Malaria is a devastating disease, affecting 200 million people worldwide and causing more than 600 000 deaths each year. In the past decade, great inroads have been made in reducing the number of infections, primarily through the implementation of insecticide-laced bed nets, and also reducing the death rate with combination therapies. However the emergence of drug-resistant malaria is rendering these therapies less effective, and there is an urgent need to develop novel therapies to cure malaria.

Vicky was last seen in Bad Newz. He will now be seen in Chhava. The film, another Dinesh Vijan production, will see Vicky play the role of Chhatrapati Sambhaji. He will then be seen in Love and War alongside Ranbir Kapoor.

Sculptor had disassembled statue only to introduce minor alignment corrections as suggested by NITK, the MLA claims

Produced by Maddock Films, the action epic will release in theatres on Christmas, 2026 

Vicky Kaushal shakes the internet with his new look as Chiranjeevi Parashurama in the new film titled Mahavatar.

Paras Aerospace Pvt. Ltd. | 9,797 followers on LinkedIn. Developing Technologies that will Revolutionize the Drones Industry in India | Augmenting UAV systems through world-class technologies! We specialize in aerial mapping, surveying and offer complete UAV integration and UAV-based services, both hardware and software. The prime verticals of the company include Military UAV, Industrial UAV ...

Background information on reasons for a parasite cleanse and simple guide to administering a herbal parasite cleanse.

Recommendation on a Parasite Cleansing Kit containing a variety of herbs that make your body inhospitable to parasites and herbal laxatives.

Welcome back, everyone, to a new episode of the Niche Pursuits News Podcast! Like every week, we’re here to talk about the latest SEO news for publishers, inspire you with some stories about our side hustles, and shock you with…

The post Runaway Parasite SEO! Google Penalizes Forbes! appeared first on Niche Pursuits.

She was born near Rome to pious parents. Since she was born on a Friday, she was named Paraskeve (Friday in Greek; literally "preparation" or "preparedness" because Friday was the Biblical Day of Preparation for the Sabbath). From early childhood she studied the scriptures, consecrated herself to a monastic life, and brought many to faith in Christ by her example and teaching. During the reign of Antoninus she was arrested because she was a Christian. When ordered to worship the idols, she answered "Let the gods that have not made heaven and the earth perish from off the earth" (Jeremiah 10:11). For this, after severe tortures she was beheaded in 140.

She was born near Rome to pious parents. Since she was born on a Friday, she was named Paraskeve (Friday in Greek; literally "preparation" or "preparedness" because Friday was the Biblical Day of Preparation for the Sabbath). From early childhood she studied the scriptures, consecrated herself to a monastic life, and brought many to faith in Christ by her example and teaching. During the reign of Antoninus she was arrested because she was a Christian. When ordered to worship the idols, she answered "Let the gods that have not made heaven and the earth perish from off the earth" (Jeremiah 10:11). For this, after severe tortures she was beheaded in 140.

She was born near Rome to pious parents. Since she was born on a Friday, she was named Paraskeve (Friday in Greek; literally "preparation" or "preparedness" because Friday was the Biblical Day of Preparation for the Sabbath). From early childhood she studied the scriptures, consecrated herself to a monastic life, and brought many to faith in Christ by her example and teaching. During the reign of Antoninus she was arrested because she was a Christian. When ordered to worship the idols, she answered "Let the gods that have not made heaven and the earth perish from off the earth" (Jeremiah 10:11). For this, after severe tortures she was beheaded in 140.

She was born near Rome to pious parents. Since she was born on a Friday, she was named Paraskeve (Friday in Greek; literally "preparation" or "preparedness" because Friday was the Biblical Day of Preparation for the Sabbath). From early childhood she studied the scriptures, consecrated herself to a monastic life, and brought many to faith in Christ by her example and teaching. During the reign of Antoninus she was arrested because she was a Christian. When ordered to worship the idols, she answered "Let the gods that have not made heaven and the earth perish from off the earth" (Jeremiah 10:11). For this, after severe tortures she was beheaded in 140.

"Saint Paraskevi of Rome," from Women of Faith, written by Calee M. Lee, illustrated by Lisa Graves (Xist Publishing, 2015)

Fr. Evan welcomes another guest co-host tonight: Fr. Ted Paraskevopoulos. Fr. Ted is heard on AFR with his iSermon and Fr. TedTalks podcasts. They field listener questions on the role of pain and suffering, making your home an Orthodox home, liturgical translations, and, from both of them, a statement of what makes Orthodoxy so special.

Aim/Purpose: Parasocial relationships are today established on social media between influencers and their followers. While marketing effects are well-researched, little is known about the meaning of such relationships and the psychological mechanisms behind them. This study, therefore, explores the questions: “How do followers on Instagram interpret explicit fiction cues from influencers?” and “What does this reveal about the meaning of parasocial attachment?” Background: With a billion-dollar advertising industry and leading in influencing opinion, Instagram is a significant societal and economic player. One factor for the effective influence of consumers is the relationship between influencer and follower. Research shows that disclosing advertisements surprisingly does not harm credibility, and sometimes even leads to greater trustworthiness and, in turn, willingness to purchase. While such reverse dynamics are measurable, the mechanisms behind them remain largely unexplored. Methodology: The study follows an explorative approach with in-depth interviews, which are analyzed with Mayring’s content analysis under a reconstructive paradigm. The findings are discussed through the lens of critical psychology. Contribution: Firstly, this study contributes to the understanding of the communicative dynamics of influencer-follower communication alongside the reality-fiction-gap model, and, secondly, it contributes empirical insights through the analysis of 22 explorative interviews. Findings: The findings show (a) how followers rationalize fiction cues and justify compulsive decision-making, (b) how followers are vulnerable to influences, and (c) how parasocial attachment formation overshadows rational logic and agency. The findings are discussed with regard to mechanisms, vulnerabilities, rationalizations and cognitive bias, and the social self, as well as the ethics of influencer marketing and politics. Recommendation for Researchers: The contribution is relevant to relationship research, group dynamics and societal organizing, well-being, identity, and health perspectives, within psychology, sociology, media studies, and pedagogy to management. Future Research: Future research might seek to understand more about (a) quantifiable vulnerabilities, such as attachment styles, dispositions, and demographics, (b) usage patterns and possible factors of prevention, (c) cognitive and emotional mechanisms involved with larger samples, (d) the impact on relationships and well-being, and (e) possible conditions for the potential of parasocial attachment.

Full Text:

Many wild southern sea otters in California are infected with the parasite Toxoplasma gondii, yet the infection is fatal for only a fraction of sea otters, which has long puzzled the scientific community. A National Science Foundation-funded study identifies the parasite's specific strains that are killing southern sea otters, tracing them back to a bobcat and feral domestic cats from nearby watersheds. The study marks the first time a genetic link has been clearly established between the Toxoplasma strains in felid hosts and parasites causing fatal disease in marine wildlife. The study's results highlight how infectious agents like Toxoplasma can spread from cat feces on land to the sea, leading to detrimental impacts on marine wildlife.

Image credit: Trina Wood/UC Davis

All complex life on Earth, including plants and animals, are made up of eukaryotic cells, which are more sophisticated than bacterial or archaeal cells..

All complex life on Earth, including plants and animals, are made up of eukaryotic cells, which are more sophisticated than bacterial or archaeal cells..

Malaria is a life-threatening disease commonly transmitted by mosquitos. Symptoms include fever, chills, vomiting, headaches, abdominal pain, and rapid hea

All complex life on Earth, including plants and animals, are made up of eukaryotic cells, which are more sophisticated than bacterial or archaeal cells..

People often contract schistosomiasis through water contaminated with infected snails and feces.

Scientists modified Toxoplasma gondii to deliver a potential Rett Syndrome therapeutic to the mouse brain. 

Researchers found that Toxoplasma gondii increased the host cell’s metabolic activity, offering insights into potential treatment strategies. 

I'm trying to find a story published on Clarkes World or tor.com or something similar, in the last ~15 years? A woman protagonist is on an exoplanet, and we become aware that she's being transformed by a parasite from the planet, but her experience of it is expansive and euphoric. I think it explicitly mentions the tongue-eating louse, though I could be misremembering that bit.

Parasols: the smart woman's protection against ogling.

The life cycle of malaria parasites in both their mammalian host and mosquito vector consists of multiple developmental stages that ensure proper replication and progeny survival. The transition between these stages is fueled by nutrients scavenged from the host and fed into specialized metabolic pathways of the parasite. One such pathway is used by Plasmodium falciparum, which causes the most severe form of human malaria, to synthesize its major phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. Much is known about the enzymes involved in the synthesis of these phospholipids, and recent advances in genetic engineering, single-cell RNA-Seq analyses, and drug screening have provided new perspectives on the importance of some of these enzymes in parasite development and sexual differentiation and have identified targets for the development of new antimalarial drugs. This Minireview focuses on two phospholipid biosynthesis enzymes of P. falciparum that catalyze phosphoethanolamine transmethylation (PfPMT) and phosphatidylserine decarboxylation (PfPSD) during the blood stages of the parasite. We also discuss our current understanding of the biochemical, structural, and biological functions of these enzymes and highlight efforts to use them as antimalarial drug targets.

Jianhua Wang
Nov 4, 2020; 0:RA120.002375v1-mcp.RA120.002375
Research

Malaria elimination is still pending on the development of novel tools that rely on a deep understanding of parasite biology. Proteins of all living cells undergo a myriad number of posttranslational modifications (PTMs) that are critical to multifarious life processes. An extensive proteome-wide dissection revealed a fine PTM map of most proteins in both Plasmodium falciparum, the causative agent of severe malaria, and the infected red blood cells. More than two-thirds of proteins of the parasite and its host cell underwent extensive and dynamic modification throughout the erythrocytic developmental stage. PTMs critically modulate the virulence factors involved in the host-parasite interaction and pathogenesis. Furthermore, P. falciparum stabilized the supporting proteins of erythrocyte origin by selective de-modification. Collectively, our multiple omic analyses, apart from having furthered a deep understanding of the systems biology of P. falciparum and malaria pathogenesis, provide a valuable resource for mining new antimalarial targets.

Pathogens are more common in polar bears living in the Chukchi Sea now than they were three decades ago, a new study suggests—but it's not yet clear what that means for the mammals' health

The film will release on Christmas 2026

A Delhi government report has attributed nearly 24 per cent of the total about 89,000 deaths registered in the national capital in 2023 to infectious and parasitic diseases like cholera, diarrhoea, tuberculosis and hepatitis B, among others.

1. Vicky Kaushal looks unrecognisable as Parashurama in Mahavatar first look. Check first poster, release date  Hindustan Times
2. Mahavatar First Poster: Vicky Kaushal Takes On The Role Of "The Eternal Warrior Of Dharma"- Parashurama  NDTV Movies
3. Vicky Kaushal drops powerful FIRST LOOK as Lord Parashurama for ‘Mahavatar’  TOI Etimes
4. entertainment News Live Today November 13, 2024: Vicky Kaushal looks unrecognisable as Parashurama in Mahavatar first look. Check first poster, release date  Hindustan Times
5. Vicky Kaushal to play Chiranjeevi Parashurama in Amar Kaushik’s Mahavatar  India Today

Read this blog for an overview to the Circuit physical verification and parasitic extraction design stage in the Custom IC Design methodology and the key design steps which can help you achieve this.(read more)

Title: Pious Parasites: Medieval Monks Battled Nasty Gut Germs
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Around 25 per cent of the world’s population has intestinal parasite infections – these could hinder the effectiveness of covid-19 vaccines, according to research in mice

The pathogen takes over the brains of its hosts and controls them for its own sinister ends

Imagine you’re a baby cocoa plant, just unfurling your first tentative roots into the fertile, welcoming soil.

Somewhere nearby, a predator stirs. It has no ears to hear you, no eyes to see you. But it knows where you are, thanks in part to the weak electric field emitted by your roots.

It is microscopic, but it’s not alone. By the thousands, the creatures converge, slithering through the waterlogged soil, propelled by their flagella. If they reach you, they will use fungal-like hyphae to penetrate and devour you from the inside. They’re getting closer. You’re a plant. You have no legs. There’s no escape.

But just before they fall upon you, they hesitate. They seem confused. Then, en masse, they swarm off in a different direction, lured by a more attractive electric field. You are safe. And they will soon be dead.

If Eleonora Moratto and Giovanni Sena get their way, this is the future of crop pathogen control.

Many variables are involved in the global food crisis, but among the worst are the pests that devastate food crops, ruining up to 40 percent of their yield before they can be harvested. One of these—the little protist in the example above, an oomycete formally known as Phytophthora palmivora—has a US $1 billion appetite for economic staples like cocoa, palm, and rubber.

There is currently no chemical defense that can vanquish these creatures without poisoning the rest of the (often beneficial) organisms living in the soil. So Moratto, Sena, and their colleagues at Sena’s group at Imperial College London settled on a non-traditional approach: They exploited P. palmivora’s electric sense, which can be spoofed.

All plant roots that have been measured to date generate external ion flux, which translates into a very weak electric field. Decades of evidence suggests that this signal is an important target for predators’ navigation systems. However, it remains a matter of some debate how much their predators rely on plants’ electrical signatures to locate them, as opposed to chemical or mechanical information. Last year, Moratto and Sena’s group found that P. palmivora spores are attracted to the positive electrode of a cell generating current densities of 1 ampere per square meter. “The spores followed the electric field,” says Sena, suggesting that a similar mechanism helps them find natural bioelectric fields emitted by roots in the soil.

That got the researchers wondering: Might such an artificial electric field override the protists’ other sensory inputs, and scramble their compasses as they tried to use plant roots’ much weaker electrical output?

To test the idea, the researchers developed two ways to protect plant roots using a constant vertical electric field. They cultivated two common snacks for P. palmivora—a flowering plant related to cabbage and mustard, and a legume often used as a livestock feed plant—in tubes in a hydroponic solution.

Two electric-field configurations were tested: A “global” vertical field [left] and a field generated by two small nearby electrodes. The global field proved to be slightly more effective.Eleonora Moratto

In the first assay, the researchers sandwiched the plant roots between rows of electrodes above and below, which completely engulfed them in a “global” vertical field. For the second set, the field was generated using two small electrodes a short distance away from the plant, creating current densities on the order of 10 A/m². Then they unleashed the protists.

With respect to the control group, both methods successfully diverted a significant portion of the predators away from the plant roots. They swarmed the positive electrode, where—since zoospores can’t survive for longer than about 2 to 3 hours without a host—they presumably starved to death. Or worse. Neil Gow, whose research presented some of the first evidence for zoospore electrosensing, has other theories about their fate. “Applied electrical fields generate toxic products and steep pH gradients near and around the electrodes due to the electrolysis of water,” he says. “The tropism towards the electrode might be followed by killing or immobilization due to the induced pH gradients.”

Not only did the technique prevent infestation, but some evidence indicates that it may also mitigate existing infections. The researchers published their results in August in Scientific Reports.

The global electric field was marginally more successful than the local. However, it would be harder to translate from lab conditions into a (literal) field trial in soil. The local electric field setup would be easy to replicate: “All you have to do is stick the little plug into the soil next to the crop you want to protect,” says Sena.

Moratto and Sena say this is a proof of concept that demonstrates a basis for a new, pesticide-free way to protect food crops. (Sena likens the technique to the decoys used by fighter jets to draw away incoming missiles by mimicking the signals of the original target.) They are now looking for funding to expand the project. The first step is testing the local setup in soil; the next is to test the approach on Phytophthora infestans, a meaner, scarier cousin of P. palmivora.

P. infestans attacks a more varied diet of crops—you may be familiar with its work during the Irish potato famine. The close genetic similarities imply another promising candidate for electrical pest control. This investigation, however, may require more funding. P. infestans research can be undertaken only under more stringent laboratory security protocols.

The work at Imperial ties into the broader—and somewhat charged—debate around electrostatic ecology; that is, the extent to which creatures including ticks make use of heretofore poorly understood electrical mechanisms to orient themselves and in other ways enhance their survival. “Most people still aren’t aware that naturally occurring electricity can play an ecological role,” says Sam England, a behavioral ecologist with Berlin’s Natural History Museum. “So I suspect that once these electrical phenomena become more well known and understood, they will inspire a greater number of practical applications like this one.”

Highlights: Scientists found Toxoplasma gondii may help deliver therapeutic proteins to the brain, a breakthrou

Highlights: Himanshi Parashar, an Indian model and actress, gained recognition for her role as Paavni in the popula

New 'copy-paste' mechanism in genetics have been identified by researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) in a malaria parasite

Berlin ; Boston : De Gruyter, [2023]

Doctors treating infections such as HIV are bewildered when Neglected Tropical Diseases are thrown in the mix.

However, court says no issue with bronze used for statue as NITK has already certified it  

The Youtube couple was found dead by their son, who works as a home nursing trainee in Ernakulam.

Former bowling coach looks back at his stint, the process that culminated with India winning the T20 World Cup, the interesting conversations and the road ahead for fast bowlers in the country