Many people who want to be healthy often try to eat a balanced diet and get regular exercise. However, most foods today simply do not contain the nutrition they did in the past. If your goal is to improve your physical and mental health, your body may still require essential nutrients. IV nutrition therapy is […]

The post Exploring the Impact of IV Nutrition Therapy on Mental Health first appeared on What is Psychology?.

Health experts agree that there is a clear connection between an individual’s dental health and mental health. But although this fact is supported by a number of clinical studies, it is rarely explored or discussed among health professionals. A person with poor oral health may experience bad breath, tooth loss, compromised speech and other symptoms […]

The post How Innovations in Dental Services Transform Patient Care and Improve Mental Health first appeared on What is Psychology?.

Millions of Americans suffer from depression, anxiety, and other mental health conditions. And yet, many do not even know about the countless self-care practices for maintaining mental health and wellbeing. We will uncover some of the most effective practices for dealing with these issues. Let’s jump right in. #1: Regular Physical Activity Exercise is a […]

The post Self-Care Practices for Maintaining Mental Health and Wellbeing first appeared on What is Psychology?.

Although common ‘disorders’ (e.g., eating disorders, anxiety, and depression) look different on the surface, there are some common underlying mechanisms. One of these is checking. I’m going to go explain the role of checking in a selection of common mental health problems. Checking in Health Anxiety Examples: – Person goes to the Dr for blood […]

The post CBT: How Checking Contributes to Mental Health Problems (Eating Disorders, Depression, Anxiety) appeared first on Dr Alice Boyes.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

School districts are competing against each other for purchases of digital devices as remote learning expands to schools across the country.

State Superintendent Steve Canavero resigned just two weeks before the state's legislative session was to begin, with more than 80 education-related proposals, including a new funding formula, is on the agenda.

Students returning to schools in Virginia and New York this fall will be required to participate in mental-health education as part of their health and physical education courses.

Teachers are using a variety of games, videos, and apps to supplement online math instruction—but not all of them are created equal.

Data on the usage of educational technology tools can provide districts with a helpful road map for improving student engagement under remote, in-person, or hybrid learning conditions. See how school districts are using such data to make smart, strategic decisions.

The target is the Georgia Network for Educational and Therapeutic Support, a network of special education programs accused of violating the Americans with Disabilities Act.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Some districts are scrambling to account for thousands of devices—a task made more urgent by the uncertainty over when students will be able to return to school buildings full-time.

Officials say a high school baseball coach and his wife were electrocuted while installing a new scoreboard at a Florida baseball field to replace one that had been destroyed by Hurricane Michael.

A school district in a small Arkansas city has installed steel safe rooms in every classroom.

Data on the usage of educational technology tools can provide districts with a helpful road map for improving student engagement under remote, in-person, or hybrid learning conditions. See how school districts are using such data to make smart, strategic decisions.

Emma Lingan and Eric Cruikshank discuss Washington Capitals center Dylan Strome, the Bruins and Red Wings coaches, Kirill Kaprizov's next contract and much more.

The Pittsburgh Penguins traded Lars Eller to the Washington Capitals for two draft picks after a blowout loss dropped them to 6-9-2 on the season.

The Pittsburgh Penguins traded Lars Eller to the Washington Capitals on Tuesday afternoon.

Former Montreal Canadiens forward Lars Eller was traded from the Pittsburgh Penguins to the Washington Capitals on Tuesday.

Washington sent a 2025 fifth-round pick and a 2027 third-round pick to Pittsburgh on Tuesday for Eller.

Nearly 17 million children lack high-speed internet at home that's considered crucial to their ability to participate in remote learning during the pandemic, according to a new study.

Kansas State football coach Chris Klieman talks about what the Wildcats did during the open week ahead of their home game against Arizona State.

Data on the usage of educational technology tools can provide districts with a helpful road map for improving student engagement under remote, in-person, or hybrid learning conditions. See how school districts are using such data to make smart, strategic decisions.

The Lady Vols beat Middle Tennessee 89-75 on Tuesday at Food City Center. Talaysia Cooper led Tennessee with 18 points

Tallahassee, FL - The South Georgia Technical College Lady Jets dropped a hard fought three-point loss, 50 – 47, to the nationally ranked Eastern Florida State College Titans before rallying to a 66 – 60 victory over Tallahassee State College in the Tallahassee Community College Classic this weekend to move to 3 – 1 on the season. “We put ourselves in a position to beat a very talented team ...

Lauren M. Hablitz
Sep 15, 2021; 41:7698-7711
Review

Yang Hu
Feb 24, 2021; 41:1699-1715
BehavioralSystemsCognitive

Danilo De Gregorio
Feb 3, 2021; 41:891-900
Symposium and Mini-Symposium

Mitchell G. Spring
Oct 9, 2024; 44:e0602242024-e0602242024
BehavioralSystemsCognitive

Serotonin modulates diverse phenotypes and functions including depressive, aggressive, impulsive, and feeding behaviors, all of which have reward-related components. To date, research has focused on understanding these effects by measuring and manipulating dorsal raphe serotonin neurons and using single-receptor approaches. These studies have led to a better understanding of the heterogeneity of serotonin actions on behavior; however, they leave open many questions about the timing and location of serotonin's actions modulating the neural circuits that drive these behaviors. Recent advances in genetically encoded fluorescent biosensors, including the GPCR activation-based sensor for serotonin (GRAB-5-HT), enable the measurement of serotonin release in mice on a timescale compatible with a single rewarding event without corelease confounds. Given substantial evidence from slice electrophysiology experiments showing that serotonin influences neural activity of the striatal circuitry, and the known role of the dorsal medial striatal (DMS) in reward-directed behavior, we focused on understanding the parameters and timing that govern serotonin release in the DMS in the context of reward consumption, external reward value, internal state, and cued reward. Overall, we found that serotonin release is associated with each of these and encodes reward anticipation, value, approach, and consumption in the DMS.

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

Sleep is known to drive the consolidation of motor memories. During nonrapid eye movement (NREM) sleep, the close temporal proximity between slow oscillations (SOs) and spindles ("nesting" of SO-spindles) is known to be essential for consolidation, likely because it is closely associated with the reactivation of awake task activity. Interestingly, recent work has found that spindles can occur in temporal clusters or "trains." However, it remains unclear how spindle trains are related to the nesting phenomenon. Here, we hypothesized that spindle trains are more likely when SOs co-occur in the prefrontal and motor cortex. We conducted simultaneous neural recordings in the medial prefrontal cortex (mPFC) and primary motor cortex (M1) of male rats training on the reach-to-grasp motor task. We found that intracortically recorded M1 spindles are organized into distinct temporal clusters. Notably, the occurrence of temporally precise SOs between mPFC and M1 was a strong predictor of spindle trains. Moreover, reactivation of awake task patterns is much more persistent during spindle trains in comparison with that during isolated spindles. Together, our work suggests that the precise coupling of SOs across mPFC and M1 may be a potential driver of spindle trains and persistent reactivation of motor memory during NREM sleep.