zing That Better Be An Amazing Roast Dinner... By clientsfromhell.tumblr.com Published On :: Sat, 01 Jan 2022 10:55:11 -0800 I was made redundant from my previous job as a design engineer. As such, I look for any work just to keep the lights on. I get approached by an employer who offers competitive rates of pay and other perks. It’s a small company but I go for the interview. When I get there it’s the grounds of a huge mansion. The interview is completed in the drawing-room and they offer to show me around. I assume we would be in an office or factory or working from home… I am wrong. I’m taken out of the house to a small shack with no heating; inside are stacks and stacks of paper. When asked about this I am told the employer doesn’t trust computers… for a computer-aided-design based business… Instead of running, I ask one final question regarding the perks: “Oh you get a Christmas dinner with us too and it’s compulsory and unpaid.” I left so fast! I got something far better three weeks later! Full Article
zing 5 Ways Behavioral Analytics is Revolutionizing Incident Response By thehackernews.com Published On :: Tue, 12 Nov 2024 16:30:00 +0530 Behavioral analytics, long associated with threat detection (i.e. UEBA or UBA), is experiencing a renaissance. Once primarily used to identify suspicious activity, it’s now being reimagined as a powerful post-detection technology that enhances incident response processes. By leveraging behavioral insights during alert triage and investigation, SOCs can transform their workflows to become more Full Article
zing Hydro-Electric Power Station In a Freezing Cold Place of Russia By englishrussia.com Published On :: Sat, 09 Apr 2022 12:04:26 +0000 The post Hydro-Electric Power Station In a Freezing Cold Place of Russia appeared first on English Russia. Full Article Photos Technology HPP kolyma
zing Pickens' amazing catch features in NFL best plays By www.bbc.com Published On :: Mon, 11 Nov 2024 11:09:38 GMT Watch the best plays from week ten in the NFL, featuring an amazing catch by Pittsburgh Steelers wide receiver George Pickens. Full Article
zing Amazing: Trump Moved 48 States toward the Republican Party By lidblog.com Published On :: Sat, 09 Nov 2024 00:41:00 +0000 When the 2024 election dust settled early on Wednesday morning, it became clear that Donald Trump didn’t just win the election, he trounced Kamala Harris. It was so bad for the Democrats that nearly every state moved to the right. The GOP hasn’t seen so many votes move their way since Ronald Reagan in 1980. […] The post Amazing: Trump Moved 48 States toward the Republican Party appeared first on The Lid. Full Article Election 2024
zing Our Interview with Lulu Delacre About Cool Green: Amazing, Remarkable Trees By www.readingrockets.org Published On :: Mon, 12 Jun 2023 09:00 EDT Lulu Delacre’s recent book, Cool Green (Candlewick) takes readers on a trip around the world, led by a grandfather with his granddaughter, introducing readers to a range of trees in lyrical text punctuated by fascinating information accompanied by informative and varied illustration. It’s a gorgeous book and Lulu has answered questions that I posed to her. Full Article
zing IT Departments Utilizing Virtualization By communicationtransformation.blogspot.com Published On :: Mon, 23 Nov 2009 12:47:00 +0000 IDC released its Worldwide Quarterly Server Tracker on September 2, 2009, which reports that "factory revenue in the worldwide server market declined 30.1% year over year to $9.8 billion in the second quarter of 2009 (2Q09)."According to IDC, this is the lowest quarterly server revenue since they began tracking this market in 1996.The obvious implication is that the economy has been awful and companies have been avoiding / deferring IT spend. But beyond that it seems that virtualization has both benefited from and contributed to this decline.With a single server now able to run multiple workloads, it seems inevitable that the server footprint is destined to continue getting smaller within the corporate data center. But the benefits of virtualization do not stop with simply running more apps on one machine; the whole datacenter becomes more agile, more flexible to deal with unexpected changes in workload.The ability to get more from fewer boxes is certainly a contributing factor to less boxes being bought. And tight budgets in the 2009 economy have certainly contributed to IT managers seeking out less costly options.It will be interesting to see how the server market rebounds.Andy Patrizio in his InternetNews.com blog quotes Rahul Agarwal, co-founder of Infiniti Research. Within the dismal sales figures, Agarwal notes that both Gartner and IDC report that unit costs are going up for server sales. Agarwal believes that this is due to sellers trying to widen margins by selling more feature-rich machines:Our view is that to offset this volume pressure, hardware vendors will beforced to improve unit margins by building in virtualization capability, memoryand I/O interfaces in the hardware.So the strategy to improve revenues will enable IT departments to further utilize virtualization, continuing the trend toward fewer individual servers.Agarwal noted that many servers out there are quite inefficient, particular amongst small-to-medium sized businesses, so the more successful players will focus on consolidation to increase efficiency and reduce the footprint. He says:The server market of tomorrow will be a value game and not a volume game. Full Article
zing Amazing: Trump Moved 48 States Toward the Republican Party By conservativefiringline.com Published On :: Sun, 10 Nov 2024 16:15:37 +0000 The following article, Amazing: Trump Moved 48 States Toward the Republican Party, was first published on Conservative Firing Line. When the 2024 election dust settled early on Wednesday morning, it became clear that Donald Trump didn’t just win the election, he trounced Kamala Harris. It was so bad for the Democrats that nearly every state moved to the right. The GOP hasn’t seen so many votes move their way since Ronald Reagan in 1980. … Continue reading Amazing: Trump Moved 48 States Toward the Republican Party ... Full Article Politics democrats Harris Republican Trump voters
zing Sport | BIG PREVIEW | SA v India: Jansen wary of India's blazing batters as Centurion run fest awaits By www.news24.com Published On :: Wednesday Nov 13 2024 05:01:33 Wednesday's third T20 between South Africa and India at SuperSport Park in Centurion is shaping up to be a run-drenched one, especially if the weather holds and SA's bowling centre doesn't. Full Article
zing World economy is fracturing, not deglobalizing By www.chathamhouse.org Published On :: Wed, 08 Feb 2023 13:15:11 +0000 World economy is fracturing, not deglobalizing Expert comment LJefferson 8 February 2023 Geopolitics are creating a more uncertain economic environment as the global economy splinters into competing blocs. There is now broad agreement among economists and commentators that the world has reached peak globalization, but there is little consensus about what comes next. One view is that we are entering a period of ‘deglobalization’, in which global trade volumes decline and cross-border capital flows recede. An alternative and more likely outcome is that the global economy starts to splinter into competing blocs. This would result in an altogether more volatile macroeconomic and market environment which would pose a formidable challenge to some countries and companies operating in vulnerable sectors. But this process needn’t involve any significant shrinkage of international flows of goods, services and capital, nor a broad reversal of other gains of globalization. Whereas the period of globalization was driven by governments and companies working in unison, fracturing is being driven by governments alone. This most recent era of globalization was underpinned by a belief that economic integration would lead to China and the former Eastern Bloc countries becoming what former World Bank Chief Robert Zoellick termed ‘responsible stakeholders’ within the global system. But China has instead emerged as a strategic rival to the US. This strategic rivalry is already forcing others to pick sides as the world splinters into two blocs: one that aligns primarily with the US and another that aligns primarily with China. Increasingly, policy choices within these blocs will be shaped by geopolitical considerations. This process can be thought of as ‘global fracturing’. Whereas the period of globalization was driven by governments and companies working in unison, fracturing is being driven by governments alone. The effects of fracturing Viewed this way, ‘deglobalization’ is by no means inevitable. There are few compelling geopolitical reasons why the US or Europe should stop importing the majority of consumer goods from China. Roll the clock forward ten years and it is likely that the West will still be buying toys and furniture from China. Instead, fracturing between the blocs will take place along fault lines that are geopolitically important. In some aspects, the effects of fracturing will be profound. But in other areas, warnings of a seismic reordering of the global economy and financial system will prove wide of the mark. For example, the politically-driven nature of fracturing will have a significant impact on the operating environment for US and European firms in those sectors that are most exposed to restrictions on trade, such as technology and pharmaceuticals. And all firms and investors will be operating in a different environment in which geopolitical considerations play a greater role in decisions over the allocation of resources. In cases where production does shift location, it is likely to be to other low-cost centres that align more clearly with the US. There will be no great ‘reshoring’ of manufacturing jobs. But where production is moved to alternative locations, this is likely to only involve the manufacture of goods that are deemed to be strategically significant. This may include those with substantial technological and/or intellectual property components: think iPhones, pharmaceuticals, or high-end engineering products. What’s more, in cases where production does shift location, it is likely to be to other low-cost centres that align more clearly with the US. There will be no great ‘reshoring’ of manufacturing jobs. Within this process, trade linkages will be reordered, rather than severed. This will result in trade’s share of global GDP flatlining in the coming years, rather than shrinking outright, as is being forecast under many attempts to quantify deglobalization’s potential impact. Finances of global fracturing There will be a substantial financial component to global fracturing, but once again the implications are likely to be more nuanced than the current debate suggests. Cross-border financial links are likely to grow more slowly, and the overall stock of cross-border claims will plateau relative to global GDP. But whereas the first era of globalization in the 1870s was followed by a broad retreat in global capital flows during the interwar years, the same is unlikely to happen today. Beijing will increasingly push its partners to settle trade in renminbi but this is unlikely to seriously challenge the dollar’s position. Similarly, while financial fracturing will fuel growing speculation about the dollar’s role as the world’s reserve currency, reports of its impending demise are exaggerated. Beijing will increasingly push its partners to settle trade in renminbi but three factors suggest that this is unlikely to seriously challenge the dollar’s position. First, while trade between China and its partners is growing, it still accounts for only six per cent of global trade. Most trade still happens between US-aligned countries, and will continue to be denominated in US dollars (see chart). Second, China runs a large current account surplus, which will make it harder for the renminbi to supplant the dollar. High demand for reserve assets means that reserve countries tend to run current account deficits. — Share of global goods and services trade (%) Source: Capital Economics Finally, the dollar still has several things working in its favour. For a currency to be widely used as an international medium of exchange, it must be readily and cheaply available around the world. In turn, that depends on foreigners being willing to hold it in large volumes: in other words, it must function as a store of value. Full Article
zing Visualizing the Data: The Evolution of Trade Tensions in Metals and Minerals Markets By www.chathamhouse.org Published On :: Tue, 19 Dec 2017 10:00:00 +0000 Visualizing the Data: The Evolution of Trade Tensions in Metals and Minerals Markets 18 January 2018 — 4:30PM TO 6:00PM Anonymous (not verified) 19 December 2017 Chatham House, London Over the past decade, producer countries such as South Africa, Zambia, Indonesia, the DRC and, most recently, Tanzania have restricted exports of unprocessed precious metals, copper, nickel, cobalt and other minerals in an attempt to support, or create, downstream processing industries and jobs or increase revenues. These moves have invariably created tensions with trading partners. Research suggests that export restrictions are not the best way to achieve such policy objectives and can instead harm the producer country’s economy and undermine the functioning of international metals and minerals. Drawing on OECD and Chatham House research on resource trade, the speaker will present analysis and data visualizations exploring the drivers of past export restrictions and their political and economic impacts. They will also consider how the drivers of ‘resource nationalist measures’ are changing, whether and where export restrictions might present strategic and economic risks in the current context, and the extent to which producer and consumer governments and international governance mechanisms are prepared to address them. Attendance at this event is by invitation only. Full Article
zing Realizing the Potential of Extractives for Industrial and Economic Development By www.chathamhouse.org Published On :: Wed, 03 Oct 2018 17:10:01 +0000 Realizing the Potential of Extractives for Industrial and Economic Development 18 October 2018 — 5:30PM TO 7:00PM Anonymous (not verified) 3 October 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE Over the past two decades, the extractives industries have risen in importance for many low- and middle- income countries their prospects for economic development and poverty reduction. During a period of rising commodities prices, the development of extractives became increasingly attractive to both governments and companies. There was - and remains - much discussion about their potential to support inclusive development.However, there are also risks and uncertainties associated with the extractives industries and many things can, and do, go wrong. Fluctuations in commodity prices can be hard to manage and can lead to considerable fiscal pressures. In the longer-term, climate change and the various policy responses to this, will profoundly affect the extractives sector as renewables replace fossil fuels in the global energy mix.Managing the extractives sectors will therefore remain highly challenging especially in low-income countries where institutions are often weak. This roundtable will bring together some of the foremost academics and practitioners working in the extractives industries and also in economic development to discuss a major new UNU-WIDER study Extractive Industries: The Management of Resources as a Driver of Sustainable Development.Attendance at this event is by invitation only. Full Article
zing Decarbonizing Heat: A New Frontier for Technologies and Business Models By www.chathamhouse.org Published On :: Mon, 03 Dec 2018 14:15:01 +0000 Decarbonizing Heat: A New Frontier for Technologies and Business Models 27 February 2019 — 8:15AM TO 9:45AM Anonymous (not verified) 3 December 2018 Chatham House | 10 St James's Square | London | SW1Y 4LE Building space and water heating accounts for over 35 percent of global energy consumption - nearly double that of transport. However, there has been limited progress in decarbonizing the sector to date. International cooperation is required to ensure harmonized policies drag low carbon heating technologies down the cost curve to the extent that low carbon heating is cost competitive and affordable. The initial presentations and discussion focus on:Demand reduction technologies and policies that speed up transformation of the sector. The different challenges for energy efficiency of retrofitting as opposed to new build.The impact of electrification on GHG emissions and the power sector.The comparative role of national and city level initiatives.The meeting concludes by looking at the challenges and risks in accelerating the transformation of heating and the lessons that can be learned from other sectors. Full Article
zing Plant-based 'Meat' and Cultured Meat: Revolutionizing the Livestock Sector By www.chathamhouse.org Published On :: Thu, 14 Mar 2019 13:36:54 +0000 Plant-based 'Meat' and Cultured Meat: Revolutionizing the Livestock Sector 10 April 2019 — 4:00PM TO 5:30PM Anonymous (not verified) 14 March 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE Consensus is building across the scientific, environmental and public health communities that a radical shift away from excessive meat-eating patterns is urgently needed to tackle the unsustainability of the livestock sector. Recognizing the scale of the challenge ahead, public policymakers, civil society and innovators have increasingly sought to prompt shifts in consumer food choices – away from the most resource-intensive meat products and towards more sustainable alternatives.Meat analogues – plant-based ‘meat’ and cultured meat also known as ‘lab-grown’ meat – mark a departure from traditional meat alternatives. Both are intended to be indistinguishable from – and in the case of cultured meat biologically equivalent to – animal-derived meat and are marketed principally at meat-eaters. Innovation and investment in meat analogues have increased significantly, but the direction and pace of growth in the meat analogue industry will depend upon a multitude of factors, including public acceptance, civil society support and incumbent industry responses.This event will explore the challenges of scaling up production and generating demand for meat alternatives. It will also look at the ways policymakers in the UK and EU can impact the direction of the industry while examining what factors will influence consumer acceptance of plant-based ‘meat’ and cultured meat as substitutes for animal-derived meat. Full Article
zing Prioritizing equity and justice in climate action By www.chathamhouse.org Published On :: Thu, 10 Jun 2021 13:45:31 +0000 Prioritizing equity and justice in climate action 30 June 2021 — 11:00AM TO 12:00PM Anonymous (not verified) 10 June 2021 Online London Climate Action Week event: Why understanding equity and justice is essential to the ability to meaningfully inform climate politics. Citizen-led climate activism is demonstrating the need to think about climate change ‘not just as a problem for science to solve’ but also as a problem of equity, human rights and justice. The disproportionate impacts of climate change on the poor and the marginalized across the world means that understanding equity and justice is essential for the ability to meaningfully inform climate politics. Excluding these issues risks ignoring, or intentionally omitting, the consequences of policies, tools and frameworks on those who are most likely to face the severe costs of any climate action or inaction. In a pivotal year for climate decision-making, this event explores the necessity of equity and justice in climate action and how the world can move the political conversation to one that is more inclusive. The speakers explore how communities themselves articulate the justice dimensions of climate change and how fairness can create a greener future for current and future generations. This event is being hosted as a part of Strengthening Climate Diplomacy, a series of events from Chatham House during London Climate Action Week 2021. Full Article
zing When will we see below-freezing temperatures in Milwaukee? First frost, snow forecasts By www.yahoo.com Published On :: 2024-11-11T21:45:13Z Full Article
zing Characterizing human {alpha}-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases [Protein Structure and Folding] By www.jbc.org Published On :: 2020-12-11T00:06:20-08:00 Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins. Additional modification of the glycan core by α-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an α-1,6-fucosyltransferase (FUT8). The importance of core fucosylation can be seen in the complex pathological phenotypes of FUT8 null mice, which display defects in cellular signaling, development, and subsequent neonatal lethality. Elevated core fucosylation has also been identified in several human cancers. However, the structural basis for FUT8 substrate specificity remains unknown.Here, using various crystal structures of FUT8 in complex with a donor substrate analog, and with four distinct glycan acceptors, we identify the molecular basis for FUT8 specificity and activity. The ordering of three active site loops corresponds to an increased occupancy for bound GDP, suggesting an induced-fit folding of the donor-binding subsite. Structures of the various acceptor complexes were compared with kinetic data on FUT8 active site mutants and with specificity data from a library of glycan acceptors to reveal how binding site complementarity and steric hindrance can tune substrate affinity. The FUT8 structure was also compared with other known fucosyltransferases to identify conserved and divergent structural features for donor and acceptor recognition and catalysis. These data provide insights into the evolution of modular templates for donor and acceptor recognition among GT-B fold glycosyltransferases in the synthesis of diverse glycan structures in biological systems. Full Article
zing Russia’s Behaviour Risks Weaponizing Outer Space By www.chathamhouse.org Published On :: Mon, 27 Jul 2020 14:19:39 +0000 27 July 2020 Dr Beyza Unal Deputy Director, International Security Programme @beyzaunal Google Scholar Mathieu Boulègue Research Fellow, Russia and Eurasia Programme @matboulegue LinkedIn Google Scholar With negotiations in Vienna between the US and Russia hoping to prevent the weaponization of space, how much do Russia’s satellites pose a threat to the peaceful use of outer space, ask Beyza Unal and Mathieu Boulègue? GettyImages-1209576417.jpg Russia's President, Vladimir Putin, during a video link with cosmonauts on the International Space Station (ISS). Photo: Getty Images. Days before the publication of last week’s report into Russian activity in the UK, and the subsequent call from several UK parliamentarians for a swift response to the ‘Russian threat’, Russia tested a new anti-satellite weapon capability releasing a small projectile from its Kosmos-2543 sub-satellite.Kosmos-2543, a small satellite contained inside a larger satellite, Kosmos-2542, and 'birthed’ into orbit in late 2019, recently came under scrutiny in January 2020 when it was reportedly caught ‘buzzing’ US spy satellites in Low Earth Orbit.By releasing a small projectile from the Kosmos-2543 sub-satellite, the US claims that Russia has launched a new projectile into orbit with relatively high speed – estimated at around 500 km per hour – leading to concerns about the potential of Russia to develop this technology as a weapon to target foreign satellites.It is not the first time Moscow has relied on a Russian doll – or matryoshka – approach to launching satellites into outer space. In October 2017, a sub-satellite, Kosmos-2521, was ejected from its main satellite, Kosmos-2519, into a high-speed object in low orbit.The Russian Ministry of Defence has declared that its latest activity is just for ‘routine’ inspections and surveillance of Russia’s other space assets, with the government’s official statement avoiding recognizing the existence of the new object while, at the same time, Kremlin spokesperson, Dmitry Peskov, recalling Russia’s commitment for the ‘complete demilitarization’ of space.While it is possible that Russia’s matryoshka satellites have indeed been developed to carry out routine repairs of Russia’s space fleet, they also have the potential to interfere with, and destroy, other satellites with such action needing to be considered a threat until Russia demonstrates otherwise.Russia’s use of outer spaceRussia is not the only state investigating anti-satellite weaponry capabilities. There is a wider trend (e.g. China, India, US) to demonstrate advanced space capabilities with nefarious, if not directly offensive, intent. But, for the past few years, Russia in particular, has been provocative in testing its space weapon capabilities. For example, in April 2020, Russia launched and tested into low orbit the PL-19 Nudol direct-ascent anti-satellite (DA-ASAT) interceptor missile system from the Plesetsk Cosmodrome demonstrating its space assets with potential offensive capabilities, in particular, Russia’s capacity to destroy satellites in Low Earth Orbit.In addition, the satellites, Kosmos-2535 and Kosmos-2536, launched in July 2019, are also suspected to be operating beyond their official mission of studying Russian orbital assets. It is reported that these satellites conducted a close proximity activity, coming within one kilometre from each other, which led to the creation of orbital debris.Russia’s space strategyBy exploiting asymmetric advantages in space, Russia seeks to leverage its capabilities against competitors in space and in other domains, falling in line with its wider military strategy as well as its current Federal Space Programme for 2016 to 2025.Russian space activities also have a cyber and electronic warfare angle. With the help of remote-sensing capabilities, Russian spy satellites potentially seek to disrupt military and civilian satellite communications and navigation systems. Indeed, in 2018, French authorities publicly accused Russia of seeking to intercept communication satellites for French and Italian armed forces putting data transmission through Western civilian and military satellites at risk of interception.Furthermore, earlier this year, both Kosmos-2542 and 2543 came within 160 kilometres of a US spy satellite, US KH-11, similarly to Russia ‘buzzing’ around the British Isles or submarine surveillance that Norway and Sweden have been subjected to recently.Shadowing and tailing in space is regarded as spying and this recent anti-satellite weapon test is part of a trend which demonstrates Russia’s persistent space strategy for close-proximity operations with foreign countries.Orbital hypocrisyDespite Russia’s calls for a treaty to prevent the placement of weapons in outer space, there remains little international trust in Russia’s behaviour in space so far with a US-Russia Space Security Exchange meeting scheduled to take place in Vienna on 27 July to discuss outer space stability and security.This is amid a backdrop of bilateral nuclear arms control talks on the extension of the extant nuclear weapons reduction treaty, New START, which is scheduled to expire in February 2021. There is no guarantee, however, that the talks will achieve anything especially since the future of outer space requires a wider multilateral dialogue with all parties involved – including China.Anti-satellite tests (ASATs) are a particularly dangerous form of weapon. Not only do they create major vulnerabilities in a domain where so much of humanity depends on for navigation, communications and environmental monitoring, they are also primarily a target for destabilization and undermining global positioning information in times of crisis.And, perhaps most significantly, they possess the highly destructive potential to create even more space debris in Earth’s orbits that endanger the peaceful use of satellites and could do serious damage to large parts of the economies of developed and developing countries.Avoiding space warfareSpace is for all but there is a risk that it is being hijacked by a few. It is time to re-assert and reinforce the rules, principles and norms of responsible state behaviour in outer space enshrined in the 1967 Outer Space Treaty and its associated international agreements.And, because the treaty specifically prohibits stationing nuclear weapons and other weapons of mass destruction in orbit or on celestial bodies, it is necessary to build on it to ban other types of weapons in space.Space has been militarized since 1957 with the launch of Soviet satellite Sputnik. But the increasing weaponization of space adds more uncertainty, and unveils more vulnerabilities, that states need to address before space warfare becomes a reality. Full Article
zing What will authorizing the return of US troops mean for Somalia? By www.chathamhouse.org Published On :: Fri, 17 Jun 2022 12:47:32 +0000 What will authorizing the return of US troops mean for Somalia? Explainer Video aboudiaf.drupal 17 June 2022 Ahmed Soliman examines what the reintroduction of US military means for Somalia. He says the strategy remains to try and reduce al-Shabaab’s threat, suppress its ability to carry out operations, and target its senior leadership. There is more of a recognition now that the focus needs to be on restoring an effective security sector within Somalia and ensuring their forces are ready, but this also requires better coordination between the federal government and federal member states which it is hoped will happen in this new administration. Full Article
zing Visualizing, quantifying, and manipulating mitochondrial DNA in vivo [Methods and Resources] By www.jbc.org Published On :: 2020-12-18T00:06:18-08:00 Mitochondrial DNA (mtDNA) encodes proteins and RNAs that support the functions of mitochondria and thereby numerous physiological processes. Mutations of mtDNA can cause mitochondrial diseases and are implicated in aging. The mtDNA within cells is organized into nucleoids within the mitochondrial matrix, but how mtDNA nucleoids are formed and regulated within cells remains incompletely resolved. Visualization of mtDNA within cells is a powerful means by which mechanistic insight can be gained. Manipulation of the amount and sequence of mtDNA within cells is important experimentally and for developing therapeutic interventions to treat mitochondrial disease. This review details recent developments and opportunities for improvements in the experimental tools and techniques that can be used to visualize, quantify, and manipulate the properties of mtDNA within cells. Full Article
zing ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPLs hydrolase domain [Images In Lipid Research] By www.jlr.org Published On :: 2020-09-01T00:05:14-07:00 Full Article
zing Optimizing the Therapeutic Index of sdAb-Based Radiopharmaceuticals Using Pretargeting By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 Single-domain antibodies (sdAbs) demonstrate favorable pharmacokinetic profiles for molecular imaging applications. However, their renal excretion and retention are obstacles for applications in targeted radionuclide therapy (TRT). Methods: Using a click-chemistry–based pretargeting approach, we aimed to reduce kidney retention of a fibroblast activation protein α (FAP)–targeted sdAb, 4AH29, for 177Lu-TRT. Key pretargeting parameters (sdAb-injected mass and lag time) were optimized in healthy mice and U87MG (FAP+) xenografts. A TRT study in a pancreatic ductal adenocarcinoma (PDAC) patient-derived xenograft (PDX) model was performed as a pilot study for sdAb-based pretargeting applications. Results: Modification of 4AH29 with trans-cyclooctene (TCO) moieties did not modify the sdAb pharmacokinetic profile. A 200-µg injected mass of 4AH29-TCO and an 8-h lag time for the injection of [177Lu]Lu-DOTA-PEG7-tetrazine resulted in the highest kidney therapeutic index (2.0 ± 0.4), which was 5-fold higher than that of [177Lu]Lu-DOTA-4AH29 (0.4 ± 0.1). FAP expression in the tumor microenvironment was validated in a PDAC PDX model with both immunohistochemistry and PET/CT imaging. Mice treated with the pretargeting high-activity approach (4AH29-TCO + [177Lu]Lu-DOTA-PEG7-tetrazine; 3 x 88 MBq, 1 injection per week for 3 wk) demonstrated prolonged survival compared with the vehicle control and conventionally treated ([177Lu]Lu-DOTA-4AH29; 3 x 37 MBq, 1 injection per week for 3 wk) mice. Mesangial expansion was reported in 7 of 10 mice in the conventional cohort, suggesting treatment-related kidney morphologic changes, but was not observed in the pretargeting cohort. Conclusion: This study validates pretargeting to mitigate sdAbs’ kidney retention with no observation of morphologic changes on therapy regimen at early time points. Clinical translation of click-chemistry–based pre-TRT is warranted on the basis of its ability to alleviate toxicities related to biovectors’ intrinsic pharmacokinetic profiles. The absence of representative animal models with extensive stroma and high FAP expression on cancer-associated fibroblasts led to a low mean tumor-absorbed dose even with high injected activity and consequently to modest survival benefit in this PDAC PDX. Full Article
zing The magical, mesmerizing migration of monarch butterflies | Jaime Rojo By www.ted.com Published On :: Wed, 09 Oct 2024 14:49:36 +0000 When monarch butterflies migrate, they produce one of the most iconic wildlife spectacles in the world — and provide us with an important indicator of ecological health, says photographer Jaime Rojo. Telling a story about our relationship to the natural world, he shares his experience photographing these mesmerizing insects deep in their remote mountain habitats in Mexico, diving into the latest research into the mysteries of their multi-thousand-mile journey and sharing how each of us can join the growing movement to protect them. Full Article Higher Education
zing 7 Tips for Not Personalizing By www.aliceboyes.com Published On :: Wed, 10 Oct 2012 02:35:23 +0000 If you want more tips for not overly personalizing events, comments and actions, and decreasing rumination, you’ll find heaps of simple, practical solutions in , especially in chapter 5 (rumination) and chapter 7 (fear of feedback and criticism). 1. Don’t catastrophize knock backs – If you get a rejection, it doesn’t mean you’re never going […] The post 7 Tips for Not Personalizing appeared first on Dr Alice Boyes. Full Article Uncategorized Cognitive Behavioural Therapy (CBT) Self-Compassion
zing How Coronavirus Is Jeopardizing Teacher Pay Raises By www.edweek.org Published On :: Thu, 26 Mar 2020 00:00:00 +0000 The momentum to raise teacher salaries in several states has ground to a halt amid fears of coronavirus’ massive economic blow. Full Article Kentucky
zing Erratum: McCosh et al., "Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice" By www.jneurosci.org Published On :: 2024-11-06T09:30:07-08:00 Full Article
zing Mobilizing resources By www.fao.org Published On :: Tue, 12 Apr 2016 00:00:00 GMT Resource Mobilization (RM) has replaced the term fundraising as it expanded to account for not only funds but also human resources, goods and services. It is a fundamental component of [...] Full Article
zing Watch an Amazing Time-Lapse of Growing Mushrooms By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 A mesmerizing 10,000-shot video captures the dramatic life cycles of several species (Owen Reiser) Full Article
zing These Mesmerizing Carvings Tell a Mysterious Tribe's Story By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Clues into the disappearance of the ancient Picts lie in the tiny Scottish village of Aberlemno: 1,700-year-old Pictish stones, marked with some very unusual carvings. Full Article
zing See 15 Mesmerizing Photos of Hidden Scenes Only Visible Through a Microscope By www.smithsonianmag.com Published On :: Mon, 21 Oct 2024 18:16:11 +0000 Winners of the Nikon Small World Photomicrography Competition captured insects, cancer cells, cat claws and more Full Article
zing See 14 Photos of the Beauty of Cuba Through Its Striking Shoreline and Buzzing Streets By www.smithsonianmag.com Published On :: Thu, 10 Oct 2024 16:13:48 +0000 These images from the Smithsonian Magazine Photo Contest capture quintessentially Cuban scenes Full Article
zing Amazing experiences along the Silk Road By www.om.org Published On :: Tue, 27 Aug 2019 15:30:18 +0000 Serving in West and Central Asia for many years, Paul and Soonok have one lasting dream: to see a church planting movement there. Full Article
zing Amazing race: Outreach edition By www.om.org Published On :: Tue, 08 May 2018 23:50:40 +0000 10 challenges, 3 people, 0 phones and 1 awesome God. Full Article
zing Moon gazing together By www.om.org Published On :: Thu, 06 Dec 2012 10:47:26 +0000 OM Hong Kong celebrates the annual Mid-Autumn Festival with South Asian friend and meets other families to learn about their needs. Full Article
zing An amazing God-given tool By www.om.org Published On :: Fri, 01 Jun 2018 21:21:23 +0000 An amazing God-given tool to mobilise and inspire people to make a difference: Global Village. Full Article
zing Bitmoji Classrooms: Why Teachers Are Buzzing About Them By www.edweek.org Published On :: Thu, 30 Jul 2020 00:00:00 +0000 Many teachers who will be leading classes remotely are building colorful virtual environments for their students featuring avatar versions of themselves. Some districts are even mandating trainings on how to create them. Full Article Classroom+management
zing Teachers Are Organizing. But What About Teachers' Unions? By www.edweek.org Published On :: Mon, 21 May 2018 00:00:00 +0000 As teacher take the lead in protests over pay, unions face an uncertain future, writes Berkeley sociologist Bruce Fuller. Full Article Unions
zing Coaches, Athletic Director Facing Charges Following Alleged Hazing Incident By blogs.edweek.org Published On :: Tue, 19 Jan 2016 00:00:00 +0000 Two high school basketball coaches and an assistant principal/athletic director are facing criminal charges stemming from an alleged hazing incident that resulted in the hospitalization of a 15-year-old boy. Full Article Lawandcourts
zing Nebraska Expands Anti-Hazing Law to Cover Primary and Secondary Schools By blogs.edweek.org Published On :: Fri, 01 Apr 2016 00:00:00 +0000 Nebraska Gov. Pete Ricketts signed a bill into law Wednesday that expands the state's anti-hazing regulations to elementary, middle, and high schools rather than just post-secondary institutions. Full Article Lawandcourts
zing Penn State faculty present on humanizing higher ed at 2024 Lilly Conference By www.psu.edu Published On :: Tue, 06 Aug 2024 11:30:00 -0400 Jennifer Jewell, teaching professor in the physical therapist assistant program at Penn State Shenango; Pamela Pologruto, teaching professor of physical therapist assistant at Penn State Fayette; Laura Cruz, research professor at Penn State's Schreyer Institute for Teaching Excellence; and faculty members from Penn State Lehigh Valley presented at the 2024 Lilly Conference in Austin, Texas. Full Article
zing Seizing every opportunity By www.om.org Published On :: Fri, 02 Aug 2019 14:18:42 +0000 Buenos Aires, Argentina :: Maintenance crew share Christ's love with local welders helping repair Logos Hope. Full Article
zing EarthTalks: Chief sustainability officer to discuss decarbonizing the University By www.psu.edu Published On :: Mon, 11 Nov 2024 12:41:44 -0500 Lara Fowler, chief sustainability officer at Penn State, director of Penn State Sustainability, and teaching professor of law, will give the talk, “Decarbonizing Penn State: How Does Law, Policy, and Financing Fit In?” at 4 p.m. on Monday, Nov. 18, in 112 Walker Building on the University Park campus, as well as via Zoom. Full Article
zing Optimizing bar label placement By blogs.sas.com Published On :: Sat, 23 Apr 2022 06:41:12 +0000 When creating bar charts, it is very common to display labels with the bars to make it easier to determine the bar values or to provide additional information in the chart. However, these labels can take away valuable data space, particularly if you generate a smaller-sized graph. As you see [...] The post Optimizing bar label placement appeared first on Graphically Speaking. Full Article Uncategorized ODS Graphics Statistical Graphics
zing Don't Throw Away Rice Water: Here Are 6 Amazing Uses For Rice Water Around The House By food.ndtv.com Published On :: Fri, 08 Nov 2024 09:39:57 +0530 Rice Water Benefits: Think rice water is just waste? Think again! From hair care to plant food, here are 6 genius ways to put rice water to use in your home. Full Article
zing Applications Now Being Accepted for Statewide Grant program Aimed At Revitalizing Neighborhoods By news.delaware.gov Published On :: Thu, 11 Dec 2014 19:26:01 +0000 A fund created to help strengthen neighborhoods throughout Delaware hit hardest by the 2008 financial crisis is now up and running. Full Article Civil Division Delaware Economic Development Office (2013-2017) Department of Justice crime fraud Mortgage
zing Levy flight and vectorizing a simulation in SAS By blogs.sas.com Published On :: Mon, 04 Nov 2024 10:23:55 +0000 A previous article shows a simulation of two different models of a foraging animal. The first model is a random walk, which assumes that the animal chooses a random direction, then takes a step that is distributed according to a Gaussian random variable. In the second model, the animal again [...] The post Levy flight and vectorizing a simulation in SAS appeared first on The DO Loop. Full Article Uncategorized Simulation vectorization
zing Battered Reliance Shares To Make A Comeback? This Analyst Sees 29% Upside Ahead - Benzinga India By news.google.com Published On :: Wed, 13 Nov 2024 04:54:40 GMT Battered Reliance Shares To Make A Comeback? This Analyst Sees 29% Upside Ahead Benzinga IndiaReliance Industries shares may see 30% upside according to CLSA, who cites this key trigger CNBCTV18RIL shares are down 20% from record high, oversold on charts; here's what analysts say Business TodaySix of India’s top 10 most valuable firms shed Rs 1.55 lakh crore in market value MoneycontrolReliance Industries Share Price Today on 13-11-2024: Reliance Industries share price are down by -0.63%, Nifty down by -0.8% Mint Full Article
zing How Cadence Is Revolutionizing Automotive Sensor Fusion By community.cadence.com Published On :: Tue, 06 Aug 2024 07:53:00 GMT The automotive industry is currently on the cusp of a radical evolution, steering towards a future where cars are not just vehicles but sophisticated, software-defined vehicles (SDV). This shift is marked by an increased reliance on automation and a significant increase in the use of sensors to improve safety and reliability. However, the increasing number of sensors has led to higher compute demands and poses challenges in managing a wide variety of data. The traditional method of using separate processors to manage each sensor's data is becoming obsolete. The current trends necessitate a unified processing system that can deal with multimodal sensor data, utilizing traditional Digital Signal Processing (DSP) and AI-driven algorithms. This approach allows for more efficient and reliable sensor fusion, significantly enhancing vehicle perception. Developers often face difficulties adhering to stringent power, performance, area, and cost (PPAC) and timing constraints while designing automotive SoCs. Cadence, with its groundbreaking products and AI-powered processors, is enabling designers and automotive manufacturers to meet the future sensor fusion demands within the automotive sector. At the recent CadenceLive Silicon Valley 2024, Amol Borkar, product marketing director at Cadence, showcased the company's dedication and forward-thinking solutions in a captivating presentation titled "Addressing Tomorrow’s Sensor Fusion Needs in Automotive Computing with Cadence." This blog aims to encapsulate the pivotal takeaways from the presentation. If you missed the chance to watch this presentation live, please click here to watch it. Significant Trends in the Automotive Market – Industry Landscape We are witnessing a revolution in automotive technology. Innovations like occupant and driver monitoring systems (OMS, DMS), 4D radar imaging, LiDAR technology, and 360-degree view are pushing the boundaries of what's possible, leading us into an era of remarkable autonomy levels—ranging from no feet or hands required to eventually no eyes needed on the road. Sensor Fusion and Increasing Processing Demands—Sensor fusion effectively integrates data from different sensors to help vehicles understand their surroundings better. Its main benefit is in overcoming the limitations of individual sensors. For example, cameras provide detailed visual information but struggle in low-light or lousy weather. On the other hand, radar is excellent at detecting objects in these conditions but lacks the detail that cameras provide. By combining the data from multiple sensors, automotive computing can take advantage of their strengths while compensating for their weaknesses, resulting in a more reliable and robust system overall. One thing to note is that the increased number of sensors produces various data types, leading to more pre-processing. On-Device Processing—As the industry moves towards autonomy, there is an increasing need for on-device data processing instead of cloud computing to enable vehicles to make informed decisions. Embracing on-device processing is a significant advancement for facilitating real-time decisions and avoiding round-trip latency. AI Adoption—AI has become integral to automotive applications, driving safety, efficiency, and user experience advancements. AI models offer superior performance and adaptability, making future-proofing a crucial consideration for automotive manufacturers. AI significantly enhances sensor fusion algorithms, offering scalability and adaptability beyond traditional rule-based approaches. Neural networks enable various fusion techniques, such as early fusion, late fusion, and mid-fusion, to optimize the integration and processing of sensor data. Future Sensor Fusion Needs Automotive architectures are continually evolving. With current trends and AI integration into radar and sensor fusion applications, SoCs should be modular, flexible, and programmable to meet market demands. Heterogeneous Architecture- Today's vehicles are loaded with various sensors, each with a unique processing requirement. Running the application on the most suitable processor is essential to achieve the best PPA. To meet such requirements, modern automotive solutions require a heterogeneous compute approach, integrating domain-specific digital signal processors (DSPs), neural processing units (NPUs), central processing unit (CPU) clusters, graphics processing unit (GPU) clusters, and hardware accelerator blocks. A balanced heterogeneous architecture gives the best PPA solution. Flexibility and Programmability- The industry has come a long way from using computer vision algorithms such as HOG (Histogram Oriented Gradient) to detect people and objects, HAR classifier to detect faces, etc., to CNN and LSTM-based AI to Transformer models and graphical neural networks (GNN). AI has evolved tremendously over the last ten years and continues to evolve. To keep up with the evolving rate of AI, SoC design must be flexible and programmable for updates if needed in the future. Addressing the Sensor Fusion Needs with Cadence Cadence offers a complete suite of hardware and software products to address the increasing compute requirements in automotive. The comprehensive portfolio of Tensilica products built on the robust 32-bit RISC architecture caters to various automotive CPU and AI needs. What makes them particularly appealing is their scalability, flexibility, and configurability, offering many options to meet diverse needs. The Xtensa family of products offers high-quality, power-efficient CPUs. Tensilica family also includes AI processors like Neo NPUs for the best power, performance, and area (PPA) for AI inference on devices or more extensive applications. Cadence also offers domain-specific products for DSPs such as HIFI DSPs, specialized DSPs and accelerators for radar and vision-based processing, and a general-purpose family of products for floating point applications. The ConnX family offers a wide range of DSPs, from compact and low-power to high-performance, optimized for radar, lidar, and communications applications in ADAS, autonomous driving, V2X, 5G/LTE/4G, wireless communications, drones, and robotics. Tensilica's ISO26262 certification ensures compliance with automotive safety standards, making it a trusted partner for advanced automotive solutions. The Cadence NeuroWeave Software Development Kit (SDK) provides customers with a uniform, scalable, and configurable ML interface and tooling that significantly improves time to market and better prepares them for a continuously evolving AI market. Cadence Tensilica offers an entire ecosystem of software frameworks and compilers for all programming styles. Tensilica's comprehensive software stack supports programming for DSPs, NPUs, and accelerators using C++, OpenCL, Halide, and various neural network approaches. Middleware libraries facilitate applications such as SLAM, radar processing, and Eigen libraries, providing robust support for automotive software development. Conclusion Cadence’s Tensilica products offer a development toolchain and various IPs tailored for the automotive industry, covering audio, vision, radar, unified DSPs, and NPUs. With ISO certification and a robust partner ecosystem, Tensilica solutions are designed to meet the future needs of automotive computing, ensuring safety, efficiency, and innovation. Learn More Cadence Automotive Solutions Cadence Automotive IP Sensor Fusion and ADAS in TSMC Automotive Processes Revolution on the Road: How Cadence is Driving the Future of Automotive Design! Taming Design Complexity in Chiplet-Based Automotive Electronics UCIe and Automotive Electronics: Pioneering the Chiplet Revolution Full Article Automotive Sensor Processing sensor fusion Automotive SoC automotive IP NPU AI