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Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes

EJ Blanchette-Mackie
Jun 1, 1995; 36:1211-1226
Articles




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Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews




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Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI

JE Hixson
Mar 1, 1990; 31:545-548
Articles




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The US Role in Shaping World Trade

Webinar Research Event

21 May 2020 - 2:00pm to 3:00pm
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Clete Willems, Partner, Akin Gump; Deputy Director, US National Economic Council, 2018 - 19
Chair: Marianne Schneider-Petsinger, Senior Research Fellow, US and Americas Programme, Chatham House

This event is  part of the Chatham House Global Trade Policy Forum and will take place virtually only.

We would like to take this opportunity to thank founding partner AIG and supporting partners Clifford Chance LLP, Diageo plc, and EY for their generous support of the Chatham House Global Trade Policy Forum.

Please note this event is taking place between 2pm to 3pm BST. 




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Virtual Roundtable: As COVID-19 Hits the Developing World, Where is the American-led Global Response?

Research Event

9 June 2020 - 2:00pm to 3:00pm
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Lord Mark Malloch-Brown, Chairman, SGO; Former Deputy Secretary-General and Chief of Staff, United Nations
Dr Elizabeth Cousens, President and CEO, United Nations Foundation
Ambassador Nicholas Burns, Roy and Barbara Goodman Family Professor of the Practice of Diplomacy and International Relations at the Harvard Kennedy School; US Under Secretary of State for Political Affairs, 2005 – 2008
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the US and Americas Programme Inaugural Virtual Roundtable Series on the US and the State of the World and will take place virtually only.

This event will take place from 14:00 – 15:00 BST.

US and Americas Programme

Department/project




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Virtual Roundtable: As COVID-19 Hits the Developing World, Where is the American-led Global Response?

Research Event

9 June 2020 - 2:00pm to 3:00pm
Add to Calendar

Lord Mark Malloch-Brown, Chairman, SGO; Former Deputy Secretary-General and Chief of Staff, United Nations
Dr Elizabeth Cousens, President and CEO, United Nations Foundation
Ambassador Nicholas Burns, Roy and Barbara Goodman Family Professor of the Practice of Diplomacy and International Relations at the Harvard Kennedy School; US Under Secretary of State for Political Affairs, 2005 – 2008
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the US and Americas Programme Inaugural Virtual Roundtable Series on the US and the State of the World and will take place virtually only.

This event will take place from 14:00 – 15:00 BST.

US and Americas Programme

Department/project




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Keeping the Peace: The New Landscape for European Security and Defence




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Stopping the Use of Chemical Weapons in Modern Conflicts




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Should Debt in the Developing World be Cancelled?




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Red Flags: The Outlook for Xi Jinping's China




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Trump’s America: Domestic and International Public Opinion




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Undercurrents: Episode 27 - Financing for Developing Countries, and Investigative Journalism in West Africa




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Ukraine’s Reform Agenda: Shaping the Future




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Subsidies and Sustainable Agriculture: Mapping the Policy Landscape

11 December 2019

Agricultural subsidies shape production and consumption patterns, with potentially significant effects on poverty, nutrition and other sustainability concerns. This paper maps the different types of support provided by governments to the agricultural sector, and highlights some of the complex political economy dynamics that underpin the relevant policies. 

Christophe Bellmann

Associate Fellow, Hoffmann Centre for Sustainable Resource Economy, Chatham House

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Aerial view of a wheat field on 24 May 2019 in Linyi, Shandong Province of China. Photo: Getty Images.

Summary

  • Agricultural subsidies, a mainstay of government policy, have a large part in shaping production and consumption patterns, with potentially significant effects as regards poverty, food security, nutrition, and other sustainability concerns such as climate change, land use practices and biodiversity.
  • There are multiple types of direct and indirect support provided by governments to various actors in the agricultural sector; and in terms of political economy, there are complex dynamics underpinning the policies that sustain these subsidies.
  • Overall, subsidies targeting producers have the most significant effect on production, and the greater trade-distorting effect. These subsidies promote domestic production and discourage imports, leading to overproduction that is largely disposed of on the international market, with the help of export subsidies. This can tend to intensify negative environmental agricultural practices, such as cultivating marginal land, unsustainable types of intensification, or incentivizing excessive pesticide and fertilizer use.
  • On the other hand, producer subsidies that are not tied to output of a specific commodity (i.e. delinked) have far fewer distorting impacts and could help to deliver sustainable outcomes. For example, this type of subsidies can require crop diversification or be linked to conservation of permanent grassland.
  • Subsidies that enable transfers to consumers, for example through food stamp programmes, also serve to delink production from consumption, can foster healthier diets, can play an important role in delivering food accessibility and security among low-income groups, and can represent one of the less trade-distorting subsidies.
  • If subsidies are to be reformed to help promote healthier diets and encourage more sustainable production, it is essential to understand not only the type and amount of support that key countries provide, but also the domestic dynamics that can shape such policies.
  • While price support, input subsidies or investment aids remain the central pillars of programmes in large developing countries such as Brazil, China or India, other economies – notably including the EU and Japan – focus on direct payments, support for general services and set-aside schemes, as well as significant border protection. The US, for its part, has tended to focus on subsidized insurance schemes and food programmes for poorer consumers.
  • If subsidies are to deliver policy objectives, their design and implementation should delink production from consumption. For example, consumer subsidies designed to deliver nutrition and food security, or payments for environmental services to enable more environmentally friendly production systems, could prove to be the most effective, least trade-distorting means of achieving more sustainable and equitable agricultural production.
  • The political economy of food means that the removal of subsidies is often highly sensitive, and tends to be met with significant resistance. However, reform that delinks support from production through a gradual transition process could ultimately prove successful in delivering effective subsidy schemes.
  • Effective subsidy schemes must by design be truly result- and performance-based, supported by robust and objective indicators. At the same time, engaging multiple actors along key commodity value chains – including leading importing and exporting countries, traders and transporters – could lead to the development of international, commodity-specific arrangements that are able to deliver effective nutrition and sustainability goals.




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Mapping the field of religious environmental politics

4 March 2020 , Volume 96, Number 2

Jeremy Kidwell

Until fairly recently, consideration of religion has been marginal or even non-existent in the scholarly discourse about environmental politics. Renewed attention to the intersection of these fields has been encouraged by a recent widening in discussions of ‘environmental values’ to include the role of religious institutions and personal belief in forming spiritual environmental values and renewed attention to the place of ethics and religious institutions in global environmental politics. Following a range of historic declarations by religious leaders, the recent encyclical by Pope Francis signalled a new level of integration between Catholic concerns for social and environmental justice. Yet, much of the continued engagement by large environmental NGOs and governments has continued to ignore the complex interrelation of local, intermediate and transnational religious political ecology. In this article, which is based on data gathered during five years of fieldwork, primarily with British Christian REMOs (religious environmental movement organizations), I probe the complexities of political engagement with religious environmentalism which arise from the many different organizational iterations these groups may take. On the basis of such investigation I suggest that effective high-level engagement with REMO groups will be greatly enhanced by a nuanced understanding of the many different shapes that these groups can take, the various scales at which these groups organize, and the unique inflection that political action and group identity can take in a religious context.




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Episode 28: The Place Beyond the Pines/From Up On Poppy Hill

  • The Place Beyond the Pines Review
  • From Up On Poppy Hill Review
  • Movie Homework: Beasts of the Southern Wild/Shame
  • What We Watched: Evil Dead, Game of Thrones, The Staircase & A Dangerous Method

Next Episode: Oblivion/Trance 




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The Hurdles to Developing a COVID-19 Vaccine: Why International Cooperation is Needed

23 April 2020

Professor David Salisbury CB

Associate Fellow, Global Health Programme

Dr Champa Patel

Director, Asia-Pacific Programme
While the world pins its hopes on vaccines to prevent COVID-19, there are scientific, regulatory and market hurdles to overcome. Furthermore, with geopolitical tensions and nationalistic approaches, there is a high risk that the most vulnerable will not get the life-saving interventions they need.

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A biologist works on the virus inactivation process in Belo Horizonte, Brazil on 24 March 2020. The Brazilian Ministry of Health convened The Technological Vaccine Center to conduct research on COVID-19 in order to diagnose, test and develop a vaccine. Photo: Getty Images.

On 10 January 2020, Chinese scientists released the sequence of the COVID-19 genome on the internet. This provided the starting gun for scientists around the world to start developing vaccines or therapies. With at least 80 different vaccines in development, many governments are pinning their hopes on a quick solution. However, there are many hurdles to overcome. 

Vaccine development

Firstly, vaccine development is normally a very long process to ensure vaccines are safe and effective before they are used. 

Safety is not a given: a recent dengue vaccine caused heightened disease in vaccinated children when they later were exposed to dengue, while Respiratory Syncytial Virus vaccine caused the same problem. Nor is effectiveness a given. Candidate vaccines that use novel techniques where minute fragments of the viruses’ genetic code are either injected directly into humans or incorporated into a vaccine (as is being pursued, or could be pursued for COVID-19) have higher risks of failure simply because they haven’t worked before. For some vaccines, we know what levels of immunity post-vaccination are likely to be protective. This is not the case for coronavirus. 

Clinical trials will have to be done for efficacy. This is not optional – regulators will need to know extensive testing has taken place before licencing any vaccine. Even if animal tests are done in parallel with early human tests, the remainder of the process is still lengthy. 

There is also great interest in the use of passive immunization, whereby antibodies to SARS-CoV-2 (collected from people who have recovered from infection or laboratory-created) are given to people who are currently ill. Antivirals may prove to be a quicker route than vaccine development, as the testing requirements would be shorter, manufacturing may be easier and only ill people would need to be treated, as opposed to all at-risk individuals being vaccinated.

Vaccine manufacturing

Developers, especially small biotechs, will have to make partnerships with large vaccine manufacturers in order to bring products to market. One notorious bottleneck in vaccine development is getting from proof-of-principle to commercial development: about 95 per cent of vaccines fail at this step. Another bottleneck is at the end of production. The final stages of vaccine production involve detailed testing to ensure that the vaccine meets the necessary criteria and there are always constraints on access to the technologies necessary to finalize the product. Only large vaccine manufacturers have these capacities. There is a graveyard of failed vaccine candidates that have not managed to pass through this development and manufacturing process.

Another consideration is adverse or unintended consequences. Highly specialized scientists may have to defer their work on other new vaccines to work on COVID-19 products and production of existing products may have to be set aside, raising the possibility of shortages of other essential vaccines. 

Cost is another challenge. Vaccines for industrialized markets can be very lucrative for pharmaceutical companies, but many countries have price caps on vaccines. Important lessons have been learned from the 2009 H1N1 flu pandemic when industrialized countries took all the vaccines first. Supplies were made available to lower-income countries at a lower price but this was much later in the evolution of the pandemic. For the recent Ebola outbreaks, vaccines were made available at low or no cost. 

Geopolitics may also play a role. Should countries that manufacture a vaccine share it widely with other countries or prioritize their own populations first? It has been reported that President Trump attempted to purchase CureVac, a German company with a candidate vaccine.  There are certainly precedents for countries prioritizing their own populations. With H1N1 flu in 2009, the Australian Government required a vaccine company to meet the needs of the Australian population first. 

Vaccine distribution

Global leadership and a coordinated and coherent response will be needed to ensure that any vaccine is distributed equitably. There have been recent calls for a G20 on health, but existing global bodies such as the Coalition for Epidemic Preparedness Innovations (CEPI) and GAVI are working on vaccines and worldwide access to them. Any new bodies should seek to boost funding for these entities so they can ensure products reach the most disadvantaged. 

While countries that cannot afford vaccines may be priced out of markets, access for poor, vulnerable or marginalized peoples, whether in developed or developing countries, is of concern. Developing countries are at particular risk from the impacts of COVID-19. People living in conflict-affected and fragile states – whether they are refugees or asylum seekers, internally displaced or stateless, or in detention facilities – are at especially high risk of devastating impacts. 

Mature economies will also face challenges. Equitable access to COVID-19 vaccine will be challenging where inequalities and unequal access to essential services have been compromised within some political systems. 

The need for global leadership 

There is an urgent need for international coordination on COVID-19 vaccines. While the WHO provides technical support and UNICEF acts as a procurement agency, responding to coronavirus needs clarity of global leadership that arches over national interests and is capable of mobilizing resources at a time when economies are facing painful recessions. We see vaccines as a salvation but remain ill-equipped to accelerate their development.

While everyone hopes for rapid availability of safe, effective and affordable vaccines that will be produced in sufficient quantities to meet everyone’s needs, realistically, we face huge hurdles. 




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Japan's ‘Indo-Pacific’ question: countering China or shaping a new regional order?

8 January 2020 , Volume 96, Number 1

Kei Koga

Japan's primary objective of the ‘free and open Indo-Pacific’ (FOIP) strategy is to shape and consolidate regional order in the Indo-Pacific region based on the existing rules-based international order. The concept initially aimed to achieve two different objectives—shaping a regional order in the Indo-Pacific and ensuring the defence of Japan; however, Japan has gradually shifted its strategic focus onto the former, separating national defence from the FOIP concept, which reflects a change in the degree of its commitment to the two objectives. On the one hand, as its overall security strategy, Japan has determined to steadily enhance its national defence by increasing its own defence capabilities and strengthening the US–Japan alliance, while transforming its partnerships with like-minded states, such as Australia and India, into a diplomatic, and potentially military, alignment. This has been brought about by shifts in the regional balance of power, particularly the rise of China and the relative decline of the United States. On the other hand, as part of its FOIP strategy, Japan's attempts to build a new regional order in the Indo-Pacific region aim to defend the existing rules-based order established by the United States from challengers, particularly China. Yet, given the strategic uncertainty over Japan's international coalition-building efforts to create a new regional order, Japan has made its approach flexible; Tokyo is using its ambiguous FOIP concept to gauge other states' responses, understand their perspectives, and change its strategic emphases accordingly—so-called ‘tactical hedging’. Japan has pursued similar means to achieve the two key objectives. Nevertheless, the country's core interest, the defence of Japan, is more imperative than building a regional order in the Indo-Pacific region, and Japan faces different types of challenges in the future.




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Pinpointing Style

Mathematics is not just numbers and brute force calculation there is considerable art and elegance to the subject. So it is natural that mathematics is now being used to analyze artists. styles and to help determine the identities of the creators of disputed works. Attempts at measuring style began with literature based on statistics of word use and have successfully identified disputed works such as some of The Federalist Papers. But drawings and paintings resisted quantification until very recently. In the case of Jackson Pollock, his paintings have a demonstrated complexity to them (corresponding to a fractal dimension between 1 and 2) that distinguishes them from simple random drips. A team examining digital photos of drawings used modern mathematical transforms known as wavelets to quantify attributes of a collection of 16th century master.s drawings. The analysis revealed measurable differences between authentic drawings and imitations, clustering the former away from the latter. This is an impressive feat for the non-experts and their model, yet the team agrees that its work, like mathematics itself, is not designed to replace humans, but to assist them. For More Information: The Style of Numbers Behind a Number of Styles, Dan Rockmore, The Chronicle of Higher Education, June 9, 2006.




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Tripping the Light-Fantastic

Invisibility is no longer confined to fiction. In a recent experiment, microwaves were bent around a cylinder and returned to their original trajectories, rendering the cylinder almost invisible at those wavelengths. This doesn't mean that we're ready for invisible humans (or spaceships), but by using Maxwell's equations, which are partial differential equations fundamental to electromagnetics, mathematicians have demonstrated that in some simple cases not seeing is believing, too. Part of this successful demonstration of invisibility is due to metamaterials electromagnetic materials that can be made to have highly unusual properties. Another ingredient is a mathematical transformation that stretches a point into a ball, "cloaking" whatever is inside. This transformation was discovered while researchers were pondering how a tumor could escape detection. Their attempts to improve visibility eventually led to the development of equations for invisibility. A more recent transformation creates an optical "wormhole," which tricks electromagnetic waves into behaving as if the topology of space has changed. We'll finish with this: For More Information: Metamaterial Electromagnetic Cloak at Microwave Frequencies, D. Schurig et al, Science, November 10, 2006.




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Keeping the beat - Part 1

The heart.s function of pumping blood may seem fairly simple but the underlying mechanisms and electrical impulses that maintain a healthy rhythm are extremely complex. Many areas of mathematics, including differential equations, dynamical systems, and topology help model the electrical behavior of cardiac cells, the connections between those cells and the heart.s overall geometry. Researchers aim to gain a better understanding of the normal operation of the heart, as well as learn how to diagnose the onset of abnormalities and correct them. Of the many things that can go wrong with a heart.s rhythm, some measure of unpredictability is (surprisingly) not one of them. A healthy heartbeat is actually quite chaotic not regular at all. Furthermore, beat patterns become less chaotic as people age and heart function diminishes. In fact, one researcher recommends that patients presented with a new medication should ask their doctors, "What is this drug going to do to my fractal dimensionality?" For More Information: Taking Mathematics to Heart: Mathematical Challenges in Cardiac Electrophysiology, John W. Cain, Notices of the AMS, April 2011, pp. 542-549.




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Keeping Things in Focus - Part 1

Some of the simplest and most well-known curves parabolas and ellipses, which can be traced back to ancient Greece are also among the most useful. Parabolas have a reflective property that is employed in many of today.s solar power technologies. Mirrors with a parabolic shape reflect all entering light to a single point called the focus, where the solar power is converted into usable energy. Ellipses, which have two foci, have a similar reflecting property that is exploited in a medical procedure called lithotripsy. Patients with kidney stones and gallstones are positioned in a tank shaped like half an ellipse so that the stones are at one focus. Acoustic waves sent from the other focus concentrate all their energy on the stones, pulverizing them without surgery. Math can sometimes throw you a curve, but that.s not necessarily a bad thing. Parabolas and ellipses are curves called conic sections. Another curve in this category is the hyperbola, which may have the most profound application of all the nature of the universe. In plane geometry, points that are a given distance from a fixed point form a circle. In space, points that are a given spacetime distance from a fixed point form one branch of a hyperbola. This is not an arbitrary mandate but instead a natural conclusion from the equations that result when the principle of relativity is reconciled with our notions of distance and causality. And although a great deal of time has elapsed since the discovery of conic sections, they continue to reap benefits today. For More Information: Practical Conic Sections: The Geometric Properties of Ellipses, Parabolas and Hyperbolas, J. W. Downs, 2010.




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Treating Tremors - Helping with Parkinson's disease - Part 1

Researcher: Christopher Butson, Scientific Computing and Imaging Institute, University of Utah. Christopher Butson talks about work he's done to help treat Parkinson's disease.




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Keeping the Roof On

Researcher: Stefan Siegmund, TU-Dresden Moment: http://www.ams.org/samplings/mathmoments/mm137-hurricane.pdf Description: Stefan Siegmund talks about his an invention to protect homes during hurricanes.




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Keeping People Alive Part 2

Steven Strogatz and Mary Bushman talk about math's role in controlling HIV and understanding malaria, respectively. Mary Bushman says, "It's really cool to try and use math to nail down some questions that have gone unanswered for a really long time."





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The report of the workshop on developing capacity for national border controls on living modified organisms in small island developing States in the Caribbean is available.




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The report of the workshop on developing capacity for national border controls on living modified organisms in Pacific small island developing States is now available.




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University spinouts: processes, benefits and risks of the system

Spinout founders, investors and insiders give their tips on turning academic research into successful businesses




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How Queen's Belfast became the UK's best spinout university

Researchers from the venture capital firm Octopus Ventures gave much of the credit to QUBIS, the university's dedicated commercialisation arm




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CBD News: Discours du Secretaire executif, M. Ahmed Djoghlaf, à l'occasion de la dixieme Conference Alpine, Evian, France, 12 Mars, 2009.




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CBD News: Statement by dr. Ahmed Djoghlaf, Executive Secretary, at the Special East Partnership Council Meeting: East Asian Seas Congress 2009, Manila, Philippines, 25 November 2009.




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CBD News: Statement to UNFCCC SBSTA 31: Agenda Item 5 Reducing Emissions from Deforestation in Developing Countries: Approaches to Stimulate Action.




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CBD Communiqué: The President of the Philippines Declares 2010 its National Year of Biodiversity.




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CBD Press Release: Philippines President hosts South-East Asian launch of the United Nations Decade on Biodiversity




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CBD Press Release: Managing biodiversity data from local government: Guidance for local authorities on publishing through the GBIF network, helping preserve knowledge about biodiversity




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CBD News: US$ 4.43 billion has been pledged by 30 donor countries for the Global Environment Facility (GEF) to support developing countries' efforts over the next four years to prevent degradation of the global environment.




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CBD News: Opening Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, to the Seventh Plenary Session of the Third United Nations Small Island Developing States (UN SIDS) Conference, Apia, Samoa, 4 September 2014




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CBD News: As cities move forward on implementing the agenda under the Convention, they will show that they can lead the way in sustainably using biodiversity and the ecosystem services it underpins, as the basis for addressing water and food security, dis




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CBD News: The GBIF Secretariat has launched the inaugural GBIF Ebbe Nielsen Challenge, hoping to inspire innovative applications of open-access biodiversity data by scientists, informaticians, data modelers, cartographers and other experts competing for a




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CBD News: Biodiversity underpins dietary diversity and access to sufficient food is a cornerstone of food security and a fundamental determinant of health.




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CBD News: To support the mobilisation and alignment of technical and financial resources for priority capacity-building needs, IPBES is developing a prototype Matchmaking Facility. This Facility aims to promote and facilitate dialogue and cooperation amon




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CBD News: Over the years, South-South cooperation has emerged as a powerful tool for enhancing international cooperation for achieving sustainable development. In fact, since 2008, developing countries have exported more to one another than to developed c




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CBD News: Biodiversity and sustainable development are inextricably linked. Biodiversity, at the level of ecosystems, species and genes, forms the foundation of the Earth's life support systems and provides the services that underpin human lives and p




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CBD News: Celebrating World Food Day, under the theme "Social protection and agriculture: breaking the cycle of rural poverty", provides an opportunity to emphasize in food systems how biodiversity underpins social protection.




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CBD News: Biodiversity and the ecosystem services it underpins can be the basis for climate change adaptation and disaster risk reduction strategies as they can deliver benefits that will, according to the outcomes of a recent technical workshop on ecosys




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CBD News: Biodiversity - the diversity of life on Earth - underpins the natural resources that provide food and livelihoods throughout the world. For many women, biodiversity serves as the cornerstone of their work, their belief systems and their basic s




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CBD News: Biological diversity underpins ecosystem functioning and the provisioning of ecosystem services essential for human well-being.




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CBD News: We, the Heads of State/Government of Brunei Darussalam, the Kingdom of Cambodia, the Republic of Indonesia, the Lao People's Democratic Republic, Malaysia, the Republic of the Union of Myanmar, the Republic of the Philippines, the Republic o




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CBD News: On behalf of the Executive Secretary of the Convention on Biological Diversity, Dr. Cristiana Pa?ca Palmer, I would like to welcome you to the "Capacity building workshop for Caribbean Small Island Developing States towards achieving Aichi