file

Generate LEF/GDS LayerMap File

I have a standard cell library containing LEF, GDS, and spice models but no OA views. I'm unable to import these files into Virtuoso without a LayerMap file. How can I obtain or generate this required LayerMap file?




file

Tool to create *.lib and *.db files for designs made in Innovus

Hi all, 

I have made a custom cell in Innovus that I will be instantiating into a bigger block, which I will also be using Innovus to do the Place & Route. 

I understand that I can generate a *.lef file and a *.lib file using Innovus. However, I need to also create a *.db file (these format of files are often used in DC Compiler synthesis tool). 

Is there a way to create the *.db file from Innovus? Or, is there a tool that I can use to create this *.db file? 

Thank you for your time. 




file

Find layer map file name and path for a library

I'm trying to write a generic piece of code that will return the layermap file location, with file name, for a variety of projects (which could potential have different layermap file naming conventions. The below code is what I've used to date, but this assumes the file name is xxxx.layermap. I can obviously do some string matching to find it, assuming the various files all contain some common characters. I thought I'd ask if there is a simpler way to find it, I know that this information is automatically loaded into the Xstream out gui, so maybe I can use the same approach to find it.

techLibName=techGetTechFile(cv)~>libName

techLibLayerMap=strcat(ddGetObj(techLibName)~>readPath "/" techLibName ".layermap")




file

Performing a net trace in a CDL file

Hi,

I am looking to perform a net trace in a CDL file.

There is a net at a lower level and would like to know the net it is connected to at the top level.

Please let me know if there is a way to analyze the CDL file to perform this net trace.

Thanks,

Mallikarjun.




file

read from text file with two values and represent that as voltage signals on two different port a and b

i want to read from text file two values  on two ports , i wrote  that  code, and i have that error that shown in the image below . and also the data in text file is shown as screenshot

 


module read_file (a,b);

electrical a,b;
integer in_file_0,data_value, valid, count0,int_value;


analog begin
@(initial_step) begin
in_file_0 = $fopen("/home/hh1667/ee610/my_library/read_file/data2.txt","r");

valid = $fscanf (in_file_0, "%b,%b" ,int_value,count0);
end

V(a) <+ int_value;
V(b) <+ count0;

end

endmodule




file

How to reuse device files for existing components

Have you ever encountered ERROR(SPMHNI-67) while importing logic? If yes, you might already know that you had to export libraries of the design and make sure that paths (devpath, padpath, and psmpath) include the location of exported files.  

Starting in SPB23.1, if you go to File > Import > Logic/Netlist and click on the Other tab, you will see an option, Reuse device files for existing components. 

After selecting this option, ERROR(SPMHNI-67) will no longer be there in the log file, because the tool will automatically extract device files and seamlessly use them for newly imported data. In other words, SPB_23.1 lets you reuse the device / component definitions already in the design without first having to dump libraries manually. An excellent improvement, don’t you think?  




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How to add wirebond profile to a die pin?

Starting SPB 23.1, a new pin property, WIREBOND_PROFILE_NAME is introduced. This property can be used to define a wirebond profile to a die pin. When adding a wirebond, the pin will use the profile defined in the WIREBOND_PROFILE_NAME property associated to the die pin.

Assign the WIREBOND_PROFILE_NAME property to the die pin using Edit > Properties and set the desired wirebond profile name in the Value field.

The following image displays the WIREBOND_PROFILE_NAME property assigned to the pin and wire profile of the Wire Bond for that pin.




file

Using oscillograph waveform file CSV as the Pspice simulation signal source

hi,

     I save the waveform file of the oscilloscope as CSV file format.

     Now, I need to use this waveform file as the source of the low-pass filter .

     I searched and read the PSPICE help documents, and did not find any  methods. 

     How to realize it?

     Are there any reference documents or examples?

     Thanks!

    




file

Path mapping for C Firmware source files when debugging

Hi,

i am compiling firmware under Windows transfer the binaries and the sources to Linux to simulate/debug there. The problem is that the paths in the DWARF debug info of the .elf file are the absolute Windows paths as set by the compiler so they are useless under Linux. Is it possible to configure mappings of these paths to the Linux paths when simulating/debugging like with e.g. GDB (https://sourceware.org/gdb/current/onlinedocs/gdb/Source-Path.html#index-set-substitute_002dpath)?

thx,

Peter




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Migrating from files Orcad Layout 16.2

I have managed to convert our old schematic and PCD file to from Layout 16.2 to 17.4

I have exported the footprints and moved them to the correct lib directory. 

I get no DRC errors and I can build a new netlist file. The problem is I can't get the PCB editor to update using the new netlist and get the following error:

I cannot figure out how to fix the Name is too long error. 

(---------------------------------------------------------------------)
(                                                                     )
(    Allegro Netrev Import Logic                                      )
(                                                                     )
(    Drawing          : 70055R2.brd                                   )
(    Software Version : 17.4S023                                      )
(    Date/Time        : Tue Dec 14 18:54:25 2021                      )
(                                                                     )
(---------------------------------------------------------------------)


------ Directives ------------

Ripup etch:                  Yes
Ripup delete first segment:  No
Ripup retain bondwire:       No
Ripup symbols:               IfSame
Missing symbol has error:    No
DRC update:                  Yes
Schematic directory:         'C:/AFS/70055 PCB Test 2'
Design Directory:            'C:/AFS/70055 PCB Test 2'
Old design name:             'C:/AFS/70055 PCB Test 2/70055R2.brd'
New design name:             'C:/AFS/70055 PCB Test 2/70055R2.brd'

CmdLine: netrev -$ -i C:/AFS/70055 PCB Test 2 -x -u -t -y 2 -h -z -q netrev_constraint_report.xml C:/AFS/70055 PCB Test 2/#Taaaaae57776.tmp

------ Preparing to read pst files ------

Starting to read C:/AFS/70055 PCB Test 2/pstchip.dat 
   Finished reading C:/AFS/70055 PCB Test 2/pstchip.dat (00:00:00.02)
Starting to read C:/AFS/70055 PCB Test 2/pstxprt.dat 
   Finished reading C:/AFS/70055 PCB Test 2/pstxprt.dat (00:00:00.00)
Starting to read C:/AFS/70055 PCB Test 2/pstxnet.dat 
   Finished reading C:/AFS/70055 PCB Test 2/pstxnet.dat (00:00:00.00)

------ Oversights/Warnings/Errors ------


#1   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'SW DPDT_9_SWITCH_OTTO_ALT_SW DPDT': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'SW DPDT_9_SWITCH_OTTO_ALT_SW DP' has library errors. Unable to transfer to Allegro.

#2   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'SW DPDT_10_SWITCH_OTTO_LIGHTS_SW DPDT': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'SW DPDT_10_SWITCH_OTTO_LIGHTS_S' has library errors. Unable to transfer to Allegro.

#3   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'SW DPDT_7_SWITCH_OTTO_ALT_SW DPDT': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'SW DPDT_7_SWITCH_OTTO_ALT_SW DP' has library errors. Unable to transfer to Allegro.

#4   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'SW DPDT_3_SWITCH_OTTO_MASTER_SW DPDT': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'SW DPDT_3_SWITCH_OTTO_MASTER_SW' has library errors. Unable to transfer to Allegro.

#5   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'SW DPDT_6_SWITCH_OTTO_LIGHTS_SW DPDT': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'SW DPDT_6_SWITCH_OTTO_LIGHTS_SW' has library errors. Unable to transfer to Allegro.

#6   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'SW DPDT_3_SWITCH_OTTO_MASTER_DPDT': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'SW DPDT_3_SWITCH_OTTO_MASTER_DP' has library errors. Unable to transfer to Allegro.

#7   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'CONNECTOR DB15_DSUBVPTM15_CONNECTOR DB15': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'CONNECTOR DB15_DSUBVPTM15_CONNE' has library errors. Unable to transfer to Allegro.

#8   ERROR(SPMHNI-176): Device library error detected.

ERROR(SPMHNI-189): Problems with the name of device 'CONNECTOR DB9_DSUBVPTM9_CONNECTOR DB9': 'Name is too long.'.

ERROR(SPMHNI-170): Device 'CONNECTOR DB9_DSUBVPTM9_CONNECT' has library errors. Unable to transfer to Allegro.

#9   ERROR(SPMHNI-175): Netrev error detected.

ERROR(SPMHDB-195): Error processing 'M6': Text line is outside of the extents..

------ Library Paths ------
MODULEPATH =  . 
           C:/Cadence/SPB_17.4/share/local/pcb/modules 

PSMPATH =  . 
           symbols 
           .. 
           ../symbols 
           C:/Cadence/SPB_17.4/share/local/pcb/symbols 
           C:/Cadence/SPB_17.4/share/pcb/pcb_lib/symbols 
           C:/Cadence/SPB_17.4/share/pcb/allegrolib/symbols 
           C:/Cadence/SPB_17.4/share/pcb/pcb_lib/symbols 

PADPATH =  . 
           symbols 
           .. 
           ../symbols 
           C:/Cadence/SPB_17.4/share/local/pcb/padstacks 
           C:/Cadence/SPB_17.4/share/pcb/pcb_lib/symbols 
           C:/Cadence/SPB_17.4/share/pcb/allegrolib/symbols 
           C:/Cadence/SPB_17.4/share/pcb/pcb_lib/symbols 


------ Summary Statistics ------


#10  Run stopped because errors were detected

netrev run on Dec 14 18:54:25 2021
   DESIGN NAME : '70055R2'
   PACKAGING ON Nov  2 2021 14:32:04

   COMPILE 'logic'
   CHECK_PIN_NAMES OFF
   CROSS_REFERENCE OFF
   FEEDBACK OFF
   INCREMENTAL OFF
   INTERFACE_TYPE PHYSICAL
   MAX_ERRORS 500
   MERGE_MINIMUM 5
   NET_NAME_CHARS '#%&()*+-./:=>?@[]^_`|'
   NET_NAME_LENGTH 24
   OVERSIGHTS ON
   REPLACE_CHECK OFF
   SINGLE_NODE_NETS ON
   SPLIT_MINIMUM 0
   SUPPRESS   20
   WARNINGS ON

 10 errors detected
 No oversight detected
 No warning detected

cpu time      0:00:27
elapsed time  0:00:00




file

Allegro 17.4 always reports new files as created in 17.2

Hello. I am using Cadence 17.4 tools. When I open a package symbol (.dra) or board file (.brd) in Allegro that was created in an older version of the tool I get a message like this one (as expected):

"The design created using release 17.2 will be updated for compatibility with the current software..."


If I create a symbol or board file from scratch in the 17.4 tool then open it later, I get the same message. (always referring to version 17.2 which is the previous version I was using here).

So far this has not caused me any problems, but I would like to understand why it is doing this in case I have something setup incorrectly.

I only have version 17.4 installed. I am not exporting to a downrev version when I save (i.e. not using File->Export->Downrev design…) and in User Preferences->Drawing I don’t have anything selected for database_compatibility_mode. What else might I check?

FYI here is the tool version information that I see after selecting Help->About Symbol:

OrCAD PCB Designer Standard 17.4-2019 S012 [10/26/2020] Windows SPB 64-bit Edition


Thanks -Jason




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Import LEF file failed due to layermap

Hi,

I have a LEF file with simple definitions of pad design which uses M8, M9, and AP layers. However, I failed to import the design with CIW > Import > LEF... as I encountered "ERROR: (OALEFDEF-90019): Ignoring the line 30 in the layer map file ... as it contains a syntax error. Each entry in the layer map file must have two values, LEFLayerName and OALayerNumber separated by a blank space." All lines in the file report the same OALEFDEF-90019 error.

The tech.layermap file looks like this:


# techLayer       techPurpose     stream# dataType

ref drawing 0 0
DNW drawing 1 0
PW drawing 2 0




file

error when generating snp files from a variable

Hello everyone, 
I have a testbench for generating s2p files from a SP simulation that was working until few months ago. Today I have reopened (w/o making changes that I am aware of) and I get the error as shown below:

first I show the testbench settings:

notice how the s2p generation is disabled: the field "file" is left blank

in the corner I defined some parameters, "filename" is the word that is suppose to generate the name for the s2p. 

where the two variables are defined as follows

And now the output log:

spectre.out file gives the following error:


When clicking on the error message at "9", the input.scs file opens up and the line 9 gets highlighted in green



now, so far I understood that the problem seem to be related tom the "pathcds" variable, but I really don't understand what the error message here means, since I don't see any error in the input.scs file

by the way - if for instance I define the variable "filename" as shown below, then I get no errors:


thanks
Tommaso




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Tagging uvm_errors in waveform file for post-processing

Hi,

Do anyone know if it's possible in simvision waveform viewer to see a timestamp of where uvm_errors/$errors occurred in a simulation via post-processing? 

Cheers,

Antonio




file

Specman Makefile generator utility

I've heard lots of people asking for a way to generate Makefiles for Specman code, and it seems there are some who don't use "irun" which takes care of this automatically. So I wrote this little utility to build a basic Makefile based on the compiled and loaded e code.

It's really easy to use: at any time load the snmakedeps.e into Specman, and use "write makefile <name> [-ignore_test]".
This will dump a Makefile with a set of variables corresponding to the loaded packages, and targets to build any compiled modules.
Using -ignore_test will avoid having the test file in the Makefile, in case you switch tests often (who doesn't?).

It also writes a stub target so you can do "make stub_ncvlog" or "make stub vhdl" etc.

The targets are pretty basic, I thought it was more useful to #include this into the main Makefile and define your own more complex targets / dependencies as required.

The package uses the "reflection" facility of the e language, which is now documented since Specman 8.1, so you can extend this utility if you want (please share any enhancements you make).

 Enjoy! :-)

Steve.




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help with automating adding CLP files to DRA files

Question for forum:
I’m currently working on a code to automatically add CLP files to DRA files and then add two classes called “APPROVED” and “CLP”. To do this manually you have to open a DRA file, click file import subdrawing and choose the clp file with the same name as dra. (path already set). You then set the clp to position x 0 0. And then click on Set Up > Subclasses > Package geometry and type in “Approved” and “Clp.”
So far we’ve recorded the macros in Allegro for all of these actions. The macros correspond to one specific file name and we want to apply this to numerous files. To do this we created a python program that locates all of the specified CLP and DRA files, and if they have a matching name, runs a for loop that puts each file name into a stored variable that runs a loop for each file. We converted this script into batch and then added a function that we thought would run Allegro macros from batch.
In order to get the script working, we need to have an allegro batch command that will run the script without opening the Allegro start popup, or closing the popup when it appears.  We need to do this to run any script from starting Allegro.
I’ve done another similar program in batch where I made a for loop for each dra file and within the loop there was a batch a2dxf command that converted all dra files to dxf files. Is there a similar batch command for adding clp files to position 0 0 and/ or adding classes? If anyone has done something similar please let me know!
Thank you very much for the help.
Jen




file

nport device S-parameter data file relative path

Hi,

In our design team, we're looking for a strategy to make all cell views self-contained. We are struggling to do so when nport devices are involved.

The nport file requires a full path, whereas what we need is a relative path to the current path of the cell in which we're using the nport.

I have browsed through the forums & cadence support pages, but could not find a solution.

1) There is a proposal from Andrew to add the file directory in ADE option "Simulation Files." :https://community.cadence.com/cadence_technology_forums/f/rf-design/27167/s-parameter-datafile-path-in-nport . This, however, is not suitable, because the cell is not self contained.

2) The new cadence version off DataSource "cellView" in nport options:

This however is not suitable for us due to two reasons:

i- Somehow we don't get this option in the nport cell (perhaps some custom modification from our PDK team)

ii- Even if we had this option, it requires to select the library, which again makes it unsuitable: We often copy design libraries for derivative products using "Hierarchical Copy" feature. And when the library is copied, the nport will still be pointing to the old library. Thus, it is still not self-contained.

In principle, it should not be difficult (technically) to point to a text file relative to the cell directory (f.ex we can make a folder under the same cell with name "sparFiles" & place all spar files under this folder), however it does not seem to be possible.

Could you perhaps recommend us a work-around to achieve our goal: making the cells which contain nport devices self-contained so that when we copy a cell, we do not have to update all the nport file destinations ?

Thanks in advance.

My Cadence Version: IC23.1-64b.ISR4.51

My Spectre version: 23.1.0.362.isr5




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Virtuoso Meets Maxwell: Getting Your Existing SiP File Into Virtuoso RF Solution

I have been involved in the Virtuoso RF Solution for the last four years. Most of the customers I work with have a SiP package already in progress. They often ask "How do I get my SiP design into Virtuoso RF Solution?" I am excited about new functionality in the latest ICADVM20.1 ISR25 release. It is a new GUI under the Tools menu called Enablement. (read more)




file

how can load the Dll files and use it in Allegro 16.6

Hello everyone!

Have you ever used the axlDllOpen function for Allegro 16.6?

It doesn't work for me. Please give me your solution.
Thank you.

HoangKhoi




file

Allegro PCB Router quit unexpectedly with an exit code of -1073741701. Also, nothing is logged in log file.

Has anyone experienced the same situation?




file

Upload Files from Ionic Angular to Firebase Storage.

Nowadays Google Firebase is my most favorite application. This is offering great web solutions like hosting, authentication, storage and database in a simple way. This article explains how to upload images(supports video) into Firebase storage with Ionic and Angular applications. This covers the user authentication part to protect storage uploads and improving default Firebase security rules. Take a look at the quick demo and try to upload under 1 mb JPEG or PNG.





file

Setup SSH authentication with PEM RSA file without password on ubuntu/linux Raspberry Pi Server

Recently I have been working with Raspberry PI and creating my own home server to host some of my demo projects. This post is about setting up SSH authentication with a PEM certificate file without password on ubuntu/linux server. Implement the following steps and improve the security.





file

FileJump's 2TB cloud storage plan is only £70 for life

FileJump's 2TB Cloud Storage Lifetime Subscription is a permanent solution for file storage, and it's on sale for £69.82 (reg. £366.34).




file

Andrew files claims against accuser

A LAWYER for Britain’s Prince Andrew on Tuesday questioned whether Virginia Giuffre is legally entitled to pursue her civil lawsuit accusing the Duke of York of sexually abusing her when she was under




file

PTI files curative review with SC in ‘bat’ symbol case

ISLAMABAD: As a last resort after losing the election symbol, PTI on Tuesday filed a curative petition with the Supreme Court, seeking to overturn the Jan 13 and Oct 21 rulings that supported the Election Commission of Pakistan’s decision to deny the party its ‘bat’ symbol.

The curative petition is a final remedy that allows the SC to reconsider a dismissed review petition.

The 32-page petition, moved by Advocate Ajmal Ghaffar Toor, says the present petition has been necessitated by circumstances during the hearing and therefore based upon the principle of natural justice.

Besides the verdict is per incuriam and not a judgement at all, argued the petition, adding the petition was relying upon the Aug 22 Mubarak Ahmed Sani case in which the Supreme Court had altered its earlier decision.

Judgement was per incuriam, 32-page petition argues

The petition argues that the judgement was per incuriam, meaning it was made in ignorance of the terms of a statute or rule having the force of a statute. A decision made per incuriam can be considered a mistake and may not be binding.

The petition also relied on the Aug 22 Mubarak Ahmed Sani case, where the SC had altered its earlier decision, setting a precedent for revisiting previous judgements.

On Oct 21, the SC headed by former chief justice Qazi Faez Isa rejected PTI’s petition, seeking to revisit Jan 13 verdict in the bat symbol case.

The review petition was dismissed on the grounds that no illegality or material error in the judgement was pointed out by the petitioner.

During the case, the senior counsel Hamid Khan had pleaded before the apex court that he did not want to argue before a bench headed by a person who “harbours bias against PTI”.

It is the case of the petitioner that both judgements of Jan 13 and Oct 21 were void and non-existent in the eyes of law. The petition has raised questions of public importance with respect to fundamental rights and interpretation of the laws relating to the electoral rights of the people who were true sovereigns, by seeking to invite SC’s attention towards two of its own judgments, the curative review says.

On May 26, 2021, PTI had moved a curative review petition before the SC against Justice Isa who had won a case on a review petition. Then the curative review petition was moved against the majority order in favour of Justice Isa.

Later on July 21, 2023, ex-CJP Umar Ata Bandial rejected in chambers PTI’s curative review petition against Justice Isa whereas Justice Syed Mansoor Ali Shah in his additional note stated that a second review or a curative review or whatever given name, was not maintainable under Article 188 since this provision envisages only one-time exercise of this jurisdiction, whether made on a review petition or suo motu in respect of any of its judgments.

Now the fresh curative petition pleads that the SC judgment of Oct 21 was virtually an ex-parte order as no substantive hearing took place in view of the objections raised against former CJP Qazi Faez Isa and therefore it would serve the interest of justice that the judgement was set aside and the review petition was fixed for hearing again.

The curative review argued that both Justice Muhammad Ali Mazhar and Justice Musarrat Hilali, who were members of the bench which heard the review petition then, signed allegedly a blatantly biased orders, dictated by then CJP and therefore they have disqualified themselves from hearing the present petition.

Published in Dawn, November 13th, 2024




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Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough?

Background

Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic cough. This study aimed to compare symptom features, such as cough triggers and associated throat sensations, of cough hypersensitivity in patients with asthmatic chronic cough and those with refractory chronic cough (RCC).

Methods

Patients with chronic cough from the Korean Chronic Cough Registry were prospectively evaluated over 6 months. Physicians determined the aetiological diagnosis based on clinical evaluations and responses to treatment at the 6-month follow-up visit. Symptoms of cough hypersensitivity and cough-specific quality of life were assessed using the Cough Hypersensitivity Questionnaire (CHQ) and the Leicester Cough Questionnaire (LCQ), respectively.

Results

The analysis included 280 patients who completed the follow-up: 79 with asthmatic cough (cough variant asthma or eosinophilic bronchitis) and 201 with RCC. Baseline CHQ scores were similar between the groups (8.3±3.7 in asthmatic cough versus 8.9±3.9 in RCC; p=0.215, adjusted for age, sex and LCQ score). There were no significant between-group differences in the LCQ and cough severity Visual Analog Scale scores. Both groups showed a similar negative correlation with LCQ scores (asthmatic cough: r=–0.427, p<0.001; RCC: r=–0.306, p<0.001).

Conclusions

The symptoms of cough hypersensitivity may not distinguish between asthmatic cough and RCC. This suggests that chronic cough is the primary diagnosis in both phenotypes. It indicates a shared mechanism in their cough pathogenesis, despite having potentially different treatable traits.




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Investigations into the Concentrations and Metabolite Profiles of Doping Agents and Antidepressants in Human Seminal Fluid Using Liquid Chromatography-Mass Spectrometry [Articles]

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

SIGNIFICANCE STATEMENT

This study demonstrates that doping agents as well as clinically relevant substances are transferred/eliminated into seminal fluid to a substantial extent and that knowledge about drug levels (and potential consequences for the male fertility and female exposure) is limited. The herein generated new dataset provides new insights into an important and yet little explored area of drug deposition and elimination, and hereby a basis for the assessment of contamination cases by seminal fluid in sports drug testing.




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Nonclinical Profile of PF-06952229 (MDV6058), a Novel TGF{beta}RI/Activin Like Kinase 5 Inhibitor Supports Clinical Evaluation in Cancer [Drug Discovery and Translational Medicine]

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

SIGNIFICANCE STATEMENT

Only a few TGFβRi have progressed for clinical evaluation due to adverse cardiac findings in pivotal nonclinical toxicity studies. The potential translations of such findings in patients are of major concern. Using a carefully optimized intermittent dosing schedule, PF-06952229 has demonstrated impressive pharmacological efficacy in the syngeneic MC38 colon carcinoma mouse model. Additionally, a nonclinical toxicology package without cardiovascular liabilities and generally monitorable toxicity profile has been completed. The compound presents an acceptable International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use S9-compliant profile for the intended-to-treat cancer patients.




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You Have Less Than a Week to File a Claim for Cash App’s $2,500 Payouts



The deadline to claim part of the $15 million Cash App settlement is November 18. Here's what to know.



  • Privacy and Security

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Cops access ex-model’s file 1400 times

A FORMER bikini model has lodged a formal complaint with the Queensland Police Service after officers accessed her personal file more than 1400 times.




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India's Hindus bathe in holy river defiled by pollution

New Delhi (AFP) Nov 7, 2024
Sweeping aside thick toxic scum, thousands of Hindu devotees ignored court warnings Thursday against bathing in the sacred but sewage-filled Yamuna river, a grim display of environmental degradation in India's capital. Thousands celebrated the festival of Chhath Puja for the Hindu sun god Surya, entering the stinking waters to pray as the evening rays set in the sky. A parliamentary repo




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File menu options in SAS Visual Analtyics Viewer

SAS admins need to know about these menu options that may not be available in SAS Visual Analytics Viewer.




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David Duchovny and Gillian Anderson didn't speak to each other for 'weeks at a time' while working on The X Files

David Duchovny and Gillian Anderson didn't speak to each other for "weeks at a time" when they worked on The X Files. The 64-year-old actor and Gillian, 56, enjoyed huge success with the iconic sci-fi series — but the duo actually had a turbulent relationship for many years. David said on the Fail Better podcast: "There was a long time, working on the show, where we were just not even dealing with one another off-camera. And there was a lot of tension. Which didn't matter, apparently, for the work cause we're both f****** crazy, I guess. We could just go out there and do what we needed to do." Gillian was amazed that they achieved so much success while their off-screen relationship was so tense.





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Date of online acknowledgement of appeal filed be considered as the date of filing appeal

The Hon'ble Karnataka High Court in the case of Hitachi Energy India Ltd. v. State of Karnataka and Ors. [Writ Petition No. 14111 of 2024 dated July 02, 2024] allowed the writ petition and further affirmed that the date of provisional acknowledgment for appeal filed would be considered as the date o




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Madras HC directs Department to hear appeal on merits filed beyond condonable period

The Hon'ble Madras High Court, in the case of M/s Sri Shanmuga Motors v. State Tax Officer [Writ Petition No. 11737 of 2024 dated June 03, 2024] had set aside the Appellate Order and directed the Department to hear the appeal on merits which has been filed beyond the condonable period for filing of






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Healthy Mouth Balances Metabolic Profiles (and) Cuts Cardiometabolic Risk

A new study reveals oral health issues such as common oral infections, periodontal diseases, and caries are linked to inflammatory metabolic profiles




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Personality Profiles Linked to Physical Activity and Health in Older Adults

A study by the Gerontology Research Centre and the Faculty of Sport and Health Sciences at the University of Jyvaskyla found associations between personality




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Karnataka Govt Files FIR Against Tejasvi Surya Over Waqf-Related Social Media Post

The Karnataka government filed an FIR against BJP National Youth President and MLA Tejasvi Surya for posting a message, based on a media report, on his social media handle alleging suicide by a farmer eight years ago after the Waqf Board issued a notice claiming ownership of his property.




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ACB Files Case Against Female Officer for Alleged Corruption In Livelihood Generation Scheme

While self-employment schemes in Jammu and Kashmir aim to support youth employment, allegations of corruption have surfaced. Anti-graft panel registered an FIR against former Assistant Director Employment Shabnam Arif Mir and others for allegedly accepting bribes from a local dealership.




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Essential Strategies for Secure File Sharing in the Digital Age

In the digital age, sharing files online is a common necessity. However, ensuring safety while doing so is crucial. Tech enthusiasts in India and beyond must be aware of the risks and best practices for secure file sharing. This article delves




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Instagram Launches Profile Card Feature For Enhanced User Connections: Here's How to Use it

Instagram has introduced a "profile card" feature, acting as a digital business card for users. This launch follows months of testing with selected creators. The feature aims to simplify sharing Instagram profiles, eliminating the need to send handles manually. Users can




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Privacy in Peril? X Rolling Out New Block Feature That Lets Blocked Users View Profiles

X, the platform once known as Twitter, recently began rolling out a new version of its block function, prompting significant user concern. The change, first announced by company owner Elon Musk in September, allows blocked users to view the profiles, posts,




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Yash's 'Toxic' Faces Legal Trouble: Forest Department Files Case Against Makers For Illegal Tree Felling

The Karnataka Forest Department has filed an FIR against the producers of Yash's 'Toxic' and officials from Canara Bank and HMT for allegedly cutting down trees on forest land during the film's shoot in Bengaluru.




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Yash's Toxic in trouble? FIR filed against producers of KGF star's upcoming actioner for illegal...

Yash's upcoming film Toxic has landed in trouble over the alleged axing of trees on forest land in Bengaluru. Read on to know more details about the same.




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The Origins of P : Literary Profiles and Strata of the Priestly Texts in Genesis 1 - Exodus 40 [Electronic book] / Jürg Hutzli.

[s.l.] : Mohr Siebeck GmbH & Co. KG, 2023.




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Alterations of the chemical profile of cholesterol in cancer tissue as traced with ToF-SIMS

Analyst, 2024, 149,5344-5352
DOI: 10.1039/D4AN01050G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Auraya Manaprasertsak, Julhash U. Kazi, Catharina Hagerling, Kenneth J. Pienta, Per Malmberg, Emma U. Hammarlund
This study uses Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) to analyze cholesterol alterations in cancer tissue, revealing changes in fragmentation and isotopes that suggest potential diagnostic vulnerabilities.
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Simulated conformality of atomic layer deposition in lateral channels: the impact of the Knudsen number on the saturation profile characteristics

Phys. Chem. Chem. Phys., 2024, Advance Article
DOI: 10.1039/D4CP00131A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christine Gonsalves, Jorge A. Velasco, Jihong Yim, Jänis Järvilehto, Ville Vuorinen, Riikka L. Puurunen
Systematic analysis of saturation profile characteristics allowed development of an extended slope method that relates the slope of the adsorption front to the sticking coefficient for any Knudsen number.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry