Henry Barajas' Death To Pachuco , a Chicano noir set in the Zoot Suit Riots, is now live on Kickstarter

1. Cindy Crossthwaite's estranged husband faces Supreme Court murder trial over mother of three's death  ABC News
2. 'Deep-seated hatred' for estranged wife led to killing, jury told  9News
3. 'Deep-seated hatred' for estranged wife led to killing, court hears  9News

Death Stranding Director’s Cut - PlayStation 5 $10.00

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One of the oldest conspiracy and 'black helicopter' frauds is now facing the hand of the law. Alex Jones is reaping what he sowed.

During a portion of his Info Wars program, Alex Jones lamented over how his show is being stripped and sold off after a just verdict against him for his lies about Sandy Hook victims and their families.

A verdict he described as a "Nazi show trial."

Sucks to be you, Alex. And it couldn't happen to a more deserving guy.

JONES: InfoWars, the equipment, InfoWars.com, InfoWarsStore.com, and a whole bunch of other stuff is at a federal bankruptcy auction from the fake judgments and the rigged trials where I was found guilty beforehand and they had literal show trials out of the Soviet Union or Nazi Germany.

Robin, I walked in here during the break after getting a glass of water, saw the auctioneers inside the building, going around surveying from the last time they were here to make sure all the stuff's here. Everything tagged, everything marked, this death.

Good riddance, you motherfrakker.

Rudy Giuliani is trying to avoid the same fate.

We need more of these creeps to face the same punishment.

read more

By Matt Solomon Published: November 12th, 2024

Elite players are taking fewer shots from further out. What is behind the trend and is it harming the game?

Sinwar, who topped Israel's most-wanted list, was a key figure believed to have been behind the 7 October attacks.

The near death and uncertain future of the US National Security Council 27 January 2023 — 9:00AM TO 10:00AM Anonymous (not verified) 9 January 2023 Chatham House

What role should the US National Security Council play in an era of great power competition?

Please plan to arrive at Chatham House from 08:45 GMT as the event will begin promptly at 09:00 GMT

Over the last three years, the US National Security Council (NSC) has gone from being neglected to necessary again, in Washington.

After former US President Donald Trump ignored and then tried to dismantle the NSC, current US President Joe Biden has restored the body but chosen not to reform it.

Born in the days before the Cold War and empowered during the War on Terror, what role should the NSC play in an era of great power competition?

Plus, how must it, and the rest of Washington, evolve to meet the challenges and opportunities that remain in the 21st century?

Sinwar’s death does not make Hamas–Fatah reconciliation more likely, whoever his successor may be Expert comment jon.wallace 22 October 2024

The killing may aid Hamas recruitment – but it will not make agreement with Fatah any easier to achieve.

Western political leaders were quick to argue that Israel’s killing of Hamas leader Yahya Sinwar on 17 October presented an opportunity for a ceasefire in Gaza and the return of Israeli hostages.

US President Joe Biden immediately called on Israeli prime minister Benjamin Netanyahu to seize the moment to negotiate, now that Israel has achieved one of its war aims.

However, that ‘moment’ has already passed. Israel’s military assault on Gaza has intensified since Sinwar was killed, leading UN Peace Process Co-ordinator Tor Wennesland to say that ‘nowhere is safe in Gaza’. It is abundantly clear Netanyahu is intent on further degrading Hamas, resetting a new ‘power balance’ and carving out a buffer zone, no matter the cost in Palestinian lives or Israeli hostages. 

But there are other implications of Sinwar’s assassination beyond the zero-sum analysis of will there or won’t there be a ceasefire.

Hamas’s ability to fight

At present, everyone has an opinion on how Sinwar’s killing will affect Hamas and its ability to resist and respond to Israel’s military. His death will have been a major blow – symbolically, operationally, and psychologically. Hamas has been downgraded and its capacity to respond compromised.

But it will recover, regenerate and retaliate in time – and Sinwar’s death will have been no surprise to Palestinians in Gaza or elsewhere. Hamas is accustomed to seeing its leaders assassinated. Since its formation in 1987, it has been ‘decapitated’ many times, only to continue with its mission to ‘liberate Palestine’.

Hamas’s portrayal of Sinwar dying in his fatigues, head wrapped in a keffiyeh and resisting until the end will persuade many young Palestinians that he died as a martyr serving the Palestinian cause. Many will be inspired to join and fortify the ranks of Hamas as a result.

The IDF’s release of drone footage showing Sinwar’s last moments will have done nothing to undermine his credibility. 

On the contrary, it will serve as a rallying call to disaffected and disenfranchised young Palestinians horrified by Israel’s bombing of civilian targets in Gaza and disaffected with Fatah’s inability to prevent Israeli settler expansion and violence in the West Bank.

Reconciliation

Some hope that if Sinwar is replaced by a more ‘moderate’ leader, his killing may smooth the path to Hamas–Fatah reconciliation – and that this could provide a foundation for a patchwork political solution when Israel and Gaza arrive at the ‘day after.’  

But the idea that a downgraded and ‘leaderless’ Hamas will be susceptible to international pressure to reconcile with Fatah is divorced from reality.  

Prospective new Hamas leaders such as Khaled al Meshaal and Khalil al-Hayya are based in Qatar. 

They may be more pliable to external pressure to reconcile with Fatah in search of a political outcome, but their ability to influence events on the ground in Gaza will be limited. That was demonstrated by the Sinwar-orchestrated attacks on 7 October 2023, which took place without the blessing of the exiled leadership in Doha.

Hamas has long gone to ground in Gaza and become far more decentralized than it was before 7 October. It is now more typical of an insurgency, where Hamas cadres exercise a great degree of operational autonomy.

In other words, the disconnect between Hamas in Gaza and its political leadership in Qatar has only grown wider since this round of conflict started.

International efforts

That will undermine international efforts made by Qatar, Egypt, Saudi Arabia, China, Russia and others to bring about a reconciliation. Moscow and Beijing already hosted reconciliation talks in February and April early this year but made no progress in closing the chasm between the two parties. Saudi Arabia has also hosted talks.

The three Arab states, none of which have so far commented publicly on Sinwar’s killing, will likely view his death as an opportunity to bolster the political wing of Hamas – backing it with pledges of political, diplomatic and financial support.

Saudi Arabia and Egypt will have next to no influence over the succession process, but Qatar’s long-established relationship with the political wing of Hamas affords it leverage over the organization, albeit limited. They may be able to strengthen the hand of those based in Doha by promising to work harder at securing a ceasefire, guaranteeing the provision of humanitarian relief, and working towards a political solution.

Nica M. Borradaile
Dec 1, 2006; 47:2726-2737
Research Articles

Saverio Cinti
Nov 1, 2005; 46:2347-2355
Research Articles

An out-of-body experience is the inspiration behind Benzly Hype's latest album Star Its The 7th Year. Released on November 7, the entertainer said the project was done to bring back joy in music and will leave its listeners in an upbeat mood....

The EGFR tyrosine kinase inhibitor gefitinib is commonly used for lung cancer patients. However, some patients eventually become resistant to gefitinib and develop progressive disease. Here, we indicate that ecto-ATP synthase, which ectopically translocated from mitochondrial inner membrane to plasma membrane, is considered as a potential therapeutic target for drug-resistant cells. Quantitative multi-omics profiling reveals that ecto-ATP synthase inhibitor mediates CK2-dependent phosphorylation of DNA topoisomerase IIα (topo IIα) at serine 1106 and subsequently increases the expression of long noncoding RNA, GAS5. Additionally, we also determine that downstream of GAS5, p53 pathway, is activated by ecto-ATP synthase inhibitor for regulation of programed cell death. Interestingly, GAS5-proteins interactomic profiling elucidates that GAS5 associates with topo IIα and subsequently enhancing the phosphorylation level of topo IIα. Taken together, our findings suggest that ecto-ATP synthase blockade is an effective therapeutic strategy via regulation of CK2/phospho-topo IIα/GAS5 network in gefitinib-resistant lung cancer cells.

Afonso Dhlakama’s Death Changes the Calculation for Peace Prospects in Mozambique Expert comment sysadmin 4 May 2018

If politicians continue to act in good faith, the death of the opposition leader may be a significant opportunity to finally draw a line under Mozambique’s long war.

The unexpected death of opposition and ex-rebel leader Afonso Dhlakama on 3 May is a game changer for Mozambique’s politics and an almost-completed peace process. The 65-year old Dhlakama, who died of a heart attack, had led Renamo for 38 years and had totally dominated his party. Dhlakama regularly boasted that he was Mozambique’s ‘father of democracy’, despite not allowing competition within his own party, and he leaves a legacy of more than 30 years of struggle, through both armed action and peaceful politics.

A long war

Originally Renamo had been a tool for the white minority regimes of Rhodesia and apartheid South Africa to challenge the socialist Frelimo political party that took power in Mozambique in 1975. But under Dhlakama’s command, by the late 1980s Renamo had become increasingly independent and rooted in Mozambique. After Renamo’s long war with Frelimo ground to a hurting stalemate, a transition led to Mozambique’s first multiparty elections in 1994, and the creation of a new joint army. A ‘pay and scatter’ programme successfully dispersed and reintegrated many thousands of ex-combatants.

But early post-election gains did not translate to lasting peace. Disarmament was a time-limited, technical process, and devoted declining resources and attention to clusters of ex-combatants that failed to disperse. In addition, Dhlakama was allowed to maintain an armed militia under the guise of a presidential guard.

Mounting economic inequality, notably in opposition strongholds such as central Mozambique, saw Renamo made political gains and Dhlakama nearly won the 1999 presidential elections. (Some believe he did.) The result focused Frelimo’s attention on the threat that Renamo posed and, ultimately, a strategy of pursuing total Frelimo domination across the country, culminating in a crushing Frelimo victory at the 2009 elections.

This humiliated and marginalized former Renamo rebels, resulting in Dhlakama ordering their return to targeted armed violence in 2013. Frelimo’s new leader, President Filipe Nyusi, took power in 2015 and sought direct dialogue with Dhlakama. Five rounds of internationally mediated peace talks took place from July to December. Finally, in late December 2016, Dhlakama announced a unilateral truce, which was extended twice and subsequently made indefinite.

New peace talks also started and, in August 2017 and February 2018, President Nyusi and Dhlakama showed the courage to meet in person, near Renamo’s base in central Mozambique, to build up mutual trust and discuss the details of the emerging peace deal – including the demobilization or integration into government security forces for Renamo’s now mostly middle-aged gunmen.

Dhlakama the ‘Big Man’

Dhlakama’s sudden death has fundamentally changed the negotiation dynamics. He never allowed for any serious succession planning, and ensured all key decisions were his and his alone. Renamo had already decided that he would be its presidential candidate for the 2019 national elections.

His party is significantly weakened by his death and unlikely able to fully recover – but needs to try and reach consensus quickly on a successor, as it will also compete in municipal elections in October and was expecting significant gains. There will be a number of contenders to succeed him including from the parliamentary wing, led by his niece Ivone Soares, its secretary general, Manuel Bissopo, and a few others.

But Renamo’s key leverage for now remains some 1,000 middle-aged gunmen in central Mozambique who have been stoically loyal to Dhlakama since the 1980s and who have little respect for the younger generation of professional politicians based in Maputo. Some may be bought off by government offers, others integrated into localised organized crime groups and others into internal Renamo sectarianism. The risk of fragmentation is real.

Renamo’s weakness could also embolden Frelimo hardliners to seek a return to unilateral domination of Mozambique’s political landscape, and to undermine the peace process. That would be a serious tactical mistake by Frelimo, as a lasting deal is close and the death of Dhlakama could actually assist in making this settlement lasting. Dhlakama was quixotic and prone to changing his mind, often influenced by the last person he spoke to – his death potentially introduces greater predictability in negotiations and in any post-deal implementation.

President Nyusi is clearly aware of this as he hailed on state television TVM that Dhlakama was ‘a citizen who has always worked for Mozambique’ and said he was distraught at the news of his death. He stated, ‘I hope that we as Mozambicans can continue to do everything so things do not go down.’ He also addressed Renamo’s support base by saying that ‘[Dhlakama] did everything so that there would be peace. The last time he spoke to me, he said he was not going to miss out anything in peace negotiations.’

Renamo’s gunmen are fatigued and want to retire with dignity but are vulnerable to manipulation and political miscalculation by Mozambican’s positioning politicians. International partners and investors can engage, by emphasizing that sustainable peace is the only pathway to poverty reduction and inclusive economic development.

This includes assisting development and reconciliation projects in areas impacted by the renewed conflict since 2013. Long-term investment for development in Renamo’s key constituencies could help avoid fragmentation at a critical time – faith groups and NGOs may also have a key role to play.

If Mozambique’s politicians continue to act in good faith, the death of Dhlakama may constitute a significant opportunity to finally draw a line under Mozambique’s long war.

Deaths from cardiovascular disease have surged among adults ages 25 to 64 living in rural areas, a new study shows.

Kevin Costner says he didn't know about his "Yellowstone" character John Dutton's death until after the episode aired on Sunday.

As the bizarre becomes ordinary, don't forget what's at stake for America's teachers during the COVID-19 pandemic, writes Justin Minkel.

The shooting death of a 10-year-old spectator at a high school football game exposes a critical vulnerability and crucial responsibility for schools: keeping people safe at events outside school buildings.

A Tallahassee, Fla., K-8 school is mourning two staff members and a former employee. All of them recently died from the virus.

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

The Black Death of 1348 was a devastating event, wiping out half the population of Britain. And in churches like this one, drawings on the wall provide a haunting visual record of the scale of the tragedy.

Uncover the dark and curious truth behind the death of one of America's most beloved authors, Edgar Allan Poe. For centuries, the circumstances surrounding his death have remained shrouded in mystery, sparking endless speculation and debate. Was it murder, disease, or something even more sinister? ___ A little more information: In 1849, Edgar Allan Poe was found delirious on the streets of Baltimore. He was taken to a hospital but died four days later, with no clear explanation for his condition. Theories about his demise range from alcoholism to rabies to a neurological disorder. Some suggest a more sinister plot, involving foul play or a conspiracy. Despite extensive speculation, Poe's death ultimately remains an enigma, adding to the haunting allure of his literary legacy. #unsolvedmysteries #gothicliterature #theraven #edgarallanpoe #truecrime #Smithsonianmagazine Subscribe: https://www.youtube.com/@SmithsonianMagazine Read more about the mystery of Edgar Allan Poe’s death here: https://www.smithsonianmag.com/history/still-mysterious-death-edgar-allan-poe-180952936/ How did Edgar Allan Poe become such a prolific and popular storyteller, even after his death? Learn more about his history here: https://www.smithsonianmag.com/arts-culture/edgar-allan-poe-became-era-premier-storyteller-180971001/ For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Get More Smithsonian Magazine: Official Site: https://www.smithsonianmag.com/ Facebook: https://www.facebook.com/smithsonianmagazine/ X: https://x.com/smithsonianmag Instagram: https://www.instagram.com/SmithsonianMagazine/ Digital Editorial Director: Brian Wolly Director of Programming: Nicki Marko Manager of Programming: Michelle Mehrtens Scriptwriter: Dan Wolf Video Editor and Narrator: Adam Benavides

In WW2, the British made destroying German dams a key strategic target in order to kneecap the German industrial effort. To accomplish this, they needed a special plane to deliver the payload: the Lancaster Bomber.

A new paper analyzes three decades of fatalities around the world and predicts how "superbugs" will affect human health in the future

Researchers say that the iconic painting's swirling sky lines up with Kolmogorov's theory of turbulence, suggesting that the artist was a careful observer of the world around him

Grizzly 399 became a celebrity of Grand Teton National Park in her lifetime. Now, her death has drawn attention to wildlife-vehicle collisions and how they might be reduced

The beloved reptile in Australia died last weekend and was thought to be up to 120 years old, though that age is only an estimate. Research on his bones might reveal a more exact number

This story and others have come to light during a project to translate and digitize a series of texts about archbishops in York, England

As Week 3 of the provincial election campaign begins, there are questions about how Nova Scotia's major political parties plan to combat the rising number of opioid overdose deaths. 

Loved ones, friends, and people from across the city have all come together to support each other at Pastel Rita, the café Jocelyn Després helped so many call home.

New Brunswick’s Court of Appeal has reserved judgment in the case of a man found guilty of criminal negligence in the death of Fredericton teenager in 2018.

A man from Calgary has been charged in the death of a worker after a 24-year-old woman sustained fatal injuries when a pickup truck crashed into a pizza restaurant in Fort McMurray. 

Sault Ste. Marie has the highest rate of opioid deaths in Ontario so far this year, according to new numbers from the province's coroner's office.

RCMP say a 23-year-old woman was found dead in a residence in central Manitoba on Tuesday. 

Details remain scarce surrounding the death of a Canada Border Services Agency (CBSA) officer at the Ambassador Bridge on Saturday. The border authority and union said an employee died by suicide while on the job on the Windsor, Ont., side of the border. 

Police said they had pulled their car over and exited the vehicle in order to help a turtle cross the street, something a close family member told CBC at the time came as no surprise. 

A 17-year-old Utah soccer player accused of killing a referee earlier this year pleaded guilty to third-degree felony homicide by assault.

The parents of a 16-year-old who died last fall from football-related brain trauma are suing the New York school districts he played for and the medical responders who tended to him the night he sustained his fatal injury.

OM workers in Central Asia minister to homeless people. Some people reject their help, but others find new life.

The final entry of Queen Elizabeth's private diary has been made public. During her record-breaking 70-year reign, the monarch, who died in 2022 at age 96, kept a private diary to take note of the events of the day and record her activities.

The final entry of Queen Elizabeth's private diary has been made public. During her record-breaking 70-year reign, the monarch, who died in 2022 at age 96, kept a private diary to take note of the events of the day and record her activities.

The DOJ’s Division of Civil Rights & Public Trust (DCRPT) has indicted a former Delaware Correctional Officer and K9 handler on three charges, including a felony, for recklessly confining and causing the death of a four-year-old law enforcement animal named Lux. “We find these stories so viscerally disturbing not only because we care for the […]

DOVER, DE (February 25, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware as of Thursday, Feb 24, 2022. COVID-19 Cases and Hospitalizations:  Total positive cases since March 11, 2020: 256,337  7-day average of new positive cases: 127, a decrease […]

 DOVER (April 12, 2022) – The Division of Public Health (DPH) is announcing the first flu-related death of the 2021-2022 flu season. The individual was a 54-year-old Kent County female infected with influenza A who died in early April. She had underlying health conditions and was not vaccinated. As of April 2, 2022, the most recent […]

Delawareans struggling with substance use disorder can call DHSS’ Division of Substance Abuse and Mental Health’s 24/7 Delaware Hope Line – a single point of contact where callers can connect to a variety of resources and information, including support from clinicians and peer specialists plus crisis assistance.