Marc A. Jones Jr. faces charges of criminal confinement while armed with a deadly weapon, rape, sexual misconduct with a minor and pointing a firearm.

Here's how grocery stores are trying to accommodate shoppers with new hours, special times for at-risk customers and other changes as of April 29.

Simon Property Group has published protocols to keep shoppers safe during coronavirus. Here's what changes the shopping mall owner is planning.

Consumers could fight back by not shopping on Thanksgiving.

More than 100 companies and nonprofits have pledged support for the Your Life Matters initiative, created to help the city's most vulnerable residents. That's a great start, but momentum is critical.

Stefanovic was on the court after scoring when Griffin stepped on his chest

First-half incident resulted in an ejection for Illini player as he stepped on Boilermakers guard

Marc A. Jones Jr. faces charges of criminal confinement while armed with a deadly weapon, rape, sexual misconduct with a minor and pointing a firearm.

Dom Bess talks about England, the Ashes and why he looks up to Australia's Nathan Lyon.

Manchester United manager Ole Gunnar Solskjaer is "ramping up" training with tools such as GPS trackers, to make sure his side will be ready for a potential return to action.

Replacing cars with bikes or walking will cut infection and address climate change, say campaigners.

Wheels turning toward college football in the fall, but no one is in charge. Expect summer chaos with push to return, few answers on coronavirus risk.

A chronology of key events

Key facts, figures and dates

Europeans face a blizzard of restrictions on their freedoms as authorities try to stop the spread.

Having a snooze proved costly for two alleged thieves from Owen Sound.

1. Virat Kohli shares a cuddly throwback photo with Anushka Sharma from their swiss vacay and we are in awe  PINKVILLA
2. Virat, Anushka donate Rs 5L each for Mumbai police welfare  Hindustan Times
3. Virat Kohli, Anushka Sharma contribute 10 lakhs to Welfare of Mumbai Police Personnel - Republic World  Republic World
4. Virat Kohli shares an unmissable throwback picture with wife Anushka Sharma from their Swiss vacation  Times of India
5. Anushka Sharma, Virat Kohli kiss and cuddle in throwback pic from a snowy vacation  Hindustan Times
6. View Full coverage on Google News

Physical distancing measures are working in southern Saskatchewan. There has been one new case in Regina in the past ten days and the South region hasn’t seen a new case since April 5.

Seeing the first Star Wars in 1977 changed the director's life. He wants viewers to be similarly moved by "Rise of the Skywalker."

How do you help millions of passengers navigate one of the world's largest airports? In Turkey, the answer is a fleet of humanoid robots.

Washington will be without their starting right guard, right tackle, left guard, left tackle, center and starting quarterback on Sunday, making the Dallas defense a very solid pickup.

Since 2002, the first year the league expanded to 32 teams, the Chargers have made the playoffs six times, just one of which saw them advance further than the divisional round. That could change this season.

The presidential candidate and Washington governor wants Rapinoe in his administration — should he get elected.

The "Father of the Bride" star spent two days meeting with lawmakers to press for foreign assistance funding.

oscon: Easily Invoke Common Protocols with Twisted - Spin up Python-friendly services with 0 lines of code http://t.co/29oTkk0isW

strataconf: A roundup from the data journalism beat http://t.co/y8RVUwHO4G Global open data, scholarships, mapping a civil war & more #strataconf

strataconf: Innovative ways journalists are using data to tell stories http://t.co/y8RVUwHO4G Global open data, scholarships, mapping a civil war & more

China’s Huawei, which for years has denied violating American trade sanctions on Iran, produced internal company records in 2010 that show it was directly involved in sending prohibited US computer equipment to Iran’s largest mobile-phone operator.

A Shopping ad is accompanied by a clickable text unit.

Please visit Search Engine Land for the full article.

The new Pinterest app on Shopify is now available in the U.S. and Canada.

Please visit Search Engine Land for the full article.

Hear about travel to the region around Island of Cebu as the Amateur Traveler talks to Tommo & Megsy from fivedollartraveller.com about their vacation in Visayas, the central group of islands in the Philippines. They visited the islands of Bohol, Cebu and Negros. 

Hear about travel to the Philippines as the Amateur Traveler talks to Julie Longland about her travel to the Cordilleras mountain region and the island of Palawan which was just named the "Best Island in the World".

These little silicone rubber bowls come in handy in so many ways.

I use them with my digital scale to measure the bulk powder supplements I take. We use them at the dinner table to hold condiments. We use them while preparing meals to hold spices and minced herbs. I keep finding new ways to use them. For instance, when I fry or scramble eggs, I now crack the eggs over one of these bowls so I can pull out shell pieces and woogers (I wish I had a wooger snatcher but the bowl will have to do). Read the rest

India top-order batsman Rohit Sharma is hopeful their tour to Australia at the end of 2020 is allowed to proceed.

Wayward Pines Synopsis Wayward Pines is a mystery thriller television series produced by Fox Network and set to premiere in May of 2015. Based on the book Pines written by Blake Crouch and produced by M. Night Shyamalan Wayward Pines follows the story of an FBI agent Ethan Bruke (played by Matt Dillon), who travels […]

From better campsite cooking to car maintenance to smartphone-free communication, here are 12 gadgets to up your car camping game.

The post Up Your Car Camping Game with These 12 Clever Gadgets appeared first on Vagabondish.

With a bright, 8.2-inch HD display and the flexibility to work in almost any vehicle, the Lanmodo Automotive Vast Night Vision System is a near-perfect alternative to factory-installed systems.

The post Brighten Up Your After-Dark Road-Tripping with Lanmodo’s Vast Automotive Night Vision System appeared first on Vagabondish.

The following article, Breaking: Justice Department Dropping Michael Flynn Criminal Case, was first published on 100PercentFedUp.com.

Michael Flynn has finally been exonerated. The Associated Press is reporting exclusively that the Justice Department said it is dropping the criminal case against President Trump’s first national security adviser, Michael Flynn. In court documents being filed Thursday, the Justice Department said it is dropping the case “after a considered review of all the facts […]

Continue reading: Breaking: Justice Department Dropping Michael Flynn Criminal Case ...

The following article, BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations, was first published on 100PercentFedUp.com.

Barack Obama knew. Documents released yesterday that were used to exonerate President Trump’s new NSA General Flynn, prove that President Barack Obama was aware of the details of Michael Flynn’s intercepted phone calls on December 16 with then-Russian Ambassador Sergey Kislyak. On January 5, 2017, then-Deputy Attorney General, Sally Yates attended an Oval Office meeting […]

Continue reading: BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations ...

At a time when store front vacancies are growing thanks to COVID-19, a new retail cannabis store in Pillette Village is hoping to open soon.

23 April 2020

Alfred C. O. Vertegaal
Dec 1, 2006; 5:2298-2310
Research

Kindlins are focal adhesion proteins that regulate integrin activation and outside-in signaling. The kindlin family consists of three members, kindlin-1, -2, and -3. Kindlin-2 is widely expressed in multiple cell types, except those from the hematopoietic lineage. A previous study has reported that the Drosophila Fit1 protein (an ortholog of kindlin-2) prevents abnormal spindle assembly; however, the mechanism remains unknown. Here, we show that kindlin-2 maintains spindle integrity in mitotic human cells. The human neuroblastoma SH-SY5Y cell line expresses only kindlin-2, and we found that when SH-SY5Y cells are depleted of kindlin-2, they exhibit pronounced spindle abnormalities and delayed mitosis. Of note, acetylation of α-tubulin, which maintains microtubule flexibility and stability, was diminished in the kindlin-2–depleted cells. Mechanistically, we found that kindlin-2 maintains α-tubulin acetylation by inhibiting the microtubule-associated deacetylase histone deacetylase 6 (HDAC6) via a signaling pathway involving AKT Ser/Thr kinase (AKT)/glycogen synthase kinase 3β (GSK3β) or paxillin. We also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, leading to spindle abnormalities not only in the SH-SY5Y cell line, but also cell lines derived from colon and breast tissues. The findings of our study highlight that kindlin-2 regulates mitotic spindle assembly and that this process is perturbed in cancer cells in a hypoxic environment.

8 January 2020 , Volume 96, Number 1

4 March 2020 , Volume 96, Number 2

Webinar Research Event

Clete Willems, Partner, Akin Gump; Deputy Director, US National Economic Council, 2018 - 19
Chair: Marianne Schneider-Petsinger, Senior Research Fellow, US and Americas Programme, Chatham House

Research Event

Lord Mark Malloch-Brown, Chairman, SGO; Former Deputy Secretary-General and Chief of Staff, United Nations
Dr Elizabeth Cousens, President and CEO, United Nations Foundation
Ambassador Nicholas Burns, Roy and Barbara Goodman Family Professor of the Practice of Diplomacy and International Relations at the Harvard Kennedy School; US Under Secretary of State for Political Affairs, 2005 – 2008
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

6 February 2014 , Volume 70, Number 1

From the point of view of a Saudi policy-maker, the country, the region and the world look to be increasingly complex places

You’ve got a short story that goes on too long? A chapter that reads at a dying snail’s pace? A challenge entry that trails beyond the maximum word count? You’re also relatively new to writing and haven’t yet dragged your way through all the millions of writing articles? If yes to the last and anything else to the rest, here’s your article.

1. Remove all redundancies. I repeat: Remove all redundancies. I repeat: ….

“Unknown strangers” or “asked a question” can be removed right away. While it may sound silly, there’s a good chance you have a few of those rummaging around in your work for you to weed out.

More significantly you will want to root out the various strings of wordy words writers conjure up. “At that point in time,” can be replaced with “back then,” or even “then,” if the placement in the sentence allows it. “Despite the fact” can be “although.” “Less than great,” is just a polite man’s “mediocre.”

As a lone appreciator of purple prose I won’t tell you to always cull all of these combos, for there’s a time and place for everything and it’s called colle… a long-form story, but if you’re trying to shorten things up these are the first words to go.

Continue reading Keeping It Short at Mythic Scribes.