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Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (Ih), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca2+-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, Ih, and death, compromising audition at the young adult stage in HCN1+/+, but not in HCN1–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca2+ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.




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Countries recognize vital role of small-scale fishers

Countries today endorsed a set of wide-reaching guidelines that will boost the already vital [...]




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Updated FAO publications catalogue out now

The October 2020 edition of the FAO publications catalogue is now available, released  to coincide with the digital Frankfurt book fair (14–18 October).

It includes the latest editions of the 



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Explore FAO's 2020 digital flagship reports in six languages

In 2020, FAO’s flagship ‘The State of the World’ collection was released in a new easy-to-read digital format, providing audiences with a responsive reading experience to discover FAO’s work and [...]




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New FAO publications series catalogue out now

This user-friendly catalogue presents FAO’s major publications series. It features all of the most active series, both new and long-standing, and is divided into areas of work, including agriculture, forestry, [...]




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Updated FAO publications catalogue out now

Released to coincide with the 166th Session of the FAO Council (26–30 April 2021), the April 2021 edition of the FAO publications catalogue is now available in English [...]




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FAO publications catalogue now available in all languages

The FAO 2021 publications catalogue is now available in ArabicChineseEnglishFrenchRussian and 



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Updated FAO publications catalogue out now

Released to coincide with the Frankfurt book fair (20-24 October 2021), the October 2021 edition of the FAO publications catalogue is now available. It shares the latest publications produced by FAO across all of its thematic [...]




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Updated FAO publications catalogue out now

Released to coincide with the London Book Fair (5−7 April),  the new edition of the FAO publications catalogue is now available.

It includes the latest edition of the Regional Overviews of Food Security and Nutrition − Statistics [...]




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Updated FAO publications catalogue out now

The October 2022 edition of the FAO publications catalogue is out now.

From the latest editions of the State of the World collection to updated technical reports, the catalogue features a [...]




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FAO in review: The first fully digital United Nations agency

Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems.




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The FAO publications catalogue 2023 is out!

Check out the 2023 edition of the FAO publications catalogue! From the State of the World collection and other major reports to freshly penned technical studies, the catalogue features a selection of FAO’s best [...]





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The World’s Tallest Water Slide Is More Than 134 Feet Tall

Riders--who will descend in inflatable rafts of four rather than alone--will reach speeds of more than 65 miles per hour




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Why Engineering Will Be Vital in a Changing Climate

Smithsonian Secretary Wayne Clough offers personal insights on the realities of climate change and the best ways for society to adapt




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Baby Talk From a Rhesus Macaque

Watch how a mother rhesus makes funny faces to her infant child to grab its attention




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The Man Who Stopped the Desert – D.C. Environmental Film Festival Trailer

Yacouba Sawadogo, a farmer from Burkina Faso, has become a pioneer in the fight against desertification – succeeding where many international agencies have failed




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National Treasure: The Hirshhorn Is Brutalism's Boldest Donut

The Hirshhorn Museum and Sculpture Garden is renowned for its striking architecture and impressive collection of contemporary art. Whether you're an art enthusiast, a history buff, or simply curious about that concrete donut on the National Mall, learn more about its Brutalist background in this new episode of National Treasure. --------- To find out more about the Hirshhorn Museum and Sculpture Garden, read below: https://www.smithsonianmag.com/smithsonian-institution/hirshhorn-museum-building-went-from-iconoclast-icon-180984914/ Digital Editorial Director: Brian Wolly Director of Programming: Nicki Marko Supervising Producer & Scriptwriter: Michelle Mehrtens Producer & Editor: Sierra Theobald Motion Designer: Ricardo Jaimes




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In the Kitchen With Top Chef Dale Talde

From the kitchen of his new restaurant in Brooklyn, the chef talks about what it takes to fuse Asian cuisine with an American twist




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Cai Guo-Qiang Makes a 40-Foot-Tall Pine Tree Explode

Read more about the event here: http://j.mp/TyPfBO The world famous Chinese artist uses pyrotechnics to turn a 40-foot-tall pine tree into an optical illusion.




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Need a New Organ? Surgeon Anthony Atala Sees a Future Where You Can Simply Print It Out

Anthony Atala | Smithsonian Magazine’s 2016 American Ingenuity Award Winner for Life Sciences The director of the Wake Forest Institute for Regenerative Medicine, Atala is a surgeon and leading expert in creating living human tissues and organs to replace those that are defective or damaged. He has spent the past decade attempting to construct living organs using 3-D printing technology. Atala implanted the world’s first laboratory-grown organ into a human in 1999 and, this year, he and his colleagues “printed” cartilage, bone and muscle tissue before successfully implanting them into a lab animal. That’s a crucial first step toward Atala’s long-term goal of overcoming the dire shortage of donated organs with custom-made body parts. Read more about Atala's work: http://smithmag.co/SiiV2J | #IngenuityAwards And more about the American Ingenuity Awards: http://smithmag.co/77xPqy




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The Quirky Ways of the Postal Service

Over the years, the mail has been delivered by train, donkey, bus, truck and even rocket (Produced by: Boaz Frankel )




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Meet the WWII Battalion of Black Women That Inspired an Army Base’s New Name

The 6888th Central Postal Directory Battalion was the only unit comprised entirely of Black women to have been deployed overseas during World War II, and it had served a critical function: clearing the backlog of mail that marked the only line of communication between American soldiers in Europe and their loved ones back home. In this episode, we speak with retired Army Colonel Edna Cummings, who made it her business to get the 6888 their belated recognition, and with Smithsonian magazine senior writer Jennie Rothenberg Gritz, who wrote about Col. Cummings' quest (https://www.smithsonianmag.com/history/how-all-black-female-WWII-unit-saved-morale-battlefield-180981540/) for the March 2023 issue of Smithsonian. NOTE: In the interval since we recorded our interview with Col. Cummings, another veteran from the 6888 has died. With the passing of Crescencia J. Garcia last month at the age of 103, there are now five women who served in the 6888 during World War II who remain alive. Learn more about the women of the 6888th Central Postal Battalion at the Women of the 6888th site (https://www.womenofthe6888th.org/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz. Music by APM Music.




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A 3D Digital Interactive of Santa Elena's Fort San Marcos

At the Coastal Discovery Museum’s exhibition, visitors will be able to view a 3D digital interactive that reconstructs the original Fort San Marcos on Santa Elena. (Credit: Coastal Discovery Museum at Honey Horn)




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Director David Lynch Wants Schools to Teach Transcendental Meditation to Reduce Stress

David Lynch | Smithsonian Magazine’s 2016 American Ingenuity Award Winner for Education As a filmmaker, Lynch has a reputation for creating dark, surreal movies such as Eraserhead, Blue Velvet and Wild at Heart as well as the TV show “Twin Peaks.” In the education world, he's becoming known for something very different: promoting inner peace. Over the past decade, the David Lynch Foundation has sponsored Transcendental Meditation classes for half a million children in places as far-flung as the Bronx, Detroit, Los Angeles, Congo and the West Bank. The program, called Quiet Time, is now at the center of one of the largest-ever studies of meditation for children—a 6,800-pupil research project conducted by the Crime Lab at the University of Chicago and designed to learn if meditation can help kids in highly stressful environments fare better at home and in school. Read more about Lynch’s work: http://smithmag.co/9sHhtm | #IngenuityAwards And more about the American Ingenuity Awards: http://smithmag.co/77xPqy




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Oldest Known Macroscopic Skeletal Organism Was Masquerading as Fossilized Feces

Some researchers initially dismissed the remains of Palaeopascichnus lineari as teeny turds from a bygone era




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In Case Humans Go Extinct, This Memory Crystal Will Store Our Genome for Billions of Years

Scientists have created "a form of information immortality" meant to instruct future species on how to recreate humans. But who, or what, will find it?




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The World's Best Pizza Is in New York City, According to Italy-Based Rankings

Una Pizza Napoletana on the Lower East Side has claimed the top spot in an annual ranking of pizzerias around the globe




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Virginia State Parks Install Viewfinders for People With Colorblindness, Just in Time for Leaf-Peeping Season

The viewfinders are outfitted with special lenses that help people with red-green colorblindness distinguish between hues




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These 3,000-Year-Old Arrowheads Are Pivotal Clues in the Mystery of 'Europe's Oldest Known Battlefield'

While no written records exist, new research has illuminated key details of the battle fought in northern Germany during the 13th century B.C.E.




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Extinct Volcanoes May Be an Untapped Source of Rare Metals

Unexplored iron-rich magma could help power current and future technologies




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Nintendo Switches Things Up With a New Museum That Embraces Nostalgia and Celebrates Gaming History

The Kyoto museum will feature interactive exhibits, gaming artifacts, workshop spaces and oversized controllers inspired by iconic video games




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Geologists Reveal a Surprising Reason Why Mount Everest Grows Taller Each Year

Earth's highest peak has gained as much as an extra 165 feet in elevation as the planet's crust adjusts due to erosion from a river, according to a new study




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Metal Detectorists Unearth 1,000-Year-Old Viking Coins on a Small Island in the Irish Sea

Experts say that the trove of silver currency is official treasure and includes coins from England and Ireland




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New 'Portal' Opens in Philadelphia, Connecting Residents to Cities Around the World With Identical Installations

The looming sculpture features a small camera above an eight-foot-tall screen, which displays live video from Lithuania, Poland and Ireland




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See the Breathtaking 14th-Century Sienese Artworks That Helped Set the Italian Renaissance in Motion

This brief chapter of art history is often overlooked. Now, an exhibition in New York City makes a strong argument for the integral role played by four artists in the city of Siena




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A Prominent Italian Dealer Has Been Charged With Trafficking Thousands of Looted Artifacts

The Manhattan district attorney's office has obtained an arrest warrant for Edoardo Almagià, who has been accused of working with looters and dealing stolen artifacts for years




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Travelers Can Now Buy a Can of '100 Percent Authentic Air' From Italy's Lake Como

It's not the first time savvy entrepreneurs have marketed canned air to tourists. Similar products have been sold at vacation destinations for decades




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Father and Son Discover Rare Trove of 16th- and 17th-Century Silver Coins While Metal Detecting in a Polish Forest

Sławomir and Szymon Milewski were searching for a Roman road when they stumbled upon the cache of coins, which is worth more than $120,000




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See 15 Remarkable Photos That Will Make You Fall in Love With Italy

These shots from the Smithsonian Magazine Photo Contest show why it’s one of the most-visited nations on earth




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KNOW WHAT I HAD FOR BREAKFAST THIS MORNING ???? PORN CATALOGS !!!




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Sea Cucumber Poop Could Revitalize Coral Reefs

In one reef, three million sea cucumbers released 64,000 metric tons of nutrient-packed poo back into the ecosystem




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Meet the Italian 'Fruit Detective' Who Investigates Centuries-Old Paintings for Clues About Produce That Has Disappeared From the Kitchen Table

Renaissance paintings, medieval archives, cloistered orchards—how one Italian scientist is uncovering secrets that could help combat a growing agricultural crisis




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Man fatally electrocuted after downed power line in Torbay Saturday

Police have reported that a man was fatally electrocuted in Torbay on Saturday evening. Two others are being treated for injuries.



  • News/Canada/Nfld. & Labrador

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Postal union gives 72-hour strike notice, putting rural N.L. Christmas deliveries at risk

After a year of negotiations, the postal union has given Canada Post a 72-hour strike notice. At a solidarity rally in St. John's last week, local president Craig Dyer says a strike could mean parcels — including Christmas presents — won't make it to rural communities.



  • News/Canada/Nfld. & Labrador

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The Smithsonian Gets Experimental and Field-Tests a New Forum for Bringing Artists to the Public

A Two-Day Festival in the historic Arts & Industries Building brings community, artists and scholars together for a “Culture Lab”




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Discover the Mysteries of Italy's Park of Monsters, a 16th-Century Garden Filled With Strange, Colossal Stone Creatures

The Sacro Bosco's meaning is the subject of debate, with scholars alternatively describing the sprawling complex as a memorial, an allegorical site or a tribute to ancient civilizations




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Sask. watchdog investigating Moose Jaw police's role in fatal crash

Saskatchewan's Serious Incident Response Team (SIRT) is investigating the role the Moose Jaw Police Service played in a crash that killed a 31-year-old man.



  • News/Canada/Saskatchewan

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Explore Catalonia's Most Beautiful Nature Parks

Roughly 30 percent of Catalonia is protected land making it a stunning place to hit the trails




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Fire at central P.E.I. roofing supply company Valley Truss deemed accidental

The Prince Edward Island Fire Marshals Office has concluded its investigation into a massive fire at Valley Truss and Metal in Kensington in October.



  • News/Canada/PEI