What does it take to govern a nation well? This question has risen to the top of my list of concerns during these challenging Covid-19 days. And yes, it has increased my level of anxiety about the future of our nation and its citizens. Like me, you’re probably experiencing nagging anxieties about staying safe. Will I find toilet paper rolls today? Am I protecting myself enough when I bring groceries into the house, or after handling the pump at the gas station? But a much broader and significant issue for me is leadership – leadership that secures the future of our well-being as individuals, families and a healthy nation. I know leadership theories and training can vary greatly, but I have found a common denominator of leadership excellence. I call it “Maturity of Self-hood.” It’s a leader who is secure as a person, who knows her strengths as well as what triggers negative reactions in her. It is someone who is passionate about new possibilities, but tempers this by listening to ideas

The COVID-19 pandemic has spurred efforts to control the spread of the virus through development of innovative digital contact tracing tools. In Singapore, Israel and India there is already an app for that. In Europe there’s debate between two competing frameworks, which have names that sound like Star Wars’ droids: PEPP-PT and DT-3T. And in the US, Apple and Google recently announced collaboration on a contact tracing feature that will eventually be integrated with updates to the mobile device operating system. Although providing promising solutions, these technologies are not without problems. First, the privacy protections for such systems need to be carefully scrutinized. The US currently does not have a general data protection law, like the EU's GDPR, that would permit government oversight and review of these contact tracing solutions. Second, contact tracing only works when a significant number of users opt-in and agree to use the technology. But there is no guarantee that

I clearly remember stories I heard as a kid from my older relatives about living through the Great Depression. The over-arching lesson I took from those accounts was this: unless you lived through it, you couldn’t truly understand what it was like. When I think of what life was like in the “Dirty 30s,” one image always comes to mind: Dorothea Lang’s “Migrant Mother,” taken in California in 1936 of Florence Thompson, a widow, with two of her seven kids huddled around her. Her look, complete with the 1,000-yard stare often associated with combat veterans, captures the quiet panic of a parent who cannot provide enough for her children. That look is also one of the fear and hopelessness of a victim of the economic system that betrayed her. She looked middle-aged 1936, but she was all of 32. As of April 24 th , close to 50,000 Americans have died from COVID-19, and 27 million have lost their jobs. On top of our catastrophe, we are sorely missing something Florence Thompson’s generation had:

“Come look!” announced my husband on an early spring morning over a month ago. “I have a surprise!” I followed him out to the backyard, and there rising up out of the cold brown earth, were a myriad of green stems with sheathed yellow flowers just beginning to make themselves known. “Two hundred daffodils!” my husband beamed brightly. “I planted them last fall in honor of our 50th wedding anniversary. Looks like they made it through the winter.” Although our 50th anniversary isn’t till June, we had scheduled a celebration trip to the island of Kauai in March, but as the frightening days of the corona virus quickly escalated, that trip was canceled. So many others have had to do the same, canceling weddings, spring breaks, graduations, and sadly, even funerals. So instead of sitting on a beach looking out at the blue Pacific as a rosy sun slid into the sea, we are sheltered at home looking out the windows to our leafless backyard. The bright spot, however, is that those 200 daffodils

Hey, all you cool cats and kittens! This is not Carol Baskin. It's Lynnea from Safe Passage. Have you hopped on the craze that is sweeping the nation? Have you fallen prey to the Tiger King? There's a lot of things to love in this series. The wacky hijinks of a gun-toting, sequin-wearing music video star and private zookeeper are just the ticket when you might be getting cabin fever in your home. But while we were all distracted by the complicated rivalry between Joe Exotic and The Big Cat Rescue, we missed a lot. Namely, we missed the abuse. For a documentary on private zoo owners, the unhappy and unsafe lives these animals were forced into was largely glossed over. Even more, the abuse the people faced hardly got a mention. Doc Antle was accused of building a coercive sexual relationship with the underage girls who came to work at his zoo. Joe Exotic was known to use drugs and gifts to lure and keep his husbands with him. Carol's history of being abused and assaulted starting at age

If you have ever skimmed a self-help book, you will be familiar with the current trend to plan ahead, strategize and focus. In a world where so much seems beyond our control, they advise we channel our efforts into well-defined goals. Unfortunately, such advice never seems to take into account the Enrique Solares approach to life. Enrique Solares was my husband's uncle and a gifted musician. When, in 1936, he was awarded a scholarship to study music in Belgium, his father threated to disinherit him. As a founder of a successful pharmaceutical company in Guatemala, Enrique's father was adamant that he abandon music and dedicate himself to the family firm. On the boat to Europe, he met a young Czech actress. Two days later the captain married them, so when he arrived in Brussels, he was not only disinherited and almost penniless, but he had a young wife in tow when Europe was on the cusp of World War II. As Viera would confess later: "most people would think we were foolish". And

As you listen to or read this essay, you will be celebrating the beginning of a brand-new month. But it is being written and recorded on another milestone -- the 50th anniversary of Earth Day. I was present for the very first one, as a student at the University of Illinois. Seminars, programs, speeches and leaflets urged the protection of our environment and an appreciation of the outdoors. For me, that appreciation would continue for a lifetime. This was the era of the "back to the land" movement and Mother Earth News. REI and Backpacker Magazine. Community cleanups and widespread tree planting. I would be fortunate enough to acquire a small hobby farm in Northern Wisconsin, if only for a few years. I often think about that property and can imagine in my mind how the land has changed, and how it hasn't. I will celebrate today not only by getting outdoors, but also by revisiting some of my favorite outdoor writers: Henry David Thoreau, Aldo Leopold, and Sigurd Olson. Their thoughts are

What day is it today? The woman on the other end of the phone asked, “How’s your day going?” “Oh, about the same as yesterday...” “Good one,” she says. At least I could inject a bit of humor. I don’t know about you, but for those of us quarantined at home, it seems as though every day is Sunday: one yawning day without very many milestones. I consider receiving the mail a major event. The governor’s daily address at 2:30 ish in the afternoon is another. At the beginning of this stay at home order I told myself that I would use noon as a cutoff: I had to be out of my pajamas by noon. Do I dare tell you that it is past 4:00 and I’m still in my nightgown? Let’s just say I’m getting in touch with my inner sloth. This order also breeds laziness. At one point I was counting out the number of underwear I had until I had to do laundry. What is wrong with me? I used to be a productive member of society: I read the newspaper daily. Now I collect the newspaper from the driveway every two days, I

Four weeks ago tonight, John Prine caught the April super moon and rode it to heaven. We knew he was sick with the virus and that his chances of recovery were slim, but it still hurt and it still does. I imagine he would have written some good tunes about our current state of being. As a “young man from a small town with a very large imagination,” he “made up songs,” along his postal route in the Chicago area. I can listen to his lyrics over and over and still get a rush of mixed emotions from his stories that are funny, absurd, devastating — and sometimes all in one song. John Prine introduced us to a colorful cast of characters: Lydia - “reading romance novels in her room,” while Donald was “envisioning romantic scenes” from the “barracks latrine,” and them “making love in their dreams.” Sam Stone returning from Vietnam with a “Purple Heart and a monkey on his back.” And the couple from “In Spite of Ourselves”- She “swears like a sailor when she shaves her legs,” and he “drinks his

With the onset of COVID-19, social media platforms show their virtues and vices once again. Millions are finding connection, entertainment, and solace, a lifeline of virtual community during a truly twisted time. Connection with friends is a blast, until someone begins posting conspiracy theories like big pharma, the World Health Organization, and the Centers for Disease Control are a cabal secretly making the world sick for profits, or opining on highly technical epidemiological research, calling into question both findings and researchers’ assumed unethical motives. COVID-19 is a new phenomenon and it takes time for researchers -- experts -- to understand it, and how to effectively and safely deal with it. Public questioning is important, but when a supermajority of experts form an informed opinion you don’t like, developing conspiracies is not a healthy path. Now, I truly believe in free speech. After all, I’m on radio. I’m just leery of the effect of unfettered, ill-informed

I love words. But sometimes this romance is a curse. I am not a word expert. But I should be. I read and write. A lot. Oh, and I’m a journalist. Words are my foundation — bricks for building stories. My touchstones for telling it as it is. And always, always my friends … for being there when I need them. But … I am not a word expert. I keep a dictionary nearby. If you’re in a newsroom you can just shout. “Help! Who knows the rule on lay vs. lie?” “No one!” someone shouts back. “Find a different word.” I use little tricks to remember proper spelling. I pronounce words wrong to get the spelling right. Like “paradigm.” I know how to pronounce it but instead tend to say pair-a-dig-em to make sure I spell it correctly. For years I stumbled over the word “facade.” I pronounced it “fay-kayed,” like it’s spelled. Silly me. I do get edgy when people abuse words. Perhaps I’m too sensitive. Like most married people, I announce my plans when leaving a room. Such as, “I’m taking my shower now.”

I’ve been watching a pair of yellow-bellied sapsuckers excavate a cavity in a dead white oak behind the shed. Since I’m home all the time, I can wander over and look at them whenever I feel like it, which is more often than you might expect. Sapsuckers, a kind of woodpecker, aren’t supposed to be here. They nest in northern Wisconsin, Minnesota, and Canada. In fact, according to the Wisconsin Breeding Bird Atlas, there has never been a confirmed nesting of yellow-bellied sapsuckers in my neck of Wisconsin. Yet here they are anyway, doing their thing in my dead oak. I guess they got lost and didn’t have a Bird Atlas. You can’t watch a woodpecker batter the trunk of a dead tree for very long without thinking about... brain trauma. I’m sure you’ve also wondered how woodpeckers sustain such head rattling without concussing themselves. My father-in-law used to say that woodpeckers could wrap their tongues around their brains to soften the blows. What an image! Without ever looking up, I

Bradley and Karen play a speech recording of Bradley's presentation at OSCON 2011, entitled 12 Years of FLOSS License Compliance: A Historical Perspective.

Show Notes:

Segment 0 (00:36)

• Bradley mentioned that time travel requires special verb tenses according to the Douglas Adams' book, The Restaurant at the End of the Universe. (01:48)
• Bradley gave a keynote at Ohio Linux Fest 2011 (01:58)

Segment 1 (05:02)

• This segment is a recording of Bradley's OSCON 2011 talk, entitled 12 Years of Copyleft License Compliance: A Historical Perspective. The slides are available on Bradley's website so you can follow along during the talk if you like.
• There is a live denting identi.ca thread from Bradley's talk. (03:50)
• Bradley wrote a blog post about a minor GPL violation in the Emacs codebase. It has since been fixed.
• RMS mentioned the NeXT/Objective C GPL violation in his essay, Copyleft: Pragmatic Idealism.

Segment 2 (52:35)

• Bradley will be speaking at the Google Summer of Code Mentor Summit 2011 and at LinuxCon Europe 2011. (55:05)

Send feedback and comments on the cast to <oggcast@faif.us>. You can keep in touch with Free as in Freedom on our IRC channel, #faif on irc.freenode.net, and by following Conservancy on on Twitter and and FaiF on Twitter.

Free as in Freedom is produced by Dan Lynch of danlynch.org. Theme music written and performed by Mike Tarantino with Charlie Paxson on drums.

The content of this audcast, and the accompanying show notes and music are licensed under the Creative Commons Attribution-Share-Alike 4.0 license (CC BY-SA 4.0).

From feeling scared to feeling resolved to see change, eight young people, ages 10 to 15, share how they're coping with the pandemic, in their own words.

From feeling scared to feeling resolved to see change, eight young people, ages 10 to 15, share how they're coping with the pandemic, in their own words.

Google Street View birding, embroidered computers, STEM and the Girl Guides, and using FortNite to teach about climate change

Mahatma Gandhi lived a life committed to social justice and human rights. In this year's lecture to honour his memory five Australian women talk about their work in indigenous communities, for people with disabilities, refugees , LGBTIQ and campaigns to reduce domestic violence.

A failure to look upward when parking by the river at a favourite roost for local pelicans has left a Port Macquarie man red-faced and his car disgraced.

B.J. Armstrong played on three NBA championship teams with Michael Jordan. He knows how Jordan is behind closed doors. He knows the sort of trials and tribulations that occur over the course of a season.

Richard Lawn has posted a new SETI Perspective entitled How did life begin on Earth and elsewhere?.

Kings fans gathered in L.A. to watch the team's Stadium Series game against the Colorado Avalanche. It's been rough lately but they recall better years.

The ways in which the game uses forced perspective and illusion to evoke the subconscious is thrilling.

Chen Weng was born in Wuhan and lives in Seattle. Both connections inspire her "Messycow Comics" strips about panic and hoarding.

Invitation Only Research Event

Event participants

Douglas E Lute, Ambassador, Permanent Representative for the United States to NATO
Sir Adam Thomson KCMG, UK Permanent Representative to NATO
Chair: Dr Robin Niblett, Director, Chatham House

Invitation Only Research Event

Invitation Only Research Event

Event participants

Niels Engelschiøn, Director-General, Department for European Affairs, Norwegian Ministry of Foreign Affairs
Chair: Dr Robin Niblett, Director; Chief Executive, Chatham House

4 March 2020 , Volume 96, Number 2

20 April 2020

Nuclear deterrence theory, with its roots in the Cold War era, may not account for all eventualities in the 21st century. Researchers at Chatham House have worked with eight experts to produce this collection of essays examining four contested themes in contemporary policymaking on deterrence.

Research Event

Event participants

Sumantra Bose, Professor of International and Comparative Politics, LSE; Author, Transforming India: Challenges to the World's Largest Democracy

Research Event

Event participants

Salih Muslim, Chairman, Democratic Union Party (PYD), Syria

4 March 2020 , Volume 96, Number 2

Invitation Only Research Event

Invitation Only Research Event

Event participants

Dr Robin Niblett CMG, Director, Chatham House  
Toshiro Mutoh, Honorary Chairman, Daiwa Institute of Research; CEO, Tokyo Organising Committee of the Olympic and Paralympic Game
José Manuel Barroso, Senior Adviser, Chatham House; President of the European Commission (2004-14); Prime Minister of Portugal (2002-04)
Akihiko Tanaka, President, National Graduate Institute for Policy Studies

The aim of this project is to provide a space to explore creative/disruptive ideas in order to make headway on perspectives concerning deterrence. This will encourage ‘responsible disruption’ in the nuclear field.

20 April 2020

Nuclear deterrence theory, with its roots in the Cold War era, may not account for all eventualities in the 21st century. Researchers at Chatham House have worked with eight experts to produce this collection of essays examining four contested themes in contemporary policymaking on deterrence.

Purpose: Although the incidence of de novo neuroendocrine prostate cancer (NEPC) is rare, recent data suggests that low expression of prostate-specific membrane antigen (PSMA) is associated with a spectrum of neuroendocrine (NE) hallmarks and androgen receptor (AR)-suppression in prostate cancer (PC). Previous clinical reports indicate that PCs with a phenotype similar to NE tumors can be more amenable to imaging by ¹⁸F-Fluorodeoxyglucose (FDG) rather than PSMA-targeting radioligands. In this study, we evaluated the association between NE gene signature and FDG uptake-associated genes including glucose transporters (GLUTs) and hexokinases, with the goal of providing a genomic signature to explain the reported FDG-avidity of PSMA-suppressed tumors. Methods: Data mining approaches, cell lines and patient-derived xenograft (PDX) models were used to study the levels of 14 members of the SLC2A family (encoding GLUT proteins), 4 members of the hexokinase family (genes: HK1 to 3 and GCK) and PSMA (FOLH1 gene) following AR-inhibition and in correlation with NE hallmarks. Also, we characterize a NE-like PC (NELPC) subset among a cohort of primary and metastatic PC samples with no NE histopathology. We measured glucose uptake in a NE-induced in vitro model and a zebrafish model by non-radioactive imaging of glucose uptake using fluorescent glucose bioprobe, GB2-Cy3. Results: This work demonstrates that a NE gene signature associates with differential expression of genes encoding GLUT and hexokinase proteins. In NELPC, elevated expression of GCK (encoding glucokinase protein) and decreased expression of SLC2A12 correlated with earlier biochemical recurrence. In tumors treated with AR-inhibitors, high expression of GCK and low expression of SLC2A12 correlated with NE histopathology and PSMA gene suppression. GLUT12-suppression and amplification of glucokinase was observed in NE-induced PC cell lines and PDX models. A higher glucose uptake was confirmed in low-PSMA tumors using a GB2-Cy3 probe in a zebrafish model. Conclusion: NE gene signature in NEPC and NELPC associates with a distinct transcriptional profile of GLUTs and HKs. PSMA-suppression correlates with GLUT12-suppression and glucokinase-amplification. Alteration of FDG uptake-associated genes correlated positively with higher glucose uptake in AR and PSMA-suppressed tumors. Zebrafish xenograft tumor models are an accurate and efficient pre-clinical method for monitoring non-radioactive glucose uptake.

Data independent acquisition (DIA) is an attractive alternative to standard shotgun proteomics methods for quantitative experiments. However, most DIA methods require collecting exhaustive, sample-specific spectrum libraries with data dependent acquisition (DDA) to detect and quantify peptides. In addition to working with non-human samples, studies of splice junctions, sequence variants, or simply working with small sample yields can make developing DDA-based spectrum libraries impractical. Here we illustrate how to acquire, queue, and validate DIA data without spectrum libraries, and provide a workflow to efficiently generate DIA-only chromatogram libraries using gas-phase fractionation (GPF). We present best-practice methods for collecting DIA data using Orbitrap-based instruments, and develop an understanding for why DIA using an Orbitrap mass spectrometer should be approached differently than when using time-of-flight instruments. Finally, we discuss several methods for analyzing DIA data without libraries.

20 April 2020

Nuclear deterrence theory, with its roots in the Cold War era, may not account for all eventualities in the 21st century. Researchers at Chatham House have worked with eight experts to produce this collection of essays examining four contested themes in contemporary policymaking on deterrence.

JW Baynes
Jan 1, 1999; 48:1-9
Articles