logic Improving Access to Disability Assessment for US Citizenship Applicants in Primary Care: An Embedded Neuropsychological Assessment Innovation [Innovations in Primary Care] By www.annfammed.org Published On :: 2024-09-23T14:00:14-07:00 Full Article
logic [Neuroscience] Reimagining Cortical Connectivity by Deconstructing Its Molecular Logic into Building Blocks By cshperspectives.cshlp.org Published On :: 2024-11-01T06:50:52-07:00 Comprehensive maps of neuronal connectivity provide a foundation for understanding the structure of neural circuits. In a circuit, neurons are diverse in morphology, electrophysiology, gene expression, activity, and other neuronal properties. Thus, constructing a comprehensive connectivity map requires associating various properties of neurons, including their connectivity, at cellular resolution. A commonly used approach is to use the gene expression profiles as an anchor to which all other neuronal properties are associated. Recent advances in genomics and anatomical techniques dramatically improved the ability to determine and associate the long-range projections of neurons with their gene expression profiles. These studies revealed unprecedented details of the gene–projection relationship, but also highlighted conceptual challenges in understanding this relationship. In this article, I delve into the findings and the challenges revealed by recent studies using state-of-the-art neuroanatomical and transcriptomic techniques. Building upon these insights, I propose an approach that focuses on understanding the gene–projection relationship through basic features in gene expression profiles and projections, respectively, that associate with underlying cellular processes. I then discuss how the developmental trajectories of projections and gene expression profiles create additional challenges and necessitate interrogating the gene–projection relationship across time. Finally, I explore complementary strategies that, together, can provide a comprehensive view of the gene–projection relationship. Full Article
logic [PERSPECTIVES] Addressing Biological Questions with Preclinical Cancer Imaging By perspectivesinmedicine.cshlp.org Published On :: 2024-11-01T07:17:20-07:00 The broad application of noninvasive imaging has transformed preclinical cancer research, providing a powerful means to measure dynamic processes in living animals. While imaging technologies are routinely used to monitor tumor growth in model systems, their greatest potential lies in their ability to answer fundamental biological questions. Here we present the broad range of potential imaging applications according to the needs of a cancer biologist with a focus on some of the common biological processes that can be used to visualize and measure. Topics include imaging metastasis; biophysical properties such as perfusion, diffusion, oxygenation, and stiffness; imaging the immune system and tumor microenvironment; and imaging tumor metabolism. We also discuss the general ability of each approach and the level of training needed to both acquire and analyze images. The overall goal is to provide a practical guide for cancer biologists interested in answering biological questions with preclinical imaging technologies. Full Article
logic New research to better understand the biological factors of suicidal behaviour By www.heraldscotland.com Published On :: Tue, 12 Nov 2024 06:30:00 +0000 New research to better understand the biological factors of suicidal behaviour Researchers at the University of Glasgow are embarking on two new PhD projects to better understand the impact that biological factors may have on suicidal behaviour. Full Article
logic Pathologic 3 devs keen to avoid "premature promises" about bringing back the Changeling in Pathologic 4 By www.rockpapershotgun.com Published On :: Fri, 01 Nov 2024 17:04:02 +0000 Like a plague doctor delicately administering another handful of leeches, Ice Pick Lodge have shared a bit more about the recently announced Pathologic 3, explaining how their plans for the cult epidemic-battling series have progressed since the release of Pathologic 2. Read more Full Article Pathologic 3 Story Rich Horror Indie Life Simulation PC RPG
logic Over 500 Amazon workers decry “non-data-driven” logic for 5-day RTO policy By arstechnica.com Published On :: Thu, 31 Oct 2024 17:16:04 +0000 “I used to be proud of my work and excited about my future here. I don't feel that anymore." Full Article Policy Tech Amazon return-to-office
logic Regulatory update for post-registration of biological products in Brazil By www.gabionline.net Published On :: Tue, 29 Oct 2024 09:23:29 +0000 <p>On 3<sup> </sup>June 2024, Resolution RDC No. 876 was published in Brazil in the Official Journal of the Union (DOU)[1], modifying the current regulations regarding the post-registration of biological products (RDC 413/2020).</p> Full Article
logic Top nine biological drugs by sales in 2023 By www.gabionline.net Published On :: Tue, 29 Oct 2024 09:38:14 +0000 <p>The global biologicals market surged to an impressive US$419.07 billion in 2023. Blood and blood products led the market, commanding a dominant 66% share. Oncology stood out as the leading application segment, accounting for 36% of the market. North America held the largest revenue share, at 46%, while the Asia-Pacific region emerged as a rising star, poised to be the fastest-growing region over the next decade.</p> Full Article
logic Transforming healthcare: CinnaGen’s leadership in follow-on biologicals/ biosimilars development and market expansion By www.gabionline.net Published On :: Fri, 08 Nov 2024 13:18:16 +0000 <p> <b>Abstract</b><br />CinnaGen, the largest biopharmaceutical company in the MENA region, is a leader in developing follow-on biologicals/biosimilars. Dr Haleh Hamedifar, Chairperson of CinnaGen, spoke to GaBI<i> </i>(Generics and Biosimilars Initiative) about the company’s strategic focus, which includes expanding its product portfolio, entering highly regulated global markets, and advancing affordable treatments for conditions such as multiple sclerosis and immunological diseases—transforming healthcare in underserved regions.</p><p><b>Keywords</b>: Biosimilars, clinical development, commercialization, MENA</p> Full Article
logic Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition By medcitynews.com Published On :: Thu, 07 Nov 2024 20:59:20 +0000 CDMO Avid Bioservices is being acquired by the private equity firms GHO Capital Partners and Ampersand Capital Partners. Avid specializes in manufacturing biologic products for companies at all stages of development. The post Private Equity Is Picking Up Biologics CDMO Avid Bioservices in $1.1B Acquisition appeared first on MedCity News. Full Article BioPharma Legal Pharma Avid Bioservices biologic drugs biopharma nl CDMO manufacturing private equity
logic Dynamics of Nuclear and Radiological Terrorism Threats to Post-Soviet Russia By www.belfercenter.org Published On :: Jun 21, 2022 Jun 21, 2022 Simon Saradzhyan was invited to publicly brief the National Academy of Sciences (NAS) committee addressing the adequacy of strategies to prevent, counter, and respond to nuclear terrorism, and identify technical, policy, and resource gaps. The consensus study is a congressionally mandated analysis included in the 2021 National Defense Authorization Act (Section 1299I) sponsored by the Office of the Secretary of Defense (Policy). Nearly 60 stakeholders concerned about this topic from the Department of Defense, US Department of Energy, National Nuclear Security Administration, State Department, National Security Council, US Congress, the National Labs, and many non-governmental organizations were in attendance. The briefings are available at the NAS event website. Video of the presentation can be found here. Full Article
logic Pest-resistant Maize Variety Opens Way for Technological Advancement By www.belfercenter.org Published On :: Sep 10, 2015 Sep 10, 2015 "It is estimated that the spotted stem borer and the African stem borer reduce Kenya's maize crop by 13 per cent or 400,000 tonnes annually. Controlling the pest using biotechnology will not only reduce Kenya's food imports, it will also equip the country with new techniques that can be redeployed for other sectors such as drug and vaccine development." Full Article
logic A theological dilemma By freethoughtblogs.com Published On :: Sun, 10 Nov 2024 12:44:10 +0000 A silly speculation: what if you die, go to heaven, and discover that a god had a set of fundamental rules that it didn’t tell anyone about? I was initially sympathetic to the idea that a god would judge you for doing harm to small helpless creatures — I avoid killing insects without cause — […] Full Article Atheism and Skepticism
logic New Dengue Related Biological Markers Discovered By www.medindia.net Published On :: Dengue is the most common mosquito-borne viral disease affecting humans globally. In 2019, the World Health Organization identified dengue as one of the Full Article
logic Biological E's Oral Polio Vaccine Gets WHO Approval By www.medindia.net Published On :: Hyderabad-based vaccine manufacturer Biological E has secured World Health Organization (WHO) pre-qualification for its medlinknovel oral polio vaccine type 2/medlink (nOPV2). Full Article
logic Treatment of Breast Cancer Linked to Accelerated Biological Aging By www.medindia.net Published On :: A recent study has found that prevalent treatments for medlinkbreast cancer/medlink, such as chemotherapy, radiation, and surgical interventions, Full Article
logic Does Sub-chronic Psychological Stress Affect Male Fertility By www.medindia.net Published On :: Sub-chronic psychological stress may adversely affect male fertility, reports a latest study conducted in the Banares Hindu University, (BHU) a Central Full Article
logic Psychological Stress may Affect Men's Sexual Health: Here's How By www.medindia.net Published On :: Psychological medlinkstress/medlink caused by lifestyle and other factors can wreak havoc on a man's sexual life, finds a new study conducted by a Full Article
logic Alzheimer's Drug Discovery Foundation Funds Amicus Therapeutics To Advance Pharmacological Chaperone Technology By www.medindia.com Published On :: Alzheimer's Drug Discovery Foundation Funds Amicus Therapeutics To Advance Pharmacological Chaperone Technology Full Article
logic Sabre and BookLogic partner to advance retailing and distribution strategies across Turkey and the Middle East By www.hospitalitynet.org Published On :: Fri, 08 Nov 2024 15:34:00 +0200 Collaboration brings SynXis® platform and global GDS/IDS connectivity and alternative distribution channels for up to 1,200 independent hotels and resorts globally with a focus on driving growth in the United Arab Emirates, Turkey, Qatar, and Saudi Arabia Full Article
logic How To Assess If You Are Ageing Well: Understanding Biological vs Chronological Age By www.oneindia.com Published On :: Thu, 03 Oct 2024 09:31:37 +0530 Life and death are the two hard truths. But we humans have long desired to live longer. In 1900 the average life expectancy was 32 years, but by 2021 it more than doubled to 71 years. Advancements in healthcare facilities, hygiene Full Article
logic Daily Horoscope, Nov 05, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Tue, 05 Nov 2024 11:52:42 +0530 Horoscope Today November 05, 2024, Tuesday: Welcome to the stars' symphony on this vibrant November 05, 2024! Today unfolds a tapestry of cosmic energies, inviting each zodiac sign to dance through the day with insight and strength. Whether it's love that's Full Article
logic Daily Horoscope, Nov 06, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Thu, 07 Nov 2024 09:41:24 +0530 Horoscope Today November 06, 2024, Wednesday: Good morning, celestial voyagers! The stars are aligned to gift us a day filled with optimistic energies and new beginnings. Today's horoscope promises enlightening insights and guidance that tune into every facet of your life. Full Article
logic Daily Horoscope, Nov 07, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Thu, 07 Nov 2024 10:10:59 +0530 Horoscope Today November 07, 2024, Thursday: Welcome to November 07, 2024, where celestial energies encourage exploration and self-discovery. Today offers a chance to engage with the world in meaningful ways. Let’s dive into the day’s opportunities. Aries Horoscope (March Full Article
logic Daily Horoscope, Nov 08, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Fri, 08 Nov 2024 08:54:50 +0530 Horoscope Today November 08, 2024, Friday: Today beckons with an energizing vibe that shimmers with possibility, inviting you to explore and embrace the subtleties of life. Set your intentions and let the cosmos guide you. Aries Horoscope (March 21 Full Article
logic Daily Horoscope, Nov 09, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Sat, 09 Nov 2024 08:04:01 +0530 Horoscope Today November 09, 2024, Saturday: Welcome to a fresh new day, full of potential and vibrant energy. Today, each zodiac sign will experience unique opportunities and challenges that can shape their paths. Stay curious and open to the wonders that Full Article
logic Daily Horoscope, Nov 10, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Mon, 11 Nov 2024 10:13:31 +0530 Horoscope Today November 10, 2024, Sunday: Welcome to an uplifting day where cosmic energies align to both inspire and challenge us. Embrace the vibrant pulsations of the universe as you navigate life’s delightful mysteries. Aries Horoscope (March 21 - Full Article
logic Daily Horoscope, Nov 11, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Mon, 11 Nov 2024 09:45:13 +0530 Horoscope Today November 11, 2024, Monday: Welcome to a day of discovery and illumination! November 11, 2024, brims with vibrant energy, offering a chance to remake the day in your image. Let the stars guide you through today’s adventures and challenges. Full Article
logic Daily Horoscope, Nov 12, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Tue, 12 Nov 2024 05:15:07 +0530 Daily Horoscope for Today, November 12, 2024: Discover what the stars have in store for Libra to Pisces, with focused insights into love, career, and well-being. Full Article
logic Daily Horoscope, Nov 13, 2024: Libra to Pisces; Astrological Prediction for all Zodiac Signs By www.boldsky.com Published On :: Wed, 13 Nov 2024 05:12:19 +0530 Daily Horoscope for Today, November 13, 2024: Discover what the stars have in store for Libra to Pisces, with focused insights into love, career, and well-being. Full Article
logic Assessment of occurrence, source appointment, and ecological risks of pharmaceuticals and personal care products in the water–sediment interface of Qiantang River in the Hangzhou region By pubs.rsc.org Published On :: Environ. Sci.: Processes Impacts, 2024, 26,1887-1897DOI: 10.1039/D4EM00355A, PaperYang Wan, Ziming Wang, Kaiping Xu, Wei Wang, Pengcheng Yao, Aiju YouTCS exhibited the highest concentration across different phases and seasons in QTR, and TCS posed high risks in surface water and low risks in sediment across all sampling sites.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
logic How do ecosystem service functions affect ecological health? Evidence from the Yangtze River Economic Belt in China By pubs.rsc.org Published On :: Environ. Sci.: Processes Impacts, 2024, Advance ArticleDOI: 10.1039/D4EM00296B, PaperWei Wang, Jun Yang, Guishan Yang, Chao Wu, Jie YuEcosystem services serve as a bridge between social and economic impacts and ecological health.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
logic You can't fight tanks with bayonets [Electronic book] : psychological warfare against the Japanese Army in the Southwest Pacific / Allison B. Gilmore. By encore.st-andrews.ac.uk Published On :: Lincoln : University of Nebraska Press, [1998] Full Article
logic Sweden and ecological governance : Straddling the fence [Electronic book] / Lennart Lundqvist. By encore.st-andrews.ac.uk Published On :: Manchester : Manchester University Press, [2018] Full Article
logic Social, health, and economic impacts of the COVID-19 pandemic and the epidemiological control measures : First results from SHARE Corona Waves 1 and 2 [Electronic book] / ed. by Axel Börsch-Supan, Anita Abramowska-Kmon, Karen Andersen-Ranberg, Agar B By encore.st-andrews.ac.uk Published On :: Berlin ; Boston : De Gruyter, [2023] Full Article
logic Social-Ecological Cooperative Housing : Gemeinschaftliches, transformatives Bauen und Wohnen [Electronic book] / hrsg. von id22: Institute for Creative Sustainability. By encore.st-andrews.ac.uk Published On :: Berlin : JOVIS Verlag GmbH, [2022] Full Article
logic Plutarch's Cosmological Ethics [Electronic book] / Bram Demulder. By encore.st-andrews.ac.uk Published On :: [s.l.] : Universitaire Pers Leuven, 2023. Full Article
logic Mythological constructs of Mexican femininity [Electronic book] / by Pilar Melero. By encore.st-andrews.ac.uk Published On :: New York : Palgrave Macmillan US : Imprint: Palgrave Pivot, 2015. Full Article
logic Meteorological Disasters in Medieval Britain (AD 1000‒1500) : Archaeological, Historical and Climatological Perspectives within a Wider European Context [Electronic book] / Peter J. Brown. By encore.st-andrews.ac.uk Published On :: Berlin ; Boston : De Gruyter, [2023] Full Article
logic Katherine Dunham : recovering an anthropological legacy, choreographing ethnographic futures [Electronic book] / edited by Elizabeth Chin. By encore.st-andrews.ac.uk Published On :: Santa Fe : School for Advanced Research Press, [2014] Full Article
logic Immeasurable Weather : Meteorological Data and Settler Colonialism from 1820 to Hurricane Sandy [Electronic book] / Sara J. Grossman. By encore.st-andrews.ac.uk Published On :: Durham : Duke University Press, [2023] Full Article
logic Human remains and mass violence : Methodological approaches [Electronic book] / ed. by Jean-Marc Dreyfus, Élisabeth Anstett. By encore.st-andrews.ac.uk Published On :: Manchester : Manchester University Press, [2017] Full Article
logic Handbook of philosophical logic. Volume 3 [Electronic book] / edited by D.M. Gabbay and F. Guenthner. By encore.st-andrews.ac.uk Published On :: Dordrecht : Springer-Science+Business Media, B.V., 2001. Full Article
logic The cosmological argument from Plato to Leibniz [Electronic book] / William Lane Craig. By encore.st-andrews.ac.uk Published On :: London : Macmillan, 1980. Full Article
logic Climatic and Ecological Change in the Americas : A Perspective from Historical Ecology [Electronic book] / James Andrew Whitaker. By encore.st-andrews.ac.uk Published On :: England : Routledge, 2023. Full Article
logic Alternative countrysides : Anthropological approaches to rural Western Europe today [Electronic book] / ed. by Jeremy Macclancy. By encore.st-andrews.ac.uk Published On :: Manchester : Manchester University Press, [2019] Full Article
logic African Ecological Ethics and Spirituality for Cosmic Flourishing : An African Commentary on Laudato Si' [Electronic book] / Stan Chu Ilo, Agbonkhianmeghe E. Orobator. By encore.st-andrews.ac.uk Published On :: Eugene, Oregon : Wipf and Stock, 2022. Full Article
logic Unraveling the Correlation between Biological Effects and Halogen Substituents in Cobalt bis(dicarbollide) By pubs.rsc.org Published On :: Inorg. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QI02296C, Research ArticleKatarzyna Zakret-Drozdowska, Bożena Szermer-Olearnik, Waldemar Goldeman, Michalina Gos, Dawid Drozdowski, Anna Gągor, Tomasz M. GoszczyńskiOver the past decade, considerable scientific attention has been given to adapting cobalt bis(dicarbollides) as innovative agents with various biomedical applications. Although the studied compounds show great potential in this...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
logic Multifunctional cardiac microphysiological system based on transparent ITO electrodes for simultaneous optical measurement and electrical signal monitoring By pubs.rsc.org Published On :: Lab Chip, 2024, 24,1903-1917DOI: 10.1039/D3LC00908D, PaperZhangjie Li, Kai Niu, Chenyang Zhou, Feifan Wang, Kangyi Lu, Yijun Liu, Lian Xuan, Xiaolin WangWe developed a multifunctional cardiac microphysiological system on transparent electrodes, enabling simultaneous electrical signal monitoring and optical observations of cardiac tissue, holding promise for applications in cardiac drug development.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
logic Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism By pubs.rsc.org Published On :: Lab Chip, 2024, 24,2080-2093DOI: 10.1039/D3LC00838J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland, Peter LoskillPancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article