Instrumentation for sub-millisecond time-resolved small-angle neutron scattering measurements at NIST is described and applied to the reorientation dynamics of elongated hematite nanoparticles.

A portable small-angle X-ray scattering instrument with geometrical dimensions suitable for installation at the D22 instrument was designed and constructed for simultaneous small-angle X-ray and neutron scattering experiments at ILL.

Neutron crystal structure analysis of hen egg-white lysozyme hydrogen/deuterium exchanged before crystallization were performed by the joint X-ray and neutron refinement. The differences in hydrogen/deuterium exchange behavior between this study and previous ones were observed.

The crystal structure of Pseudomonas aeruginosa Fis is composed of an N-terminal flexible loop and a C-terminal helix–turn–helix motif.

The structure of the Pseudomonas aeruginosa T6SS PldB immunity protein PA5086 is reported at 1.9 Å resolution. Comparison of PA5086 with its homologs PA5087 and PA5088 showed great similarities in sequence and structure, but vast divergences in electrostatic potential surfaces.

While studying bats recently at the Academy of Natural Sciences in Philadelphia, Smithsonian mammalogist Kristofer Helgen discovered a new species of flying fox bat from […]

The post Smithsonian Scientist Discovers Two New Bat Species Hiding in Museum Collections for More Than 150 Years appeared first on Smithsonian Insider.

The Smithsonian’s National Air and Space Museum has opened a new Public Observatory that contains a 16-inch, 3,000-pound Boller and Chivens telescope, on loan from the Smithsonian Astrophysical Observatory. Through this powerful telescope, museum visitors can now observe the sun (with a special filter), the moon and the brighter stars and planets, such as Venus, Jupiter and Saturn, during daylight hours. Funding for the project was provided by the National Science Foundation.

The post The Smithsonian’s National Air and Space Museum opens new Public Observatory on the Mall in Washington, D.C. appeared first on Smithsonian Insider.

A major new exhibition hall dedicated to the discovery and understanding of human origins will open next year at the Smithsonian's National Museum of Natural History: The David H. Koch Hall of Human Origins

The post Hall of Human Origins to open at Smithsonian’s Natural History Museum, March 17, 2010 appeared first on Smithsonian Insider.

The newfound world, GJ1214b, is about 6.5 times as massive as the Earth. Its host star, GJ1214, is a small, red type M star about one-fifth the size of the Sun. GJ1214b orbits its star once every 38 hours at a distance of only 1.3 million miles. Astronomers estimate the planet's temperature to be about 400 degrees Fahrenheit. Although warm as an oven, it is still cooler than any other known transiting planet because it orbits a very dim star.

The post Astronomers Find Super-Earth Using Amateur, Off-the-Shelf Technology appeared first on Smithsonian Insider.

The Stephen L. Wood collection brings the collection of bark beetles held in the Natural History Museum’s Department of Entomology to an impressive 180,000 specimens, making it one of the most extensive collections in world.

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This circa 1910 Yup'ik mask from Good News Bay, Alaska--made of driftwood, baleen, feathers, paint and cotton twine--is part of "Infinity of Nations: Art and History in the Collections of the National Museum of the American Indian," an exhibition at the National Museum of the American Indian, opening Saturday, Oct. 23.

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The Scarlet Knight, as the glider is called, made nautical history as the first submersible glider to successfully cross the Atlantic Ocean.

The post Rutgers glider added to the collections of the National Museum of Natural History appeared first on Smithsonian Insider.

For two weeks the team recorded and documented the community’s elders, families and llamas along a pilgrimage of remembrance in Pisaq, Peru.

The post American Indian Museum launches Chawaytiri documentation project in Peru appeared first on Smithsonian Insider.

A. sediba was discovered in 2008 in the Malapa Cave at the Cradle of Humankind World Heritage Site located outside Johannesburg.

The post Skeletal casts of early hominin ancestor from Africa donated to National Museum of Natural History appeared first on Smithsonian Insider.

NASA's Chandra X-ray Observatory has discovered the first direct evidence for a superfluid, a bizarre, friction-free state of matter, at the core of a neutron star.

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In a recent study of the mating behavior of these Asian spiders, researchers found that 87.5 percent of males had both palps amputated during copulation.

The post Don’t pick a fight with a eunuch spider. It has nothing to lose appeared first on Smithsonian Insider.

Discovery, the longest-serving orbiter in the space shuttle fleet, will be accepted into the Smithsonian’s National Air and Space Museum collection. The space shuttle has been the icon for American spaceflight for a generation, and Discovery has flown every type of mission during its 27-year career.

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The new research reveals that from the period between 1100-1600 small agricultural settlements up and down the Delaware River Valley caused a 50-percent increase in sediment runoff into the Delaware River.

The post Study reveals environmental impact of American Indian farms centuries before Europeans arrived in North America appeared first on Smithsonian Insider.

A study published in the journal Global Change Biology finds that while fertilizer has been the dominant source of nitrogen pollution in Caribbean coastal ecosystems for the past 50 years, such pollution is on the decline, thanks in part to the introduction of more advanced, environmentally responsible agricultural practices during the last decade.

The post National Museum of Natural History’s coral collection used in Caribbean agricultural and sewage pollution study appeared first on Smithsonian Insider.

The Smithsonian’s National Museum of the American Indian is hosting a series of public satellite broadcasts featuring a multinational team of researchers, engineers and archaeologists who are working in Peru on the origins and engineering of the Inka Road of South America.

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The fossil represents the youngest nodosaur ever discovered, and the only known specimen of a new genus and species of dinosaur that lived approximately 110 million years ago during the Early Cretaceous Era.

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One problem in unraveling the mystery of quasars is that many (perhaps most) quasar nuclei seem to be surrounded by a torus of obscuring dust that makes them difficult to study.

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The National Museum of Natural History will construct a new dinosaur exhibition hall made possible by a $35 million donation from David H. Koch, executive vice president of Koch Industries and philanthropist.

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Rope, golf balls, sweat pants, bottles and aluminum cans are a few of the discarded items biologist Matt Klope says he has found inside the […]

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The Smithsonian’s National Air and Space Museum announced that it will receive a $6 million donation from the Thomas W. Haas Foundation to establish an […]

The post Air and Space Museum receives $6 million donation for Public Observatory Program appeared first on Smithsonian Insider.

To download the free e-book Best of Both Worlds: Museums, Libraries, and Archives in a Digital Age, by G. Wayne Clough, Secretary of the Smithsonian, […]

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Roses, carnations and lilies are today among the most popular flowers people use to express sympathy and condolence. The simple act of sending flowers to […]

The post Funeral flowers in the Stone Age: Q&A with Smithsonian anthropologist Reuven Yeshurun appeared first on Smithsonian Insider.

Santa Claus and his sleigh full of gifts has been upstaged early this holiday season by news of autonomous drones possibly delivering packages to your […]

The post Package-delivering drones? Q&A with Roger Connor of the National Air and Space Museum appeared first on Smithsonian Insider.

How did the earliest birds take wing? Did they fall from trees and learn to flap their forelimbs to avoid crashing? Or did they run […]

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The Smithsonian’s National Air and Space Museum has acquired a large collection from the Sir Arthur C. Clarke Trust. The collection consists of 87 cubic […]

The post Arthur C. Clarke papers come to Air and Space Museum Archives appeared first on Smithsonian Insider.

Tucked in the shadow of the towering Skylab exhibit at the Smithsonian’s National Air and Space Museum, there’s an inferno raging. Lucky for all of […]

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  In the store-rooms of the National Museum of American History curators recently discovered a small microscope made around 1750 by John Cuff (1708-1772), a […]

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Fat, toxic and nocturnal, cane toads (Rhinella marina) are abundant today in Hawaii, even though they are South American natives. Released on the Hawaiian Islands […]

The post Two invasive species have Hawaiian reunion after 80-year separation appeared first on Smithsonian Insider.

Washington, D.C. is a city of symbols. The rites, rituals, and places that define Washington capture the aspirations of our nation and its citizens. Just […]

The post Trusted Sources: Why Museums and Libraries Are More Relevant Than Ever appeared first on Smithsonian Insider.

Mycoplasma hyopneumoniae is a prokaryotic pathogen that colonizes the respiratory ciliated epithelial cells in swine. Infected animals suffer respiratory lesions, causing major economic losses in the porcine industry. Characterization of the immunodominant membrane-associated proteins from M. hyopneumoniae may be instrumental in the development of new therapeutic approaches. Here, the crystal structure of P46, one of the main surface-antigen proteins, from M. hyopneumoniae is presented and shows N- and C-terminal α/β domains connected by a hinge. The structures solved in this work include a ligand-free open form of P46 (3.1 Å resolution) and two ligand-bound structures of P46 with maltose (2.5 Å resolution) and xylose (3.5 Å resolution) in open and closed conformations, respectively. The ligand-binding site is buried in the cleft between the domains at the hinge region. The two domains of P46 can rotate with respect to each other, giving open or closed alternative conformations. In agreement with this structural information, sequence analyses show similarities to substrate-binding members of the ABC transporter superfamily, with P46 facing the extracellular side as a functional subunit. In the structure with xylose, P46 was also bound to a high-affinity (Kd = 29 nM) Fab fragment from a monoclonal antibody, allowing the characterization of a structural epitope in P46 that exclusively involves residues from the C-terminal domain. The Fab structure in the complex with P46 shows only small conformational rearrangements in the six complementarity-determining regions (CDRs) with respect to the unbound Fab (the structure of which is also determined in this work at 1.95 Å resolution). The structural information that is now available should contribute to a better understanding of sugar nutrient intake by M. hyopneumoniae. This information will also allow the design of protocols and strategies for the generation of new vaccines against this important swine pathogen.

Leucocyte common antigen-related protein (LAR) is a post-synaptic type I transmembrane receptor protein that is important for neuronal functionality and is genetically coupled to neuronal disorders such as attention deficit hyperactivity disorder (ADHD). To understand the molecular function of LAR, structural and biochemical studies of protein fragments derived from the ectodomain of human LAR have been performed. The crystal structure of a fragment encompassing the first four FNIII domains (LARFN1–4) showed a characteristic L shape. SAXS data suggested limited flexibility within LARFN1–4, while rigid-body refinement of the SAXS data using the X-ray-derived atomic model showed a smaller angle between the domains defining the L shape compared with the crystal structure. The capabilities of the individual LAR fragments to interact with heparin was examined using microscale thermophoresis and heparin-affinity chromatography. The results showed that the three N-terminal immunoglobulin domains (LARIg1–3) and the four C-terminal FNIII domains (LARFN5–8) both bound heparin, while LARFN1–4 did not. The low-molecular-weight heparin drug Innohep induced a shift in hydrodynamic volume as assessed by size-exclusion chromatography of LARIg1–3 and LARFN5–8, while the chemically defined pentameric heparin drug Arixtra did not. Together, the presented results suggest the presence of an additional heparin-binding site in human LAR.

Some of the earliest humans to inhabit America came from Europe according to a new book "Across Atlantic Ice: The Origin of America's Clovis Culture."

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For the first time in its history the Smithsonian’s National Museum of African Art opened an exhibition on the continent of Africa. “Chief S.O. Alonge: […]

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Yung-An Huang, Chih-Hsuan Hsu, Ho-Chieh Chiu, Pei-Yu Hsi, Chris T. Ho, Wei-Lun Lo, and Eric Hwang

Microtubule (MT) is the most abundant cytoskeleton in neurons and controls multiple facets of their development. While the MT-organizing center (MTOC) in mitotic cells is typically located at the centrosome, MTOC in neurons switches to non-centrosomal sites. A handful of cellular components have been shown to promote non-centrosomal MT (ncMT) formation in neurons, yet the regulation mechanism remains unknown. Here we demonstrate that the small GTPase Ran is a key regulator of ncMTs in neurons. Using an optogenetic tool that enables light-induced local production of RanGTP, we demonstrate that RanGTP promotes ncMT plus-end growth along the neurite. Additionally, we discovered that actin waves drive the anterograde transport of RanGTP. Pharmacological disruption of actin waves abolishes the enrichment of RanGTP and reduces growing ncMT plus-ends at the neurite tip. These observations identify a novel regulation mechanism of ncMTs and pinpoint an indirect connection between the actin and MT cytoskeletons in neurons.

Olga Kopach, Noemi Esteras, Selina Wray, Dmitri A. Rusakov, and Andrey Y. Abramov

Frontotemporal dementia and parkinsonism (FTDP-17) caused by the 10+16 splice-site mutation in the MAPT provides an established platform to model tau-related dementia in vitro. Human iPSC-derived neurons have been shown to recapitulate the neurodevelopmental profile of tau pathology during in vitro corticogenesis as in the adult human brain. However, the neurophysiological phenotype of these cells has remained unknown, leaving unanswered questions over the functional relevance and the gnostic power of this disease model. Here we used electrophysiology to explore the membrane properties and intrinsic excitability of the generated neurons to find that human cells mature by ~150 days of neurogenesis to become compatible with matured cortical neurons. In earlier FTDP-17, neurons, however, exhibited a depolarized resting membrane potential associated with increased resistance and reduced voltage-gated Na⁺- and K⁺-channel-mediated conductance. The Na_v1.6 protein was reduced in FTDP-17. These led to a reduced cell capability of induced firing and changed action potential waveform in FTDP-17. The revealed neuropathology may thus contribute to the clinicopathological profile of the disease. This sheds new light on the significance of human models of dementia in vitro.

The Smithsonian’s National Museum of Natural History recently acquired four remarkable gemstones and jewelry pieces for the Smithsonian’s National Gem Collection in celebration of the 100th anniversary of the museum.

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More than 500 carats of rough diamonds were recently donated to the Department of Mineral Sciences of the Smithsonian’s Natural History Museum by Jewlers Mutual Insurance Co. of Neenah, Wis.

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The National Museum of Natural History will permanently display the Dom Pedro Aquamarine, which is the largest single piece of cut-gem aquamarine in the world, beginning Dec. 6.

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Admired from afar by the ancient Romans, the moon was once deified as a goddess, Luna. Today, two-thousand years later, geologists who scrutinize the moon’s […]

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Monday, Aug. 21 was an unusual day across North America. Early in the morning, families, colleagues and tourists were searching for special solar glasses with […]

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X-ray emission under electron-channelling conditions is used to distinguish between a non-centrosymmetric half-Heusler and a centrosymmetric full-Heusler crystal. For TiCo1.5+xSn the space-group determination based on a Rietveld refinement procedure became challenging for increasing Co content (x > 0.2), while electron channelling proved successful for higher Co content (x = 0.35). This technique can be used on crystals as small as (10 nm)3.

John Ososky, preparator in the Osteology Laboratory at the Smithsonian's National Museum of Natural History in Washington, D.C., explains how skeletons of animal specimens are prepared for exhibtion and for study—with the assistance of nearly 1 million flesh-eating beetles.

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Chip Clark came to the Smithsonian's National Museum of Natural History in 1973, with a degree in biology and an interest in photography. He has been a photographer on staff ever since, documenting thousands of specimens and exhibits, and accompanying scientists on research trips around the world. He died June 12, 2010. This video interview was made by Lauren Dare, an intern with the Smithsonian Institution Archives, on May 27, 2010, as part of an oral history project for the National Museum of Natural History's Centennial (2010-2011). To learn more about Chip Clark, see his page on the Centennial website-- www.mnh.si.edu/onehundredyears/profiles/Chip_Clark.html -- where you also can find more videos and stories about the people and the work of the NMNH.

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The post Roland Kays, curator of mammals at the New York State Museum, discusses a new Smithsonian Website for sharing camera-trap images of wild animals appeared first on Smithsonian Insider.