logic

Improving Access to Disability Assessment for US Citizenship Applicants in Primary Care: An Embedded Neuropsychological Assessment Innovation [Innovations in Primary Care]




logic

[Neuroscience] Reimagining Cortical Connectivity by Deconstructing Its Molecular Logic into Building Blocks

Comprehensive maps of neuronal connectivity provide a foundation for understanding the structure of neural circuits. In a circuit, neurons are diverse in morphology, electrophysiology, gene expression, activity, and other neuronal properties. Thus, constructing a comprehensive connectivity map requires associating various properties of neurons, including their connectivity, at cellular resolution. A commonly used approach is to use the gene expression profiles as an anchor to which all other neuronal properties are associated. Recent advances in genomics and anatomical techniques dramatically improved the ability to determine and associate the long-range projections of neurons with their gene expression profiles. These studies revealed unprecedented details of the gene–projection relationship, but also highlighted conceptual challenges in understanding this relationship. In this article, I delve into the findings and the challenges revealed by recent studies using state-of-the-art neuroanatomical and transcriptomic techniques. Building upon these insights, I propose an approach that focuses on understanding the gene–projection relationship through basic features in gene expression profiles and projections, respectively, that associate with underlying cellular processes. I then discuss how the developmental trajectories of projections and gene expression profiles create additional challenges and necessitate interrogating the gene–projection relationship across time. Finally, I explore complementary strategies that, together, can provide a comprehensive view of the gene–projection relationship.




logic

[PERSPECTIVES] Addressing Biological Questions with Preclinical Cancer Imaging

The broad application of noninvasive imaging has transformed preclinical cancer research, providing a powerful means to measure dynamic processes in living animals. While imaging technologies are routinely used to monitor tumor growth in model systems, their greatest potential lies in their ability to answer fundamental biological questions. Here we present the broad range of potential imaging applications according to the needs of a cancer biologist with a focus on some of the common biological processes that can be used to visualize and measure. Topics include imaging metastasis; biophysical properties such as perfusion, diffusion, oxygenation, and stiffness; imaging the immune system and tumor microenvironment; and imaging tumor metabolism. We also discuss the general ability of each approach and the level of training needed to both acquire and analyze images. The overall goal is to provide a practical guide for cancer biologists interested in answering biological questions with preclinical imaging technologies.




logic

New research to better understand the biological factors of suicidal behaviour

New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour.




logic

Pathologic 3 devs keen to avoid "premature promises" about bringing back the Changeling in Pathologic 4

Like a plague doctor delicately administering another handful of leeches, Ice Pick Lodge have shared a bit more about the recently announced Pathologic 3, explaining how their plans for the cult epidemic-battling series have progressed since the release of Pathologic 2.

Read more




logic

Over 500 Amazon workers decry “non-data-driven” logic for 5-day RTO policy

“I used to be proud of my work and excited about my future here. I don't feel that anymore."




logic

Regulatory update for post-registration of biological products in Brazil

<p>On 3<sup>&nbsp;</sup>June 2024,&nbsp;Resolution&nbsp;RDC No. 876 was published in Brazil in the Official Journal of the Union (DOU)[1],&nbsp;modifying the current regulations regarding the post-registration of biological products (RDC 413/2020).</p>




logic

Top nine biological drugs by sales in 2023

<p>The global biologicals market surged to an impressive US$419.07 billion in 2023. Blood and blood products led the market, commanding a dominant 66% share. Oncology stood out as the leading application segment, accounting for 36% of the market. North America held the largest revenue share, at 46%, while the Asia-Pacific region emerged as a rising star, poised to be the fastest-growing region over the next decade.</p>




logic

Transforming healthcare: CinnaGen’s leadership in follow-on biologicals/ biosimilars development and market expansion

<p> <b>Abstract</b><br />CinnaGen, the largest biopharmaceutical company in the MENA region, is a leader in developing follow-on biologicals/biosimilars. Dr&nbsp;Haleh Hamedifar, Chairperson of CinnaGen, spoke to GaBI<i>&nbsp;</i>(Generics and Biosimilars Initiative) about the company’s strategic focus, which includes expanding its product portfolio, entering highly regulated global markets, and advancing affordable treatments for conditions such as multiple sclerosis and&nbsp;immunological diseases—transforming healthcare in underserved regions.</p><p><b>Keywords</b>: Biosimilars, clinical development, commercialization, MENA</p>




logic

Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition

CDMO Avid Bioservices is being acquired by the private equity firms GHO Capital Partners and Ampersand Capital Partners. Avid specializes in manufacturing biologic products for companies at all stages of development.

The post Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition appeared first on MedCity News.




logic

Dynamics of Nuclear and Radiological Terrorism Threats to Post-Soviet Russia

Simon Saradzhyan was invited to publicly brief the National Academy of Sciences (NAS) committee addressing the adequacy of strategies to prevent, counter, and respond to nuclear terrorism, and identify technical, policy, and resource gaps. The consensus study is a congressionally mandated analysis included in the 2021 National Defense Authorization Act (Section 1299I) sponsored by the Office of the Secretary of Defense (Policy).  Nearly 60 stakeholders concerned about this topic from the Department of Defense, US Department of Energy, National Nuclear Security Administration, State Department, National Security Council, US Congress, the National Labs, and many non-governmental organizations were in attendance. The briefings are available at the NAS event website. Video of the presentation can be found here.




logic

Pest-resistant Maize Variety Opens Way for Technological Advancement

"It is estimated that the spotted stem borer and the African stem borer reduce Kenya's maize crop by 13 per cent or 400,000 tonnes annually. Controlling the pest using biotechnology will not only reduce Kenya's food imports, it will also equip the country with new techniques that can be redeployed for other sectors such as drug and vaccine development."




logic

A theological dilemma

A silly speculation: what if you die, go to heaven, and discover that a god had a set of fundamental rules that it didn’t tell anyone about? I was initially sympathetic to the idea that a god would judge you for doing harm to small helpless creatures — I avoid killing insects without cause — […]



  • Atheism and Skepticism

logic

New Dengue Related Biological Markers Discovered

Dengue is the most common mosquito-borne viral disease affecting humans globally. In 2019, the World Health Organization identified dengue as one of the




logic

Biological E's Oral Polio Vaccine Gets WHO Approval

Hyderabad-based vaccine manufacturer Biological E has secured World Health Organization (WHO) pre-qualification for its medlinknovel oral polio vaccine type 2/medlink (nOPV2).




logic

Treatment of Breast Cancer Linked to Accelerated Biological Aging

A recent study has found that prevalent treatments for medlinkbreast cancer/medlink, such as chemotherapy, radiation, and surgical interventions,




logic

Does Sub-chronic Psychological Stress Affect Male Fertility

Sub-chronic psychological stress may adversely affect male fertility, reports a latest study conducted in the Banares Hindu University, (BHU) a Central




logic

Psychological Stress may Affect Men's Sexual Health: Here's How

Psychological medlinkstress/medlink caused by lifestyle and other factors can wreak havoc on a man's sexual life, finds a new study conducted by a




logic

Alzheimer's Drug Discovery Foundation Funds Amicus Therapeutics To Advance Pharmacological Chaperone Technology

Alzheimer's Drug Discovery Foundation Funds Amicus Therapeutics To Advance Pharmacological Chaperone Technology




logic

Sabre and BookLogic partner to advance retailing and distribution strategies across Turkey and the Middle East

Collaboration brings SynXis® platform and global GDS/IDS connectivity and alternative distribution channels for up to 1,200 independent hotels and resorts globally with a focus on driving growth in the United Arab Emirates, Turkey, Qatar, and Saudi Arabia




logic

How To Assess If You Are Ageing Well: Understanding Biological vs Chronological Age

Life and death are the two hard truths. But we humans have long desired to live longer. In 1900 the average life expectancy was 32 years, but by 2021 it more than doubled to 71 years. Advancements in healthcare facilities, hygiene




logic

Daily Horoscope, Nov 05, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 05, 2024, Tuesday: Welcome to the stars' symphony on this vibrant November 05, 2024! Today unfolds a tapestry of cosmic energies, inviting each zodiac sign to dance through the day with insight and strength. Whether it's love that's




logic

Daily Horoscope, Nov 06, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 06, 2024, Wednesday: Good morning, celestial voyagers! The stars are aligned to gift us a day filled with optimistic energies and new beginnings. Today's horoscope promises enlightening insights and guidance that tune into every facet of your life.




logic

Daily Horoscope, Nov 07, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 07, 2024, Thursday: Welcome to November 07, 2024, where celestial energies encourage exploration and self-discovery. Today offers a chance to engage with the world in meaningful ways. Let’s dive into the day’s opportunities. Aries Horoscope (March




logic

Daily Horoscope, Nov 08, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 08, 2024, Friday: Today beckons with an energizing vibe that shimmers with possibility, inviting you to explore and embrace the subtleties of life. Set your intentions and let the cosmos guide you. Aries Horoscope (March 21




logic

Daily Horoscope, Nov 09, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 09, 2024, Saturday: Welcome to a fresh new day, full of potential and vibrant energy. Today, each zodiac sign will experience unique opportunities and challenges that can shape their paths. Stay curious and open to the wonders that




logic

Daily Horoscope, Nov 10, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 10, 2024, Sunday: Welcome to an uplifting day where cosmic energies align to both inspire and challenge us. Embrace the vibrant pulsations of the universe as you navigate life’s delightful mysteries. Aries Horoscope (March 21 -




logic

Daily Horoscope, Nov 11, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Horoscope Today November 11, 2024, Monday: Welcome to a day of discovery and illumination! November 11, 2024, brims with vibrant energy, offering a chance to remake the day in your image. Let the stars guide you through today’s adventures and challenges.




logic

Daily Horoscope, Nov 12, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Daily Horoscope for Today, November 12, 2024: Discover what the stars have in store for Libra to Pisces, with focused insights into love, career, and well-being.




logic

Daily Horoscope, Nov 13, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs

Daily Horoscope for Today, November 13, 2024: Discover what the stars have in store for Libra to Pisces, with focused insights into love, career, and well-being.




logic

Assessment of occurrence, source appointment, and ecological risks of pharmaceuticals and personal care products in the water–sediment interface of Qiantang River in the Hangzhou region

Environ. Sci.: Processes Impacts, 2024, 26,1887-1897
DOI: 10.1039/D4EM00355A, Paper
Yang Wan, Ziming Wang, Kaiping Xu, Wei Wang, Pengcheng Yao, Aiju You
TCS exhibited the highest concentration across different phases and seasons in QTR, and TCS posed high risks in surface water and low risks in sediment across all sampling sites.
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logic

How do ecosystem service functions affect ecological health? Evidence from the Yangtze River Economic Belt in China

Environ. Sci.: Processes Impacts, 2024, Advance Article
DOI: 10.1039/D4EM00296B, Paper
Wei Wang, Jun Yang, Guishan Yang, Chao Wu, Jie Yu
Ecosystem services serve as a bridge between social and economic impacts and ecological health.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




logic

You can't fight tanks with bayonets [Electronic book] : psychological warfare against the Japanese Army in the Southwest Pacific / Allison B. Gilmore.

Lincoln : University of Nebraska Press, [1998]




logic

Sweden and ecological governance : Straddling the fence [Electronic book] / Lennart Lundqvist.

Manchester : Manchester University Press, [2018]




logic

Social, health, and economic impacts of the COVID-19 pandemic and the epidemiological control measures : First results from SHARE Corona Waves 1 and 2 [Electronic book] / ed. by Axel Börsch-Supan, Anita Abramowska-Kmon, Karen Andersen-Ranberg, Agar B

Berlin ; Boston : De Gruyter, [2023]




logic

Social-Ecological Cooperative Housing : Gemeinschaftliches, transformatives Bauen und Wohnen [Electronic book] / hrsg. von id22: Institute for Creative Sustainability.

Berlin : JOVIS Verlag GmbH, [2022]




logic

Plutarch's Cosmological Ethics [Electronic book] / Bram Demulder.

[s.l.] : Universitaire Pers Leuven, 2023.




logic

Mythological constructs of Mexican femininity [Electronic book] / by Pilar Melero.

New York : Palgrave Macmillan US : Imprint: Palgrave Pivot, 2015.




logic

Meteorological Disasters in Medieval Britain (AD 1000‒1500) : Archaeological, Historical and Climatological Perspectives within a Wider European Context [Electronic book] / Peter J. Brown.

Berlin ; Boston : De Gruyter, [2023]




logic

Katherine Dunham : recovering an anthropological legacy, choreographing ethnographic futures [Electronic book] / edited by Elizabeth Chin.

Santa Fe : School for Advanced Research Press, [2014]




logic

Immeasurable Weather : Meteorological Data and Settler Colonialism from 1820 to Hurricane Sandy [Electronic book] / Sara J. Grossman.

Durham : Duke University Press, [2023]




logic

Human remains and mass violence : Methodological approaches [Electronic book] / ed. by Jean-Marc Dreyfus, Élisabeth Anstett.

Manchester : Manchester University Press, [2017]




logic

Handbook of philosophical logic. Volume 3 [Electronic book] / edited by D.M. Gabbay and F. Guenthner.

Dordrecht : Springer-Science+Business Media, B.V., 2001.




logic

The cosmological argument from Plato to Leibniz [Electronic book] / William Lane Craig.

London : Macmillan, 1980.




logic

Climatic and Ecological Change in the Americas : A Perspective from Historical Ecology [Electronic book] / James Andrew Whitaker.

England : Routledge, 2023.




logic

Alternative countrysides : Anthropological approaches to rural Western Europe today [Electronic book] / ed. by Jeremy Macclancy.

Manchester : Manchester University Press, [2019]




logic

African Ecological Ethics and Spirituality for Cosmic Flourishing : An African Commentary on Laudato Si' [Electronic book] / Stan Chu Ilo, Agbonkhianmeghe E. Orobator.

Eugene, Oregon : Wipf and Stock, 2022.




logic

Unraveling the Correlation between Biological Effects and Halogen Substituents in Cobalt bis(dicarbollide)

Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02296C, Research Article
Katarzyna Zakret-Drozdowska, Bożena Szermer-Olearnik, Waldemar Goldeman, Michalina Gos, Dawid Drozdowski, Anna Gągor, Tomasz M. Goszczyński
Over the past decade, considerable scientific attention has been given to adapting cobalt bis(dicarbollides) as innovative agents with various biomedical applications. Although the studied compounds show great potential in this...
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logic

Multifunctional cardiac microphysiological system based on transparent ITO electrodes for simultaneous optical measurement and electrical signal monitoring

Lab Chip, 2024, 24,1903-1917
DOI: 10.1039/D3LC00908D, Paper
Zhangjie Li, Kai Niu, Chenyang Zhou, Feifan Wang, Kangyi Lu, Yijun Liu, Lian Xuan, Xiaolin Wang
We developed a multifunctional cardiac microphysiological system on transparent electrodes, enabling simultaneous electrical signal monitoring and optical observations of cardiac tissue, holding promise for applications in cardiac drug development.
The content of this RSS Feed (c) The Royal Society of Chemistry




logic

Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism

Lab Chip, 2024, 24,2080-2093
DOI: 10.1039/D3LC00838J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland, Peter Loskill
Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.
The content of this RSS Feed (c) The Royal Society of Chemistry