mohmand tribal district.Speaking to journalists, social workers and elders including Malik Jehanzeb, Malik Salim, Malik Rasool Khan and others said that on the one hand coronavirus has created a risk to lives...

CALVINIA - A 56-year-old Johannesburg man was arrested by South African Police Service (SAPS) officers during a roadblock at Calvinia this past week after drugs with an estimated street value of almost R4 million...