Title: Awareness of Memory Problems Fades a Few Years Before Dementia: Study
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM

Title: Brain Zaps Give Month-Long Memory Boost
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

Binding of arbitrary information into distinct memory representations that can be used to guide behavior is a hallmark of relational memory. What is and is not bound into a memory representation and how those things influence the organization of that representation remain topics of interest. While some information is intentionally and effortfully bound—often the information that is consistent with task goals or expectations about what information may be required later—other information appears to be bound automatically. The present set of experiments sought to investigate whether spatial memory would be systematically influenced by the presence and absence of distinct categories of stimuli on a spatial reconstruction task. In this task, participants must learn multiple item-location bindings and place each item back in its studied location after a short delay. Across three experiments, participants made significantly more within-category errors (i.e., misassigning one item to the location of a different item from the same category) than between-category errors (i.e., misassigning one item to the location of an item from a different category) when categories were perceptually or semantically distinct. These data reveal that category information contributed to the organization of the memory representation and influenced spatial reconstruction performance. Together, these results suggest that categorical information can influence memory organization, and not always to the benefit of overall task performance.

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As the philanthropic partner of IEEE, the IEEE Foundation expands the organization’s charitable body of work by inspiring philanthropic engagement that ignites a donor’s innermost interests and values.

One way the Foundation does so is by partnering with IEEE units to create memorial funds, which pay tribute to members, family, friends, teachers, professors, students, and others. This type of giving honors someone special while also supporting future generations of engineers and celebrating innovation.

Below are three recently created memorial funds that not only have made an impact on their beneficiaries and perpetuated the legacy of the namesake but also have a deep meaning for those who launched them.

EPICS in IEEE Fischer Mertel Community of Projects

The EPICS in IEEE Fischer Mertel Community of Projects was established to support projects “designed to inspire multidisciplinary teams of engineering students to collaborate and engineer solutions to address local community needs.”

The fund was created by the children of Joe Fischer and Herb Mertel to honor their fathers’ passion for mentoring students. Longtime IEEE members, Fischer and Mertel were active with the IEEE Electromagnetic Compatibility Society. Fischer was the society’s 1972 president and served on its board of directors for six years. Mertel served on the society’s board from 1979 to 1983 and again from 1989 to 1993.

“The EPICS in IEEE Fischer Mertel Community of Projects was established to inspire and support outstanding engineering ideas and efforts that help communities worldwide,” says Tina Mertel, Herb’s daughter. “Joe Fischer and my father had a lifelong friendship and excelled as engineering leaders and founders of their respective companies [Fischer Custom Communications and EMACO]. I think that my father would have been proud to know that their friendship and work are being honored in this way.”

The nine projects supported thus far have the potential to impact more than 104,000 people because of the work and collaboration of 190 students worldwide. The projects funded are intended to represent at least two of the EPICS in IEEE’s focus categories: education and outreach; human services; environmental; and access and abilities.

Here are a few of the projects:

• The Engineering Outreach at San Diego K–12 Schools project aims to bridge the city’s STEM education gap by sending IEEE members to schools to teach project-based lessons in mechanical, aerospace, electrical and computer engineering, as well as computer science. The project is led by the IEEE–Eta Kappa Nu honor society’s Kappa Psi chapter at the University of California San Diego and the San Diego Unified School District.
• Students from the Sahrdaya College of Engineering and Technology student branch in Kodakara, India, are developing an exoskeleton for nurses to support their lumbar spine region.
• Volunteers from the IEEE Uganda Section and local engineering students are designing and fabricating a stationary bicycle to act as a generator, providing power to families living in underserved communities. The goal of the project is to reduce air pollution caused by generators and supply reliable, affordable power to people in need.
• The IEEE Colombian Caribbean Section’s Increasing Inclusion of Visually Impaired People with a Mobile Application for English Learning project aims to ensure visually impaired students can learn to read, write, and speak English alongside their peers. The section’s members are developing a mobile app to help accomplish their goal.

IEEE AESS Michael C. Wicks Radar Student Travel Grant

The IEEE Michael C. Wicks Radar Student Travel Grant was established by IEEE Fellow Michael Wicks prior to his death in 2022. The grant provides travel support for graduate students who are the primary authors on a paper being presented at the annual IEEE Radar Conference. Wicks was an electronics engineer and a radio industry leader who was known for developing knowledge-based space-time adaptive processing. He believed in investing in the next generation and he wanted to provide an opportunity for that to happen.Ten graduate students have been awarded the Wicks grant to date. This year two students from Region 8 (Africa, Europe, Middle East) and two students from Region 10 (Asia and Pacific) were able to travel to Denver to attend the IEEE Radar Conference and present their research. The papers they presented are “Target Shape Reconstruction From Multi-Perspective Shadows in Drone-Borne SAR Systems” and “Design of Convolutional Neural Networks for Classification of Ships from ISAR Images.”

Life Fellow Fumio Koyama and IEEE Fellow Constance J. Chang-Hasnain proudly display their IEEE Nick Holonyak, Jr. Medal for Semiconductor Optoelectronic Technologies at this year’s IEEE Honors Ceremony. They are accompanied by IEEE President-Elect Kathleen Kramer and IEEE President Tom Coughlin.Robb Cohen

IEEE Nick Holonyak Jr. Medal for Semiconductor Optoelectronic Technologies

The IEEE Nick Holonyak Jr. Medal for Semiconductor Optoelectronic Technologies was created with a memorial fund supported by some of Holonyak’s former graduate students to honor his work as a professor and mentor. Presented on behalf of the IEEE Board of Directors, the medal recognizes outstanding contributions to semiconductor optoelectronic devices and systems including high-energy-efficiency semiconductor devices and electronics.

Holonyak was a prolific inventor and longtime professor of electrical engineering and physics. In 1962, while working as a scientist at General Electric’s Advanced Semiconductor Laboratory in Syracuse, N.Y., he invented the first practical visible-spectrum LED and laser diode. His innovations are the basis of the devices now used in high-efficiency light bulbs and laser diodes. He left GE in 1963 to join the University of Illinois Urbana-Champaign as a professor of electrical engineering and physics at the invitation of John Bardeen, his Ph.D. advisor and a two-time Nobel Prize winner in physics. Holonyak retired from UIUC in 2013 but continued research collaborations at the university with young faculty members.

“In addition to his remarkable technical contributions, he was an excellent teacher and mentor to graduate students and young electrical engineers,” says Russell Dupuis, one of his doctoral students. “The impact of his innovations has improved the lives of most people on the earth, and this impact will only increase with time. It was my great honor to be one of his students and to help create this important IEEE medal to ensure that his work will be remembered in the future.”

The award was presented for the first time at this year’s IEEE Honors Ceremony, in Boston, to IEEE Fellow Constance Chang-Hasnain and Life Fellow Fumio Koyama for “pioneering contributions to vertical cavity surface-emitting laser (VCSEL) and VCSEL-based photonics for optical communications and sensing.”

Establishing a memorial fund through the IEEE Foundation is a gratifying way to recognize someone who has touched your life while also advancing technology for humanity. If you are interested in learning more about memorial and tribute funds, reach out to the IEEE Foundation team: donate@ieee.org.

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May 24, 2024

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Manchester : Manchester University Press, [2019]

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Durham : Duke University Press, [2023]

New York : Routledge, 2023.

Toronto : University of Toronto Press, [2023]

Barnsley, S. Yorkshire : Greenhill Books, 2018.

Ciudad de México : Bonilla Artigas Editores ; Universidad Autónoma del Estado de Morelos, 2020.

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