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Grand Canyon National Park Returns to Level 1 Water Conservation; Limited Water on Trails Due to Seasonal Shut-off

Following a series of breaks in the Transcanyon Waterline earlier this month, Grand Canyon National Park now has enough water in storage to scale back to Level 1 basic water conservation measures. https://www.nps.gov/grca/learn/news/level-1-water-conservation-seasonal-trail-water.htm




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Grand Canyon National Park Transitions to Limited Services

Grand Canyon National Park is announcing modifications to operations to implement the latest guidance from the White House, Centers for Disease Control & Prevention (CDC), and local and state authorities. 03/19/2020 https://www.nps.gov/grca/learn/news/grca-np-transitions-to-limited-services-03-19-2020.htm




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Efficient conditional ALU instruction in read-port limited register file microprocessor

A microprocessor having performs an architectural instruction that instructs it to perform an operation on first and second source operands to generate a result and to write the result to a destination register only if its architectural condition flags satisfy a condition specified in the architectural instruction. A hardware instruction translator translates the instruction into first and second microinstructions. To execute the first microinstruction, an execution pipeline performs the operation on the source operands to generate the result. To execute the second microinstruction, it writes the destination register with the result generated by the first microinstruction if the architectural condition flags satisfy the condition, and writes the destination register with the current value of the destination register if the architectural condition flags do not satisfy the condition.




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Time division multiplexed limited switch dynamic logic

A limited switch dynamic logic (LSDL) circuit includes a dynamic logic circuit and a static logic circuit. The dynamic logic circuit includes a precharge device configured to precharge a dynamic node during a precharge phase of a first evaluation clock signal and a second evaluation clock signal. A first evaluation tree is configured to evaluate the dynamic node to a first logic value in response to one or more first input signals during an evaluation phase of the first evaluation clock signal. A second evaluation tree is configured to evaluate the dynamic node to a second logic value in response to one or more second input signals during an evaluation phase of the second evaluation clock signal. A static logic circuit is configured to provide an output of the LSDL circuit in response to the dynamic node according to an output latch clock signal.




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Time division multiplexed limited switch dynamic logic

A method for increasing performance in a limited switch dynamic logic (LSDL) circuit includes precharging a dynamic node during a precharge phase of a first and second evaluation clock signal. The dynamic node is evaluated to a first logic value in response to one or more first input signals of a first evaluation tree during an evaluation phase of the first evaluation clock signal. The dynamic node is evaluated to a second logic value in response one or more second input signals of a second evaluation tree during an evaluation phase of the second evaluation clock signal. A signal of the LSDL circuit is outputted in response to the dynamic node according to an output latch clock signal.




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Load limited actuator

An actuator includes a first piston and a second piston. The first piston has a piston ring that separates a first chamber from a second chamber of the actuator. The first piston has an interior chamber that communicates with the first chamber. The second piston is disposed within the interior chamber of the first piston so as to be movable with respect thereto. The second piston has a surface that interfaces with the second chamber.




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Distributed code repository with limited synchronization locking

A system for a distributed repository includes an input interface and a processor. The input interface is to receive a request to change a portion of code. The processor is to determine a change reference and an existing reference, indicate to lock one or more repositories, determine whether swapping references is approved by a vote, and in the event that swapping references is approved by a vote, swap the references and indicate to unlock the one or more repositories.




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Scribblenauts Unlimited - Nintendo Wii U, 3DS, PC

Reviewed On: Wii U




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Drum Depot Total Drums Bundle delivers 5 GB of drums in limited edition package

Marco Scherer has announced availability of the Total Drums Bundle, a limited edition collection of all 11 Drum Depot series featuring 5 GB of drum sounds. The bundle features 175 drum kits from classic and modern drum machines like TR-808, Erica‘s Techno System, JoMoX AirBase-99, Arturia DrumBrute and others, but also obscure and very rare […]

The post Drum Depot Total Drums Bundle delivers 5 GB of drums in limited edition package appeared first on rekkerd.org.




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Download Waves Audio Sibilance vocal de-esser FREE for limited time

VST Buzz is offering a free download of the Sibilance plugin by Waves Audio, a clever, fast, powerful de-esser specifically designed for vocals and voiceovers. Sibilance allows precise identification of unwanted sibilant sounds such as ‘s’ and ‘sh’ with exceptional quality, allowing you to make your vocals brighter without harshness. Powered by Waves’ innovative Organic […]

The post Download Waves Audio Sibilance vocal de-esser FREE for limited time appeared first on rekkerd.org.




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Function Loops launches Art of Sound 2020 limited time offer

Function Loops has announced the release of Art of Sound 2020, a premium bundle pack containing a huge collection of over 1,200 audio files. This special bundle has been compiled from Function Loops best selling packs and is grouped into mini-kits for ease of navigation. It is multi-genre (everyone will find inspiration) and comes with […]

The post Function Loops launches Art of Sound 2020 limited time offer appeared first on rekkerd.org.




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Samsung resumes limited operations at Noida plant

The state government has given permission to various companies, including Samsung, to start operations with a maximum of 3,000 employees in a manufacturing unit.




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Pentagon watchdog, in probe limited by White House, clears Microsoft’s $10 billion cloud-computing win over Amazon


The 317-page report by the inspector general also found that giving the contract to a single company — Microsoft — rather than dividing it among competitors was "consistent with applicable acquisition standards."






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Olive growers face challenging season with limited water supply, extreme heat

With the olive harvest starting in some parts of South Australia, some farmers are now seeing fruit that has not developed or has shrivelled due to a lack of water.




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Victoria's Latrobe Regional Hospital mental health staff under limited supervision, review finds

A report on the workplace culture at a major hospital in Victoria uncovers limited supervision of junior mental health staff, as well as allegations of bullying and sexual harassment.




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Pandemic Hampers Outreach To Voters Who Speak Limited Or No English

The in-person events that were the heart of voter outreach efforts have been put on hold. But Multnomah County election officials are still holding office hours, as they also go virtual.




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Report: 2020 MLB Amateur Draft limited to 5 rounds




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Trikona Advisers Limited v. Chugh

(United States Second Circuit) - In a complaint alleging breach of fiduciary duty by defendant, a former partner and fifty percent owner of plaintiff corporation, the district court's grant of summary judgment to defendants is affirmed over plaintiff's meritless arguments that: 1) the district court incorrectly applied the doctrine of collateral estoppel; and 2) Chapter 15 of the United States Bankruptcy Code prevents the district court from giving preclusive effect to the Cayman court's factual findings.




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Trikona Advisers Limited v. Chugh

(California Court of Appeal) - In a complaint alleging breach of fiduciary duty by defendant, a former partner and fifty percent owner of plaintiff corporation, the district court's grant of summary judgment to defendants is affirmed over plaintiff's meritless arguments that: 1) the district court incorrectly applied the doctrine of collateral estoppel; and 2) Chapter 15 of the United States Bankruptcy Code prevents the district court from giving preclusive effect to the Cayman court's factual findings.




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VRA FAMILY LIMITED PARTNERSHIP v. SALON MANAGEMENT USA LLC

(NY Supreme Court) - 2019–09206 Index No. 604223/16




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Trikona Advisers Limited v. Chugh

(United States Second Circuit) - In a complaint alleging breach of fiduciary duty by defendant, a former partner and fifty percent owner of plaintiff corporation, the district court's grant of summary judgment to defendants is affirmed over plaintiff's meritless arguments that: 1) the district court incorrectly applied the doctrine of collateral estoppel; and 2) Chapter 15 of the United States Bankruptcy Code prevents the district court from giving preclusive effect to the Cayman court's factual findings.




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Trikona Advisers Limited v. Chugh

(California Court of Appeal) - In a complaint alleging breach of fiduciary duty by defendant, a former partner and fifty percent owner of plaintiff corporation, the district court's grant of summary judgment to defendants is affirmed over plaintiff's meritless arguments that: 1) the district court incorrectly applied the doctrine of collateral estoppel; and 2) Chapter 15 of the United States Bankruptcy Code prevents the district court from giving preclusive effect to the Cayman court's factual findings.




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In re Boon Global Limited

(United States Ninth Circuit) - Addressed whether Hong Kong- and Vietnam-based companies could be forced into arbitration in a software development dispute. The issue involved whether nonsignatories may be bound by an arbitration agreement. Denied the companies' request for a writ of mandamus.




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NAF Holdings, LLC v. Li & Fund (Trading) Limited

(United States Second Circuit) - In a dispute arising out of a merger, and in light of Delaware Supreme Court's answer to a certified question that plaintiff was not required to bring its breach of contract claim as a derivative action, the district court's grant of summary judgment in favor defendant is vacated where plaintiff is not barred from pursuing its claim directly.




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UK's Debut Album To Be Released On Limited Edition 180 Gram Vinyl

It Will Be Released On April 21st, And Available Exclusively To Record Store Day Participating Retailers Worldwide.




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Franchise Tax Bd. Limited Liability Corp. Tax Refund Cases

(California Court of Appeal) - Reversed the denial of class certification in a case involving tax refund claims filed by limited liability companies (LLCs) which sought refunds of a levy they had paid pursuant to a California tax statute that was later determined to be unconstitutional. When the district court denied the LLCs' motion for class certification on multiple grounds including predominance and superiority, they appealed. Agreeing with the LLCs that this case was suitable for treatment on a classwide basis, the First Appellate District reversed and remanded for certification of a class or classes consistent with its opinion.




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Limited Ferry Service To Resume On Monday

Starting Monday, May 11th, the ferry service “will resume under a reduced operating schedule with limited passenger capacity.” A...




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In re Boon Global Limited

(United States Ninth Circuit) - Addressed whether Hong Kong- and Vietnam-based companies could be forced into arbitration in a software development dispute. The issue involved whether nonsignatories may be bound by an arbitration agreement. Denied the companies' request for a writ of mandamus.




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New Video About The Making Of Magma's New Album “Zëss” On Limited Edition Gold Colored Vinyl

Limited Edition Of 1500 Numbered Copies On 180 Gram Audiophile Gold Colored Vinyl




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In re Ondova Limited Co.

(United States Fifth Circuit) - Held that bankruptcy trustees are entitled to qualified immunity for personal harms caused by actions that, while not pursuant to a court order, fall within the scope of their official duties. Affirmed the dismissal of an adversary proceeding against a bankruptcy trustee.




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Nicolas Cage to star as Joe Exotic in limited TV series

The Joe Exotic phenomenon keeps growing, with Nicolas Cage to star in a TV miniseries about the colorful wild animal owner made famous by the “Tiger King” docuseries.





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Kathy Parker Joins Bacardi Limited As CMO

Bacardi Limited announced the appointment of Kathy Parker as Chief Marketing Officer for Patrón tequila and Grey Goose vodka, with Ms Parker set to relocate to Bermuda with her family in August. The company said, “Bacardi Limited, the largest privately held spirits company in the world, today announces the appointment of Kathy Parker as Chief Marketing Officer […]

(Click to read the full article)




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Australian Settlements Limited Taps IBM Cloud in Preparation for New Payments Platform

ASL to benefit from IBM Cloud and IBM PureApplication to deliver for secure real time payments for NPP Australia



  • Banking and Financial Services


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PM Studios "Stay Safe" Sale - Featuring Switch/PS4, and Limited Run Games.

PM Studios online store is back and they made a new sale featuring new reprints, overall deals and restock on rare out-of-print titles from Limited Run Games.

 

https://twitter.com/PMStudiosUSA/status/1253401043414781959

 

Also all orders over $49.99 will get Cytus Alpha Limited Edition Original Soundtrack CD for free with the Coupon "FREEGIFT".

 

Kinda sick move they did now.

 

https://www.pm-studios.com/store

 

Edit: Price list.

 

Reprints/Pre-Orders: 
 
Horizon Chase Turbo (Switch) - $29.99
Ministry of Broadcast (Steelbook Edition) (Switch) - $39.99 
 
Deals:
 
Deemo (Switch) $39.99 - $19.99
Opus Collection (Switch) $39.99 - 19.99
Horizon Chase Turbo (First Print - PS4) $29.99 - $14.99
Hover (Switch) - $29.99 - $24.99
WILL: A Wonderful World Limited Edition (Plush, 120 page Artbook, etc) : $79.99 $69.99
WILL: A Wonderful World - Artbook: $29.99 - $24.99

Limited Run Games products:
Mercenaries Series Double Pack (PAX Exclusive): $69.99
Mercenaries Wings Limited Edition (PS4 - LRG) : $59.99
Mercenaries Wings Limited Edition (Switch - LRG): $59.99
Musynx First Print (Vita - LRG): $29.99
Deemo: The Last Recital (Vita - LRG): $29.99
  • -->




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    Book week 2019: David Adger's Language Unlimited

    Welcome to the second review post of Book Week 2019. See the intro to Book Week 2019 to understand more about what I'm doing this week. Next up we have:

    Language unlimited
    the science behind our most creative power

    by David Adger
    Oxford University Press, 2019


    This is a book for people who like to think about HOW THINGS WORK. It's a serious work of popular science writing, which carefully spells out the mysteries of syntax. And by mysteries, I mean things you've probably never even noticed about language. But once they're pointed out, you have to sit back and say "Whoa." Because even though you hadn't noticed these things, you know them. Remember a few years ago, when the internet was hopping with posts about how we subconsciously know which order to put adjectives in? That's kid's play compared with the stuff that Adger'll teach you about the things you know but don't know about.

    Adger (who is Professor of Linguistics at Queen Mary University, London) describes the situation carefully, clearly, and engagingly, using copious examples and analogies to communicate some really subtle points. (I particularly liked the explanation of form versus function in language, which drew on the form versus the function of alcohol. Chin-chin!) He draws in evidence from neurology, psychology, and computer science to both corroborate his points and to introduce further questions about how language works.

    As I said in the intro to Book week, I have not read all the books I'm reviewing absolutely cover-to-cover. In this case, of the ten chapters, I read 1–3, 7, and 10—and skimmed through the other chapters. The early chapters make the case that there's more to linguistic structure than meets the eye and that human linguistic abilities must consist of something special—they must be qualitatively different from the types of cognition that other animals use and that humans use in non-linguistic communication. Later ones cover issues like how children experience and acquire their first language and what happens when computers try to learn human language. Throughout, the examples feature Adger's partner Anson and his cat Lilly.  I almost feel like I know them now. Hi Anson and Lilly!

    Adger makes clear from the start that his book makes a particular argument in favo(u)r of a particular way of explaining language's mysteries—and that particular way is a Chomskyan way. This means that he makes the case for a Universal Grammar that underlies all human language. I was struck by his willingness and ability to take this all the way for a lay audience. By chapter 9, he is explaining Merge, the key tool of Chomsky's Minimalist Program

    Now, here I have to say: this is not the kind of linguistics I do. It's not just that I'm not a syntactician—though I have, from time to time, dipped my toe into theories grammatical. It's also that I lost faith in theoretical monotheism when I moved from a very Chomskyan undergraduate degree to a more ecumenical linguistics department for my (post)graduate studies. When I arrived for my PhD studies, the department wanted to know which syntactic theories I'd studied, so they could determine which courses I needed to take. I could not tell them. After four years of studying Chomskyan linguistics, I thought I had spent four undergraduate years studying "Syntax". No one had told me that I was studying a theory of syntax, just one among several theories.

    Ever since, I have tended to agnosticism and s{c/k}epticism when it comes to syntactic theory. (This is probably how I ended up as not-a-syntactician; I don't know that it's possible to have a career in grammatical studies without adhering to one theoretical church or another.) Being a lexicologist has meant that I don't have to take sides on these things. And so I play around with different theories and see how they deal with the phenomena I study. When I listen to the evangelists, I listen warily. I tend to find that they oversimplify the approaches of competitor theories, and don't learn as much from them as they could (or, at least, sometimes don't give them credit for their contributions). This is all a very long explanation of why I skipped to chapter 7—the chapter where Adger responds to some non-Chomskyan ideas (mostly personified in the chapter by Joan Bybee).

    So (mostly BrE*) all credit to Adger for spending a chapter on this, and for citing recent work in it. I generally thought his points were fair, but I did what I usually do in response to such theoretical take-downs: I thought "ok, but what about..." I do think he's right that some facts point to the existence of a Universal Grammar, but I also think it's not the only interesting part of the story, and that it's premature to discount arguments that explore the possibility that much of what happens in language learning is based in experience of language and general cognitive abilities. But then, I would think that.

    I definitely recommend the book for people who are interested in the scientific approach to language, but I'd skip the final chapter (10). It is an oddly tacked-on bit about sociolinguistic phenomena, precisely the kinds of things that are not even approached in the theory the rest of the book has been arguing for.

    I congratulate Adger on this strong work that makes extraordinarily abstract concepts clear.





    P.S. Since I'm not doing Differences of the Day on Twitter this week, here's little chart of use of all credit to (frequency per million words) in the Corpus of Global Web-Based English, for good measure.





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    Clippers, L.A. artist Mister Cartoon release limited-edition gear for coronavirus relief

    The Clippers and L.A. artist Mister Cartoon release a collection of two T-shirts and a hooded sweatshirt to benefit local coronavirus relief efforts.




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    Strict rules, limited access as California Legislature resumes work on coronavirus needs

    Seven weeks after public health concerns over the coronavirus brought the work of the California Legislature to a sudden halt, only members of the Assembly are returning to Sacramento this week, with the Senate choosing to do so on May 11.




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    Following coronavirus closure, Mt. Baldy ski resort reopening in limited capacity

    The plan to reopen the San Bernardino County ski destination in a limited capacity marks the latest effort to allow limited recreation amid the coronavirus outbreak.




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    Channel Rosie the Riveter in this limited-edition jumpsuit from L.A. brand the Great

    For Women's Month, L.A. brand the Great teamed with Cotton Inc. for a new cotton-denim jumpsuit inspired by the WWII icon.




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    Portillo's brings back its luscious lemon cake for limited time

    Indy residents just getting acquainted with Portillo's Chicago-style hotdogs will get to try another new delicacy starting Tuesday: lemon cake

          




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    Garden centres open while retail stores struggle with looming limited reopening

    Some garden centres in the area opened Friday morning with physical distancing measures in place after the provincial government lifted the closures earlier this week.




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    SBA Disaster Loans Capped at $150K, Limited to Agriculture

    The Economic Injury Disaster Loan program is now limiting both the amount and recipients it will consider for the emergency loans.




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    Allies Beware: Americans Support a More Limited Role for the US

    12 May 2016

    Bruce Stokes

    Associate Fellow, US and the Americas Programme (based in the US)

    Xenia Wickett

    Former Head, US and the Americas Programme; Former Dean, The Queen Elizabeth II Academy for Leadership in International Affairs
    While not as isolationist or unilateralist as some campaign rhetoric might suggest, new polling shows the American public broadly supports less engagement with the rest of the world.

    2016-05-11-US-Philippines.jpg

    US military personnel take part in joint military exercises with the Philippines, Australia and Japan in Crow Valley on 14 April 2016. Photo by Getty Images.

    While the American election cycle could be perceived as an occasionally amusing distraction, the rise of new factions and sentiments among the electorate will have an impact not just in America’s domestic politics but also with respect to its role in the world. Recent polling by the Pew Research Center shows clearly the desire among many Americans for a different international engagement for the US, one that could have significant implications for America’s allies.

    Polling

    To date, the campaign rhetoric of both the Republican and Democratic contenders for the White House has raised questions about America’s continuing global commitment.

    But what does the public think? The Pew Research Center has recently released its periodic survey of how Americans view America’s place in the world. The results suggest that stereotypes of Americans’ isolationism or protectionism do not capture the nuance in public sentiment. Wariness of international engagement coexists with assertiveness on some issues and a belief that the US is a force for good in the world. And these views often divide along partisan lines and between generations.

    A majority of Americans (57%) think the U.S. should deal with its own problems and let other countries deal with theirs as best they can, a sentiment that has increased from 46% in 2010. Moreover, roughly two-thirds say ‘we should not think so much in international terms but concentrate more on our own national problems’. In part this may be the case because a plurality of Americans thinks the United States does too much (41% too much, 27% too little) in helping solve world problems.

    The fact that six-in-ten Americans believe that problems in the world would be even worse without US involvement will not reassure many non-Americans who care deeply about how and where the US is engaged, not just that it is.

    American isolationism is a partisan affair. Republicans (62%) are far more likely than Democrats (47%) to voice the view that the US should deal with its own problems. Notably, about two-thirds of registered Republicans or Republican-leaning independents who favour Donald Trump (68%) express such isolationist sentiments, as do more than half of the Democratic backers of Sen. Bernie Sanders (54%). At the same time, over half of registered Democrats and Democratic-leaning independents who favour Hillary Clinton (52%) believe the US should help other countries deal with their problems.

    The US has often been seen by its allies as acting in a unilateralist fashion, but the polling is more nuanced than this. About half (51%) believe that the US should take into account the views of its major allies when deciding its foreign policies. However, of more concern for America’s allies (and potentially adversaries), roughly four-in-ten (42%) believe Washington should go it alone in international matters.

    Despite Trump’s criticisms, 53% of the American public holds a positive view of NATO and 77% voice the view that US membership in the security alliance has been a good thing for the United States.

    In addition to some wariness with regards to engaging internationally in security arenas, Americans are also generally wary of global economic engagement – protectionist sentiment is rising. Only 44% believe such US involvement is a good thing; more (49%) say such engagement is bad, lowering wages and costing jobs. These views also differ along partisan lines with more on the right than left thinking US involvement in the world economy has been a bad thing. Trump supporters are even more against economic globalization.

    Rising scepticism

    The results do not show an unambiguous move towards more American isolationism or unilateralism. But the trends broadly show that the American public is moving towards, as President Obama put it in 2012, a focus on ‘nation building at home’. It should come as no surprise – President Obama has presided over a period in which the US has increasingly limited its extraterritorial ambitions to those that more directly affect its vital national interests. It is therefore worth noting that this more limited engagement is one that is, broadly, supported by the public on both sides of the aisle.

    There are, as have been noted, partisan differences. But the next president will govern over all Americans not just those from their own party. They will have to function in the context of an American public, the majority of whom wants the US to deal with its own problems, letting other countries manage as best they can. While who becomes president clearly matters – they have the capacity to lead their populations in certain directions - the rising scepticism among many Americans for investing in the globalized world will resonate regardless of who takes office.

    The implications for America’s allies are significant. For those issues that are not directly of concern to the United States, longstanding partners are going to have to find ways to manage on their own or with less American support. And even on those issues that are of direct national interest, they might find the US less sensitive to their interests and concerns. This could hold true not just in the realm of security but on economic issues also – if America becomes more protectionist, others will surely follow.  

    Many of America’s allies have perceived the United States to be an unreliable ally in recent years. Asian partners, such as Japan and South Korea, have started to take more responsibility for their own security and are working to build additional partnerships with neighbours. European allies have been, at times, disappointed by what they perceive to be a less engaged America, such as in Libya and Syria. If the next president follows the public majority, these allies will need to get used to this new role for the United States.

    This article has been published jointly with Real Clear World.

    To comment on this article, please contact Chatham House Feedback




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    Why Turkey’s Disapproval of the West’s Response to the Coup Has Limited Merit

    10 August 2016

    Fadi Hakura

    Consulting Fellow, Europe Programme
    Although Turks across the political and ideological spectrum are seething at the West’s apparently lukewarm condemnation of the abortive coup on 15 July, there are valid reasons behind the response.

    2016-08-10-Turkey-coup-fallout.jpg

    A Turkish flag attached to helium balloons as people gather to protest at Konak Square, Izmir during the July 15 failed military coup attempt. Photo by Getty Images

    Signs of growing anger at the restrained denunciation of Pennsylvania-based Muslim cleric Fethullah Gulen - whose followers are thought to have played a key role in the attempted coup - are being vocalised more and more, but this criticism only shows part of the true picture.

    It is true that prominent liberal Turkish intellectual Soli Ozel spoke for many when he criticised EU politicians and Western media for failing to recognise the “invaluable democratic resistance shown by all political parties in a parliament bombed by war planes”, as well as demonstrating “a lack of sensitivity, empathy and solidarity that cannot be easily digested” by not sending anyone from an EU institution to offer solidarity with the Turkish parliament.

    The criticism is reasonable - officials from Western governments and regional institutions such as the Council of Europe exhibited unconditional solidarity with Ukraine during its bitter feud with Russia, which leads some to believe that Muslim-majority Turkey does not apparently deserve the same treatment as its neighbours also experiencing an unlawful attempt to seize control of the state.

    Moral authority at risk

    It is also right that the West should have censured the coup plotters more forcefully and built upon Turkey’s fragile unity to encourage the country to pursue further democratic reform. To quote former Swedish Prime Minister and Foreign Minister Carl Bildt: “Europe risks losing its moral authority if it does not appear particularly engaged in dealing with the coup itself.”

    In addition, the EU’s strong criticism of Turkey but not France, for imposing a state of emergency and for temporarily suspending the European Convention on Human Rights, undeniably, smacks of double-standards.

    However, some of the criticism falls short. To begin with, the West’s tepidity can be explained (though not wholly justified) by Erdogan’s abrasive behaviour at home and towards Western and international media.

    Just three days after the coup, Erdogan threatened in his characteristically defiant tone to revive the controversial construction plans that sparked the 2013 Gezi Park protests, saying: “If we want to preserve our history, we must rebuild this historic [Ottoman-era barracks] structure, [and] we will rebuild it.”

    It is also fair for Turkey to be reproached for the widespread crackdown against tens of thousands of suspected Gulenists in the aftermath of the coup. Even if it is conceivable that all 1,577 university deans who were forced to resign were Gulenists, this action will also have a lasting negative impact on the reputations and career prospects of academics unconnected to Gulen.

    Fervour against Gulenism

    The vigilance by the West is understandable given the Turkish government’s fervour against Gulenism in the immediate post-coup period. It would make no sense for the West to attack the coup and yet, at the same time, equivocate on flagrant violations of due process and human rights. Both efforts are mutually inclusive and identifying such violations has the greatest potential to encourage policy reversals or corrective measures.

    Similarly understandable is the attention on Erdogan himself. He is the most formidable and powerful figure in a hierarchical and top-down political system, able to make fateful decisions with few effective checks and balances. He single-handedly replaced Ahmet Davutoglu as prime minister with Binali Yildirim in a clear breach of the Turkish constitution.

    Despite Erdogan’s tactical attempts at embracing all the opposition parties apart from the pro-Kurdish Peoples’ Democratic Party (HDP), his refusal to renounce his ambition to transform Turkey into a powerful executive presidency indicates that this fragile political unity will not last.

    Only the West has the wherewithal to moderate his policies by continuing to express its friendship with Turkey, whilst not shying away from closely monitoring, scrutinising and commenting on the post-coup developments.

    Contact Chatham House Feedback

    Join the conversation about this piece on Facebook




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    How to Make Sound Decisions with Limited Data During the Coronavirus Pandemic

    Thursday, April 2, 2020 - 13:00

    Coronavirus presents an unprecedented predicament: Everyday, leaders must make momentous decisions with life or death consequences for many—but there is a dearth of data. Oded Netzer is a Columbia Business School professor and Data Science Institute affiliate who builds statistical and econometric models to measure consumer behavior that help business leaders make data-driven decisions. Here, he discusses how leaders from all fields can make sound decisions with scarce data to guide them.




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    PARP-1-targeted Auger emitters display high-LET cytotoxic properties in vitro but show limited therapeutic utility in solid tumor models of human neuroblastoma

    The currently available therapeutic radiopharmaceutical for high-risk neuroblastoma, 131I-MIBG, is ineffective at targeting micrometastases due to the low linear energy transfer (LET) properties of high-energy beta particles. In contrast, Auger radiation has high-LET properties with nanometer ranges in tissue, efficiently causing DNA damage when emitted in close proximity to DNA. The aim of this study was to evaluate the cytotoxicity of targeted Auger therapy in pre-clinical models of high-risk neuroblastoma. Methods: Using a radiolabeled poly(ADP-ribose) polymerase (PARP) inhibitor, 125I-KX1, we delivered an Auger emitter iodine-125 to PARP-1: a chromatin-binding enzyme overexpressed in neuroblastoma. In vitro cytotoxicity of 125I-KX1 was assessed in nineteen neuroblastoma cell lines, followed by in-depth pharmacological analysis in a sensitive and resistant pair of cell lines. Immunofluorescence microscopy was used to characterize 125I-KX1-induced DNA damage. Finally, in vitro/in vivo microdosimetry was modeled from experimentally derived pharmacological variables. Results: 125I-KX1 was highly cytotoxic in vitro across a panel of neuroblastoma cell lines, directly causing double strand DNA breaks. Based on subcellular dosimetry, 125I-KX1 was approximately twice as effective compared to 131I-KX1, whereas cytoplasmic 125I-MIBG demonstrated low biological effectiveness. Despite the ability to deliver focused radiation dose to the cell nuclei, 125I-KX1 remained less effective than its alpha-emitting analog 211At-MM4, and required significantly higher activity for equivalent in vivo efficacy based on tumor microdosimetry. Conclusion: Chromatin-targeted Auger therapy is lethal to high-risk neuroblastoma cells with potential use in micrometastatic disease. This study provides the first evidence for cellular lethality from a PARP-1 targeted Auger emitter, calling for further investigation into targeted Auger therapy.